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Select item 110916531.

The 5HT2b Receptor in Alzheimer’s Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction

Erica Acquarone, Elentina K. Argyrousi, Ottavio Arancio, D. Martin Watterson, Saktimayee M. Roy

J Alzheimers Dis. 2024; 98(4): 1349–1360. Prepublished online 2024 Apr 3. Published online 2024 Apr 16. doi: 10.3233/JAD-240063

PMCID:: PMC11091653

Abstract Article PDF–264K

Select item 105306672.

Synergistic Interaction of 5-HT_1B and 5-HT_2B Receptors in Cytoplasmic Ca²⁺ Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies

Elena Yu. Rybakova, Piotr P. Avdonin, Sergei K. Trufanov, Nikolay V. Goncharov, Pavel V. Avdonin

Int J Mol Sci. 2023 Sep; 24(18): 13833. Published online 2023 Sep 8. doi: 10.3390/ijms241813833

PMCID:: PMC10530667

Abstract Article PDF–3.6M

Select item 103626393.

Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case–control study

Juliana Regina Chamlian Zucare Penno, Daniele Pereira Santos-Bezerra, Ana Mercedes Cavaleiro, Ana Maria da Silva Sousa, Tatiana Assunção Zaccara, Rafaela Alkmin da Costa, Rossana Pulcineli Vieira Francisco, Maria Lucia Correa-Giannella

Eur J Med Res. 2023; 28: 243. Published online 2023 Jul 21. doi: 10.1186/s40001-023-01211-6

PMCID:: PMC10362639

Abstract Article PDF–937K

Select item 99224684.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 95830765.

Signaling snapshots of 5-HT_2B serotonin receptor activated by the prototypical psychedelic LSD

Can Cao, Ximena Barros-Álvarez, Shicheng Zhang, Kuglae Kim, Marc A. Dämgen, Ouliana Panova, Carl-Mikael Suomivuori, Jonathan F. Fay, Xiaofang Zhong, Brian E. Krumm, Ryan H. Gumpper, Alpay B. Seven, Michael J. Robertson, Nevan J. Krogan, Ruth Hüttenhain, David E. Nichols, Ron O. Dror, Georgios Skinotis, Bryan L. Roth

Neuron. Author manuscript; available in PMC 2023 Oct 5.

Published in final edited form as: Neuron. 2022 Oct 5; 110(19): 3154–3167.e7. Published online 2022 Sep 9. doi: 10.1016/j.neuron.2022.08.006

PMCID:: PMC9583076

Abstract Article PDF–4.0M

Select item 88362046.

Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma

Manel Benhassine, Gaëtan Le-Bel, Sylvain L. Guérin

Int J Mol Sci. 2022 Feb; 23(3): 1564. Published online 2022 Jan 29. doi: 10.3390/ijms23031564

PMCID:: PMC8836204

Abstract Article PDF–3.2M

Select item 77253987.

Free energy calculations of the functional selectivity of 5-HT_2B G protein-coupled receptor

Brandon L. Peters, Jinxia Deng, Andrew L. Ferguson

PLoS One. 2020; 15(12): e0243313. Published online 2020 Dec 9. doi: 10.1371/journal.pone.0243313

PMCID:: PMC7725398

Abstract Article PDF–2.2M

Select item 64517658.

Molecular interactions between general anesthetics and the 5HT_2B receptor

Felipe Matsunaga, Lu Gao, Xi-Ping Huang, Jeffery G. Saven, Bryan L. Roth, Renyu Liu

J Biomol Struct Dyn. Author manuscript; available in PMC 2019 Apr 7.

Published in final edited form as: J Biomol Struct Dyn. 2015; 33(1): 211–218. Published online 2013 Dec 23. doi: 10.1080/07391102.2013.869483

PMCID:: PMC6451765

Abstract Article PDF–531K

Select item 62817829.

Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response

Janitza L. Montalvo-Ortiz, Hang Zhou, Ivana D’Andrea, Luc Maroteaux, Adriana Lori, Alicia Smith, Kerry J. Ressler, Yaira Z. Nuñez, Lindsay A. Farrer, Hongyu Zhao, Henry R. Kranzler, Joel Gelernter

Mol Psychiatry. Author manuscript; available in PMC 2019 Jan 3.

Published in final edited form as: Mol Psychiatry. 2018 Dec; 23(12): 2277–2286. Published online 2018 Jun 6. doi: 10.1038/s41380-018-0077-6

PMCID:: PMC6281782

Abstract Article PDF–875K

Select item 623718310.

