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Select item 107596961.

Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes

Lihong Wang, Zhoujunhao Zhou, Xinming Xu, Yue Li, Rui Zhang, Zhiyan Yu, Xinmei Huang, Shufei Zang, Tiange Sun

Reprod Biol Endocrinol. 2024; 22: 2. Published online 2024 Jan 2. doi: 10.1186/s12958-023-01170-x

PMCID:: PMC10759696

Abstract Article PDF–1.5M

Select item 103140672.

Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis

Scott R Henderson, Harry Horsley, Paul Frankel, Maryam Khosravi, Talya Goble, Stephen Carter, Marilina Antonelou, Rhys D R Evans, Xiang Zhang, Tai-Ying Chu, Hsi-Hsien Lin, Siamon Gordon, Alan David Salama

Ann Rheum Dis. 2023 Jun; 82(6): 848–856. Published online 2023 Feb 17. doi: 10.1136/ard-2021-221800

PMCID:: PMC10314067

Abstract Article PDF–1.5M

Select item 100695783.

Risk of relapse of ANCA-associated vasculitis among patients homozygous for the proteinase 3 gene Val119Ile polymorphism

Marta Casal Moura, Zuoming Deng, Stephen R Brooks, Wei Tew, Fernando C Fervenza, Cees G M Kallenberg, Carol A Langford, Peter A Merkel, Paul A Monach, Philip Seo, Robert F Spiera, E William St Clair, John H Stone, Marco Prunotto, Peter C Grayson, Ulrich Specks

RMD Open. 2023; 9(1): e002935. Published online 2023 Mar 29. doi: 10.1136/rmdopen-2022-002935

PMCID:: PMC10069578

Abstract Article PDF–1.2M

Select item 99774964.

PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease

Dhruti P. Chen, Claudia P. Aiello, DeMoris McCoy, Taylor Stamey, Jiajin Yang, Susan L. Hogan, Yichun Hu, Vimal K. Derebail, Eveline Y. Wu, J. Charles Jennette, Ronald J. Falk, Dominic J. Ciavatta

JCI Insight. 2023 Feb 22; 8(4): e166107. Published online 2023 Feb 22. doi: 10.1172/jci.insight.166107

PMCID:: PMC9977496

Abstract Article PDF–590K

Select item 93426285.

Immunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity

Dhruti P. Chen, Elizabeth A. McInnis, Eveline Y. Wu, Katherine G. Stember, Susan L. Hogan, Yichun Hu, Candace D. Henderson, Lauren N. Blazek, Simon Mallal, Edita Karosiene, Bjoern Peters, John Sidney, Eddie A. James, William W. Kwok, J. Charles Jennette, Dominic J. Ciavatta, Ronald J. Falk, Meghan E. Free

J Am Soc Nephrol. 2022 Aug; 33(8): 1517–1527. Published online 2022 Aug. doi: 10.1681/ASN.2021081142

PMCID:: PMC9342628

Abstract Article

Select item 90991546.

Human Proteinase 3, an important autoantigen of c-ANCA associated vasculitis, shares cross-reactive epitopes with serine protease allergens from mites: an in silico analysis

Emiro Buendía, Múnera Marlon, Orlando Parra, María Sánchez, Andrés Sánchez, Jorge Sánchez, Diego Viasus

Version 2. F1000Res. 2021; 10: 47. Published online 2022 Feb 3. doi: 10.12688/f1000research.28225.2

PMCID:: PMC9099154

Abstract Article PDF–3.0M

Select item 88576477.

Competitively disrupting the neutrophil-specific receptor–autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation

Stephen F. Marino, Uwe Jerke, Susanne Rolle, Oliver Daumke, Ralph Kettritz

J Biol Chem. 2022 Mar; 298(3): 101598. Published online 2022 Jan 19. doi: 10.1016/j.jbc.2022.101598

PMCID:: PMC8857647

Abstract Article PDF–2.3M

Select item 85818248.

Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis

Eric K Patterson, Carolina Gillio-Meina, Claudio M Martin, Douglas D Fraser, Logan R Van Nynatten, Marat Slessarev, Gediminas Cepinskas

Exp Biol Med (Maywood) 2021 Nov; 246(21): 2338–2345. Published online 2021 Jul 22. doi: 10.1177/15353702211029284

PMCID:: PMC8581824

Abstract Article PDF–516K

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 793033510.

Pathogenicity of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody in Granulomatosis With Polyangiitis: Implications as Biomarker and Future Therapies

Jérôme Granel, Brice Korkmaz, Dalila Nouar, Stefanie A. I. Weiss, Dieter E. Jenne, Roxane Lemoine, Cyrille Hoarau

Front Immunol. 2021; 12: 571933. Published online 2021 Feb 18. doi: 10.3389/fimmu.2021.571933

PMCID:: PMC7930335

Abstract Article PDF–1.0M

Select item 768511211.

