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Items: 1 to 20 of 27

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
IL‐3 is essential for ICOS‐L stabilization on mast cells, and sustains the IL‐33‐induced RORγt+ Treg generation via enhanced IL‐6 induction
Sebastian Drube, Sylvia Müller, Franziska Weber, Philine Wegner, Romy Böttcher‐Loschinski, Matthias Gaestel, Andreas Hutloff, Thomas Kamradt, Nico Andreas
Immunology. 2021 May; 163(1): 86–97. Published online 2021 Jan 27. doi: 10.1111/imm.13305
PMCID:
PMC8044339
AbstractArticlePDF–901K
3.
HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure
Beth A Firulli, Rajani M George, Jade Harkin, Kevin P Toolan, Hongyu Gao, Yunlong Liu, Wenjun Zhang, Loren J Field, Ying Liu, Weinian Shou, Ronald Mark Payne, Michael Rubart-von der Lohe, Anthony B Firulli
Cardiovasc Res. 2020 Mar 1; 116(3): 605–618. Published online 2019 Jul 9. doi: 10.1093/cvr/cvz182
PMCID:
PMC7252443
AbstractArticlePDF–1.8M
4.
The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells
Christiane Helbig, Franziska Weber, Nico Andreas, Thomas Herdegen, Matthias Gaestel, Thomas Kamradt, Sebastian Drube
Sci Rep. 2020; 10: 8152. Published online 2020 May 18. doi: 10.1038/s41598-020-65072-3
PMCID:
PMC7235212
AbstractArticlePDF–1.9M
5.
MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection
Katharina Köther, Carolin Nordhoff, Dörthe Masemann, Georg Varga, Jay H. Bream, Matthias Gaestel, Viktor Wixler, Stephan Ludwig
FASEB J. 2014 Oct; 28(10): 4235–4246. doi: 10.1096/fj.14-249599
PMCID:
PMC6188229
AbstractArticle
6.
Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome
Xiaojing Nie, Melinda A. Chanley, Ruma Pengal, David B. Thomas, Shipra Agrawal, William E. Smoyer
Am J Physiol Renal Physiol. 2018 Apr 1; 314(4): F602–F613. Published online 2017 Nov 29. doi: 10.1152/ajprenal.00207.2017
Correction in:
Am J Physiol Renal Physiol. 2022 May 1; 322(5): F573–F574.
PMCID:
PMC5966757
AbstractArticle
7.
Differential control of Toll-like receptor 4–induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases
Ruhcha V. Sutavani, Iain R. Phair, Rebecca Barker, Alison McFarlane, Natalia Shpiro, Stuart Lang, Andrew Woodland, J. Simon C. Arthur
J Biol Chem. 2018 Feb 16; 293(7): 2302–2317. Published online 2017 Dec 11. doi: 10.1074/jbc.M117.805424
PMCID:
PMC5818195
AbstractArticlePDF–3.9M
8.
Characterization of a novel MK3 splice variant from murine
Nadège Moïse, Dharmendra Dingar, Aida M. Mamarbachi, Louis R. Villeneuve, Nada Farhat, Matthias Gaestel, Maya Khairallah, Bruce G. Allen
Cell Signal. Author manuscript; available in PMC 2017 Feb 9.
Published in final edited form as: Cell Signal. 2010 Oct; 22(10): 1502–1512. Published online 2010 Jun 4. doi: 10.1016/j.cellsig.2010.05.019
PMCID:
PMC5300773
AbstractArticlePDF–1.5M
9.
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction
Morisada Hayakawa, Hiroko Hayakawa, Tsvetana Petrova, Patcharee Ritprajak, Ruhcha V. Sutavani, Guillermina Yanek Jiménez-Andrade, Yasuyo Sano, Min-Kyung Choo, John Seavitt, Ram K. C. Venigalla, Kinya Otsu, Katia Georgopoulos, J. Simon C. Arthur, Jin Mo Park
J Biol Chem. 2017 Feb 3; 292(5): 1762–1772. Published online 2016 Dec 23. doi: 10.1074/jbc.M116.764548
PMCID:
PMC5290950
AbstractArticlePDF–3.5M
10.
Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity
Lale Ozcan, Xiaoming Xu, Shi-Xian Deng, Devram S. Ghorpade, Tiffany Thomas, Serge Cremers, Brian Hubbard, Michael H. Serrano-Wu, Matthias Gaestel, Donald W. Landry, Ira Tabas
Diabetes. 2015 Oct; 64(10): 3396–3405. Published online 2015 Jun 11. doi: 10.2337/db14-1945
PMCID:
PMC4587644
AbstractArticlePDF–1.4M
11.
Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development
Roel Quintens, Tine Verreet, Ann Janssen, Mieke Neefs, Liselotte Leysen, Arlette Michaux, Mieke Verslegers, Nada Samari, Giuseppe Pani, Joris Verheyde, Sarah Baatout, Mohammed A. Benotmane
Biol Open. 2015 Mar 15; 4(3): 331–344. Published online 2015 Feb 13. doi: 10.1242/bio.20149969
PMCID:
PMC4359739
AbstractArticlePDF–1.3M
12.
The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility
Katherine L. Eales, Oleg Palygin, Thomas O’Loughlin, Seyed Rasooli-Nejad, Matthias Gaestel, Jürgen Müller, Dawn R. Collins, Yuriy Pankratov, Sonia A.L. Corrêa
Nat Commun. 2014 Aug 19; 5: 4701. Published online 2014 Aug 19. doi: 10.1038/ncomms5701
PMCID:
PMC4143933
AbstractArticlePDF–3.7M
13.
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
Frederik Köpper, Cathrin Bierwirth, Margarete Schön, Meike Kunze, Ingegerd Elvers, Dominique Kranz, Priyanka Saini, Manoj B. Menon, David Walter, Claus Storgaard Sørensen, Matthias Gaestel, Thomas Helleday, Michael P. Schön, Matthias Dobbelstein
Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42): 16856–16861. Published online 2013 Sep 30. doi: 10.1073/pnas.1304355110
PMCID:
PMC3801042
AbstractArticlePDF–1005K
14.
Mitogen-Activated Protein Kinase-Activated Protein Kinases 2 and 3 Regulate SERCA2a Expression and Fiber Type Composition To Modulate Skeletal Muscle and Cardiomyocyte Function
Madeleine Scharf, Stefan Neef, Robert Freund, Cornelia Geers-Knörr, Mirita Franz-Wachtel, Almuth Brandis, Dorothee Krone, Heike Schneider, Stephanie Groos, Manoj B. Menon, Kin-Chow Chang, Theresia Kraft, Joachim D. Meissner, Kenneth R. Boheler, Lars S. Maier, Matthias Gaestel, Renate J. Scheibe
Mol Cell Biol. 2013 Jul; 33(13): 2586–2602. doi: 10.1128/MCB.01692-12
PMCID:
PMC3700115
AbstractArticlePDF–3.4M
15.
Crucial Roles of the Protein Kinases MK2 and MK3 in a Mouse Model of Glomerulonephritis
Adam J. Guess, Rose Ayoob, Melinda Chanley, Joshua Manley, Mariana M. Cajaiba, Shipra Agrawal, Ruma Pengal, Amy L. Pyle, Brian Becknell, Jeffrey B. Kopp, Natalia Ronkina, Matthias Gaestel, Rainer Benndorf, William E. Smoyer
PLoS One. 2013; 8(1): e54239. Published online 2013 Jan 23. doi: 10.1371/journal.pone.0054239
PMCID:
PMC3553169
AbstractArticlePDF–709K
16.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
17.
Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3: MK2 MEDIATES LIPOPOLYSACCHARIDE-INDUCED SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION 3 (STAT3) ACTIVATION BY PREVENTING NEGATIVE REGULATORY EFFECTS OF MK3
Christian Ehlting, Natalia Ronkina, Oliver Böhmer, Ute Albrecht, Konrad A. Bode, Karl S. Lang, Alexey Kotlyarov, Danuta Radzioch, Matthias Gaestel, Dieter Häussinger, Johannes G. Bode
J Biol Chem. 2011 Jul 8; 286(27): 24113–24124. Published online 2011 May 17. doi: 10.1074/jbc.M111.235275
PMCID:
PMC3129192
AbstractArticlePDF–1.8M
18.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
19.
p38 MAP Kinase and MAPKAP Kinases MK2/3 Cooperatively Phosphorylate Epithelial Keratins
Manoj B. Menon, Jessica Schwermann, Anurag Kumar Singh, Mirita Franz-Wachtel, Oliver Pabst, Ursula Seidler, M. Bishr Omary, Alexey Kotlyarov, Matthias Gaestel
J Biol Chem. 2010 Oct 22; 285(43): 33242–33251. Published online 2010 Aug 19. doi: 10.1074/jbc.M110.132357
PMCID:
PMC2963412
AbstractArticlePDF–2.0M
20.
MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells
Jessica Schwermann, Chozhavendan Rathinam, Maria Schubert, Stefanie Schumacher, Fatih Noyan, Haruhiko Koseki, Alexey Kotlyarov, Christoph Klein, Matthias Gaestel
EMBO J. 2009 May 20; 28(10): 1392–1406. Published online 2009 Apr 16. doi: 10.1038/emboj.2009.100
PMCID:
PMC2688528
AbstractArticlePDF–2.0M

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