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Select item 111910061.

Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3

Jiacheng Li, Ruopu Li, Xue Bai, Wenlong Zhang, Yu Nie, Shengshou Hu

Chin Med J (Engl) 2024 Jun 5; 137(11): 1351–1359. Published online 2024 May 9. doi: 10.1097/CM9.0000000000003088

PMCID:: PMC11191006

Abstract Article PDF–5.4M

Select item 91374522.

Excess Neuropeptides in Lung Signal through Endothelial Cells to Impair Gas Exchange

Jinhao Xu, Le Xu, Pengfei Sui, Jiyuan Chen, Esteban A. Moya, Patrick Hume, William J. Janssen, Jason M. Duran, Patricia Thistlethwaite, Aaron Carlin, Peter Gulleman, Brandon Banaschewski, Mary Kate Goldy, Jason X.-J. Yuan, Atul Malhotra, Gloria Pryhuber, Laura Crotty-Alexander, Gail Deutsch, Lisa R. Young, Xin Sun

Dev Cell. Author manuscript; available in PMC 2023 Apr 11.

Published in final edited form as: Dev Cell. 2022 Apr 11; 57(7): 839–853.e6. Published online 2022 Mar 17. doi: 10.1016/j.devcel.2022.02.023

PMCID:: PMC9137452

Abstract Article PDF–2.9M

Select item 91332313.

Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the cartilage hypertrophic zone, but it does not trigger ectopic differentiation in immature chondrocytes

Nicole Bell, Sanket Bhagat, Shanmugam Muruganandan, Ryunhyung Kim, Kailing Ho, Rachel Pierce, Elena Kozhemyakina, Andrew B. Lassar, Laura Gamer, Vicki Rosen, Andreia M. Ionescu

Bone. Author manuscript; available in PMC 2023 Jul 1.

Published in final edited form as: Bone. 2022 Jul; 160: 116418. Published online 2022 Apr 6. doi: 10.1016/j.bone.2022.116418

PMCID:: PMC9133231

Abstract Article PDF–3.8M

Select item 82537614.

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver

Najla AlOgayil, Klara Bauermeister, Jose Hector Galvez, Varun S. Venkatesh, Qinwei Kim-wee Zhuang, Matthew L. Chang, Rachel A. Davey, Jeffrey D. Zajac, Kinuyo Ida, Akihide Kamiya, Teruko Taketo, Guillaume Bourque, Anna K. Naumova

Sci Rep. 2021; 11: 13766. Published online 2021 Jul 2. doi: 10.1038/s41598-021-93216-6

Correction in:: Sci Rep. 2021; 11: 22975.

PMCID:: PMC8253761

Abstract Article PDF–7.9M

Select item 81299115.

FoxA-dependent DNA demethylation initiates epigenetic control of cellular stability

Yitzhak Reizel, Ashleigh Morgan, Long Gao, Jonathan Schug, Sarmistha Mukherjee, Meilín M. Fernández García, Greg Donahue, Joseph A. Baur, Kenneth S Zaret, Klaus H Kaestner

Dev Cell. Author manuscript; available in PMC 2022 Mar 8.

Published in final edited form as: Dev Cell. 2021 Mar 8; 56(5): 602–612.e4. Published online 2021 Feb 25. doi: 10.1016/j.devcel.2021.02.005

PMCID:: PMC8129911

Abstract Article PDF–1.7M

Select item 73978526.

Collapse of the hepatic gene regulatory network in the absence of FoxA factors

Yitzhak Reizel, Ashleigh Morgan, Long Gao, Yemin Lan, Elisabetta Manduchi, Eric L. Waite, Amber W. Wang, Andrew Wells, Klaus H. Kaestner

Genes Dev. 2020 Aug 1; 34(15-16): 1039–1050. doi: 10.1101/gad.337691.120

PMCID:: PMC7397852

Abstract Article PDF–5.6M

Select item 70783857.

Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Abir Yamak, Dongjian Hu, Nikhil Mittal, Jan W. Buikema, Sheraz Ditta, Pierre G. Lutz, Christel Moog-Lutz, Patrick T. Ellinor, Ibrahim J. Domian

iScience. 2020 Mar 27; 23(3): 100959. Published online 2020 Mar 4. doi: 10.1016/j.isci.2020.100959

PMCID:: PMC7078385

Abstract Article PDF–14M

Select item 69260518.

WNT/RYK signaling restricts goblet cell differentiation during lung development and repair

Hyun-Taek Kim, Wenguang Yin, Yuko Nakamichi, Paolo Panza, Beate Grohmann, Carmen Buettner, Stefan Guenther, Clemens Ruppert, Yasuhiro Kobayashi, Andreas Guenther, Didier Y. R. Stainier

Proc Natl Acad Sci U S A. 2019 Dec 17; 116(51): 25697–25706. Published online 2019 Nov 27. doi: 10.1073/pnas.1911071116

PMCID:: PMC6926051

Abstract Article PDF–2.9M

Select item 67242219.

