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Items: 1 to 20 of 55

1.
Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity
Stephanie Oertel, Klaus Scholich, Andreas Weigert, Dominique Thomas, Julia Schmetzer, Sandra Trautmann, Marthe-Susanna Wegner, Heinfried H. Radeke, Natalie Filmann, Bernhard Brüne, Gerd Geisslinger, Irmgard Tegeder, Sabine Grösch
Cell Mol Life Sci. 2017 Aug; 74(16): 3039–3055. Published online 2017 Apr 12. doi: 10.1007/s00018-017-2518-9
PMCID:
PMC11107765
AbstractArticlePDF–5.7M
2.
IL-10 constrains sphingolipid metabolism to limit inflammation
Autumn G. York, Mathias H. Skadow, Joonseok Oh, Rihao Qu, Quan D. Zhou, Wei-Yuan Hsieh, Walter K. Mowel, J. Richard Brewer, Eleanna Kaffe, Kevin J. Williams, Yuval Kluger, Stephen T. Smale, Jason M. Crawford, Steven J. Bensinger, Richard A. Flavell
Nature. 2024; 627(8004): 628–635. Published online 2024 Feb 21. doi: 10.1038/s41586-024-07098-5
PMCID:
PMC10954550
AbstractArticlePDF–4.3M
3.
Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2
Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanović, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernández-Hernández, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya
Nat Commun. 2024; 15: 2315. Published online 2024 Mar 14. doi: 10.1038/s41467-024-46718-6
PMCID:
PMC10940294
AbstractArticlePDF–6.0M
4.
LASS2/TMSG1过表达抑制人肺癌A549细胞增殖和促进A549细胞凋亡：基于上调神经酰胺和p38 MAPK进而启动级联信号传导通路
刘 峥璐, 宣 成睿, 韩 希然, 郑 泽泽, 肖 瑞, 宝 鲁日, 徐 晓艳
Nan Fang Yi Ke Da Xue Xue Bao. 2023 Feb 20; 43(2): 166–174. Chinese. doi: 10.12122/j.issn.1673-4254.2023.02.02
PMCID:
PMC10034540
AbstractArticlePDF–3.2M
5.
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Miriam Cnop, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S. Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C. Brüning, Bengt-Frederik Belgardt
Nat Cell Biol. 2023; 25(1): 20–29. Published online 2022 Dec 21. doi: 10.1038/s41556-022-01027-2
PMCID:
PMC9859757
AbstractArticlePDF–11M
6.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
7.
Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle
Ben D. McNally, Dean F. Ashley, Lea Hänschke, Hélène N. Daou, Nicole T. Watt, Steven A. Murfitt, Amanda D. V. MacCannell, Anna Whitehead, T. Scott Bowen, Francis W. B. Sanders, Michele Vacca, Klaus K. Witte, Graeme R. Davies, Reinhard Bauer, Julian L. Griffin, Lee D. Roberts
Nat Commun. 2022; 13: 1748. Published online 2022 Apr 1. doi: 10.1038/s41467-022-29363-9
PMCID:
PMC8975934
AbstractArticlePDF–2.2M
8.
Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis
Jiyoon L. Kim, Beatriz Mestre, Sergey Malitsky, Maxim Itkin, Meital Kupervaser, Anthony H. Futerman
J Biol Chem. 2022 Apr; 298(4): 101735. Published online 2022 Feb 16. doi: 10.1016/j.jbc.2022.101735
PMCID:
PMC8931434
AbstractArticlePDF–1.7M
9.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
10.
Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells
Sun-Hye Shin, Kyung-Ah Cho, Hee-Soo Yoon, So-Yeon Kim, Hee-Yeon Kim, Yael Pewzner-Jung, Sung-Ae Jung, Woo-Jae Park, Anthony H. Futerman, Joo-Won Park
Int J Mol Sci. 2021 Mar; 22(5): 2713. Published online 2021 Mar 8. doi: 10.3390/ijms22052713
PMCID:
PMC7962461
AbstractArticlePDF–3.9M
11.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
12.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
13.
