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Select item 115131481.

The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi

Yannick Weyer, Sinead I. Schwabl, Xuechen Tang, Astha Purwar, Konstantin Siegmann, Angela Ruepp, Theresia Dunzendorfer-Matt, Michael A. Widerin, Veronika Niedrist, Noa J. M. Mutsters, Maria G. Tettamanti, Sabine Weys, Bettina Sarg, Leopold Kremser, Klaus R. Liedl, Oliver Schmidt, David Teis

Nat Commun. 2024; 15: 9257. Published online 2024 Oct 26. doi: 10.1038/s41467-024-53676-6

PMCID:: PMC11513148

Abstract Article PDF–5.3M

Select item 108724772.

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle

Michael J. O’Brien, Athar Ansari

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2024 Jan 1; 1872(1): 140968. Published online 2023 Oct 19. doi: 10.1016/j.bbapap.2023.140968

PMCID:: PMC10872477

Abstract Article PDF–1.7M

Select item 105509673.

Structure of the ceramide-bound SPOTS complex

Jan-Hannes Schäfer, Carolin Körner, Bianca M. Esch, Sergej Limar, Kristian Parey, Stefan Walter, Dovile Januliene, Arne Moeller, Florian Fröhlich

Nat Commun. 2023; 14: 6196. Published online 2023 Oct 4. doi: 10.1038/s41467-023-41747-z

PMCID:: PMC10550967

Abstract Article PDF–11M

Select item 96309864.

A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans

Phoebe Y T Lu, Alyssa C Kirlin, Maria J Aristizabal, Hilary T Brewis, Nancy Lévesque, Dheva T Setiaputra, Nikita Avvakumov, Joris J Benschop, Marian Groot Koerkamp, Frank C P Holstege, Nevan J Krogan, Calvin K Yip, Jacques Côté, Michael S Kobor

Genetics. 2022 Nov; 222(3): iyac136. Published online 2022 Sep 6. doi: 10.1093/genetics/iyac136

PMCID:: PMC9630986

Abstract Article PDF–2.2M

Select item 92098115.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 75074026.

Systematic analysis of bypass suppression of essential genes

Jolanda van Leeuwen, Carles Pons, Guihong Tan, Zi Yang Wang, Jing Hou, Jochen Weile, Marinella Gebbia, Wendy Liang, Ermira Shuteriqi, Zhijian Li, Maykel Lopes, Matej Ušaj, Andreia Dos Santos Lopes, Natascha van Lieshout, Chad L Myers, Frederick P Roth, Patrick Aloy, Brenda J Andrews, Charles Boone

Mol Syst Biol. 2020 Sep; 16(9): e9828. Published online 2020 Sep 17. doi: 10.15252/msb.20209828

PMCID:: PMC7507402

Abstract Article PDF–1.9M

Select item 74788467.

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae

Bianca M. Esch, Sergej Limar, André Bogdanowski, Christos Gournas, Tushar More, Celine Sundag, Stefan Walter, Jürgen J. Heinisch, Christer S. Ejsing, Bruno André, Florian Fröhlich

PLoS Genet. 2020 Aug; 16(8): e1008745. Published online 2020 Aug 26. doi: 10.1371/journal.pgen.1008745

PMCID:: PMC7478846

Abstract Article PDF–3.5M

Select item 74435078.

TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast

Oliver Schmidt, Yannick Weyer, Simon Sprenger, Michael A. Widerin, Sebastian Eising, Verena Baumann, Mihaela Angelova, Robbie Loewith, Christopher J. Stefan, Michael W. Hess, Florian Fröhlich, David Teis

J Biol Chem. 2020 Aug 21; 295(34): 12028–12044. Published online 2020 Jul 1. doi: 10.1074/jbc.RA120.013222

PMCID:: PMC7443507

Abstract Article PDF–3.8M

Select item 73298999.