The emergent landscape of the mouse gut endoderm at single-cell resolution

Sonja Nowotschin, Manu Setty, Ying-Yi Kuo, Vincent Liu, Vidur Garg, Roshan Sharma, Claire S. Simon, Nestor Saiz, Rui Gardner, Stéphane C. Boutet, Deanna M. Church, Pamela A. Hoodless, Anna-Katerina Hadjantonakis, Dana Pe’er

Nature. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Nature. 2019 May; 569(7756): 361–367. Published online 2019 Apr 8. doi: 10.1038/s41586-019-1127-1

PMCID:: PMC6724221

Abstract Article PDF–6.5M

Select item 635149910.

A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis

Matthew R. Jones, Salma Dilai, Arun Lingampally, Cho-Ming Chao, Soula Danopoulos, Gianni Carraro, Regina Mukhametshina, Jochen Wilhelm, Eveline Baumgart-Vogt, Denise Al Alam, Chengshui Chen, Parviz Minoo, Jin San Zhang, Saverio Bellusci

Front Genet. 2018; 9: 746. Published online 2019 Jan 23. doi: 10.3389/fgene.2018.00746

PMCID:: PMC6351499

Abstract Article PDF–5.6M

Select item 562653611.

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation

Jiayi Yao, Pierre J. Guihard, Xiuju Wu, Ana M. Blazquez-Medela, Melissa J. Spencer, Medet Jumabay, Peter Tontonoz, Alan M. Fogelman, Kristina I. Boström, Yucheng Yao

J Cell Biol. 2017 Oct 2; 216(10): 3369–3385. doi: 10.1083/jcb.201612122

PMCID:: PMC5626536

Abstract Article PDF–3.8M

Select item 481366812.

Functional screen identifies regulators of murine hematopoietic stem cell repopulation

Per Holmfeldt, Miguel Ganuza, Himangi Marathe, Bing He, Trent Hall, Guolian Kang, Joseph Moen, Jennifer Pardieck, Angelica C. Saulsberry, Alba Cico, Ludovic Gaut, Daniel McGoldrick, David Finkelstein, Kai Tan, Shannon McKinney-Freeman

J Exp Med. 2016 Mar 7; 213(3): 433–449. doi: 10.1084/jem.20150806

Correction in:: J Exp Med. 2016 Oct 17; 213(11): 2525.

PMCID:: PMC4813668

Abstract Article PDF–3.0M

Select item 481276813.

Forkhead box A3 mediates glucocorticoid receptor function in adipose tissue

Xinran Ma, Lingyan Xu, Elisabetta Mueller

Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12): 3377–3382. Published online 2016 Mar 8. doi: 10.1073/pnas.1601281113

PMCID:: PMC4812768

Abstract Article PDF–1.4M

Select item 442197914.

A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation

Kirk J. Wangensteen, Sophia Zhang, Linda E. Greenbaum, Klaus H. Kaestner

Genes Dev. 2015 May 1; 29(9): 904–909. doi: 10.1101/gad.258855.115

PMCID:: PMC4421979

Abstract Article PDF–327K

Select item 431955915.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 419179416.

Role of forkhead box protein A3 in age-associated metabolic decline

Xinran Ma, Lingyan Xu, Oksana Gavrilova, Elisabetta Mueller

Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39): 14289–14294. Published online 2014 Sep 15. doi: 10.1073/pnas.1407640111

PMCID:: PMC4191794

Abstract Article PDF–1.1M

Select item 397773117.

Foxa3 Induces Goblet Cell Metaplasia and Inhibits Innate Antiviral Immunity

Gang Chen, Thomas R. Korfhagen, Christopher L. Karp, Soren Impey, Yan Xu, Scott H. Randell, Joseph Kitzmiller, Yutaka Maeda, Hans Michael Haitchi, Anusha Sridharan, Albert P. Senft, Jeffrey A. Whitsett

Am J Respir Crit Care Med. 2014 Feb 1; 189(3): 301–313. Published online 2014 Feb 1. doi: 10.1164/rccm.201306-1181OC

PMCID:: PMC3977731

Abstract Article PDF–3.2M

Select item 375385618.

The Winged Helix Transcription Factor Foxa3 Regulates Adipocyte Differentiation and Depot-Selective Fat Tissue Expansion

Lingyan Xu, Valentine Panel, Xinran Ma, Chen Du, Lynne Hugendubler, Oksana Gavrilova, Alice Liu, Tracey McLaughlin, Klaus H. Kaestner, Elisabetta Mueller

Mol Cell Biol. 2013 Sep; 33(17): 3392–3399. doi: 10.1128/MCB.00244-13

PMCID:: PMC3753856

Abstract Article PDF–2.1M

Select item 359478919.

Protein or Amino Acid Deprivation Differentially Regulates the Hepatic Forkhead Box Protein A (FOXA) Genes Through an Activating Transcription Factor-4–Independent Pathway

Nan Su, Michelle M. Thiaville, Keytam Awad, Altin Gjymishka, Jason O. Brant, Thomas P. Yang, Michael S. Kilberg

Hepatology. Author manuscript; available in PMC 2013 Mar 12.

Published in final edited form as: Hepatology. 2009 Jul; 50(1): 282–290. doi: 10.1002/hep.22971

PMCID:: PMC3594789

Abstract Article PDF–4.6M

Select item 350729320.

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways

Olivier Boucherat, Jamila Chakir, Lucie Jeannotte

Biol Open. 2012 Jul 15; 1(7): 677–691. Published online 2012 May 29. doi: 10.1242/bio.20121701

PMCID:: PMC3507293

Abstract Article PDF–11M

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