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Select item 103197181.

IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis

Franziska G. Thiel, Saeedeh Asgarbeik, Juliane Glaubitz, Anika Wilden, Markus M. Lerch, Frank Ulrich Weiss, Matthias Sendler

Sci Rep. 2023; 13: 10833. Published online 2023 Jul 4. doi: 10.1038/s41598-023-37930-3

PMCID:: PMC10319718

Abstract Article PDF–11M

Select item 100650812.

IL-1 receptor–associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy

Gürcan Tunalı, Marta Rúbies Bedós, Divya Nagarajan, Patrik Fridh, Irineos Papakyriacou, Yumeng Mao

J Clin Invest. 2023 Apr 3; 133(7): e161084. Published online 2023 Apr 3. doi: 10.1172/JCI161084

PMCID:: PMC10065081

Abstract Article PDF–10M

Select item 99184853.

IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis

Yuanyuan Wang, Shanshan Pei, Zhuhe Liu, Yuewen Ding, Tinglin Qian, Haixia Wen, Ssu-Wei Hsu, Zheyi Zhou, Jun Zhang, Honghao Wang

Cell Death Dis. 2023 Feb; 14(2): 103. Published online 2023 Feb 10. doi: 10.1038/s41419-023-05621-6

PMCID:: PMC9918485

Abstract Article PDF–4.4M

Select item 82782774.

Kisha Pradhan, Shuo Geng, Yao Zhang, Rui-Ci Lin, Liwu Li

J Immunol. 2021 Jun 15; 206(12): 2980–2988. Published online 2021 Jun 15. doi: 10.4049/jimmunol.2000978

PMCID:: PMC8278277

Abstract Article PDF–1.7M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 77171186.

Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M

Josept Mari S. Poblete, Megan N. Ballinger, Shengying Bao, Miriam Alghothani, Jose B. Nevado, Jr., Timothy D. Eubank, John W. Christman, Ulysses J. Magalang

Am J Physiol Endocrinol Metab. 2020 May 1; 318(5): E689–E700. Published online 2020 Mar 10. doi: 10.1152/ajpendo.00174.2019

PMCID:: PMC7717118

Abstract Article

Select item 73567307.

IRAK-M regulates monocyte trafficking to the lungs in response to bleomycin challenge.

Brenda F. Reader, Shruthi Sethurman, Bryan R. Hay, Rose Viguna Thomas Becket, Manjula Karpurapu, Sangwoon Chung, Yong Gyu Lee, John W. Christman, Megan N. Ballinger

J Immunol. Author manuscript; available in PMC 2020 Nov 15.

Published in final edited form as: J Immunol. 2020 May 15; 204(10): 2661–2670. Published online 2020 Apr 6. doi: 10.4049/jimmunol.1900466

PMCID:: PMC7356730

Abstract Article PDF–1.8M

Select item 69537928.

Neutrophils Deficient in Innate Suppressor IRAK-M Enhances Anti-tumor Immune Responses

Yao Zhang, Na Diao, Christina K. Lee, Hong Wei Chu, Lan Bai, Liwu Li

Mol Ther. 2020 Jan 8; 28(1): 89–99. Published online 2019 Sep 23. doi: 10.1016/j.ymthe.2019.09.019

PMCID:: PMC6953792

Abstract Article PDF–2.9M

Select item 69438789.

Critical Role of IRAK-M in Regulating Antigen-Induced Airway Inflammation

Mingqiang Zhang, Wei Chen, Weixun Zhou, Yan Bai, Jinming Gao

Am J Respir Cell Mol Biol. 2017 Nov; 57(5): 547–559. doi: 10.1165/rcmb.2016-0370OC

PMCID:: PMC6943878

Abstract Article PDF–2.2M

Select item 634430110.

IRAK-M associates with susceptibility to adult-onset asthma and promotes chronic airway inflammation

Yi Liu, Mingqiang Zhang, Lili Lou, Lun Li, Youming Zhang, Wei Chen, Weixun Zhou, Yan Bai, Jinming Gao

J Immunol. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: J Immunol. 2019 Feb 1; 202(3): 899–911. Published online 2019 Jan 7. doi: 10.4049/jimmunol.1800712

PMCID:: PMC6344301

Abstract Article PDF–2.0M

Select item 630830511.

IRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice

Chenfei Lyu, Yongfang Zhang, Minhua Gu, Yusheng Huang, Guanghui Liu, Chen Wang, Miaodan Li, Shumin Chen, Suyue Pan, Yong Gu

Front Cell Neurosci. 2018; 12: 504. Published online 2018 Dec 21. doi: 10.3389/fncel.2018.00504

PMCID:: PMC6308305

Abstract Article PDF–5.9M

Select item 626472412.