Proper regulation of inositolphosphorylceramide levels is required for acquirement of low pH resistance in budding yeast

Mikiko Otsu, Moeko Toume, Yutaro Yamaguchi, Motohiro Tani

Sci Rep. 2020; 10: 10792. Published online 2020 Jul 1. doi: 10.1038/s41598-020-67734-8

PMCID:: PMC7329899

Abstract Article PDF–8.9M

Select item 666992210.

Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism

Oliver Schmidt, Yannick Weyer, Verena Baumann, Michael A Widerin, Sebastian Eising, Mihaela Angelova, Alexander Schleiffer, Leopold Kremser, Herbert Lindner, Matthias Peter, Florian Fröhlich, David Teis

EMBO J. 2019 Aug 1; 38(15): e101433. Published online 2019 May 27. doi: 10.15252/embj.2018101433

PMCID:: PMC6669922

Abstract Article PDF–2.8M

Select item 661571011.

The nucleotide sequence of Saccharomyces cerevisiae chromosome XII

M. Johnston, L. Hillier, L. Riles, other members of the Genome Sequencing Center, K. Albermann, B. André, W. Ansorge, V. Benes, M. Brückner, H. Delius, E. Dubois, A. Düsterhöft, K.-D. Entian, M. Floeth, A. Goffeau, U. Hebling, K. Heumann, D. Heuss-Neitzel, H. Hilbert, F. Hilger, K. Kleine, P. Kötter, E. J. Louis, F. Messenguy, H. W. Mewes, T. Miosga, D. Möstl, S. Müller-Auer, U. Nentwich, B. Obermaier, E. Piravandi, T. M. Pohl, D. Portetelle, B. Purnelle, S. Rechmann, M. Rieger, M. Rinke, M. Rose, M. Scharfe, B. Scherens, P. Scholler, C. Schwager, S. Schwarz, A. P. Underwood, L. A. Urrestarazu, M. Vandenbol, P. Verhasselt, F. Vierendeels, M Voet, G. Volckaert, H. Voss, R. Wambutt, E. Wedler, H. Wedler, F. K. Zimmermann, A. Zollner, J. Hani, J. D. Hoheisel

Nature. Author manuscript; available in PMC 2019 Jul 9.

Published in final edited form as: Nature. 1997 May 29; 387(6632 Suppl): 87–90.

PMCID:: PMC6615710

Abstract Article PDF–424K

Select item 657276012.

Novel interconnections of HOG signaling revealed by combined use of two proteomic software packages

Marion Janschitz, Natalie Romanov, Gina Varnavides, David Maria Hollenstein, Gabriela Gérecová, Gustav Ammerer, Markus Hartl, Wolfgang Reiter

Cell Commun Signal. 2019; 17: 66. Published online 2019 Jun 17. doi: 10.1186/s12964-019-0381-z

PMCID:: PMC6572760

Abstract Article PDF–2.7M

Select item 644206513.

The ORMDL/Orm–serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes

Deanna L. Davis, Kenneth Gable, John Suemitsu, Teresa M. Dunn, Binks W. Wattenberg

J Biol Chem. 2019 Mar 29; 294(13): 5146–5156. Published online 2019 Jan 30. doi: 10.1074/jbc.RA118.007291

PMCID:: PMC6442065

Abstract Article PDF–1.2M

Select item 637348914.

The ORMs Interact with Transmembrane Domain 1 of Lcb1 and Regulate Serine Palmitoyltransferase Oligomerization, Activity and Localization

Gongshe Han, Sita D. Gupta, Kenneth Gable, Dagmar Bacikova, Nivedita Sengupta, Niranjanakumari Somashekarappa, Richard L. Proia, Jeffrey M. Harmon, Teresa M. Dunn

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar; 1864(3): 245–259. Published online 2018 Dec 6. doi: 10.1016/j.bbalip.2018.11.007

PMCID:: PMC6373489

Abstract Article PDF–1.7M

Select item 634170215.

