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Select item 112721841.

BRCA1 and 53BP1 Regulate Reprogramming Efficiency by Mediating DNA Repair Pathway Choice at Replication-associated Double-Strand Breaks

Daniela Georgieva, Ning Wang, Angelo Taglialatela, Stepan Jerabek, Colleen R. Reczek, Pei Xin Lim, Julie Sung, Qian Du, Michiko Horiguchi, Maria Jasin, Alberto Ciccia, Richard Baer, Dieter Egli

Cell Rep. Author manuscript; available in PMC 2024 Jul 25.

Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 114006. Published online 2024 Mar 30. doi: 10.1016/j.celrep.2024.114006

PMCID:: PMC11272184

Abstract Article PDF–2.7M

Select item 110594082.

Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions

Saori Yoshimura, Ryuki Shimada, Koji Kikuchi, Soichiro Kawagoe, Hironori Abe, Sakie Iisaka, Sayoko Fujimura, Kei-ichiro Yasunaga, Shingo Usuki, Naoki Tani, Takashi Ohba, Eiji Kondoh, Tomohide Saio, Kimi Araki, Kei-ichiro Ishiguro

Nat Commun. 2024; 15: 3330. Published online 2024 Apr 29. doi: 10.1038/s41467-024-47601-0

PMCID:: PMC11059408

Abstract Article PDF–8.4M

Select item 110209153.

GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer

Xuejie Wang, Feng Bai, Xiong Liu, Bin Peng, Xingzhi Xu, Hongquan Zhang, Li Fu, Wei-Guo Zhu, Bin Wang, Xin-Hai Pei

BMC Biol. 2024; 22: 85. Published online 2024 Apr 16. doi: 10.1186/s12915-024-01881-6

PMCID:: PMC11020915

Abstract Article PDF–6.2M

Select item 109488694.

Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection

Tirza Bidany-Mizrahi, Aya Shweiki, Kian Maroun, Lina Abu-Tair, Bella Mali, Rami I. Aqeilan

Cell Death Discov. 2024; 10: 145. Published online 2024 Mar 18. doi: 10.1038/s41420-024-01878-8

PMCID:: PMC10948869

Abstract Article PDF–4.5M

Select item 108774105.

BRCA1 protein dose-dependent risk for embryonic oxidative DNA damage, embryopathies and neurodevelopmental disorders with and without ethanol exposure

Danielle M. Drake, Kian Afsharian, Benjamin Or, Aaron M. Shapiro, Michelle L. Lai, Lutfiya Miller, Peter G. Wells

Redox Biol. 2024 Apr; 70: 103070. Published online 2024 Feb 8. doi: 10.1016/j.redox.2024.103070

PMCID:: PMC10877410

Abstract Article PDF–5.5M

Select item 108465306.

Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model

Giusy Tornillo, Lauren Warrington, Howard Kendrick, Adam T. Higgins, Trevor Hay, Sam Beck, Matthew J. Smalley

Dis Model Mech. 2024 Jan 1; 17(1): dmm050211. Published online 2024 Jan 25. doi: 10.1242/dmm.050211

PMCID:: PMC10846530

Abstract Article

Select item 107437537.

Exploiting Synthetic Lethality between Germline BRCA1 Haploinsufficiency and PARP Inhibition in JAK2V617F-Positive Myeloproliferative Neoplasms

Max Bermes, Maria Jimena Rodriguez, Marcelo Augusto Szymanski de Toledo, Sabrina Ernst, Gerhard Müller-Newen, Tim Henrik Brümmendorf, Nicolas Chatain, Steffen Koschmieder, Julian Baumeister

Int J Mol Sci. 2023 Dec; 24(24): 17560. Published online 2023 Dec 16. doi: 10.3390/ijms242417560

PMCID:: PMC10743753

Abstract Article PDF–8.2M

Select item 106872508.

Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting

George E. Ronson, Katarzyna Starowicz, Elizabeth J. Anthony, Ann Liza Piberger, Lucy C. Clarke, Alexander J. Garvin, Andrew D. Beggs, Celina M. Whalley, Matthew J. Edmonds, James F. J. Beesley, Joanna R. Morris

Nat Commun. 2023; 14: 7834. Published online 2023 Nov 29. doi: 10.1038/s41467-023-43677-2

PMCID:: PMC10687250

Abstract Article PDF–4.6M

Select item 106680319.

A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancer

Jianhao Zeng, Shambhavi Singh, Xian Zhou, Ying Jiang, Eli Casarez, Kristen A. Atkins, Kevin A. Janes, Hui Zong

Dis Model Mech. 2023 Nov 1; 16(11): dmm050219. Published online 2023 Nov 13. doi: 10.1242/dmm.050219

PMCID:: PMC10668031

Abstract Article

Select item 1060286810.

RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

Rehna Krishnan, Mariah Lapierre, Brandon Gautreau, Kevin C J Nixon, Samah El Ghamrasni, Parasvi S Patel, Jun Hao, V Talya Yerlici, Kiran Kumar Naidu Guturi, Jonathan St-Germain, Francesca Mateo, Amine Saad, Arash Algouneh, Rebecca Earnshaw, Duan Shili, Alma Seitova, Joshua Miller, Negin Khosraviani, Adam Penn, Brandon Ho, Otto Sanchez, M Prakash Hande, Jean-Yves Masson, Grant W Brown, Moulay Alaoui-Jamali, John J Reynolds, Cheryl Arrowsmith, Brian Raught, Miguel A Pujana, Karim Mekhail, Grant S Stewart, Anne Hakem, Razqallah Hakem

Nucleic Acids Res. 2023 Oct 27; 51(19): 10484–10505. Published online 2023 Sep 11. doi: 10.1093/nar/gkad733

PMCID:: PMC10602868

Abstract Article PDF–2.1M

Select item 1045063411.

BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury

Emily Leung, Daria Taskina, Nicole Schwab, Lili-Naz Hazrati

Front Neurosci. 2023; 17: 1225226. Published online 2023 Aug 10. doi: 10.3389/fnins.2023.1225226

PMCID:: PMC10450634

Abstract Article PDF–15M

Select item 1036114412.

p18INK4C and BRCA1 inhibit follicular cell proliferation and dedifferentiation in thyroid cancer

Feng Bai, Xiong Liu, Xu Zhang, Zhuo Mao, He Wen, Jinshan Ma, Xin-Hai Pei

Cell Cycle. 2023; 22(13): 1637–1653. Published online 2023 Jun 22. doi: 10.1080/15384101.2023.2225938

PMCID:: PMC10361144

Abstract Article PDF–4.2M

Select item 1035588513.

Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors

Dannielle H. Upton, Emily S. Fuller, Emily K. Colvin, Kirsty A. Walters, Mark Jimenez, Reena Desai, David J. Handelsman, Viive M. Howell, Charles M. Allan

Horm Cancer. 2015 Aug; 6(4): 142–152. Published online 2015 May 6. doi: 10.1007/s12672-015-0222-5

PMCID:: PMC10355885

Abstract Article PDF–1.3M

Select item 1029450914.

LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer

Goutam Dey, Rashmi Bharti, Chad Braley, Ravi Alluri, Emily Esakov, Katie Crean-Tate, Keith McCrae, Amy Joehlin-Price, Peter G. Rose, Justin Lathia, Zihua Gong, Ofer Reizes

J Ovarian Res. 2023; 16: 122. Published online 2023 Jun 27. doi: 10.1186/s13048-023-01194-2

PMCID:: PMC10294509

Abstract Article PDF–8.5M

Select item 1018950215.

Dichotomous ovarian cancer-initiating potential of Pax8+ cells revealed by a mouse genetic mosaic model

Jianhao Zeng, Astrid Catalina Alvarez-Yela, Eli Casarez, Ying Jiang, Lixin Wang, Brianna E. Kelly, Taylor Jenkins, Eugene Ke, Kristen A. Atkins, Kevin A. Janes, Jill K. Slack-Davis, Hui Zong

iScience. 2023 May 19; 26(5): 106742. Published online 2023 Apr 25. doi: 10.1016/j.isci.2023.106742

PMCID:: PMC10189502

Abstract Article PDF–7.8M

Select item 986997416.

BRCA1 and TP53 codeficiency causes a PARP inhibitor–sensitive erythroproliferative neoplasm

Gerardo Lopez-Perez, Ranjula Wijayatunge, Kelly B. McCrum, Sam R. Holmstrom, Victoria E. Mgbemena, Theodora S. Ross

JCI Insight. 2022 Dec 22; 7(24): e158257. Published online 2022 Dec 22. doi: 10.1172/jci.insight.158257

PMCID:: PMC9869974

Abstract Article PDF–5.6M

Select item 973267117.

PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells

Sarah C. Edwards, Ann Hedley, Wilma H.M. Hoevenaar, Robert Wiesheu, Teresa Glauner, Anna Kilbey, Robin Shaw, Katerina Boufea, Nizar Batada, Shinya Hatano, Yasunobu Yoshikai, Karen Blyth, Crispin Miller, Kristina Kirschner, Seth B. Coffelt

J Exp Med. 2023 Feb 6; 220(2): e20211431. Published online 2022 Dec 7. doi: 10.1084/jem.20211431

PMCID:: PMC9732671

Abstract Article PDF–7.5M

Select item 969431218.

Brca1 Is Regulated by the Transcription Factor Gata3, and Its Silencing Promotes Neural Differentiation in Retinal Neurons

Jiejie Zhuang, Pei Chen, Yihui Wu, Qian Luo, Qiyun Wang, Shuilian Chen, Xi Chen, Zihua Jiang, Jin Qiu, Yan Li, Zhaohui Yuan, Jing Zhuang

Int J Mol Sci. 2022 Nov; 23(22): 13860. Published online 2022 Nov 10. doi: 10.3390/ijms232213860

PMCID:: PMC9694312

Abstract Article PDF–3.5M

Select item 942319819.

BRCA1 affects global DNA methylation through regulation of DNMT1

Vivek Shukla, Xavier Coumoul, Tyler Lahusen, Rui-Hong Wang, Xiaoling Xu, Athanassios Vassilopoulos, Cuiying Xiao, Mi-Hye Lee, Yan-Gao Man, Mutsuko Ouchi, Toru Ouchi, Chu-Xia Deng

Cell Res. Author manuscript; available in PMC 2022 Aug 29.

Published in final edited form as: Cell Res. 2010 Nov; 20(11): 1201–1215. Published online 2010 Sep 7. doi: 10.1038/cr.2010.128

PMCID:: PMC9423198

Abstract Article PDF–1.7M

Select item 927112320.

Disrupted BRCA1-PALB2 Interaction Induces Tumor Immunosuppression and T-Lymphocyte Infiltration in Hepatocellular Carcinoma Through cGAS-STING Pathway

Hui Ma, Zhihua Kang, Tzeh Keong Foo, Zhiyuan Shen, Bing Xia

Hepatology. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Hepatology. 2023 Jan 1; 77(1): 33–47. Published online 2022 Feb 15. doi: 10.1002/hep.32335

PMCID:: PMC9271123

Abstract Article PDF–4.5M

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