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation

Cun-Jin Zhang, Meiling Jiang, Hao Zhou, Weiwei Liu, Chenhui Wang, Zizhen Kang, Bing Han, Quanri Zhang, Xing Chen, Jianxin Xiao, Amanda Fisher, William J. Kaiser, Masanori A. Murayama, Yoichiro Iwakura, Ji Gao, Julie Carman, Ashok Dongre, George Dubyak, Derek W. Abbott, Fu-Dong Shi, Richard M. Ransohoff, Xiaoxia Li

J Clin Invest. 2018 Dec 3; 128(12): 5399–5412. Published online 2018 Oct 29. doi: 10.1172/JCI121901

PMCID:: PMC6264724

Abstract Article PDF–13M

Select item 609123413.

Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M

Yi-An Ko, Yueh-Hsuan Chan, Chin-Hsiu Liu, Jian-Jong Liang, Tsung-Hsien Chuang, Yi-Ping Hsueh, Yi-Ling Lin, Kuo-I Lin

Front Immunol. 2018; 9: 1828. Published online 2018 Aug 7. doi: 10.3389/fimmu.2018.01828

PMCID:: PMC6091234

Abstract Article PDF–6.5M

Select item 599551514.

TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c⁺ adipose tissue macrophage production in obese mice

Cameron Griffin, Leila Eter, Nico Lanzetta, Simin Abrishami, Mita Varghese, Kaitlin McKernan, Lindsey Muir, Jamie Lane, Carey N. Lumeng, Kanakadurga Singer

J Biol Chem. 2018 Jun 8; 293(23): 8775–8786. Published online 2018 Apr 10. doi: 10.1074/jbc.RA117.001526

PMCID:: PMC5995515

Abstract Article PDF–2.9M

Select item 591313415.

The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation

Morris Nechama, Jeahoo Kwon, Shuo Wei, Adrian Tun-Kyi, Robert S. Welner, Iddo Z. Ben-Dov, Mohamed S. Arredouani, John M. Asara, Chun-Hau Chen, Cheng-Yu Tsai, Kyle F. Nelson, Koichi S Kobayashi, Elliot Israel, Xiao Zhen Zhou, Linda K. Nicholson, Kun Ping Lu

Nat Commun. 2018; 9: 1603. Published online 2018 Apr 23. doi: 10.1038/s41467-018-03886-6

Correction in:: Nat Commun. 2023; 14: 3622.

PMCID:: PMC5913134

Abstract Article PDF–3.9M

Select item 561243616.

A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection

Di Jiang, Jennifer Matsuda, Reena Berman, Niccolette Schaefer, Connor Stevenson, James Gross, Bicheng Zhang, Amelia Sanchez, Liwu Li, Hong Wei Chu

Innate Immun. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Innate Immun. 2017 Feb; 23(2): 206–215. Published online 2016 Dec 18. doi: 10.1177/1753425916684202

PMCID:: PMC5612436

Abstract Article PDF–1.3M

Select item 523381317.

Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M

Daniel E. Rothschild, Yao Zhang, Na Diao, Christina K. Lee, Keqiang Chen, Clayton C. Caswell, Daniel J. Slade, Richard F. Helm, Tanya LeRoith, Liwu Li, Irving C. Allen

EBioMedicine. 2017 Feb; 15: 36–47. Published online 2016 Dec 3. doi: 10.1016/j.ebiom.2016.11.039

PMCID:: PMC5233813

Abstract Article PDF–1.8M

Select item 510517618.

The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis

Shuo Geng, Keqiang Chen, Ruoxi Yuan, Liang Peng, Urmila Maitra, Na Diao, Chun Chen, Yao Zhang, Yuan Hu, Chen-Feng Qi, Susan Pierce, Wenhua Ling, Huabao Xiong, Liwu Li

Nat Commun. 2016; 7: 13436. Published online 2016 Nov 8. doi: 10.1038/ncomms13436

PMCID:: PMC5105176

Abstract Article PDF–2.4M

Select item 468965419.

The role of Interleukin Receptor Associated Kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction

Amit Saxena, Arti V Shinde, Zaffar Haque, Yi-Jin Wu, Wei Chen, Ya Su, Nikolaos G Frangogiannis

J Mol Cell Cardiol. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: J Mol Cell Cardiol. 2015 Dec; 89(0 0): 223–231. Published online 2015 Nov 2. doi: 10.1016/j.yjmcc.2015.11.001

PMCID:: PMC4689654

Abstract Article PDF–1.7M

Select item 451778120.

Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes

Mark W. Julian, Heather R. Strange, Megan N. Ballinger, Richard S. Hotchkiss, Tracey L. Papenfuss, Elliott D. Crouser

PLoS One. 2015; 10(7): e0132921. Published online 2015 Jul 28. doi: 10.1371/journal.pone.0132921

PMCID:: PMC4517781

Abstract Article PDF–3.1M

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