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Select item 112312811.

Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment

Hideyuki Masui, Kenji Kawada, Yoshiro Itatani, Hideyo Hirai, Yuki Nakanishi, Yoshiyuki Kiyasu, Keita Hanada, Michio Okamoto, Wataru Hirata, Yasuyo Nishikawa, Naoko Sugimoto, Takuya Tamura, Yoshiharu Sakai, Kazutaka Obama

Br J Cancer. 2024 Jul 27; 131(1): 63–76. Published online 2024 May 15. doi: 10.1038/s41416-024-02710-x

PMCID:: PMC11231281

Abstract Article PDF–5.2M

Select item 110214822.

CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis

Chengyu Yin, Boyu Liu, Zishan Dong, Sai Shi, Chenxing Peng, Yushuang Pan, Xiaochen Bi, Huimin Nie, Yunwen Zhang, Yan Tai, Qimiao Hu, Xuan Wang, Xiaomei Shao, Hailong An, Jianqiao Fang, Chuan Wang, Boyi Liu

Nat Commun. 2024; 15: 3263. Published online 2024 Apr 16. doi: 10.1038/s41467-024-47640-7

PMCID:: PMC11021482

Abstract Article PDF–9.3M

Select item 109646133.

Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease

Siyuan Cui, Xin Chen, Jiayu Li, Wei Wang, Deqi Meng, Shenglong Zhu, Shiwei Shen

Cell Commun Signal. 2024; 22: 191. Published online 2024 Mar 25. doi: 10.1186/s12964-024-01565-2

PMCID:: PMC10964613

Abstract Article PDF–7.1M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105145155.

The Cxcr2⁺ subset of the S100a8⁺ gastric granylocytic myeloid-derived suppressor cell population (G-MDSC) regulates gastric pathology

Krystal D. Kao, Helmut Grasberger, Mohamad El-Zaatari

Front Immunol. 2023; 14: 1147695. Published online 2023 Sep 8. doi: 10.3389/fimmu.2023.1147695

PMCID:: PMC10514515

Abstract Article PDF–15M

Select item 103779846.

CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A

Valentina La Cognata, Agata Grazia D’Amico, Grazia Maugeri, Giovanna Morello, Maria Guarnaccia, Benedetta Magrì, Eleonora Aronica, Velia D’Agata, Sebastiano Cavallaro

Cells. 2023 Jul; 12(14): 1813. Published online 2023 Jul 9. doi: 10.3390/cells12141813

PMCID:: PMC10377984

Abstract Article PDF–7.7M

Select item 102391197.

CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth

J. Yang, K. Bergdorf, C. Yan, W. Luo, S. C. Chen, G.D. Ayers, Q. Liu, X. Liu, M. Boothby, V.L. Weiss, S. M. Groves, A. N. Oleskie, X. Zhang, D. Y. Maeda, J. A. Zebala, V. Quaranta, A. Richmond

Mol Cancer. 2023; 22: 92. Published online 2023 Jun 3. doi: 10.1186/s12943-023-01789-9

PMCID:: PMC10239119

Abstract Article PDF–2.2M

Select item 100704618.

Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma

Zhihong Chen, Nishant Soni, Gonzalo Pinero, Bruno Giotti, Devon J. Eddins, Katherine E. Lindblad, James L. Ross, Montserrat Puigdelloses Vallcorba, Tanvi Joshi, Angelo Angione, Wes Thomason, Aislinn Keane, Nadejda M. Tsankova, David H. Gutmann, Sergio A. Lira, Amaia Lujambio, Eliver E. B. Ghosn, Alexander M. Tsankov, Dolores Hambardzumyan

Nat Commun. 2023; 14: 1839. Published online 2023 Apr 3. doi: 10.1038/s41467-023-37361-8

PMCID:: PMC10070461

Abstract Article PDF–5.5M

Select item 98328409.

PGF_2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR⁺CXC chemokine expression

Yan Zhao, Yi Lei, Huying Ning, Yaqiang Zhang, Guilin Chen, Chenchen Wang, Qiangyou Wan, Shumin Guo, Qian Liu, Ruotian Xie, Yujuan Zhuo, Shuai Yan, Jing Zhao, Fengjiang Wei, Lu Wang, Xiaohong Wang, Weidong Li, Hua Yan, Ying Yu

EMBO Mol Med. 2023 Jan; 15(1): e16373. Published online 2022 Dec 13. doi: 10.15252/emmm.202216373

PMCID:: PMC9832840

Abstract Article PDF–23M

Select item 967523710.

CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis

Can Yang, Zhiyuan Feng, Hong Deng, Lu Dai, Ling He, Linlin Yin, Jing Zhao

BMC Neurosci. 2022; 23: 67. Published online 2022 Nov 19. doi: 10.1186/s12868-022-00749-1

PMCID:: PMC9675237

Abstract Article PDF–1.7M

Select item 960668211.

CXCR2 intrinsically drives the maturation and function of neutrophils in mice

Pauline Delobel, Benjamin Ginter, Eliane Rubio, Karl Balabanian, Gwendal Lazennec

Front Immunol. 2022; 13: 1005551. Published online 2022 Oct 13. doi: 10.3389/fimmu.2022.1005551

PMCID:: PMC9606682

Abstract Article PDF–6.3M

Select item 945465512.

Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice

Carolina Rodriguez-Tirado, David Entenberg, Jiufeng Li, Bin-Zhi Qian, John S. Condeelis, Jeffrey W. Pollard

Cancers (Basel) 2022 Sep; 14(17): 4336. Published online 2022 Sep 5. doi: 10.3390/cancers14174336

PMCID:: PMC9454655

Abstract Article PDF–7.8M

Select item 943168113.

Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2

Naiyuan Cheng, Ki-Hyun Kim, Lester F. Lau

JCI Insight. 2022 Jul 22; 7(14): e158207. Published online 2022 Jun 16. doi: 10.1172/jci.insight.158207

PMCID:: PMC9431681

Abstract Article PDF–4.1M

Select item 941860514.

CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration

Shuai Wang, Jie Bai, Yun-Long Zhang, Qiu-Yue Lin, Xiao Han, Wei-Kun Qu, Peng-Fei Zhang, Yu-Song Ge, Qi Zhao, Hui-Hua Li

Redox Biol. 2022 Oct; 56: 102438. Published online 2022 Aug 13. doi: 10.1016/j.redox.2022.102438

PMCID:: PMC9418605

Abstract Article PDF–17M

Select item 904395815.

EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice

Zili Lei, Wanwan Liu, Ya Nie, Yanhong Yang, Guibin Chen, Li Huang, Huijuan Wu, Yuting Lei, Lei Chen, Qing Hu, Hedong Rong, Siping Yu, Qi Song, Fengxue Tong, Jiao Guo

Front Immunol. 2022; 13: 843378. Published online 2022 Apr 13. doi: 10.3389/fimmu.2022.843378

PMCID:: PMC9043958

Abstract Article PDF–8.1M

Select item 867831316.

Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells

Gang Xue, Ningbo Zheng, Jing Fang, Guangxu Jin, Xiaoyin Li, Gianpietro Dotti, Qing Yi, Yong Lu

Cancer Cell. Author manuscript; available in PMC 2022 Dec 13.

Published in final edited form as: Cancer Cell. 2021 Dec 13; 39(12): 1610–1622.e9. Published online 2021 Oct 21. doi: 10.1016/j.ccell.2021.09.011

PMCID:: PMC8678313

Abstract Article PDF–2.1M

Select item 863160217.

MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model

Pathricia Veronica Tilstam, Wibke Schulte, Thomas Holowka, Bong-Sung Kim, Jessica Nouws, Maor Sauler, Marta Piecychna, Georgios Pantouris, Elias Lolis, Lin Leng, Jürgen Bernhagen, Günter Fingerle-Rowson, Richard Bucala

J Clin Invest. 2021 Dec 1; 131(23): e127171. Published online 2021 Dec 1. doi: 10.1172/JCI127171

PMCID:: PMC8631602

Abstract Article PDF–4.8M

Select item 857151418.

Therapeutic responses to Roseomonas mucosa in atopic dermatitis may involve lipid-mediated TNF-related epithelial repair

Ian A. Myles, Carlo R. Castillo, Kent D. Barbian, Kishore Kanakabandi, Kimmo Virtaneva, Emily Fitzmeyer, Monica Paneru, Francisco Otaizo-Carrasquero, Timothy G. Myers, Tovah E. Markowitz, Ian N. Moore, Xue Liu, Marc Ferrer, Yosuke Sakamachi, Stavros Garantziotis, Muthulekha Swamydas, Michail S. Lionakis, Erik D. Anderson, Noah J. Earland, Sundar Ganesan, Ashleigh A. Sun, Jenna R.E. Bergerson, Robert A. Silverman, Maureen Petersen, Craig A. Martens, Sandip K. Datta

Sci Transl Med. Author manuscript; available in PMC 2021 Nov 6.

Published in final edited form as: Sci Transl Med. 2020 Sep 9; 12(560): eaaz8631. doi: 10.1126/scitranslmed.aaz8631

PMCID:: PMC8571514

Abstract Article PDF–2.1M

Select item 847170519.

CXCR1/2 Inhibitor Ladarixin Ameliorates the Insulin Resistance of 3T3-L1 Adipocytes by Inhibiting Inflammation and Improving Insulin Signaling

Vanessa Castelli, Laura Brandolini, Michele d’Angelo, Cristina Giorgio, Margherita Alfonsetti, Pasquale Cocchiaro, Francesca Lombardi, Annamaria Cimini, Marcello Allegretti

Cells. 2021 Sep; 10(9): 2324. Published online 2021 Sep 6. doi: 10.3390/cells10092324

PMCID:: PMC8471705

Abstract Article PDF–5.3M

Select item 846468120.

Nintedanib Regulates GRK2 and CXCR2 to Reduce Neutrophil Recruitment in Endotoxin-Induced Lung Injury

Vincent Yi-Fong Su, Wei-Chih Chen, Wen-Kuang Yu, Huai-Hsuan Wu, Hao Chen, Kuang-Yao Yang

Int J Mol Sci. 2021 Sep; 22(18): 9898. Published online 2021 Sep 13. doi: 10.3390/ijms22189898

PMCID:: PMC8464681

Abstract Article PDF–4.0M

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