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Items: 1 to 20 of 156

1.
PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections
Ryan M. Shepard, Anghesom Ghebremedhin, Isaraphorn Pratumchai, Sally R. Robinson, Courtney Betts, Jingjing Hu, Roman Sasik, Kathleen M. Fisch, Jaroslav Zak, Hui Chen, Marc Paradise, Jason Rivera, Mohammad Amjad, Satoshi Uchiyama, Hideya Seo, Alejandro D. Campos, Denise Ann Dayao, Saul Tzipori, Cesar Piedra-Mora, Soumita Das, Farnaz Hasteh, Hana Russo, Xin Sun, Le Xu, Laura Crotty Alexander, Jason M. Duran, Mazen Odish, Victor Pretorius, Nell C. Kirchberger, Shao-ming Chin, Tami Von Schalscha, David Cheresh, John D. Morrey, Rossitza Alargova, Brenda O’Connell, Theodore A. Martinot, Sandip P. Patel, Victor Nizet, Amanda J. Martinot, Lisa M. Coussens, John R. Teijaro, Judith A. Varner
Sci Transl Med. Author manuscript; available in PMC 2024 Jul 25.
Published in final edited form as: Sci Transl Med. 2024 Jul 3; 16(754): eadi6887. Published online 2024 Jul 3. doi: 10.1126/scitranslmed.adi6887
PMCID:
PMC11272418
AbstractArticlePDF–4.7M
2.
Portrait of PTEN: Messages from mutant mice
Akira Suzuki, Toru Nakano, Tak Wah Mak, Takehiko Sasaki
Cancer Sci. 2008 Feb; 99(2): 209–213. Published online 2008 Jan 15. doi: 10.1111/j.1349-7006.2007.00670.x
PMCID:
PMC11158684
AbstractArticlePDF–188K
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma
Cristina Mastini, Marco Campisi, Enrico Patrucco, Giulia Mura, Antonio Ferreira, Carlotta Costa, Chiara Ambrogio, Giulia Germena, Cinzia Martinengo, Silvia Peola, Ines Mota, Elena Vissio, Luca Molinaro, Maddalena Arigoni, Martina Olivero, Raffaele Calogero, Nina Prokoph, Fabrizio Tabbò, Brent Shoji, Laurence Brugieres, Birgit Geoerger, Suzanne D. Turner, Carlos Cuesta-Mateos, Deborah D’Aliberti, Luca Mologni, Rocco Piazza, Carlo Gambacorti-Passerini, Giorgio G. Inghirami, Valeria Chiono, Roger D. Kamm, Emilio Hirsch, Raphael Koch, David M. Weinstock, Jon C. Aster, Claudia Voena, Roberto Chiarle
Sci Transl Med. Author manuscript; available in PMC 2024 Jun 28.
Published in final edited form as: Sci Transl Med. 2023 Jun 28; 15(702): eabo3826. Published online 2023 Jun 28. doi: 10.1126/scitranslmed.abo3826
PMCID:
PMC10804420
AbstractArticlePDF–1.6M
5.
Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ
Yu Sun, Kate Stenson, Maradumane L. Mohan, Manveen K. Gupta, Nick Wanner, Kewal Asosingh, Serpil Erzurum, Sathyamangla V. Naga Prasad
Circ Res. Author manuscript; available in PMC 2024 Mar 17.
Published in final edited form as: Circ Res. 2023 Mar 17; 132(6): 690–703. Published online 2023 Feb 13. doi: 10.1161/CIRCRESAHA.122.321735
PMCID:
PMC10023460
AbstractArticlePDF–1.2M
6.
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation and reduced inflammation in obstructive airway diseases
Alessandra Ghigo, Alessandra Murabito, Valentina Sala, Anna Rita Pisano, Serena Bertolini, Ambra Gianotti, Emanuela Caci, Alessio Montresor, Aiswarya Premchandar, Flora Pirozzi, Kai Ren, Angela Della Sala, Marco Mergiotti, Wito Richter, Eyleen de Poel, Michaela Matthey, Sara Caldrer, Rosa A. Cardone, Federica Civiletti, Andrea Costamagna, Nancy L. Quinney, Cosmin Butnarasu, Sonja Visentin, Maria Rosaria Ruggiero, Simona Baroni, Simonetta Geninatti Crich, Damien Ramel, Muriel Laffargue, Carlo G. Tocchetti, Renzo Levi, Marco Conti, Xiao-Yun Lu, Paola Melotti, Claudio Sorio, Virginia De Rose, Fabrizio Facchinetti, Vito Fanelli, Daniela Wenzel, Bernd K. Fleischmann, Marcus A. Mall, Jeffrey Beekman, Carlo Laudanna, Martina Gentzsch, Gergely L. Lukacs, Nicoletta Pedemonte, Emilio Hirsch
Sci Transl Med. Author manuscript; available in PMC 2023 Mar 30.
