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Select item 101302251.

Single-molecule dynamics of DNA gyrase in evolutionarily distant bacteria Mycobacterium tuberculosis and Escherichia coli

Cooper J. Galvin, Matthew Hobson, Jonathan Xianglong Meng, Athena Ierokomos, Ivan E. Ivanov, James M. Berger, Zev Bryant

J Biol Chem. 2023 May; 299(5): 103003. Published online 2023 Feb 11. doi: 10.1016/j.jbc.2023.103003

PMCID:: PMC10130225

Abstract Article PDF–3.1M

Select item 40074282.

Fluoroquinolone-Gyrase-DNA Complexes: TWO MODES OF DRUG BINDING

Arkady Mustaev, Muhammad Malik, Xilin Zhao, Natalia Kurepina, Gan Luan, Lisa M. Oppegard, Hiroshi Hiasa, Kevin R. Marks, Robert J. Kerns, James M. Berger, Karl Drlica

J Biol Chem. 2014 May 2; 289(18): 12300–12312. Published online 2014 Feb 4. doi: 10.1074/jbc.M113.529164

PMCID:: PMC4007428

Abstract Article PDF–3.0M

Select item 29950793.

A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function

Allyn J. Schoeffler, Andrew P. May, James M. Berger

Nucleic Acids Res. 2010 Nov; 38(21): 7830–7844. Published online 2010 Jul 31. doi: 10.1093/nar/gkq665

PMCID:: PMC2995079

Abstract Article PDF–19M

Select item 29509024.

ATP control of dynamic P1 ParA–DNA interactions: a key role for the nucleoid in plasmid partition

Anthony G Vecchiarelli, Yong-Woon Han, Xin Tan, Michiyo Mizuuchi, Rodolfo Ghirlando, Christian Biertümpfel, Barbara E Funnell, Kiyoshi Mizuuchi

Mol Microbiol. 2010 Oct; 78(1): 78–91. Published online 2010 Aug 18. doi: 10.1111/j.1365-2958.2010.07314.x

PMCID:: PMC2950902

Abstract Article PDF–1.0M

Select item 27120425.

Internal Dynamics of Supercoiled DNA Molecules

Thomas Kalkbrenner, Axel Arnold, Sander J. Tans

Biophys J. 2009 Jun 17; 96(12): 4951–4955. doi: 10.1016/j.bpj.2009.03.056

PMCID:: PMC2712042

Abstract Article PDF–251K

Select item 27052436.

Dynamics of the Trimeric AcrB Transporter Protein Inferred From a B-Factor Analysis of the Crystal Structure

W.C. Lu, C.Z. Wang, E.W. Yu, K.M. Ho

Proteins. Author manuscript; available in PMC 2009 Jul 2.

Published in final edited form as: Proteins. 2006 Jan 1; 62(1): 152–158. doi: 10.1002/prot.20743

PMCID:: PMC2705243

Abstract Article PDF–2.1M

Select item 26472927.

Bacterial DNA topology and infectious disease

Charles J. Dorman, Colin P. Corcoran

Nucleic Acids Res. 2009 Feb; 37(3): 672–678. Published online 2008 Dec 10. doi: 10.1093/nar/gkn996

PMCID:: PMC2647292

Abstract Article PDF–122K

Select item 25731088.

Use of Gyrase Resistance Mutants To Guide Selection of 8-Methoxy-Quinazoline-2,4-Diones

Nadezhda German, Muhammad Malik, Jonathan D. Rosen, Karl Drlica, Robert J. Kerns

Antimicrob Agents Chemother. 2008 Nov; 52(11): 3915–3921. Published online 2008 Sep 2. doi: 10.1128/AAC.00330-08

PMCID:: PMC2573108

Abstract Article PDF–510K

Select item 24907539.

YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase

Sugopa Sengupta, Valakunja Nagaraja

Nucleic Acids Res. 2008 Aug; 36(13): 4310–4316. Published online 2008 Jun 27. doi: 10.1093/nar/gkn355

PMCID:: PMC2490753

Abstract Article PDF–337K

Select item 244681010.

