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Select item 82576221.

Bromodomain protein BRDT directs ΔNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas

Xin Wang, Ana P. Kutschat, Moyuru Yamada, Evangelos Prokakis, Patricia Böttcher, Koji Tanaka, Yuichiro Doki, Feda H. Hamdan, Steven A. Johnsen

Cell Death Differ. 2021 Jul; 28(7): 2207–2220. Published online 2021 Mar 3. doi: 10.1038/s41418-021-00751-w

PMCID:: PMC8257622

Abstract Article PDF–3.7M

Select item 79362712.

Discovery and characterization of bromodomain 2–specific inhibitors of BRDT

Zhifeng Yu, Angela F. Ku, Justin L. Anglin, Rajesh Sharma, Melek Nihan Ucisik, John C. Faver, Feng Li, Pranavanand Nyshadham, Nicholas Simmons, Kiran L. Sharma, Sureshbabu Nagarajan, Kevin Riehle, Gundeep Kaur, Banumathi Sankaran, Marta Storl-Desmond, Stephen S. Palmer, Damian W. Young, Choel Kim, Martin M. Matzuk

Proc Natl Acad Sci U S A. 2021 Mar 2; 118(9): e2021102118. Published online 2021 Feb 26. doi: 10.1073/pnas.2021102118

PMCID:: PMC7936271

Abstract Article PDF–2.3M

Select item 76103283.

BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma

Pei Wan, Zhilin Chen, Weifeng Zhong, Huiming Jiang, Zhicheng Huang, Dong Peng, Qiang He, Nanhui Chen

Oncol Rep. 2020 Dec; 44(6): 2475–2486. Published online 2020 Oct 8. doi: 10.3892/or.2020.7796

PMCID:: PMC7610328

Abstract Article PDF–982K

Select item 69420444.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 67632425.

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development

Pu Wang, Feng Yan, Zhijun Li, Yanbao Yu, Scott E. Parnell, Yue Xiong

J Clin Invest. 2019 Oct 1; 129(10): 4393–4407. Published online 2019 Sep 9. doi: 10.1172/JCI129107

PMCID:: PMC6763242

Abstract Article PDF–12M

Select item 63757296.

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Jean-Philippe Lambert, Sarah Picaud, Takao Fujisawa, Huayun Hou, Pavel Savitsky, Liis Uusküla-Reimand, Gagan D. Gupta, Hala Abdouni, Zhen-Yuan Lin, Monika Tucholska, James D.R. Knight, Beatriz Gonzalez-Badillo, Nicole St-Denis, Joseph A. Newman, Manuel Stucki, Laurence Pelletier, Nuno Bandeira, Michael D. Wilson, Panagis Filippakopoulos, Anne-Claude Gingras

Mol Cell. 2019 Feb 7; 73(3): 621–638.e17. doi: 10.1016/j.molcel.2018.11.006

PMCID:: PMC6375729

Abstract Article PDF–10M

Select item 61319027.

FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma

Bo Wang, Ping Fan, Jingyuan Zhao, Heyu Wu, Xin Jin, Heshui Wu

J Exp Clin Cancer Res. 2018; 37: 224. Published online 2018 Sep 10. doi: 10.1186/s13046-018-0888-y

PMCID:: PMC6131902

Abstract Article PDF–5.7M

Select item 59707958.

Metabolically-derived lysine acylations and neighboring modifications tune BET bromodomain binding to histone H4

Michael D. Olp, Nan Zhu, Brian C. Smith

Biochemistry. Author manuscript; available in PMC 2018 Oct 17.

Published in final edited form as: Biochemistry. 2017 Oct 17; 56(41): 5485–5495. Published online 2017 Oct 5. doi: 10.1021/acs.biochem.7b00595

PMCID:: PMC5970795

Abstract Article PDF–1.0M

Select item 53867339.

Whole-exome sequencing identified a homozygous BRDT mutation in a patient with acephalic spermatozoa

Lin Li, Yanwei Sha, Xi Wang, Ping Li, Jing Wang, Kehkooi Kee, Binbin Wang

Oncotarget. 2017 Mar 21; 8(12): 19914–19922. Published online 2017 Feb 10. doi: 10.18632/oncotarget.15251

PMCID:: PMC5386733

Abstract Article PDF–2.3M

Select item 468531210.

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis

Giorgio Oliviero, Nayla Munawar, Ariane Watson, Gundula Streubel, Gwendolyn Manning, Vivian Bardwell, Adrian P. Bracken, Gerard Cagney

Sci Rep. 2015; 5: 18388. Published online 2015 Dec 21. doi: 10.1038/srep18388

PMCID:: PMC4685312

Abstract Article PDF–1.5M

Select item 458732211.

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage

Romain Drissi, Marie-Line Dubois, Mélanie Douziech, François-Michel Boisvert

Mol Cell Proteomics. 2015 Jul; 14(7): 2002–2013. Published online 2015 May 11. doi: 10.1074/mcp.M115.048991

PMCID:: PMC4587322

Abstract Article PDF–3.0M

Select item 429813812.

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

Fade Gong, Li-Ya Chiu, Ben Cox, François Aymard, Thomas Clouaire, Justin W. Leung, Michael Cammarata, Mercedes Perez, Poonam Agarwal, Jennifer S. Brodbelt, Gaëlle Legube, Kyle M. Miller

Genes Dev. 2015 Jan 15; 29(2): 197–211. doi: 10.1101/gad.252189.114

PMCID:: PMC4298138

Abstract Article PDF–2.5M

Select item 347474013.

E2F6 Associates with BRG1 in Transcriptional Regulation

Janet Y. Leung, Joseph R. Nevins

PLoS One. 2012; 7(10): e47967. Published online 2012 Oct 17. doi: 10.1371/journal.pone.0047967

PMCID:: PMC3474740

Abstract Article PDF–647K

Select item 332652314.

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

Panagis Filippakopoulos, Sarah Picaud, Maria Mangos, Tracy Keates, Jean-Philippe Lambert, Dalia Barsyte-Lovejoy, Ildiko Felletar, Rudolf Volkmer, Susanne Müller, Tony Pawson, Anne-Claude Gingras, Cheryl H. Arrowsmith, Stefan Knapp

Cell. 2012 Mar 30; 149(1): 214–231. doi: 10.1016/j.cell.2012.02.013

PMCID:: PMC3326523

Abstract Article PDF–2.8M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 289646416.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 195944317.

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

Dwayne A. Bisgrove, Tokameh Mahmoudi, Peter Henklein, Eric Verdin

Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34): 13690–13695. Published online 2007 Aug 9. doi: 10.1073/pnas.0705053104

PMCID:: PMC1959443

Abstract Article PDF–460K

Select item 135612918.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 52892819.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 31094820.

DNA Cloning Using In Vitro Site-Specific Recombination

James L. Hartley, Gary F. Temple, Michael A. Brasch

Genome Res. 2000 Nov; 10(11): 1788–1795. doi: 10.1101/gr.143000

PMCID:: PMC310948

Abstract Article PDF–1.7M

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