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Select item 112224141.

KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2

Shilei Bi, Lijun Huang, Yongjie Chen, Zhenhua Hu, Shanze Li, Yifan Wang, Baoying Huang, Lizi Zhang, Yuanyuan Huang, Beibei Dai, Lili Du, Zhaowei Tu, Yijing Wang, Dan Xu, Xiaotong Xu, Wen Sun, Julia Kzhyshkowska, Haibin Wang, Dunjin Chen, Fengchao Wang, Shuang Zhang

Nat Commun. 2024; 15: 5602. Published online 2024 Jul 3. doi: 10.1038/s41467-024-49930-6

PMCID:: PMC11222414

Abstract Article PDF–5.9M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106873393.

Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions

Xinghong Guo, Kai Liang, Longqing Xia, Xu Zhang, Jinbo Liu, Chuan Wang, Jinquan Li, Xiangzhi Li, Xinguo Hou, Li Chen

iScience. 2023 Dec 15; 26(12): 108446. Published online 2023 Nov 14. doi: 10.1016/j.isci.2023.108446

PMCID:: PMC10687339

Abstract Article PDF–9.8M

Select item 103620624.

MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters

Dongmei Wang, Haimin Li, Navdeep S. Chandel, Yali Dou, Rui Yi

Nat Commun. 2023; 14: 4404. Published online 2023 Jul 21. doi: 10.1038/s41467-023-40108-0

PMCID:: PMC10362062

Abstract Article PDF–9.3M

Select item 84238205.

MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness

Yahui Liu, Juan Du, Xinnan Liu, Lingbiao Wang, Yichao Han, Chunrong Huang, Rui Liang, Fang Zheng, Guochao Shi, Bin Li

Signal Transduct Target Ther. 2021; 6: 321. Published online 2021 Sep 8. doi: 10.1038/s41392-021-00667-4

PMCID:: PMC8423820

Article PDF–1.0M

Select item 83462116.

Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells

Cecilia Pessoa Rodrigues, Asifa Akhtar

Sci Adv. 2021 Aug; 7(32): eabi5987. Published online 2021 Aug 6. doi: 10.1126/sciadv.abi5987

PMCID:: PMC8346211

Abstract Article PDF–3.9M

Select item 79485727.

Dysregulation of intercellular signaling by MOF deletion leads to liver injury

Hongwei Lei, Aaron D. denDekker, Guobing Li, Zhiguo Zhang, Liang Sha, Matthew A. Schaller, Steven L. Kunkel, Liangyou Rui, Kaixiong Tao, Yali Dou

J Biol Chem. 2021 Jan-Jun; 296: 100235. Published online 2021 Jan 7. doi: 10.1074/jbc.RA120.016079

PMCID:: PMC7948572

Abstract Article PDF–4.4M

Select item 73145558.

Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate

Cecilia Pessoa Rodrigues, Josip Stefan Herman, Benjamin Herquel, Claudia Isabelle Keller Valsecchi, Thomas Stehle, Dominic Grün, Asifa Akhtar

Sci Adv. 2020 May; 6(21): eaaz4815. Published online 2020 May 20. doi: 10.1126/sciadv.aaz4815

PMCID:: PMC7314555

Abstract Article PDF–3.2M

Select item 72696009.

Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability

Lin Li, Mohammad Ghorbani, Monika Weisz-Hubshman, Justine Rousseau, Isabelle Thiffault, Rhonda E. Schnur, Catherine Breen, Renske Oegema, Marjan M.M. Weiss, Quinten Waisfisz, Sara Welner, Helen Kingston, Jordan A. Hills, Elles M.J. Boon, Lina Basel-Salmon, Osnat Konen, Hadassa Goldberg-Stern, Lily Bazak, Shay Tzur, Jianliang Jin, Xiuli Bi, Michael Bruccoleri, Kirsty McWalter, Megan T. Cho, Maria Scarano, G. Bradley Schaefer, Susan S. Brooks, Susan Starling Hughes, K.L.I. van Gassen, Johanna M. van Hagen, Tej K. Pandita, Pankaj B. Agrawal, Philippe M. Campeau, Xiang-Jiao Yang

J Clin Invest. 2020 Mar 2; 130(3): 1431–1445. Published online 2020 Feb 4. doi: 10.1172/JCI131145

PMCID:: PMC7269600

Abstract Article PDF–7.0M

Select item 714138810.

TNF-α regulates diabetic macrophage function through the histone acetyltransferase MOF

Aaron D. denDekker, Frank M. Davis, Amrita D. Joshi, Sonya J. Wolf, Ronald Allen, Jay Lipinski, Brenda Nguyen, Joseph Kirma, Dylan Nycz, Jennifer Bermick, Bethany B. Moore, Johann E. Gudjonsson, Steven L. Kunkel, Katherine A. Gallagher

JCI Insight. 2020 Mar 12; 5(5): e132306. Published online 2020 Mar 12. doi: 10.1172/jci.insight.132306

PMCID:: PMC7141388

Abstract Article PDF–1.9M

Select item 653458211.

