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Select item 110956321.

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability

Florence Authier, Nina Ondruskova, Andrew T. Ferenbach, Alison D. McNeilly, Daan M. F. van Aalten

Dis Model Mech. 2024 Apr 1; 17(4): dmm050671. Published online 2024 Apr 25. doi: 10.1242/dmm.050671

PMCID:: PMC11095632

Abstract Article

Select item 109817002.

Paternal DDT exposure induces sex-specific programming of fetal growth, placenta development and offspring’s health phenotypes in a mouse model

Elaine Chen, Raquel Santana da Cruz, Aallya Nascimento, Meghali Joshi, Duane Gischewski Pereira, Odalys Dominguez, Gabriela Fernandes, Megan Smith, Sara P. C. Paiva, Sonia de Assis

Sci Rep. 2024; 14: 7567. Published online 2024 Mar 30. doi: 10.1038/s41598-024-58176-7

PMCID:: PMC10981700

Abstract Article PDF–3.0M

Select item 107112263.

Cardioprotective O-GlcNAc signaling is elevated in murine female hearts via enhanced O-GlcNAc transferase activity

Bhargavi Narayanan, Prithvi Sinha, Roger Henry, Russell A. Reeves, Nazareno Paolocci, Mark J. Kohr, Natasha E. Zachara

J Biol Chem. 2023 Dec; 299(12): 105447. Published online 2023 Nov 8. doi: 10.1016/j.jbc.2023.105447

PMCID:: PMC10711226

Abstract Article PDF–2.4M

Select item 106264434.

Nutritional and metabolic control of germ cell fate through O‐GlcNAc regulation

Yohei Hayashi, Yukiko Tando, Yumi Ito‐Matsuoka, Kaho Ikuta, Asuka Takehara, Katsutaro Morino, Hiroshi Maegawa, Yasuhisa Matsui

EMBO Rep. 2023 Nov; 24(11): e56845. Published online 2023 Oct 16. doi: 10.15252/embr.202356845

PMCID:: PMC10626443

Abstract Article PDF–2.9M

Select item 102863675.

Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway

Xiaoxue Dong, Liqi Shu, Jinyu Zhang, Xu Yang, Xuejun Cheng, Xingsen Zhao, Wenzheng Qu, Qiang Zhu, Yikai Shou, Guoping Peng, Binggui Sun, Wen Yi, Qiang Shu, Xuekun Li

J Neuroinflammation. 2023; 20: 146. Published online 2023 Jun 22. doi: 10.1186/s12974-023-02824-8

PMCID:: PMC10286367

Abstract Article PDF–3.4M

Select item 101787796.

Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoE^-/- Mice In Vivo

Saugat Khanal, Neha Bhavnani, Amy Mathias, Jason Lallo, Shreya Gupta, Vahagn Ohanyan, Jessica M. Ferrell, Priya Raman

Int J Mol Sci. 2023 May; 24(9): 7899. Published online 2023 Apr 26. doi: 10.3390/ijms24097899

PMCID:: PMC10178779

Abstract Article PDF–11M

Select item 100650787.

O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission

Jun Fan, Fang Guo, Ran Mo, Liang-Yu Chen, Jia-Wen Mo, Cheng-Lin Lu, Jing Ren, Qiu-Ling Zhong, Xiao-Jing Kuang, You-Lu Wen, Ting-Ting Gu, Jin-Ming Liu, Shu-Ji Li, Ying-Ying Fang, Cunyou Zhao, Tian-Ming Gao, Xiong Cao

J Clin Invest. 2023 Apr 3; 133(7): e160016. Published online 2023 Apr 3. doi: 10.1172/JCI160016

PMCID:: PMC10065078

Abstract Article PDF–4.3M

Select item 100326558.

O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors

Zengdi Zhang, Zan Huang, Mohamed Awad, Mohammed Elsalanty, James Cray, Lauren E Ball, Jason C Maynard, Alma L Burlingame, Hu Zeng, Kim C Mansky, Hai-Bin Ruan

eLife. 2023; 12: e85464. Published online 2023 Mar 2. doi: 10.7554/eLife.85464

PMCID:: PMC10032655

Abstract Article PDF–15M

Select item 99326569.

Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion

Alicia Wong, Samantha Pritchard, Mackenzie Moore, Brian Akhaphong, Nandini Avula, Megan Beetch, Yoshio Fujitani, Emilyn U. Alejandro

J Biol Chem. 2023 Feb; 299(2): 102878. Published online 2023 Jan 6. doi: 10.1016/j.jbc.2023.102878

PMCID:: PMC9932656

Abstract Article PDF–3.4M

Select item 973790010.

O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis

Yu Cao, Meng Zhang, Ye Li, Jingjing Lu, Wanhui Zhou, Xiaoshuang Li, Hao Shi, Bin Xu, Shize Li

Int J Mol Sci. 2022 Dec; 23(23): 14520. Published online 2022 Nov 22. doi: 10.3390/ijms232314520

PMCID:: PMC9737900

Abstract Article PDF–5.1M

Select item 943282811.

Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity

Qi Wang, Bichen Zhang, Bernardo Stutz, Zhong-Wu Liu, Tamas L. Horvath, Xiaoyong Yang

Sci Adv. 2022 Sep; 8(35): eabn8092. Published online 2022 Aug 31. doi: 10.1126/sciadv.abn8092

PMCID:: PMC9432828

Abstract Article PDF–8.2M

Select item 940746512.

O-GlcNAcylation promotes cerebellum development and medulloblastoma oncogenesis via SHH signaling

Liping Chen, Ying Li, Zhihong Song, Saisai Xue, Fengjiao Liu, Xin Chang, Yan Wu, Xiaotao Duan, Haitao Wu

Proc Natl Acad Sci U S A. 2022 Aug 23; 119(34): e2202821119. Published online 2022 Aug 15. doi: 10.1073/pnas.2202821119

PMCID:: PMC9407465

Abstract Article PDF–3.2M

Select item 930495213.

An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism

Zengdi Zhang, Oscar C. Salgado, Bing Liu, Zahra Moazzami, Kristin A. Hogquist, Michael A. Farrar, Hai-Bin Ruan

Front Immunol. 2022; 13: 874863. Published online 2022 Jul 8. doi: 10.3389/fimmu.2022.874863

PMCID:: PMC9304952

Abstract Article PDF–8.3M

Select item 910949914.

Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C

Ming Zhao, Kaiqun Ren, Xiwen Xiong, Yue Xin, Yujie Zou, Jason C. Maynard, Angela Kim, Alexander P. Battist, Navya Koneripalli, Yusu Wang, Qianyue Chen, Ruyue Xin, Chenyan Yang, Rong Huang, Jiahui Yu, Zan Huang, Zengdi Zhang, Haiguang Wang, Daoyuan Wang, Yihui Xiao, Oscar C. Salgado, Nicholas N. Jarjour, Kristin A Hogquist, Xavier S. Revelo, Alma L. Burlingame, Xiang Gao, Jakob von Moltke, Zhaoyu Lin, Hai-Bin Ruan

Immunity. Author manuscript; available in PMC 2023 Apr 12.

Published in final edited form as: Immunity. 2022 Apr 12; 55(4): 623–638.e5. Published online 2022 Apr 5. doi: 10.1016/j.immuni.2022.03.009

Correction in:: Immunity. 2022 Jul 12; 55(7): 1327.

PMCID:: PMC9109499

Abstract Article PDF–3.3M

Select item 890262115.

Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine

Kimihiro Nishimura, Yukihiro Fujita, Shogo Ida, Tsuyoshi Yanagimachi, Natsuko Ohashi, Kiyoto Nishi, Atsushi Nishida, Yasumasa Iwasaki, Katsutaro Morino, Satoshi Ugi, Eiichiro Nishi, Akira Andoh, Hiroshi Maegawa

Mol Metab. 2022 May; 59: 101458. Published online 2022 Feb 19. doi: 10.1016/j.molmet.2022.101458

PMCID:: PMC8902621

Abstract Article PDF–4.5M

Select item 853482316.

Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice

Ramkumar Mohan, Seokwon Jo, Elina Da Sol Chung, Eunice Oribamise, Amber Lockridge, Juan E. Abrahante-Lloréns, Hai-Bin Ruan, Xiao-Yong Yang, Emilyn U. Alejandro

Cells. 2021 Oct; 10(10): 2801. Published online 2021 Oct 19. doi: 10.3390/cells10102801