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Select item 112242691.

SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis

Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, Markus Seeliger, Cheng-Kui Qu, Armelle Yart, Maria I. Kontaridis, Kiran Mahajan, Nupam P. Mahajan

Nat Commun. 2024; 15: 5629. Published online 2024 Jul 4. doi: 10.1038/s41467-024-49978-4

PMCID:: PMC11224269

Abstract Article PDF–2.1M

Select item 111903442.

Developmental effect of RASopathy mutations on neuronal network activity on a chip

Eva-Maria Weiss, Debarpan Guhathakurta, Aneta Petrušková, Verena Hundrup, Martin Zenker, Anna Fejtová

Front Cell Neurosci. 2024; 18: 1388409. Published online 2024 Jun 7. doi: 10.3389/fncel.2024.1388409

PMCID:: PMC11190344

Abstract Article PDF–2.2M

Select item 109870403.

Deficiency of the Src homology phosphatase 2 in podocytes is associated with renoprotective effects in mice under hyperglycemia

Ming-Fo Hsu, Yoshihiro Ito, Maryam Afkarian, Fawaz G. Haj

Cell Mol Life Sci. Author manuscript; available in PMC 2024 Apr 2.

Published in final edited form as: Cell Mol Life Sci. 2022 Sep 14; 79(10): 516. Published online 2022 Sep 14. doi: 10.1007/s00018-022-04517-6

PMCID:: PMC10987040

Abstract Article PDF–2.9M

Select item 109686894.

The low expression of miR-155 promotes the expression of SHP2 by inhibiting the activation of the ERK1/2 pathway and improves cell pyroptosis induced by I/R in mice

Mengru Liu, Dongliang Fu, Tong Gao, Hong Jiang, Peng Yang, Xianlun Li

Aging (Albany NY) 2024 Mar 15; 16(5): 4778–4788. Published online 2024 Mar 6. doi: 10.18632/aging.205631

PMCID:: PMC10968689

Abstract Article PDF–1.4M

Select item 107560875.

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation

Qian Gao, Yonggang Lu, Weiling Zhou

Aging (Albany NY) 2023 Dec 15; 15(23): 14323–14332. Published online 2023 Dec 13. doi: 10.18632/aging.205305

PMCID:: PMC10756087

Abstract Article PDF–1.0M

Select item 106460726.

Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution

Meng Liu, Mengjun Ji, Jianghong Cheng, Yingzhe Li, Yingpu Tian, Hui Zhao, Yang Wang, Sijing Zhu, Leilei Zhang, Xinmei Xu, Gen-Sheng Feng, Xiaohuan Liang, Haili Bao, Yedong Tang, Shuangbo Kong, Jinhua Lu, Haibin Wang, Zhongxian Lu, Wenbo Deng

Nat Commun. 2023; 14: 7356. Published online 2023 Nov 14. doi: 10.1038/s41467-023-43102-8

PMCID:: PMC10646072

Abstract Article PDF–6.3M

Select item 103532177.

LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection

Yuantao Li, Jingjing Guo, Haixia Zhang, Zhidan Li, Yushan Ren, Yuzhu Jiang, Xianbing Liu, Xuemei Hu

Parasit Vectors. 2023; 16: 237. Published online 2023 Jul 17. doi: 10.1186/s13071-023-05856-4

PMCID:: PMC10353217

Abstract Article PDF–4.9M

Select item 103049058.

SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor

Lin Chen, Weijie Zhao, Mengxiong Li, Yazhu Yang, Chengzi Tian, Dengyang Zhang, Zhiguang Chang, Yunzhe Zhang, Zhizhuang Joe Zhao, Yun Chen, Lin Ma

Reproduction. 2023 Jul 1; 166(1): 37–53. Prepublished online 2023 May 15. Published online 2023 Jun 9. doi: 10.1530/REP-22-0367

PMCID:: PMC10304905

Abstract Article PDF–15M

Select item 102079619.

Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals

XUELIANG WU, SHAOYU GUAN, YONGGANG LU, JUN XUE, XIANGYANG YU, QI ZHANG, XIMO WANG, TIAN LI

Oncol Res. 2023; 31(2): 125–139. Published online 2023 Apr 10. doi: 10.32604/or.2023.028657

PMCID:: PMC10207961

Abstract Article PDF–19M

Select item 1014079510.

Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages

Li Du, Yichun Ji, Bing Xin, Jiemeng Zhang, Li-Chun Lu, Christopher K. Glass, Gen-Sheng Feng

Cell Mol Gastroenterol Hepatol. 2023; 15(6): 1351–1369. Published online 2023 Feb 23. doi: 10.1016/j.jcmgh.2023.02.011

PMCID:: PMC10140795

Abstract Article PDF–7.5M

Select item 1012414011.

