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Items: 1 to 20 of 31

1.
Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation
Remi Marrocco, Isabelle Bernard, Emeline Joulia, Rebecca Barascud, Anne S. Dejean, Renaud Lesourne, Abdelhadi Saoudi
Cell Mol Life Sci. 2024 Dec; 81(1): 161. Published online 2024 Apr 2. doi: 10.1007/s00018-024-05203-5
PMCID:
PMC10987373
AbstractArticlePDF–2.2M
2.
Themis controls T cell activation, effector functions, and metabolism of peripheral CD8+ T cells
Namrata Gautam, Lukasz Wojciech, Jiawei Yap, Yen Leong Chua, Eyan MW Ding, Don CN Sim, Alrina SM Tan, Patricia J Ahl, Mukul Prasad, Desmond WH Tung, John E Connolly, Giulia Adriani, Joanna Brzostek, Nicholas RJ Gascoigne
Life Sci Alliance. 2023 Dec; 6(12): e202302156. Published online 2023 Sep 22. doi: 10.26508/lsa.202302156
PMCID:
PMC10517225
AbstractArticlePDF–3.4M
3.
Themis suppresses the effector function of CD8+ T cells in acute viral infection
Jian Tang, Xian Jia, Jian Li, Junchen Dong, Jiayu Wang, Wanyun Li, Yuzhen Zhu, Yanyan Hu, Bowen Hou, Chunjie Lin, Yu Cong, Tong Ren, Changsheng Yan, Hongying Yang, Qian Lai, Haiping Zheng, Yuzhou Bao, Namrata Gautam, Hong-Rui Wang, Bing Xu, Xiao Lei Chen, Qing Li, Nicholas R. J. Gascoigne, Guo Fu
Cell Mol Immunol. 2023 May; 20(5): 512–524. Published online 2023 Mar 28. doi: 10.1038/s41423-023-00997-z
PMCID:
PMC10203318
AbstractArticlePDF–5.8M
4.
GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1
Seeyoung Choi, Teri Hatzihristidis, Guillaume Gaud, Avik Dutta, Jan Lee, Awadhesh Arya, Lauren M. Clubb, Daniel B. Stamos, Adrienn Markovics, Katalin Mikecz, Paul Love
J Exp Med. 2023 Jul 3; 220(7): e20221649. Published online 2023 Apr 17. doi: 10.1084/jem.20221649
PMCID:
PMC10114920
AbstractArticlePDF–4.4M
5.
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice
Mukul Prasad, Lukasz Wojciech, Joanna Brzostek, Jianfang Hu, Yen Leong Chua, Desmond Wai Hon Tung, Jiawei Yap, Vasily Rybakin, Nicholas R. J. Gascoigne
Front Immunol. 2021; 12: 644483. Published online 2021 Apr 7. doi: 10.3389/fimmu.2021.644483
PMCID:
PMC8058184
AbstractArticlePDF–5.3M
6.
THEMIS-SHP1 Recruitment by 4–1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells
Chuang Sun, Peishun Shou, Hongwei Du, Koichi Hirabayashi, Yuhui Chen, Laura E. Herring, Sarah Ahn, Yang Xu, Kyogo Suzuki, Guangming Li, Ourania Tsahouridis, Lishan Su, Barbara Savoldo, Gianpietro Dotti
Cancer Cell. Author manuscript; available in PMC 2021 Feb 10.
Published in final edited form as: Cancer Cell. 2020 Feb 10; 37(2): 216–225.e6. Published online 2020 Jan 30. doi: 10.1016/j.ccell.2019.12.014
PMCID:
PMC7397569
AbstractArticlePDF–2.6M
7.
CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation
Courtney A. Matson, Seeyoung Choi, Ferenc Livak, Bin Zhao, Apratim Mitra, Paul E. Love, Nevil J. Singh
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14342–14353. Published online 2020 Jun 8. doi: 10.1073/pnas.1922525117
PMCID:
PMC7322041
AbstractArticlePDF–1.9M
8.
Thymic-specific regulation of TCR signaling by Tespa1
Jun Lyu, Pengfei Wang, Ting Xu, Yichao Shen, Zejin Cui, Mingzhu Zheng, Guo Fu, Linrong Lu
Cell Mol Immunol. 2019 Dec; 16(12): 897–907. Published online 2019 Jul 17. doi: 10.1038/s41423-019-0259-4
PMCID:
PMC6884599
AbstractArticlePDF–4.5M
9.
Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics
Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen
Nat Immunol. Author manuscript; available in PMC 2020 Apr 7.
Published in final edited form as: Nat Immunol. 2019 Nov 1; 20(11): 1530–1541. Published online 2019 Oct 7. doi: 10.1038/s41590-019-0489-8
PMCID:
PMC6859066
AbstractArticlePDF–2.9M
10.
Themis-associated phosphatase activity controls signaling in T cell development
Monika Mehta, Joanna Brzostek, Elijah W. Chen, Desmond W. H. Tung, Shuting Chen, Shvetha Sankaran, Jiawei Yap, Vasily Rybakin, Nicholas R. J. Gascoigne
Proc Natl Acad Sci U S A. 2018 Nov 27; 115(48): E11331–E11340. Published online 2018 Nov 9. doi: 10.1073/pnas.1720209115
PMCID:
PMC6275480
AbstractArticlePDF–1.2M
11.