Proteinase 3 Autoreactivity in Anti‐Neutrophil Cytoplasmic Antibody–associated vasculitis—Immunological versus clinical features

Ravi K. Sharma, Björn Lövström, Iva Gunnarsson, Vivianne Malmström

Scand J Immunol. 2020 Nov; 92(5): e12958. Published online 2020 Oct 27. doi: 10.1111/sji.12958

PMCID:: PMC7685112

Abstract Article PDF–673K

Select item 758404212.

Immunopathogenesis of ANCA-Associated Vasculitis

Andreas Kronbichler, Keum Hwa Lee, Sara Denicolò, Daeun Choi, Hyojeong Lee, Donghyun Ahn, Kang Hyun Kim, Ji Han Lee, HyungTae Kim, Minha Hwang, Sun Wook Jung, Changjun Lee, Hojune Lee, Haejune Sung, Dongkyu Lee, Jaehyuk Hwang, Sohee Kim, Injae Hwang, Do Young Kim, Hyung Jun Kim, Geonjae Cho, Yunryoung Cho, Dongil Kim, Minje Choi, Junhye Park, Junseong Park, Kalthoum Tizaoui, Han Li, Lee Smith, Ai Koyanagi, Louis Jacob, Philipp Gauckler, Jae Il Shin

Int J Mol Sci. 2020 Oct; 21(19): 7319. Published online 2020 Oct 3. doi: 10.3390/ijms21197319

PMCID:: PMC7584042

Abstract Article PDF–1.4M

Select item 726179113.

Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases

Timothy J. Herdendorf, Daphne A. C. Stapels, Suzan H. M. Rooijakkers, Brian V. Geisbrecht

J Biol Chem. 2020 May 29; 295(22): 7753–7762. Published online 2020 Apr 17. doi: 10.1074/jbc.RA120.013601

PMCID:: PMC7261791

Abstract Article PDF–2.4M

Select item 701437214.

Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

Zhirong Fu, Srinivas Akula, Michael Thorpe, Lars Hellman

Int J Mol Sci. 2020 Jan; 21(2): 651. Published online 2020 Jan 19. doi: 10.3390/ijms21020651

PMCID:: PMC7014372

Abstract Article PDF–2.5M

Select item 676324215.

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development

Pu Wang, Feng Yan, Zhijun Li, Yanbao Yu, Scott E. Parnell, Yue Xiong

J Clin Invest. 2019 Oct 1; 129(10): 4393–4407. Published online 2019 Sep 9. doi: 10.1172/JCI129107

PMCID:: PMC6763242

Abstract Article PDF–12M

Select item 645039116.

SERPINB1-mediated checkpoint of inflammatory caspase activation

Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan, Alvin Lu, Jianbin Ruan, Hye-Ra Lee, Hao Wu, Brad Spellberg, Jae U. Jung

Nat Immunol. Author manuscript; available in PMC 2019 Apr 5.

Published in final edited form as: Nat Immunol. 2019 Mar; 20(3): 276–287. Published online 2019 Jan 28. doi: 10.1038/s41590-018-0303-z

Correction in:: Nat Immunol. 2019 May; 20(5): 664.

PMCID:: PMC6450391

Abstract Article PDF–2.8M

Select item 614918117.

Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases

Helena Crisford, Elizabeth Sapey, Robert A. Stockley

Respir Res. 2018; 19: 180. Published online 2018 Sep 20. doi: 10.1186/s12931-018-0883-z

PMCID:: PMC6149181

Abstract Article PDF–1.0M

Select item 609952918.

Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation

Tian-Hui Yang, Lisa S. St. John, Haven R. Garber, Celine Kerros, Kathryn E. Ruisaard, Karen Clise-Dwyer, Gheath Alatrash, Qing Ma, Jeffrey J. Molldrem

J Immunol. 2018 Sep 1; 201(5): 1389–1399. Published online 2018 Jul 18. doi: 10.4049/jimmunol.1800324

PMCID:: PMC6099529

Abstract Article PDF–1.3M

Select item 585869819.

Interaction between tumor cell surface receptor RAGE and proteinase 3 mediates prostate cancer metastasis to bone

Mikhail G. Kolonin, Anna Sergeeva, Daniela I. Staquicini, Tracey L. Smith, Christy A. Tarleton, Jeffrey J. Molldrem, Richard L. Sidman, Serena Marchiò, Renata Pasqualini, Wadih Arap

Cancer Res. Author manuscript; available in PMC 2018 Jun 15.

Published in final edited form as: Cancer Res. 2017 Jun 15; 77(12): 3144–3150. Published online 2017 Apr 20. doi: 10.1158/0008-5472.CAN-16-0708

PMCID:: PMC5858698

Abstract Article PDF–1.8M

Select item 583915820.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

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