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Select item 89833901.

Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases

Paul C. Marcogliese, Samantha L. Deal, Jonathan Andrews, J. Michael Harnish, V. Hemanjani Bhavana, Hillary K. Graves, Sharayu Jangam, Xi Luo, Ning Liu, Danqing Bei, Yu-Hsin Chao, Brooke Hull, Pei-Tseng Lee, Hongling Pan, Pradnya Bhadane, Mei-Chu Huang, Colleen M. Longley, Hsiao-Tuan Chao, Hyung-lok Chung, Nele A. Haelterman, Oguz Kanca, Sathiya N. Manivannan, Linda Z. Rossetti, Ryan J. German, Amanda Gerard, Eva Maria Christina Schwaibold, Sarah Fehr, Renzo Guerrini, Annalisa Vetro, Eleina England, Chaya N. Murali, Tahsin Stefan Barakat, Marieke F. van Dooren, Martina Wilke, Marjon van Slegtenhorst, Gaetan Lesca, Isabelle Sabatier, Nicolas Chatron, Catherine A. Brownstein, Jill A. Madden, Pankaj B. Agrawal, Boris Keren, Thomas Courtin, Laurence Perrin, Melanie Brugger, Timo Roser, Steffen Leiz, Frederic Tran Mau-Them, Julian Delanne, Elena Sukarova-Angelovska, Slavica Trajkova, Erik Rosenhahn, Vincent Strehlow, Konrad Platzer, Roberto Keller, Lisa Pavinato, Alfredo Brusco, Jill A. Rosenfeld, Ronit Marom, Michael F. Wangler, Shinya Yamamoto

Cell Rep. Author manuscript; available in PMC 2022 Apr 6.

Published in final edited form as: Cell Rep. 2022 Mar 15; 38(11): 110517. doi: 10.1016/j.celrep.2022.110517

PMCID:: PMC8983390

Abstract Article PDF–2.9M

Select item 78472632.

Mistargeting of secretory cargo in retromer-deficient cells

Sarah D. Neuman, Erica L. Terry, Jane E. Selegue, Amy T. Cavanagh, Arash Bashirullah

Dis Model Mech. 2021 Jan 1; 14(1): dmm046417. Published online 2021 Jan 22. doi: 10.1242/dmm.046417

PMCID:: PMC7847263

Abstract Article

Select item 77100953.

Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling

Mohamed Y. Aboukilila, Josephine D. Sami, Jingtian Wang, Whitney England, Robert C. Spitale, Michael D. Cleary

PLoS One. 2020; 15(12): e0240386. Published online 2020 Dec 2. doi: 10.1371/journal.pone.0240386

PMCID:: PMC7710095

Abstract Article PDF–1.6M

Select item 69615784.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 65482275.

Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease

Claudia H Huichalaf, Ismael Al-Ramahi, Kyung-Won Park, Stacy D Grunke, Nan Lu, Maria de Haro, Karla El-Zein, Tatiana Gallego-Flores, Alma M Perez, Sung Yun Jung, Juan Botas, Huda Y Zoghbi, Joanna L Jankowsky

Hum Mol Genet. 2019 Jun 15; 28(12): 2014–2029. Published online 2019 Feb 12. doi: 10.1093/hmg/ddz034

PMCID:: PMC6548227

Abstract Article PDF–24M

Select item 61403246.

Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila

Carlos I. Ayala, Jung Kim, Thomas P. Neufeld

J Cell Sci. 2018 Sep 1; 131(17): jcs216127. Published online 2018 Sep 7. doi: 10.1242/jcs.216127

PMCID:: PMC6140324

Abstract Article

Select item 59197327.

Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells

Stephanie E. Mohr, Kirstin Rudd, Yanhui Hu, Wei Roc Song, Quentin Gilly, Michael Buckner, Benjamin E. Housden, Colleen Kelley, Jonathan Zirin, Rong Tao, Gabriel Amador, Katarzyna Sierzputowska, Aram Comjean, Norbert Perrimon

G3 (Bethesda) 2018 Feb; 8(2): 631–641. Published online 2017 Dec 9. doi: 10.1534/g3.117.300447

PMCID:: PMC5919732

Abstract Article PDF–1.0M

Select item 58989128.

A gene-specific T2A-GAL4 library for Drosophila

Pei-Tseng Lee, Jonathan Zirin, Oguz Kanca, Wen-Wen Lin, Karen L Schulze, David Li-Kroeger, Rong Tao, Colby Devereaux, Yanhui Hu, Verena Chung, Ying Fang, Yuchun He, Hongling Pan, Ming Ge, Zhongyuan Zuo, Benjamin E Housden, Stephanie E Mohr, Shinya Yamamoto, Robert W Levis, Allan C Spradling, Norbert Perrimon, Hugo J Bellen

eLife. 2018; 7: e35574. Published online 2018 Mar 22. doi: 10.7554/eLife.35574

PMCID:: PMC5898912

Abstract Article PDF–4.9M

Select item 57078059.