Published in final edited form as: Sci Transl Med. 2022 Mar 30; 14(638): eabl6328. Published online 2022 Mar 30. doi: 10.1126/scitranslmed.abl6328
PMCID:
PMC9869178
AbstractArticlePDF–2.4M
7.
PI3Kγ INHIBITION ALLEVIATES SYMPTOMS AND INCREASES AXON NUMBER IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MICE
H. LI, D. PARK, P. M. ABDUL-MUNEER, B. XU, H. WANG, B. XING, D. WU, S. LI
Neuroscience. Author manuscript; available in PMC 2022 Oct 3.
Published in final edited form as: Neuroscience. 2013 Dec 3; 253: 89–99. Published online 2013 Sep 3. doi: 10.1016/j.neuroscience.2013.08.051
PMCID:
PMC9529370
AbstractArticlePDF–1.5M
8.
Phosphoinositide 3 Kinase γ Plays a Critical Role in Acute Kidney Injury
Xiaogao Jin, Qinjun Chu, Liwei Sun, Melanie Tran, Yanlin Wang
Cells. 2022 Mar; 11(5): 772. Published online 2022 Feb 23. doi: 10.3390/cells11050772
PMCID:
PMC8909888
AbstractArticlePDF–1.9M
9.
PI3Kγ Mediates Microglial Proliferation and Cell Viability via ROS
Caroline Schmidt, Nadine Schneble-Löhnert, Trim Lajqi, Reinhard Wetzker, Jörg P. Müller, Reinhard Bauer
Cells. 2021 Oct; 10(10): 2534. Published online 2021 Sep 24. doi: 10.3390/cells10102534
PMCID:
PMC8534080
AbstractArticlePDF–1.4M
10.
The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis
Flavian Thelen, Stefanie Wissmann, Nora Ruef, Jens V. Stein
Front Immunol. 2021; 12: 716405. Published online 2021 Sep 9. doi: 10.3389/fimmu.2021.716405
PMCID:
PMC8458560
AbstractArticlePDF–1001K
11.
ACTH treatment promotes murine cardiac allograft acceptance
Jing Zhao, Liwei Jiang, Mayuko Uehara, Naima Banouni, Basmah S. Al Dulaijan, Jamil Azzi, Takaharu Ichimura, Xiaofei Li, Petr Jarolim, Paolo Fiorina, Stefan G. Tullius, Joren C. Madsen, Vivek Kasinath, Reza Abdi
JCI Insight. 2021 Jul 8; 6(13): e143385. Published online 2021 Jul 8. doi: 10.1172/jci.insight.143385
PMCID:
PMC8410061
AbstractArticlePDF–12M
12.
Biophysical and structural characterization of novel RAS-binding domains (RBDs) of PI3Kα and PI3Kγ
Nicholas G. Martinez, David F. Thieker, Leiah M. Carey, Juhi A. Rasquinha, Samantha K. Kistler, Brian A. Kuhlman, Sharon L. Campbell
J Mol Biol. Author manuscript; available in PMC 2022 Apr 16.
Published in final edited form as: J Mol Biol. 2021 Apr 16; 433(8): 166838. Published online 2021 Feb 1. doi: 10.1016/j.jmb.2021.166838
PMCID:
PMC8005443
AbstractArticlePDF–1.4M
13.
The Role of the Pathogen Dose and PI3Kγ in Immunometabolic Reprogramming of Microglia for Innate Immune Memory
Trim Lajqi, Christian Marx, Hannes Hudalla, Fabienne Haas, Silke Große, Zhao-Qi Wang, Regine Heller, Michael Bauer, Reinhard Wetzker, Reinhard Bauer
Int J Mol Sci. 2021 Mar; 22(5): 2578. Published online 2021 Mar 4. doi: 10.3390/ijms22052578
PMCID:
PMC7961448
AbstractArticlePDF–3.3M
14.
