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Items: 1 to 20 of 48

1.
Gain-of-function variants in GSDME cause pyroptosis and apoptosis associated with post-lingual hearing loss
Yun Xiao, Lei Chen, Kaifan Xu, Meijuan Zhou, Yuechen Han, Jianfen Luo, Yu Ai, Mingming Wang, Yu Jin, Ruifeng Qiao, Shuhui Kong, Zhaomin Fan, Lei Xu, Haibo Wang
Hum Genet. 2024; 143(8): 979–993. Published online 2024 Jul 27. doi: 10.1007/s00439-024-02694-x
PMCID:
PMC11303571
AbstractArticlePDF–6.5M
2.
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation
Si-Jia Sun, Xiao-Dong Jiao, Zhi-Gang Chen, Qi Cao, Jia-Hui Zhu, Qi-Rui Shen, Yi Liu, Zhen Zhang, Fang-Fang Xu, Yu Shi, Jie Tong, Shen-Xi Ouyang, Jiang-Tao Fu, Yi Zhao, Jun Ren, Dong-Jie Li, Fu-Ming Shen, Pei Wang
Nat Commun. 2024; 15: 6640. Published online 2024 Aug 5. doi: 10.1038/s41467-024-50996-5
PMCID:
PMC11300882
AbstractArticlePDF–18M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation
Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen
Cell Death Dis. 2024 Mar; 15(3): 180. Published online 2024 Mar 1. doi: 10.1038/s41419-024-06545-5
PMCID:
PMC10907691
AbstractArticlePDF–9.3M
5.
Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death
Fengxia Ma, Laxman Ghimire, Qian Ren, Yuping Fan, Tong Chen, Arumugam Balasubramanian, Alan Hsu, Fei Liu, Hongbo Yu, Xuemei Xie, Rong Xu, Hongbo R. Luo
Nat Commun. 2024; 15: 386. Published online 2024 Jan 9. doi: 10.1038/s41467-023-44669-y
PMCID:
PMC10776763
AbstractArticlePDF–4.6M
6.
Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms
Sören Reinke, Eirini Pantazi, Gabrielle R. Chappell, Alexandra Sanchez-Martinez, Romain Guyon, Joannah R. Fergusson, Ahmed M. Salman, Anjum Aktar, Ekta Mukhopadhyay, Roland A. Ventura, Floriane Auderset, Patrice M. Dubois, Nicolas Collin, Adrian V.S. Hill, Jelena S. Bezbradica, Anita Milicic
Cell Rep Med. 2023 Nov 21; 4(11): 101245. Published online 2023 Oct 31. doi: 10.1016/j.xcrm.2023.101245
PMCID:
PMC10694591
AbstractArticlePDF–4.7M
7.
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice
Stefan A. Fattinger, Luca Maurer, Petra Geiser, Elliott M. Bernard, Ursina Enz, Suwannee Ganguillet, Ersin Gül, Sanne Kroon, Benjamin Demarco, Vanessa Mack, Markus Furter, Manja Barthel, Pawel Pelczar, Feng Shao, Petr Broz, Mikael E. Sellin, Wolf-Dietrich Hardt
Proc Natl Acad Sci U S A. 2023 Nov 28; 120(48): e2315503120. Published online 2023 Nov 21. doi: 10.1073/pnas.2315503120
PMCID:
PMC10691232
AbstractArticlePDF–7.1M
8.
NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity
Martin S. Minns, Karl Liboro, Tatiane S. Lima, Serena Abbondante, Brandon A. Miller, Michaela E. Marshall, Jolynn Tran Chau, Alicia Roistacher, Arne Rietsch, George R. Dubyak, Eric Pearlman
Nat Commun. 2023; 14: 5832. Published online 2023 Sep 20. doi: 10.1038/s41467-023-41391-7
PMCID:
PMC10511713
AbstractArticlePDF–2.1M
9.
Iron induces B cell pyroptosis through Tom20–Bax–caspase–gasdermin E signaling to promote inflammation post-spinal cord injury
Chengjie Wu, Lining Wang, Sixian Chen, Lei Shi, Mengmin Liu, Pengcheng Tu, Jie Sun, Ruihua Zhao, Yafeng Zhang, Jianwei Wang, Yalan Pan, Yong Ma, Yang Guo
J Neuroinflammation. 2023; 20: 171. Published online 2023 Jul 22. doi: 10.1186/s12974-023-02848-0
PMCID:
PMC10362643
AbstractArticlePDF–17M
10.
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Dylan V Neel, Himanish Basu, Georgia Gunner, Matthew D Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza Brody, Xin Jiang, Edward Lee, Michelle E Watts, Christine Marques, Aaron Held, Brian Wainger, Clotilde Lagier-Tourenne, Yong-Jie Zhang, Leonard Petrucelli, Tracey L. Young-Pearse, Alice S Chen-Plotkin, Lee L. Rubin, Judy Lieberman, Isaac M Chiu
Neuron. Author manuscript; available in PMC 2024 Apr 19.