Structural Determinants of 5-HT_2B Receptor Activation and Biased Agonism

John D. McCorvy, Daniel Wacker, Sheng Wang, Bemnat Agegnehu, Jing Liu, Katherine Lansu, Alexandra R. Tribo, Reid H.J. Olsen, Tao Che, Jian Jin, Bryan L. Roth

Nat Struct Mol Biol. Author manuscript; available in PMC 2018 Nov 15.

Published in final edited form as: Nat Struct Mol Biol. 2018 Sep; 25(9): 787–796. Published online 2018 Aug 20. doi: 10.1038/s41594-018-0116-7

PMCID:: PMC6237183

Abstract Article PDF–1.1M

Select item 621414211.

Transcription of the Human 5-Hydroxytryptamine Receptor 2B (HTR2B) Gene Is under the Regulatory Influence of the Transcription Factors NFI and RUNX1 in Human Uveal Melanoma

Manel Benhassine, Sylvain L. Guérin

Int J Mol Sci. 2018 Oct; 19(10): 3272. Published online 2018 Oct 21. doi: 10.3390/ijms19103272

PMCID:: PMC6214142

Abstract Article PDF–4.4M

Select item 616668212.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 585645713.

Serotonin Receptor 2B Signaling with Interstitial Cell Activation and Leaflet Remodeling in Degenerative Mitral Regurgitation

Kathryn H Driesbaugh, Emanuela Branchetti, Juan B Grau, Samuel J. Keeney, Kimberly Glass, Mark A Oyama, Nancy Rioux, Salma Ayoub, Michael S Sacks, John Quackenbush, Robert J Levy, Giovanni Ferrari

J Mol Cell Cardiol. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: J Mol Cell Cardiol. 2018 Feb; 115: 94–103. Published online 2017 Dec 30. doi: 10.1016/j.yjmcc.2017.12.014

PMCID:: PMC5856457

Abstract Article PDF–1.6M

Select item 578885314.

Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells

Attila Szabo, Peter Gogolak, Gabor Koncz, Zsofia Foldvari, Kitti Pazmandi, Noemi Miltner, Szilard Poliska, Attila Bacsi, Srdjan Djurovic, Eva Rajnavolgyi

Sci Rep. 2018; 8: 1765. Published online 2018 Jan 29. doi: 10.1038/s41598-018-20173-y

PMCID:: PMC5788853

Abstract Article PDF–2.4M

Select item 569065015.

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT_2A and 5-HT_2B receptors in chondrocytes

Ayaka Hori, Takashi Nishida, Shogo Takashiba, Satoshi Kubota, Masaharu Takigawa

PLoS One. 2017; 12(11): e0188014. Published online 2017 Nov 16. doi: 10.1371/journal.pone.0188014

PMCID:: PMC5690650

Abstract Article PDF–8.5M

Select item 554759816.

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

Andrii Ishchenko, Daniel Wacker, Mili Kapoor, Ai Zhang, Gye Won Han, Shibom Basu, Nilkanth Patel, Marc Messerschmidt, Uwe Weierstall, Wei Liu, Vsevolod Katritch, Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov

Proc Natl Acad Sci U S A. 2017 Aug 1; 114(31): 8223–8228. Published online 2017 Jul 17. doi: 10.1073/pnas.1700891114

PMCID:: PMC5547598

Abstract Article PDF–1.5M

Select item 539176317.

Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT_2C protomers

Imane Moutkine, Emily Quentin, Bruno P. Guiard, Luc Maroteaux, Stephane Doly

J Biol Chem. 2017 Apr 14; 292(15): 6352–6368. Published online 2017 Mar 3. doi: 10.1074/jbc.M117.779041

PMCID:: PMC5391763

Abstract Article PDF–3.8M

Select item 537173018.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 528931119.

Crystal structure of an LSD-bound human serotonin receptor

Daniel Wacker, Sheng Wang, John D. McCorvy, Robin M. Betz, A. J. Venkatakrishnan, Anat Levit, Katherine Lansu, Zachary L. Schools, Tao Che, David E. Nichols, Brian K. Shoichet, Ron O. Dror, Bryan L. Roth

Cell. Author manuscript; available in PMC 2018 Jan 26.

Published in final edited form as: Cell. 2017 Jan 26; 168(3): 377–389.e12. doi: 10.1016/j.cell.2016.12.033

PMCID:: PMC5289311

Abstract Article PDF–2.5M

Select item 506876320.

Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon

R Tikkanen, J Tiihonen, M R Rautiainen, T Paunio, L Bevilacqua, R Panarsky, D Goldman, M Virkkunen

Transl Psychiatry. 2015 Nov; 5(11): e681. Published online 2015 Nov 17. doi: 10.1038/tp.2015.170

PMCID:: PMC5068763

Abstract Article PDF–398K

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