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1
Alberta Iacono, Andrea Pompa, Francesca De Marchis, Eleonora Panfili, Francesco A Greco, Alice Coletti, Ciriana Orabona, Claudia Volpi, Maria L Belladonna, Giada Mondanelli, Elisa Albini, Carmine Vacca, Marco Gargaro, Francesca Fallarino, Roberta Bianchi, Carine De Marcos Lousa, Emilia MC Mazza, Silvio Bicciato, Elisa Proietti, Francesca Milano, Maria P Martelli, Ioana M Iamandii, Mariona Graupera Garcia‐Mila, Judith Llena Sopena, Phillip Hawkins, Sabine Suire, Klaus Okkenhaug, Anne‐Katrien Stark, Fabio Grassi, Michele Bellucci, Paolo Puccetti, Laura Santambrogio, Antonio Macchiarulo, Ursula Grohmann, Maria T Pallotta
EMBO Rep. 2020 Dec 3; 21(12): e49756. Published online 2020 Nov 7. doi: 10.15252/embr.201949756
PMCID:
PMC7726814
AbstractArticlePDF–5.6M
15.
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils
Natalie K. Rynkiewicz, Karen E. Anderson, Sabine Suire, Daniel M. Collins, Eleftherios Karanasios, Oscar Vadas, Roger Williams, David Oxley, Jonathan Clark, Len R. Stephens, Phillip T. Hawkins
Sci Signal. Author manuscript; available in PMC 2021 May 3.
Published in final edited form as: Sci Signal. 2020 Nov 3; 13(656): eaaz4003. Published online 2020 Nov 3. doi: 10.1126/scisignal.aaz4003
PMCID:
PMC7610408
AbstractArticlePDF–1.9M
16.
Impact of ambient temperature on inflammation-induced encephalopathy in endotoxemic mice—role of phosphoinositide 3-kinase gamma
Guang-Ping Lang, Bernadin Ndongson-Dongmo, Trim Lajqi, Michael Brodhun, Yingying Han, Reinhard Wetzker, Martin G. Frasch, Reinhard Bauer
J Neuroinflammation. 2020; 17: 292. Published online 2020 Oct 7. doi: 10.1186/s12974-020-01954-7
PMCID:
PMC7541275
AbstractArticlePDF–1.8M
17.
Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis
Anne J. Beer, David Hertz, Eric Seemann, Martina Beretta, Martin Westermann, Reinhard Bauer, Michael Bauer, Michael M. Kessels, Britta Qualmann
Sci Rep. 2020; 10: 13110. Published online 2020 Aug 4. doi: 10.1038/s41598-020-69901-3
PMCID:
PMC7403153
AbstractArticlePDF–7.0M
18.
Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation
Anne-Katrien Stark, Elizabeth C. M. Davenport, Daniel T. Patton, Cheryl L. Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A. Garden, Klaus Okkenhaug
J Immunol. 2020 Jul 1; 205(1): 78–89. Published online 2020 May 15. doi: 10.4049/jimmunol.2000043
PMCID:
PMC7311201
AbstractArticlePDF–1.8M
19.
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation
Louise van der Weyden, Agnieszka Swiatkowska, Vivek Iyer, Anneliese O. Speak, David J. Adams
G3 (Bethesda) 2020 Jun; 10(6): 1869–1877. Published online 2020 Apr 3. doi: 10.1534/g3.120.401128
PMCID:
PMC7263671
AbstractArticlePDF–1.0M
20.
Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation
Lisa M. Grove, Maradumane L. Mohan, Susamma Abraham, Rachel G. Scheraga, Brian D. Southern, James F. Crish, Sathyamangla V. Naga Prasad, Mitchell A. Olman
Sci Signal. Author manuscript; available in PMC 2020 Feb 5.
Published in final edited form as: Sci Signal. 2019 Nov 12; 12(607): eaau1533. Published online 2019 Nov 12. doi: 10.1126/scisignal.aau1533
PMCID:
PMC7001959
AbstractArticlePDF–2.7M

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