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Select item 93912471.

Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis

Yunhui Zhang, Wenjie Liu, Weiquan Yuan, Zhaopeng Cai, Guiwen Ye, Guan Zheng, Chenhao Xu, Xinglang Wang, Chenying zeng, Rujia Mi, Pei Feng, Fenglei Chen, Yanfeng Wu, Huiyong Shen, Peng Wang

Cell Mol Life Sci. 2022 Sep; 79(9): 488. Published online 2022 Aug 19. doi: 10.1007/s00018-022-04511-y

PMCID:: PMC9391247

Abstract Article PDF–16M

Select item 85994932.

The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages

Kelvin Ka Lok Wu, KeKao Long, Huige Lin, Parco Ming Fai Siu, Ruby Lai Chong Hoo, Dewei Ye, Aimin Xu, Kenneth King Yip Cheng

Nat Commun. 2021; 12: 6637. Published online 2021 Nov 17. doi: 10.1038/s41467-021-26987-1

PMCID:: PMC8599493

Abstract Article PDF–3.3M

Select item 83830313.

Adiponectin inhibits D-gal-induced cardiomyocyte senescence via AdipoR1/APPL1

Ruiying Liu, Jing Meng, Danfei Lou

Mol Med Rep. 2021 Oct; 24(4): 719. Published online 2021 Aug 10. doi: 10.3892/mmr.2021.12358

PMCID:: PMC8383031

Abstract Article PDF–1.5M

Select item 83732634.

Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons

Yu Wu, Xinyou Lv, Haiting Wang, Kai Qian, Jinjun Ding, Jiejie Wang, Shushan Hua, Tiancheng Sun, Yiting Zhou, Lina Yu, Shuang Qiu

J Mol Cell Biol. 2021 May; 13(5): 335–346. Published online 2020 Oct 26. doi: 10.1093/jmcb/mjaa058

PMCID:: PMC8373263

Abstract Article PDF–862K

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 75819596.

APPL1 negatively regulates bone mass, possibly by controlling the fate of bone marrow mesenchymal progenitor cells

Yuan-Yu LIN, Lily Q. DONG

Proc Jpn Acad Ser B Phys Biol Sci. 2020 Oct 9; 96(8): 364–371. doi: 10.2183/pjab.96.027

PMCID:: PMC7581959

Abstract Article PDF–3.5M

Select item 66215267.

Adaptor Protein APPL1 Couples Synaptic NMDA Receptor with Neuronal Prosurvival Phosphatidylinositol 3-Kinase/Akt Pathway

Yu-bin Wang, Jie-jie Wang, Shao-hua Wang, Shuang-Shuang Liu, Jing-yuan Cao, Xiao-ming Li, Shuang Qiu, Jian-hong Luo

J Neurosci. 2012 Aug 29; 32(35): 11919–11929. doi: 10.1523/JNEUROSCI.3852-11.2012

PMCID:: PMC6621526

Abstract Article PDF–2.8M

Select item 63853198.

Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome

Livia Goto-Silva, Marisa P. McShane, Sara Salinas, Yannis Kalaidzidis, Giampietro Schiavo, Marino Zerial

Sci Rep. 2019; 9: 2433. Published online 2019 Feb 21. doi: 10.1038/s41598-019-38637-0

PMCID:: PMC6385319

Abstract Article PDF–4.3M

Select item 59277719.

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon

eLife. 2018; 7: e32866. Published online 2018 Apr 20. doi: 10.7554/eLife.32866

PMCID:: PMC5927771

Abstract Article PDF–9.1M

Select item 591245210.

Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function

Amanda K. Galan-Davila, Jiyoon Ryu, Kun Dong, Yang Xiao, Zhe Dai, Deling Zhang, Zhi Li, Amanda M. Dick, Kevin D. Liu, Amrita Kamat, Min Lu, Qunfeng Dong, Feng Liu, Lily Q. Dong

J Biol Chem. 2018 Apr 20; 293(16): 6064–6074. Published online 2018 Feb 26. doi: 10.1074/jbc.RA118.002162

PMCID:: PMC5912452

Abstract Article PDF–2.3M

Select item 564508211.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 556378212.

