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Select item 113435651.

Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

Yohei Nitta, Jiro Osaka, Ryuto Maki, Satoko Hakeda-Suzuki, Emiko Suzuki, Satoshi Ueki, Takashi Suzuki, Atsushi Sugie

eLife. 2024; 12: RP87880. Published online 2024 Aug 23. doi: 10.7554/eLife.87880

PMCID:: PMC11343565

Abstract Article PDF–10M

Select item 111756122.

A microRNA that controls the emergence of embryonic movement

Jonathan AC Menzies, André Maia Chagas, Tom Baden, Claudio R Alonso

eLife. 2024; 13: RP95209. Published online 2024 Jun 13. doi: 10.7554/eLife.95209

PMCID:: PMC11175612

Abstract Article PDF–3.6M

Select item 110123513.

Mitochondrial Differentiation during Spermatogenesis: Lessons from Drosophila melanogaster

Viktor Vedelek, Ferenc Jankovics, János Zádori, Rita Sinka

Int J Mol Sci. 2024 Apr; 25(7): 3980. Published online 2024 Apr 3. doi: 10.3390/ijms25073980

PMCID:: PMC11012351

Abstract Article PDF–7.4M

Select item 106450794.

Structure and molecular basis of spermatid elongation in the Drosophila testis

Qiuru Huang, Xia Chen, Hao Yu, Li Ji, Yi Shi, Xinmeng Cheng, Hao Chen, Jun Yu

Open Biol. 2023 Nov; 13(11): 230136. Published online November 8, 2023. doi: 10.1098/rsob.230136

PMCID:: PMC10645079

Abstract Article PDF–1.0M

Select item 104650055.

Optogenetic cleavage of the Miro GTPase reveals the direct consequences of real-time loss of function in Drosophila

Francesca Mattedi, Ethlyn Lloyd-Morris, Frank Hirth, Alessio Vagnoni

PLoS Biol. 2023 Aug; 21(8): e3002273. Published online 2023 Aug 17. doi: 10.1371/journal.pbio.3002273

PMCID:: PMC10465005

Abstract Article PDF–3.7M

Select item 104505806.

Milton assembles large mitochondrial clusters, mitoballs, to sustain spermatogenesis

Andy Y. Z. Li, Ying Di, Sumaera Rathore, Ason C.-Y. Chiang, Jan Jezek, Hansong Ma

Proc Natl Acad Sci U S A. 2023 Aug 22; 120(34): e2306073120. Published online 2023 Aug 14. doi: 10.1073/pnas.2306073120

PMCID:: PMC10450580

Abstract Article PDF–8.2M

Select item 101509637.

Insights from Drosophila on Aβ- and tau-induced mitochondrial dysfunction: mechanisms and tools

Vanlalrinchhani Varte, Jeremy W. Munkelwitz, Diego E. Rincon-Limas

Front Neurosci. 2023; 17: 1184080. Published online 2023 Apr 17. doi: 10.3389/fnins.2023.1184080

PMCID:: PMC10150963

Abstract Article PDF–3.9M

Select item 100129558.

HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury

Thomas J. Krzystek, Joseph A. White, Rasika Rathnayake, Layne Thurston, Hayley Hoffmar-Glennon, Yichen Li, Shermali Gunawardena

Autophagy. 2023; 19(4): 1199–1220. Published online 2022 Sep 9. doi: 10.1080/15548627.2022.2119351

PMCID:: PMC10012955

Abstract Article PDF–7.7M

Select item 94705879.

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

Seungjae Lee, Yen-Chung Chen, FCA Consortium, Austin E. Gillen, J. Matthew Taliaferro, Bart Deplancke, Hongjie Li, Eric C. Lai

Nat Commun. 2022; 13: 5372. Published online 2022 Sep 13. doi: 10.1038/s41467-022-32305-0

PMCID:: PMC9470587

Abstract Article PDF–5.3M

Select item 923148910.

Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain

Johannes Knabbe, Jil Protzmann, Niklas Schneider, Michael Berger, Dominik Dannehl, Shoupeng Wei, Christopher Strahle, Michèle Tegtmeier, Astha Jaiswal, Hongwei Zheng, Marcus Krüger, Karl Rohr, Rainer Spanagel, Ainhoa Bilbao, Maren Engelhardt, Henrike Scholz, Sidney B. Cambridge

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2122477119. Published online 2022 Jun 14. doi: 10.1073/pnas.2122477119

PMCID:: PMC9231489

Abstract Article PDF–2.3M

Select item 824741311.

Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease

Young Won Kim, Ismael Al‐Ramahi, Amanda Koire, Stephen J. Wilson, Daniel M. Konecki, Samantha Mota, Shirin Soleimani, Juan Botas, Olivier Lichtarge

Alzheimers Dement. 2021 May; 17(5): 831–846. Published online 2020 Dec 7. doi: 10.1002/alz.12240

PMCID:: PMC8247413

Abstract Article PDF–1.9M

Select item 820506312.

Sunday Driver Mediates Multi-Compartment Golgi Outposts Defects Induced by Amyloid Precursor Protein

Qianqian Du, Jin Chang, Guo Cheng, Yinyin Zhao, Wei Zhou

Front Neurosci. 2021; 15: 673684. Published online 2021 Jun 1. doi: 10.3389/fnins.2021.673684

PMCID:: PMC8205063

Abstract Article PDF–4.4M

Select item 780680813.

Increasing neuronal glucose uptake attenuates brain aging and promotes life span under dietary restriction in Drosophila

Mikiko Oka, Emiko Suzuki, Akiko Asada, Taro Saito, Koichi M. Iijima, Kanae Ando

iScience. 2021 Jan 22; 24(1): 101979. Published online 2021 Jan 5. doi: 10.1016/j.isci.2020.101979

PMCID:: PMC7806808

Abstract Article PDF–9.3M

Select item 752622614.

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

Carl Grant Mangleburg, Timothy Wu, Hari K. Yalamanchili, Caiwei Guo, Yi-Chen Hsieh, Duc M. Duong, Eric B. Dammer, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu, Joshua M. Shulman

Mol Neurodegener. 2020; 15: 56. Published online 2020 Sep 29. doi: 10.1186/s13024-020-00405-4

PMCID:: PMC7526226

Abstract Article PDF–1.4M

Select item 750397315.

Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster

Akari Takai, Masamitsu Yamaguchi, Hideki Yoshida, Tomohiro Chiyonobu

Int J Mol Sci. 2020 Sep; 21(17): 6442. Published online 2020 Sep 3. doi: 10.3390/ijms21176442

PMCID:: PMC7503973

Abstract Article PDF–1.6M

Select item 733750516.

Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation

Zhe Chen, Zong-Heng Wang, Guofeng Zhang, Christopher K.E. Bleck, Dillon J. Chung, Grey P. Madison, Eric Lindberg, Christian Combs, Robert S. Balaban, Hong Xu

J Cell Biol. 2020 Jul 6; 219(7): e201905160. Published online 2020 May 6. doi: 10.1083/jcb.201905160

PMCID:: PMC7337505

Abstract Article PDF–4.3M

Select item 733128017.

Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington’s disease

Joseph A. White, II, Thomas J. Krzystek, Hayley Hoffmar-Glennon, Claire Thant, Katherine Zimmerman, Gary Iacobucci, Julia Vail, Layne Thurston, Saad Rahman, Shermali Gunawardena

Acta Neuropathol Commun. 2020; 8: 97. Published online 2020 Jul 1. doi: 10.1186/s40478-020-00964-z

PMCID:: PMC7331280

Abstract Article PDF–6.0M

Select item 718633518.

Drosophila VCP/p97 Mediates Dynein-Dependent Retrograde Mitochondrial Motility in Axons

Ashley E. Gonzalez, Xinnan Wang

Front Cell Dev Biol. 2020; 8: 256. Published online 2020 Apr 21. doi: 10.3389/fcell.2020.00256

PMCID:: PMC7186335

Abstract Article PDF–3.3M

Select item 696157819.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 675092620.

Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis

Jia Zhou, Lingna Xu, Xiuying Duan, Wei Liu, Xiaocui Zhao, Xi Wang, Weina Shang, Xuefei Fang, Huan Yang, Lijun Jia, Jian Bai, Jiayao Zhao, Liquan Wang, Chao Tong

Sci Adv. 2019 Sep; 5(9): eaax0365. Published online 2019 Sep 18. doi: 10.1126/sciadv.aax0365