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1
Seeyoung Choi, Claude Warzecha, Ekaterina Zvezdova, Jan Lee, Jérémy Argenty, Renaud Lesourne, L. Aravind, Paul E. Love
Nat Immunol. Author manuscript; available in PMC 2018 Feb 9.
Published in final edited form as: Nat Immunol. 2017 Apr; 18(4): 433–441. Published online 2017 Feb 27. doi: 10.1038/ni.3692
PMCID:
PMC5807080
AbstractArticlePDF–1.1M
12.
Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function
Fanny Duguet, Marie Locard-Paulet, Marlène Marcellin, Karima Chaoui, Isabelle Bernard, Olivier Andreoletti, Renaud Lesourne, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Abdelhadi Saoudi
Mol Cell Proteomics. 2017 Aug; 16(8): 1416–1432. Published online 2017 Apr 3. doi: 10.1074/mcp.M116.062745
PMCID:
PMC5546195
AbstractArticlePDF–3.0M
13.
In vivo functional mapping of the conserved protein domains within murine Themis1
Ekaterina Zvezdova, Jan Lee, Dalal El-Khoury, Valarie Barr, Itoro Akpan, Lawrence Samelson, Paul E. Love
Immunol Cell Biol. Author manuscript; available in PMC 2015 Apr 29.
Published in final edited form as: Immunol Cell Biol. 2014 Sep; 92(8): 721–728. Published online 2014 Jun 17. doi: 10.1038/icb.2014.43
PMCID:
PMC4414023
AbstractArticlePDF–1.5M
14.
A THEMIS:SHP1 complex promotes T-cell survival
Wolfgang Paster, Annika M Bruger, Kristin Katsch, Claude Grégoire, Romain Roncagalli, Guo Fu, Nicholas RJ Gascoigne, Konstantina Nika, Andre Cohnen, Stephan M Feller, Philip C Simister, Kelly C Molder, Shaun-Paul Cordoba, Omer Dushek, Bernard Malissen, Oreste Acuto
EMBO J. 2015 Feb 3; 34(3): 393–409. Published online 2014 Dec 22. doi: 10.15252/embj.201387725
PMCID:
PMC4339124
AbstractArticlePDF–1.3M
15.
THEMIS Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis
Sabrina Torre, Sebastien P. Faucher, Nassima Fodil, Silayuv E. Bongfen, Joanne Berghout, Jeremy A. Schwartzentruber, Jacek Majewski, Mark Lathrop, Andrea M. Cooper, Silvia M. Vidal, Philippe Gros
Infect Immun. 2015 Feb; 83(2): 759–768. Prepublished online 2014 Dec 1. Published online 2015 Jan 14. doi: 10.1128/IAI.02586-14
PMCID:
PMC4294254
AbstractArticlePDF–2.0M
16.
Themis sets the signal threshold for positive and negative selection in T-cell development
Guo Fu, Javier Casas, Stephanie Rigaud, Vasily Rybakin, Florence Lambolez, Joanna Brzostek, John A.H. Hoerter, Wolfgang Paster, Oreste Acuto, Hilde Cheroutre, Karsten Sauer, Nicholas R.J. Gascoigne
Nature. Author manuscript; available in PMC 2014 Jun 19.
Published in final edited form as: Nature. 2013 Dec 19; 504(7480): 441–445. Published online 2013 Nov 13. doi: 10.1038/nature12718
PMCID:
PMC3977001
ArticlePDF–5.4M
17.
Differential Function of Themis CABIT Domains during T Cell Development
Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Akiko Takashima, Hiroyo Oda, Norimasa Tamehiro, Motohito Goto, Tadashi Okamura, Michael S. Patrick, Harumi Suzuki
PLoS One. 2014; 9(2): e89115. Published online 2014 Feb 21. doi: 10.1371/journal.pone.0089115
PMCID:
PMC3931654
AbstractArticlePDF–1.9M
18.
GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development
Wolfgang Paster, Claudia Brockmeyer, Guo Fu, Philip C. Simister, Ben de Wet, Ana Martinez-Riaño, John A. H. Hoerter, Stephan M. Feller, Christoph Wülfing, Nicholas R. J. Gascoigne, Oreste Acuto
J Immunol. 2013 Apr 1; 190(7): 3749–3756. Published online 2013 Mar 4. doi: 10.4049/jimmunol.1203389
PMCID:
PMC3607403
AbstractArticlePDF–1.9M
19.
Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function
Renaud Lesourne, Ekaterina Zvezdova, Ki-Duk Song, Dalal El-Khoury, Shoji Uehara, Valarie A. Barr, Lawrence E. Samelson, Paul E. Love
J Immunol. Author manuscript; available in PMC 2013 Aug 1.
Published in final edited form as: J Immunol. 2012 Aug 1; 189(3): 1154–1161. Published online 2012 Jun 25. doi: 10.4049/jimmunol.1200123
PMCID:
PMC3401357
AbstractArticlePDF–1.3M
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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