WDFY4 is required for cross-presentation in response to viral and tumor antigens
Derek J. Theisen, Jesse T. Davidson, IV, Carlos G. Briseño, Marco Gargaro, Elvin J. Lauron, Qiuling Wang, Pritesh Desai, Vivek Durai, Prachi Bagadia, Joshua R. Brickner, Wandy L. Beatty, Herbert W. Virgin, William E. Gillanders, Nima Mosammaparast, Michael S. Diamond, L. David Sibley, Wayne Yokoyama, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy
Science. Author manuscript; available in PMC 2019 Jul 24.
Published in final edited form as: Science. 2018 Nov 9; 362(6415): 694–699. doi: 10.1126/science.aat5030
PMCID:
PMC6655551
AbstractArticlePDF–1020K
14.
TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells
Christophe Paget, Shenglou Deng, Daphnée Soulard, David A. Priestman, Silvia Speca, Johanna von Gerichten, Anneliese O. Speak, Ashish Saroha, Yael Pewzner-Jung, Anthony H. Futerman, Thierry Mallevaey, Christelle Faveeuw, Xiaobo Gu, Frances M. Platt, Roger Sandhoff, François Trottein
PLoS Biol. 2019 Mar; 17(3): e3000169. Published online 2019 Mar 1. doi: 10.1371/journal.pbio.3000169
PMCID:
PMC6420026
AbstractArticlePDF–3.1M
15.
Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes
Jennifer Kurz, Julia Barthelmes, Leonard Blum, Thomas Ulshöfer, Marthe-Susanna Wegner, Nerea Ferreirós, Luise Roser, Gerd Geisslinger, Sabine Grösch, Susanne Schiffmann
Sci Rep. 2019; 9: 747. Published online 2019 Jan 24. doi: 10.1038/s41598-018-37342-8
PMCID:
PMC6345911
AbstractArticlePDF–1.9M
16.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
17.
Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each
Afzal M. Dogar, Ramona Pauchard-Batschulat, Barbara Grisoni-Neupert, Larry Richman, Alexandra Paillusson, Sylvain Pradervand, Otto Hagenbüchle, Giovanna Ambrosini, Christoph D. Schmid, Philipp Bucher, Lukas C. Kühn
PLoS One. 2018; 13(11): e0206823. Published online 2018 Nov 12. doi: 10.1371/journal.pone.0206823
PMCID:
PMC6231638
AbstractArticlePDF–3.8M
18.
Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure
Kenji Mizumura, Matthew J. Justice, Kelly S. Schweitzer, Sheila Krishnan, Irina Bronova, Evgeny V. Berdyshev, Walter C. Hubbard, Yael Pewzner-Jung, Anthony H. Futerman, Augustine M. K. Choi, Irina Petrache
FASEB J. 2018 Apr; 32(4): 1880–1890. Published online 2018 Jan 5. doi: 10.1096/fj.201700571R
PMCID:
PMC5893175
AbstractArticle
19.
Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate‐induced colitis in mice due to increased intestinal permeability
Ye‐Ryung Kim, Giora Volpert, Kyong‐Oh Shin, So‐Yeon Kim, Sun‐Hye Shin, Younghay Lee, Sun Hee Sung, Yong‐Moon Lee, Jung‐Hyuck Ahn, Yael Pewzner‐Jung, Woo‐Jae Park, Anthony H. Futerman, Joo‐Won Park
J Cell Mol Med. 2017 Dec; 21(12): 3565–3578. Published online 2017 Jul 12. doi: 10.1111/jcmm.13267
PMCID:
PMC5706577
AbstractArticlePDF–2.2M
20.
Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development
Shan Li, Amy Teegarden, Emily M. Bauer, Jaewoo Choi, Nadia Messaddeq, David A. Hendrix, Gitali Ganguli-Indra, Mark Leid, Arup K. Indra
Sci Rep. 2017; 7: 13427. Published online 2017 Oct 18. doi: 10.1038/s41598-017-13347-7
PMCID:
PMC5647389
AbstractArticlePDF–5.2M

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