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Piero Sanfilippo, Jiayu Wen, Eric C. Lai

Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0

PMCID:: PMC5707805

Abstract Article PDF–3.2M

Select item 568900210.

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira

RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117

PMCID:: PMC5689002

Abstract Article PDF–4.0M

Select item 554424311.

A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure

Shanshan Zhou, Sarah E. Luoma, Genevieve E. St. Armour, Esha Thakkar, Trudy F. C. Mackay, Robert R. H. Anholt

PLoS Genet. 2017 Jul; 13(7): e1006907. Published online 2017 Jul 21. doi: 10.1371/journal.pgen.1006907

PMCID:: PMC5544243

Abstract Article PDF–6.6M

Select item 500460912.

The role of acroblast formation during Drosophila spermatogenesis

Karolina Fári, Sándor Takács, Dániel Ungár, Rita Sinka

Biol Open. 2016 Aug 15; 5(8): 1102–1110. Published online 2016 Aug 1. doi: 10.1242/bio.018275

PMCID:: PMC5004609

Abstract Article PDF–3.6M

Select item 461022413.

The lysosomal enzyme receptor protein (LERP) is not essential, but is implicated in lysosomal function in Drosophila melanogaster

Medina Hasanagic, Eline van Meel, Shan Luan, Rajeev Aurora, Stuart Kornfeld, Joel C. Eissenberg

Biol Open. 2015 Oct 15; 4(10): 1316–1325. Published online 2015 Sep 24. doi: 10.1242/bio.013334

PMCID:: PMC4610224

Abstract Article PDF–819K

Select item 452833014.

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders

Madeline A. Crosby, L. Sian Gramates, Gilberto dos Santos, Beverley B. Matthews, Susan E. St. Pierre, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, David B. Emmert, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1737–1749. Published online 2015 Jun 24. doi: 10.1534/g3.115.018937

PMCID:: PMC4528330

Abstract Article PDF–2.2M

Select item 452832915.

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data

Beverley B. Matthews, Gilberto dos Santos, Madeline A. Crosby, David B. Emmert, Susan E. St. Pierre, L. Sian Gramates, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, Victor Strelets, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1721–1736. Published online 2015 Jun 24. doi: 10.1534/g3.115.018929

PMCID:: PMC4528329

Abstract Article PDF–4.9M

Select item 449592516.

Survival Rate and Transcriptional Response upon Infection with the Generalist Parasite Beauveria bassiana in a World-Wide Sample of Drosophila melanogaster

Francesco Paparazzo, Aurélien Tellier, Wolfgang Stephan, Stephan Hutter

PLoS One. 2015; 10(7): e0132129. Published online 2015 Jul 8. doi: 10.1371/journal.pone.0132129

PMCID:: PMC4495925

Abstract Article PDF–592K

Select item 439805017.

The Genetic Basis for Variation in Olfactory Behavior in Drosophila melanogaster

Gunjan H. Arya, Michael M. Magwire, Wen Huang, Yazmin L. Serrano-Negron, Trudy F.C. Mackay, Robert R.H. Anholt

Chem Senses. 2015 May; 40(4): 233–243. Published online 2015 Feb 15. doi: 10.1093/chemse/bjv001

PMCID:: PMC4398050

Abstract Article PDF–8.9M

Select item 435288718.

The Release 6 reference sequence of the Drosophila melanogaster genome

Roger A. Hoskins, Joseph W. Carlson, Kenneth H. Wan, Soo Park, Ivonne Mendez, Samuel E. Galle, Benjamin W. Booth, Barret D. Pfeiffer, Reed A. George, Robert Svirskas, Martin Krzywinski, Jacqueline Schein, Maria Carmela Accardo, Elisabetta Damia, Giovanni Messina, María Méndez-Lago, Beatriz de Pablos, Olga V. Demakova, Evgeniya N. Andreyeva, Lidiya V. Boldyreva, Marco Marra, A. Bernardo Carvalho, Patrizio Dimitri, Alfredo Villasante, Igor F. Zhimulev, Gerald M. Rubin, Gary H. Karpen, Susan E. Celniker

Genome Res. 2015 Mar; 25(3): 445–458. doi: 10.1101/gr.185579.114

PMCID:: PMC4352887

Abstract Article PDF–1022K

Select item 433166219.

Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development

Elisabeth Kowalewski-Nimmerfall, Philipp Schähs, Daniel Maresch, Dubravko Rendic, Helmut Krämer, Lukas Mach

Biochim Biophys Acta Mol Cell Res. 2014 Dec; 1843(12): 2900–2912. doi: 10.1016/j.bbamcr.2014.08.012

PMCID:: PMC4331662

Abstract Article

Select item 427152720.

Phylostratigraphic Bias Creates Spurious Patterns of Genome Evolution

Bryan A. Moyers, Jianzhi Zhang

Mol Biol Evol. 2015 Jan 1; 32(1): 258–267. Published online 2014 Oct 13. doi: 10.1093/molbev/msu286

Correction in:: Mol Biol Evol. 2016 Nov; 33(11): 3031.

PMCID:: PMC4271527

Abstract Article PDF–618K

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