The protein kinase Cmk2 negatively regulates the calcium/calcineurin signalling pathway and expression of calcium pump genes PMR1 and PMC1 in budding yeast

Huihui Xu, Tianshu Fang, Hongbo Yan, Linghuo Jiang

Cell Commun Signal. 2019; 17: 7. Published online 2019 Jan 21. doi: 10.1186/s12964-019-0320-z

PMCID:: PMC6341702

Abstract Article PDF–1.3M

Select item 621091716.

Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway

Jihui Ren, Essa M. Saied, Aaron Zhong, Justin Snider, Christian Ruiz, Christoph Arenz, Lina M. Obeid, Geoffrey D. Girnun, Yusuf A. Hannun

J Lipid Res. 2018 Nov; 59(11): 2126–2139. Published online 2018 Aug 28. doi: 10.1194/jlr.M088195

PMCID:: PMC6210917

Abstract Article PDF–1.6M

Select item 592252817.

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Harley O’Connor Mount, Nicole M. Revie, Robert T. Todd, Kaitlin Anstett, Cathy Collins, Michael Costanzo, Charles Boone, Nicole Robbins, Anna Selmecki, Leah E. Cowen

PLoS Genet. 2018 Apr; 14(4): e1007319. Published online 2018 Apr 27. doi: 10.1371/journal.pgen.1007319

PMCID:: PMC5922528

Abstract Article PDF–7.1M

Select item 576535918.

Genome-Wide Mapping of Decay Factor–mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4

Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese

G3 (Bethesda) 2018 Jan; 8(1): 315–330. Published online 2017 Nov 20. doi: 10.1534/g3.117.300415

PMCID:: PMC5765359

Abstract Article PDF–2.2M

Select item 575387319.

Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes

Adriana Espinosa-Cantú, Diana Ascencio, Selene Herrera-Basurto, Jiewei Xu, Assen Roguev, Nevan J. Krogan, Alexander DeLuna

Genetics. 2018 Jan; 208(1): 419–431. Published online 2017 Nov 10. doi: 10.1534/genetics.117.300377

PMCID:: PMC5753873

Abstract Article PDF–1.5M

Select item 566188520.

A global interaction network maps a wiring diagram of cellular function

Michael Costanzo, Benjamin VanderSluis, Elizabeth N. Koch, Anastasia Baryshnikova, Carles Pons, Guihong Tan, Wen Wang, Matej Usaj, Julia Hanchard, Susan D. Lee, Vicent Pelechano, Erin B. Styles, Maximilian Billmann, Jolanda van Leeuwen, Nydia van Dyk, Zhen-Yuan Lin, Elena Kuzmin, Justin Nelson, Jeff S. Piotrowski, Tharan Srikumar, Sondra Bahr, Yiqun Chen, Raamesh Deshpande, Christoph F. Kurat, Sheena C. Li, Zhijian Li, Mojca Mattiazzi Usaj, Hiroki Okada, Natasha Pascoe, Bryan-Joseph San Luis, Sara Sharifpoor, Emira Shuteriqi, Scott W. Simpkins, Jamie Snider, Harsha Garadi Suresh, Yizhao Tan, Hongwei Zhu, Noel Malod-Dognin, Vuk Janjic, Natasa Przulj, Olga G. Troyanskaya, Igor Stagljar, Tian Xia, Yoshikazu Ohya, Anne-Claude Gingras, Brian Raught, Michael Boutros, Lars M. Steinmetz, Claire L. Moore, Adam P. Rosebrock, Amy A. Caudy, Chad L. Myers, Brenda Andrews, Charles Boone

Science. Author manuscript; available in PMC 2017 Oct 30.

Published in final edited form as: Science. 2016 Sep 23; 353(6306): aaf1420. doi: 10.1126/science.aaf1420

PMCID:: PMC5661885

Abstract Article PDF–2.6M

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