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Select item 114674101.

BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA

Feiye Zhou, Chunxiang Sheng, Xiaoqin Ma, Tianjiao Li, Xing Ming, Shushu Wang, Jialin Tan, Yulin Yang, Haipeng Sun, Jieli Lu, Jianmin Liu, Ruyuan Deng, Xiao Wang, Libin Zhou

Cell Death Dis. 2024 Oct; 15(10): 736. Published online 2024 Oct 10. doi: 10.1038/s41419-024-07071-0

PMCID:: PMC11467410

Abstract Article PDF–3.3M

Select item 102089582.

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome

Brianna K. Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M. Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W. Doble, Laurence Faivre, Antonio Vitobello, Stephen W. Scherer, Yu Lu, Peter Penzes, Karun K. Singh

Mol Psychiatry. 2023; 28(4): 1747–1769. Published online 2023 Jan 6. doi: 10.1038/s41380-022-01937-5

PMCID:: PMC10208958

Abstract Article PDF–7.0M

Select item 96334253.

Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure

Danielle Murashige, Jae Woo Jung, Michael D. Neinast, Michael G. Levin, Qingwei Chu, Jonathan P. Lambert, Joanne F. Garbincius, Boa Kim, Atsushi Hoshino, Ingrid Marti-Pamies, Kendra McDaid, Swapnil V. Shewale, Emily Flam, Steven Yang, Emilia Roberts, Li Li, Michael P. Morley, Kenneth C. Bedi, Jr., Matthew C. Hyman, David S. Frankel, Kenneth B. Margulies, Richard K. Assoian, John W. Elrod, Cholsoon Jang, Joshua D. Rabinowitz, Zoltan Arany

Cell Metab. Author manuscript; available in PMC 2023 Nov 1.

Published in final edited form as: Cell Metab. 2022 Nov 1; 34(11): 1749–1764.e7. Published online 2022 Oct 11. doi: 10.1016/j.cmet.2022.09.008

PMCID:: PMC9633425

Abstract Article PDF–2.8M

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74690055.

BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity

Anna Mizusawa, Ayako Watanabe, Minori Yamada, Rina Kamei, Yoshiharu Shimomura, Yasuyuki Kitaura

Nutrients. 2020 Aug; 12(8): 2267. Published online 2020 Jul 29. doi: 10.3390/nu12082267

PMCID:: PMC7469005

Abstract Article PDF–1008K

Select item 66023006.

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules

Richa Das, Lukas Schwintzer, Stanislav Vinopal, Eva Aguado Roca, Marc Sylvester, Ana-Maria Oprisoreanu, Susanne Schoch, Frank Bradke, Meike Broemer

J Cell Sci. 2019 Jun 15; 132(12): jcs229252. Published online 2019 Jun 17. doi: 10.1242/jcs.229252

PMCID:: PMC6602300

Abstract Article

Select item 63651917.

Quantitative analysis of the whole-body metabolic fate of branched chain amino acids

Michael D. Neinast, Cholsoon Jang, Sheng Hui, Danielle S. Murashige, Qingwei Chu, Raphael J. Morscher, Xiaoxuan Li, Le Zhan, Eileen White, Tracy G. Anthony, Joshua D. Rabinowitz, Zoltan Arany

Cell Metab. Author manuscript; available in PMC 2020 Feb 5.

Published in final edited form as: Cell Metab. 2019 Feb 5; 29(2): 417–429.e4. Published online 2018 Nov 15. doi: 10.1016/j.cmet.2018.10.013

PMCID:: PMC6365191

Abstract Article PDF–2.1M

Select item 63334608.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 62980409.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 579538810.

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes

Fan Liu, Philip Lössl, Beverley M. Rabbitts, Robert S. Balaban, Albert J. R. Heck

Mol Cell Proteomics. 2018 Feb; 17(2): 216–232. Published online 2017 Dec 8. doi: 10.1074/mcp.RA117.000470

PMCID:: PMC5795388

Abstract Article PDF–4.4M

Select item 555493511.

Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder

Dora C. Tarlungeanu, Elena Deliu, Christoph P. Dotter, Majdi Kara, Philipp Christoph Janiesch, Mariafrancesca Scalise, Michele Galluccio, Mateja Tesulov, Emanuela Morelli, Fatma Mujgan Sonmez, Kaya Bilguvar, Ryuichi Ohgaki, Yoshikatsu Kanai, Anide Johansen, Seham Esharif, Tawfeg Ben-Omran, Meral Topcu, Avner Schlessinger, Cesare Indiveri, Kent Duncan, Ahmet Okay Caglayan, Murat Gunel, Joseph G. Gleeson, Gaia Novarino

Cell. Author manuscript; available in PMC 2017 Aug 14.

Published in final edited form as: Cell. 2016 Dec 1; 167(6): 1481–1494.e18. doi: 10.1016/j.cell.2016.11.013

PMCID:: PMC5554935

Abstract Article PDF–3.3M

Select item 551543112.

Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism

Minjun Xu, Yasuyuki Kitaura, Takuya Ishikawa, Yoshihiro Kadota, Chihaya Terai, Daichi Shindo, Takashi Morioka, Miki Ota, Yukako Morishita, Kengo Ishihara, Yoshiharu Shimomura

PLoS One. 2017; 12(7): e0180989. Published online 2017 Jul 18. doi: 10.1371/journal.pone.0180989

PMCID:: PMC5515431

Abstract Article PDF–3.0M

Select item 520974613.

Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition

Takuya Ishikawa, Yasuyuki Kitaura, Yoshihiro Kadota, Yukako Morishita, Miki Ota, Fumiya Yamanaka, Minjun Xu, Masahito Ikawa, Naokazu Inoue, Fuminori Kawano, Naoya Nakai, Taro Murakami, Shinji Miura, Yukino Hatazawa, Yasutomi Kamei, Yoshiharu Shimomura

Sci Rep. 2017; 7: 39825. Published online 2017 Jan 4. doi: 10.1038/srep39825

PMCID:: PMC5209746

Abstract Article PDF–1.2M

Select item 489127714.

A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent

H Cao, W Yu, X Li, J Wang, S Gao, N E Holton, S Eliason, T Sharp, B A Amendt

Gene Ther. 2016 Jun; 23(6): 527–542. Prepublished online 2016 Mar 2. Published online 2016 Apr 7. doi: 10.1038/gt.2016.22

Correction in:: Gene Ther. 2016 Jul; 23(7): 634.

PMCID:: PMC4891277

Abstract Article PDF–3.2M

Select item 476764715.

Ronin (Thap11) is an essential transcriptional regulator of genes required for mitochondrial function in the developing retina

Ross A. Poché, Min Zhang, Elda M. Rueda, Xuefei Tong, Melissa L. McElwee, Leeyean Wong, Chih-Wei Hsu, Marion Dejosez, Alan R. Burns, Donald A. Fox, James F. Martin, Thomas P. Zwaka, Mary E. Dickinson

Cell Rep. Author manuscript; available in PMC 2016 Mar 9.

Published in final edited form as: Cell Rep. 2016 Feb 23; 14(7): 1684–1697. Published online 2016 Feb 11. doi: 10.1016/j.celrep.2016.01.039

PMCID:: PMC4767647

Abstract Article PDF–1.4M

Select item 395646116.

PGC-1α-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle

Yukino Hatazawa, Miki Tadaishi, Yuta Nagaike, Akihito Morita, Yoshihiro Ogawa, Osamu Ezaki, Takako Takai-Igarashi, Yasuyuki Kitaura, Yoshiharu Shimomura, Yasutomi Kamei, Shinji Miura

PLoS One. 2014; 9(3): e91006. Published online 2014 Mar 17. doi: 10.1371/journal.pone.0091006

PMCID:: PMC3956461

Abstract Article PDF–1.1M

Select item 386277617.

Oral Leucine Supplementation Is Sensed by the Brain but neither Reduces Food Intake nor Induces an Anorectic Pattern of Gene Expression in the Hypothalamus

Thais T. Zampieri, João A. B. Pedroso, Isadora C. Furigo, Julio Tirapegui, Jose Donato, Jr.

PLoS One. 2013; 8(12): e84094. Published online 2013 Dec 13. doi: 10.1371/journal.pone.0084094

PMCID:: PMC3862776

Abstract Article PDF–1.5M

Select item 382943518.

General Control Nonderepressible 2 (GCN2) Kinase Protects Oligodendrocytes and White Matter during Branched-chain Amino Acid Deficiency in Mice

Pengxiang She, Piyawan Bunpo, Judy K. Cundiff, Ronald C. Wek, Robert A. Harris, Tracy G. Anthony

J Biol Chem. 2013 Oct 25; 288(43): 31250–31260. Published online 2013 Sep 9. doi: 10.1074/jbc.M113.498469

PMCID:: PMC3829435

Abstract Article PDF–1.4M

Select item 370416519.

Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy

Gaia Novarino, Paul El-Fishawy, Hulya Kayserili, Nagwa A. Meguid, Eric M. Scott, Jana Schroth, Jennifer L. Silhavy, Majdi Kara, Rehab O. Khalil, Tawfeg Ben-Omran, A. Gulhan Ercan-Sencicek, Adel F. Hashish, Stephan J. Sanders, Abha R. Gupta, Hebatalla S. Hashem, Dietrich Matern, Stacey Gabriel, Larry Sweetman, Yasmeen Rahimi, Robert A. Harris, Matthew W. State, Joseph G. Gleeson

Science. Author manuscript; available in PMC 2013 Jul 8.

Published in final edited form as: Science. 2012 Oct 19; 338(6105): 394–397. Published online 2012 Sep 6. doi: 10.1126/science.1224631

PMCID:: PMC3704165

Abstract Article PDF–1.6M

Select item 368370720.

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase

Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Jacinta L. Chuang, Lorraine K. Morlock, Amy L. Wallace, Kamran Ahmed, Sunil Laxman, Philippe M. Campeau, Brendan H. Lee, Susan M. Hutson, Benjamin P. Tu, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, David T. Chuang

Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24): 9728–9733. Published online 2013 May 28. doi: 10.1073/pnas.1303220110

PMCID:: PMC3683707

Abstract Article PDF–820K

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