Serine 707 of APPL1 is Critical for the Synaptic NMDA Receptor-Mediated Akt Phosphorylation Signaling Pathway

Jiejie Wang, Wen Lu, Lin Chen, Ping Zhang, Tingting Qian, Wei Cao, Jianhong Luo

Neurosci Bull. 2016 Aug; 32(4): 323–330. Published online 2016 Jun 14. doi: 10.1007/s12264-016-0042-9

PMCID:: PMC5563782

Abstract Article PDF–2.1M

Select item 550974013.

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

Brent Wilkinson, Jing Li, Marcelo P. Coba

Sci Rep. 2017; 7: 5272. Published online 2017 Jul 13. doi: 10.1038/s41598-017-05588-3

PMCID:: PMC5509740

Abstract Article PDF–4.6M

Select item 472803714.

Appl1 and Appl2 are Expendable for Mouse Development but are Essential for HGF-induced Akt Activation and Migration in Mouse Embryonic Fibroblasts

Yinfei Tan, Xiaoban Xin, Francis J. Coffey, David L. Wiest, Lily Q. Dong, Joseph R. Testa

J Cell Physiol. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: J Cell Physiol. 2016 May; 231(5): 1142–1150. Published online 2015 Oct 21. doi: 10.1002/jcp.25211

PMCID:: PMC4728037

Abstract Article PDF–1.6M

Select item 455623615.

Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function

Chen Wang, Xiaowen Li, Kaida Mu, Ling Li, Shihong Wang, Yunxia Zhu, Mingliang Zhang, Jiyoon Ryu, Zhifang Xie, Dongyun Shi, Weiping J. Zhang, Lily Q. Dong, Weiping Jia

Diabetologia. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Diabetologia. 2013 Sep; 56(9): 1999–2009. Published online 2013 Jun 22. doi: 10.1007/s00125-013-2971-4

PMCID:: PMC4556236

Abstract Article PDF–534K

Select item 452589416.

APPL1 acts as a protective factor against podocytes injury in high glucose environment

Zhenzhong Ji, Zhengguo Hu, Yancheng Xu

Int J Clin Exp Pathol. 2015; 8(6): 6764–6771. Published online 2015 Jun 1.

PMCID:: PMC4525894

Abstract Article PDF–980K

Select item 438026817.

APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

Jiyoon Ryu, Amanda K. Galan, Xiaoban Xin, Feng Dong, Muhammad A. Abdul-Ghani, Lijun Zhou, Changhua Wang, Cuiling Li, Bekke M. Holmes, Lauren B. Sloane, Steven N. Austad, Shaodong Guo, Nicolas Musi, Ralph A. DeFronzo, Chuxia Deng, Morris F. White, Feng Liu, Lily Q. Dong

Cell Rep. Author manuscript; available in PMC 2015 May 22.

Published in final edited form as: Cell Rep. 2014 May 22; 7(4): 1227–1238. Published online 2014 May 10. doi: 10.1016/j.celrep.2014.04.006

PMCID:: PMC4380268

Abstract Article PDF–2.2M

Select item 434203018.

Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages

Jeremy C. Yeo, Adam A. Wall, Lin Luo, Jennifer L. Stow

Mol Biol Cell. 2015 Mar 1; 26(5): 952–965. doi: 10.1091/mbc.E14-10-1457

PMCID:: PMC4342030

Abstract Article PDF–7.3M

Select item 420170819.

Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway

Liufeng Mao, Wanhua Lin, Tao Nie, Xiaoyan Hui, Xuefei Gao, Kuai Li, Mengxiao Ding, Xiaofeng Tang, Peng Li, Yu Wang, Aimin Xu, Pentao Liu, Donghai Wu

Cell Biosci. 2014; 4: 60. Published online 2014 Oct 2. doi: 10.1186/2045-3701-4-60

PMCID:: PMC4201708

Abstract Article PDF–2.5M

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

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