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

Yi Zhang, Younghoon Jang, Ji-Eun Lee, JaeWoo Ahn, Longxia Xu, Michael R. Holden, Evan M. Cornett, Krzysztof Krajewski, Brianna J. Klein, Shu-Ping Wang, Yali Dou, Robert G. Roeder, Brian D. Strahl, Scott B. Rothbart, Xiaobing Shi, Kai Ge, Tatiana G. Kutateladze

Nat Commun. 2019; 10: 2314. Published online 2019 May 24. doi: 10.1038/s41467-019-10324-8

PMCID:: PMC6534582

Abstract Article PDF–3.2M

Select item 644688012.

KAT8 selectively inhibits antiviral immunity by acetylating IRF3

Wanwan Huai, Xingguang Liu, Chunmei Wang, Yunkai Zhang, Xi Chen, Xiang Chen, Sheng Xu, Tim Thomas, Nan Li, Xuetao Cao

J Exp Med. 2019 Apr 1; 216(4): 772–785. Published online 2019 Mar 6. doi: 10.1084/jem.20181773

Correction in:: J Exp Med. 2019 Apr 1; 216(4): 1001.

PMCID:: PMC6446880

Abstract Article PDF–2.9M

Select item 601981913.

MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice

Hanwei Jiang, Qian Gao, Wei Zheng, Shi Yin, Liu Wang, Liangwen Zhong, Asim Ali, Teka Khan, Qiaomei Hao, Hui Fang, Xiaoling Sun, Peng Xu, Tej K. Pandita, Xiaohua Jiang, Qinghua Shi

PLoS Genet. 2018 May; 14(5): e1007300. Published online 2018 May 24. doi: 10.1371/journal.pgen.1007300

PMCID:: PMC6019819

Abstract Article PDF–29M

Select item 550129314.

Histone acetyltransferase activity of MOF is required for MLL-AF9 leukemogenesis

Daria G. Valerio, Haiming Xu, Chun-Wei Chen, Takayuki Hoshii, Meghan E. Eisold, Christopher Delaney, Monica Cusan, Aniruddha J. Deshpande, Chun-Hao Huang, Amaia Lujambio, George Zheng, Johannes Zuber, Tej K. Pandita, Scott W. Lowe, Scott A. Armstrong

Cancer Res. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Cancer Res. 2017 Apr 1; 77(7): 1753–1762. Published online 2017 Feb 15. doi: 10.1158/0008-5472.CAN-16-2374

PMCID:: PMC5501293

Abstract Article PDF–1.6M

Select item 548299315.

Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels

Shi Yin, Xiaohua Jiang, Hanwei Jiang, Qian Gao, Fang Wang, Suixing Fan, Teka Khan, Nazish Jabeen, Manan Khan, Asim Ali, Peng Xu, Tej K. Pandita, Heng-Yu Fan, Yuanwei Zhang, Qinghua Shi

Development. 2017 Jun 15; 144(12): 2165–2174. doi: 10.1242/dev.149518

PMCID:: PMC5482993

Abstract Article

Select item 546946316.

PEG3 control on the mammalian MSL complex

An Ye, Hana Kim, Joomyeong Kim

PLoS One. 2017; 12(6): e0178363. Published online 2017 Jun 13. doi: 10.1371/journal.pone.0178363

PMCID:: PMC5469463

Abstract Article PDF–4.0M

Select item 521626417.

Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice

Daria G. Valerio, Haiming Xu, Meghan E. Eisold, Carolien M. Woolthuis, Tej K. Pandita, Scott A. Armstrong

Blood. 2017 Jan 5; 129(1): 48–59. Prepublished online 2016 Nov 8. doi: 10.1182/blood-2016-05-714568

PMCID:: PMC5216264

Abstract Article

Select item 502989018.

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis

Ryusuke Nakajima, Hideyuki Okano, Toshiaki Noce

PLoS One. 2016; 11(9): e0163466. Published online 2016 Sep 20. doi: 10.1371/journal.pone.0163466

PMCID:: PMC5029890

Abstract Article PDF–4.6M

Select item 489363419.

MOF maintains transcriptional programs regulating cellular stress response

B N Sheikh, W Bechtel-Walz, J Lucci, O Karpiuk, I Hild, B Hartleben, J Vornweg, M Helmstädter, A H Sahyoun, V Bhardwaj, T Stehle, S Diehl, O Kretz, A K Voss, T Thomas, T Manke, T B Huber, A Akhtar

Oncogene. 2016 May; 35(21): 2698–2710. Published online 2015 Sep 21. doi: 10.1038/onc.2015.335

PMCID:: PMC4893634

Abstract Article PDF–3.6M

Select item 441684020.

The Chromatin Regulator Brpf1 Regulates Embryo Development and Cell Proliferation

Linya You, Kezhi Yan, Jinfeng Zou, Hong Zhao, Nicholas R. Bertos, Morag Park, Edwin Wang, Xiang-Jiao Yang

J Biol Chem. 2015 May 1; 290(18): 11349–11364. Published online 2015 Mar 15. doi: 10.1074/jbc.M115.643189

PMCID:: PMC4416840

Abstract Article PDF–7.8M

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