Potential clinical use of azacitidine and MEK inhibitor combination therapy in PTPN11-mutated juvenile myelomonocytic leukemia

Santhosh Kumar Pasupuleti, Karen Chao, Baskar Ramdas, Rahul Kanumuri, Lakshmi Reddy Palam, Sheng Liu, Jun Wan, Colleen Annesley, Mignon L. Loh, Elliot Stieglitz, Michael J. Burke, Reuben Kapur

Mol Ther. 2023 Apr 5; 31(4): 986–1001. Published online 2023 Feb 3. doi: 10.1016/j.ymthe.2023.01.030

PMCID:: PMC10124140

Abstract Article PDF–5.8M

Select item 1004625612.

G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin and the Tyrosine Phosphatase Shp-2

Federica Bono, Zaira Tomasoni, Veronica Mutti, Giulia Sbrini, Rajesh Kumar, Francesca Longhena, Chiara Fiorentini, Cristina Missale

Biomolecules. 2023 Mar; 13(3): 473. Published online 2023 Mar 3. doi: 10.3390/biom13030473

PMCID:: PMC10046256

Abstract Article PDF–5.5M

Select item 991718813.

The Cell-Specific Role of SHP2 in Regulating Bone Homeostasis and Regeneration Niches

Jie Zhang, Chengxinyue Ye, Yufan Zhu, Jun Wang, Jin Liu

Int J Mol Sci. 2023 Feb; 24(3): 2202. Published online 2023 Jan 22. doi: 10.3390/ijms24032202

PMCID:: PMC9917188

Abstract Article PDF–1.6M

Select item 981053414.

SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses

Anthos Christofides, Xanthi-Lida Katopodi, Carol Cao, Dimitra Karagkouni, Konstantinos Aliazis, Sasitorn Yenyuwadee, Halil-Ibrahim Aksoylar, Rinku Pal, Mohamed A. A. Mahmoud, Laura Strauss, Natalia M. Tijaro-Ovalle, Louis Boon, John Asara, Ioannis S. Vlachos, Nikolaos Patsoukis, Vassiliki A. Boussiotis

Nat Immunol. 2023; 24(1): 55–68. Published online 2022 Dec 29. doi: 10.1038/s41590-022-01385-x

PMCID:: PMC9810534

Abstract Article PDF–8.3M

Select item 976420915.

Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling

Xiaoli Wei, Lanping Zheng, Yingpu Tian, Haibin Wang, Youqiang Su, Gensheng Feng, Chao Wang, Zhongxian Lu

J Mol Cell Biol. 2022 Jul; 14(7): mjac048. Published online 2022 Aug 24. doi: 10.1093/jmcb/mjac048

PMCID:: PMC9764209

Abstract Article PDF–4.3M

Select item 975951416.

Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis

Yuhan Yan, Chao Chen, Zhiguo Li, Jing Zhang, Narin Park, Cheng-Kui Qu

Sci Rep. 2022; 12: 21832. Published online 2022 Dec 17. doi: 10.1038/s41598-022-24554-2

PMCID:: PMC9759514

Abstract Article PDF–1.7M

Select item 963885517.

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses

Pedro M O Ventura, Milica Gakovic, Berenice A Fischer, Laura Spinelli, Giorgia Rota, Shalini Pathak, Hanif J Khameneh, Alessandro Zenobi, Sarah Thomson, Walter Birchmeier, Doreen A Cantrell, Greta Guarda

EMBO Rep. 2022 Nov; 23(11): e55399. Published online 2022 Oct 4. doi: 10.15252/embr.202255399

PMCID:: PMC9638855

Abstract Article PDF–963K

Select item 946860318.

α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes

Chien-Chun Tseng, Ru-Hsuan Zheng, Ting-Wei Lin, Chih-Chiang Chou, Yu-Chia Shih, Shao-Wei Liang, Hsiao-Hui Lee

Life Sci Alliance. 2022 Nov; 5(11): e202201557. Published online 2022 Sep 12. doi: 10.26508/lsa.202201557

PMCID:: PMC9468603

Abstract Article PDF–3.0M

Select item 937933719.

T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation

Clemens Cammann, Nicole Israel, Sarah Frentzel, Andreas Jeron, Eylin Topfstedt, Thomas Schüler, Luca Simeoni, Martin Zenker, Hans Joerg Fehling, Burkhart Schraven, Dunja Bruder, Ulrike Seifert

Front Immunol. 2022; 13: 958616. Published online 2022 Aug 2. doi: 10.3389/fimmu.2022.958616