Chromosomal Toxin-Antitoxin Systems May Act as Antiaddiction Modules

Manuel Saavedra De Bast, Natacha Mine, Laurence Van Melderen

J Bacteriol. 2008 Jul; 190(13): 4603–4609. Published online 2008 Apr 25. doi: 10.1128/JB.00357-08

PMCID:: PMC2446810

Abstract Article PDF–341K

Select item 241575511.

Biological Activities of Novel Gyrase Inhibitors of the Aminocoumarin Class

Christine Anderle, Martin Stieger, Matthew Burrell, Stefan Reinelt, Anthony Maxwell, Malcolm Page, Lutz Heide

Antimicrob Agents Chemother. 2008 Jun; 52(6): 1982–1990. Published online 2008 Mar 17. doi: 10.1128/AAC.01235-07

PMCID:: PMC2415755

Abstract Article PDF–469K

Select item 229217712.

Protein abundance profiling of the Escherichia coli cytosol

Yasushi Ishihama, Thorsten Schmidt, Juri Rappsilber, Matthias Mann, F Ulrich Hartl, Michael J Kerner, Dmitrij Frishman

BMC Genomics. 2008; 9: 102. Published online 2008 Feb 27. doi: 10.1186/1471-2164-9-102

PMCID:: PMC2292177

Abstract Article PDF–1.0M

Select item 214463013.

Temperature-sensitive suppressor mutations of the Escherichia coli DNA gyrase B protein.

S. J. Blance, N. L. Williams, Z. A. Preston, J. Bishara, M. S. Smyth, A. Maxwell

Protein Sci. 2000 May; 9(5): 1035–1037. doi: 10.1110/ps.9.5.1035

PMCID:: PMC2144630

Summary PDF–374K

Select item 209405614.

Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases

Sara N. Richter, Giulia Giaretta, Valentina Comuzzi, Elisabetta Leo, Lesley A. Mitchenall, L. Mark Fisher, Anthony Maxwell, Manlio Palumbo

Nucleic Acids Res. 2007 Sep; 35(18): 6075–6085. Published online 2007 Aug 30. doi: 10.1093/nar/gkm653

PMCID:: PMC2094056

Abstract Article PDF–1.0M

Select item 204326315.

Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening

David A. Ostrov, José A. Hernández Prada, Patrick E. Corsino, Kathryn A. Finton, Nhan Le, Thomas C. Rowe

Antimicrob Agents Chemother. 2007 Oct; 51(10): 3688–3698. Published online 2007 Aug 6. doi: 10.1128/AAC.00392-07

PMCID:: PMC2043263

Abstract Article PDF–831K

Select item 195205016.

Growth Rate Toxicity Phenotypes and Homeostatic Supercoil Control Differentiate Escherichia coli from Salmonella enterica Serovar Typhimurium

Keith Champion, N. Patrick Higgins

J Bacteriol. 2007 Aug; 189(16): 5839–5849. Published online 2007 Mar 30. doi: 10.1128/JB.00083-07

PMCID:: PMC1952050

Abstract Article PDF–396K

Select item 184794917.

Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli

Daniel J Dwyer, Michael A Kohanski, Boris Hayete, James J Collins

Mol Syst Biol. 2007; 3: 91. Published online 2007 Mar 13. doi: 10.1038/msb4100135

PMCID:: PMC1847949

Abstract Article PDF–429K

Select item 179773918.

Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds

Trudy H. Grossman, Douglas J. Bartels, Steve Mullin, Christian H. Gross, Jonathan D. Parsons, Yusheng Liao, Anne-Laure Grillot, Dean Stamos, Eric R. Olson, Paul S. Charifson, Nagraj Mani

Antimicrob Agents Chemother. 2007 Feb; 51(2): 657–666. Published online 2006 Nov 20. doi: 10.1128/AAC.00596-06