Published in final edited form as: Neuron. 2023 Apr 19; 111(8): 1222–1240.e9. Published online 2023 Mar 13. doi: 10.1016/j.neuron.2023.02.019
PMCID:
PMC10121894
AbstractArticlePDF–4.5M
11.
Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Naoto Watamura, Hiroki Sasaguri, Yuhei Takado, Yoshihiro Yoshihara, Takashi Saito, Takaomi C. Saido
Sci Rep. 2023; 13: 1109. Published online 2023 Jan 20. doi: 10.1038/s41598-023-27653-w
PMCID:
PMC9859798
AbstractArticlePDF–3.1M
12.
Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins
Changhoon Oh, Lupeng Li, Ambika Verma, Arianna D. Reuven, Edward A. Miao, James B. Bliska, Youssef Aachoui
Cell Rep. Author manuscript; available in PMC 2023 Jan 9.
Published in final edited form as: Cell Rep. 2022 Nov 22; 41(8): 111688. doi: 10.1016/j.celrep.2022.111688
PMCID:
PMC9827617
AbstractArticlePDF–1.1M
13.
Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens
Bolei Dai, Ren Zhang, Shuhong Qi, Lei Liu, Xian Zhang, Deqiang Deng, Jie Zhang, Yilun Xu, Fanxuan Liu, Zheng Liu, Qingming Luo, Zhihong Zhang
Theranostics. 2022; 12(17): 7603–7623. Published online 2022 Oct 31. doi: 10.7150/thno.75966
PMCID:
PMC9691348
AbstractArticlePDF–4.0M
14.
GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils
Yujie Chen, Ni Lian, Sihan Chen, Ta Xiao, Yangying Ke, Yiqun Zhang, Changjun Song, Yong Yang, Song Xu, Heng Gu, Xu Chen
Cell Death Dis. 2022 Oct; 13(10): 841. Published online 2022 Oct 1. doi: 10.1038/s41419-022-05276-9
PMCID:
PMC9526747
AbstractArticlePDF–7.5M
15.
Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis
Zeqing Zhai, Fangyuan Yang, Wenchao Xu, Jiaochan Han, Guihu Luo, Yehao Li, Jian Zhuang, Hongyu Jie, Xing Li, Xingliang Shi, Xinai Han, Xiaoqing Luo, Rui Song, Yonghong Chen, Jianheng Liang, Shufan Wu, Yi He, Erwei Sun
Arthritis Rheumatol. 2022 Mar; 74(3): 427–440. Published online 2022 Jan 18. doi: 10.1002/art.41963
PMCID:
PMC9305212
AbstractArticlePDF–7.8M
16.
Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection
Siwen Dong, Yujin Shi, Xiaojing Dong, Xia Xiao, Jianli Qi, Lili Ren, Zichun Xiang, Zhuo Zhou, Jianwei Wang, Xiaobo Lei
J Biol Chem. 2022 May; 298(5): 101850. Published online 2022 Mar 23. doi: 10.1016/j.jbc.2022.101850
PMCID:
PMC9035723
AbstractArticlePDF–3.0M
17.
Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele
eLife. 2022; 11: e75753. Published online 2022 Mar 4. doi: 10.7554/eLife.75753
PMCID:
PMC8923664
AbstractArticlePDF–7.4M
18.
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince
Immunity. 2022 Mar 8; 55(3): 423–441.e9. Published online 2022 Feb 8. doi: 10.1016/j.immuni.2022.01.003
PMCID:
PMC8822620
AbstractArticlePDF–6.5M
19.
Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina
Binxiang Cai, Chunyan Liao, Danxue He, Jingmeng Chen, Jiahuai Han, Jiaying Lu, Kaiqi Qin, Wenxu Liang, Xiaoling Wu, Zuguo Liu, Yalin Wu
J Biol Chem. 2022 Feb; 298(2): 101553. Published online 2021 Dec 29. doi: 10.1016/j.jbc.2021.101553
PMCID:
PMC8800116
AbstractArticlePDF–5.7M
20.
Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis
Elke De Schutter, Jana Ramon, Benjamin Pfeuty, Caroline De Tender, Stephan Stremersch, Koen Raemdonck, Ken Op de Beeck, Wim Declercq, Franck B. Riquet, Kevin Braeckmans, Peter Vandenabeele
Cell Mol Life Sci. 2022 Jan; 79(1): 19. Published online 2021 Dec 31. doi: 10.1007/s00018-021-04078-0
PMCID:
PMC8720079
AbstractArticlePDF–4.6M

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