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Select item 114053951.

A common mechanism for recruiting the Rrm3 and RTEL1 accessory helicases to the eukaryotic replisome

Ottavia Olson, Simone Pelliciari, Emma D Heron, Tom D Deegan

EMBO J. 2024 Sep; 43(18): 3846–3875. Published online 2024 Jul 22. doi: 10.1038/s44318-024-00168-4

PMCID:: PMC11405395

Abstract Article PDF–3.3M

Select item 113417642.

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms

Tomoki Tamai, Giordano Reginato, Ryusei Ojiri, Issei Morita, Alexandra Avrutis, Petr Cejka, Miki Shinohara, Katsunori Sugimoto

Nat Commun. 2024; 15: 7221. Published online 2024 Aug 22. doi: 10.1038/s41467-024-51493-5

PMCID:: PMC11341764

Abstract Article PDF–3.6M

Select item 111937143.

Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation in Saccharomyces cerevisiae

Bechara Zeinoun, Maria Teresa Teixeira, Aurélia Barascu

Commun Biol. 2024; 7: 761. Published online 2024 Jun 22. doi: 10.1038/s42003-024-06464-3

PMCID:: PMC11193714

Abstract Article PDF–833K

Select item 109544704.

Rif2 interaction with Rad50 counteracts Tel1 functions in checkpoint signalling and DNA tethering by releasing Tel1 from MRX binding

Paolo Pizzul, Erika Casari, Carlo Rinaldi, Marco Gnugnoli, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Nucleic Acids Res. 2024 Mar 21; 52(5): 2355–2371. Published online 2024 Jan 5. doi: 10.1093/nar/gkad1246

PMCID:: PMC10954470

Abstract Article PDF–2.4M

Select item 108724775.

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle

Michael J. O’Brien, Athar Ansari

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2024 Jan 1; 1872(1): 140968. Published online 2023 Oct 19. doi: 10.1016/j.bbapap.2023.140968

PMCID:: PMC10872477

Abstract Article PDF–1.7M

Select item 107001386.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 105019927.

How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication

Morgan L. Jones, Valentina Aria, Yasemin Baris, Joseph T.P. Yeeles

Mol Cell. 2023 Aug 17; 83(16): 2911–2924.e16. doi: 10.1016/j.molcel.2023.06.035

PMCID:: PMC10501992

Abstract Article

Select item 104218828.

Hydroxyurea and inactivation of checkpoint kinase MEC1 inhibit transcription termination and pre-mRNA cleavage at polyadenylation sites in budding yeast

Pritpal Kaur, Shreya Nagar, Riddhi Mehta, Kyle Sahadeo, Ales Vancura

Sci Rep. 2023; 13: 13106. Published online 2023 Aug 11. doi: 10.1038/s41598-023-40294-3

PMCID:: PMC10421882

Abstract Article PDF–4.5M

Select item 102977009.

The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions

Janhavi A. Kolhe, Neethu L. Babu, Brian C. Freeman

Mol Cell. Author manuscript; available in PMC 2024 Jun 15.

Published in final edited form as: Mol Cell. 2023 Jun 15; 83(12): 2035–2044.e7. Published online 2023 Jun 8. doi: 10.1016/j.molcel.2023.05.021

PMCID:: PMC10297700

Abstract Article PDF–2.0M

Select item 1025942010.

Mec1-independent activation of the Rad53 checkpoint kinase revealed by quantitative analysis of protein localization dynamics

Brandon Ho, Ethan J Sanford, Raphael Loll-Krippleber, Nikko P Torres, Marcus B Smolka, Grant W Brown

eLife. 2023; 12: e82483. Published online 2023 Jun 6. doi: 10.7554/eLife.82483

PMCID:: PMC10259420

Abstract Article PDF–2.1M

Select item 1023336811.

A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon

Nir Cohen, Naama Aviram, Maya Schuldiner

EMBO J. 2023 Jun; 42(11): e113385. Published online 2023 Apr 19. doi: 10.15252/embj.2022113385

PMCID:: PMC10233368

Abstract Article PDF–1.2M

Select item 1019503112.

Activation of the Budding Yeast Securin Pds1 but Not Rad53 Correlates with Double-Strand Break-Associated G₂/M Cell Cycle Arrest in a mec1 Hypomorphic Mutant

Mingzeng Sun, Michael Fasullo

Cell Cycle. Author manuscript; available in PMC 2023 May 18.

Published in final edited form as: Cell Cycle. 2007 Aug 1; 6(15): 1896–1902. Published online 2007 May 25. doi: 10.4161/cc.6.15.4510

PMCID:: PMC10195031

Abstract Article PDF–1.1M

Select item 1015141013.

Deletion of MEC1 suppresses the replicative senescence of the cdc13-2 mutant in Saccharomyces cerevisiae

Yue Yao, Enikő Fekete-Szücs, Fernando R Rosas Bringas, Michael Chang

G3 (Bethesda) 2023 May; 13(5): jkad065. Published online 2023 Mar 22. doi: 10.1093/g3journal/jkad065

PMCID:: PMC10151410

Abstract Article PDF–470K

Select item 1008355514.

A DNA damage–induced phosphorylation circuit enhances Mec1^ATR Ddc2^ATRIP recruitment to Replication Protein A

Luke A. Yates, Elias A. Tannous, R. Marc Morgan, Peter M. Burgers, Xiaodong Zhang

Proc Natl Acad Sci U S A. 2023 Apr 4; 120(14): e2300150120. Published online 2023 Mar 30. doi: 10.1073/pnas.2300150120

PMCID:: PMC10083555

Abstract Article PDF–2.3M

Select item 991046015.

Mec1 regulates PAS recruitment of Atg13 via direct binding with Atg13 during glucose starvation-induced autophagy

Weijing Yao, Yixing Li, Yingcong Chen, Yuting Chen, Pengwei Zhao, Yi Zhang, Qiang Jiang, Yuyao Feng, Fan Yang, Choufei Wu, Huiming Zhong, Yiting Zhou, Qiming Sun, Liqin Zhang, Wei Liu, Cong Yi

Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2215126120. Published online 2022 Dec 27. doi: 10.1073/pnas.2215126120

PMCID:: PMC9910460

Abstract Article PDF–1.4M

Select item 983602216.

The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction

Héloïse Coutelier, Oana Ilioaia, Jeanne Le Peillet, Marion Hamon, Damien D’Amours, Maria Teresa Teixeira, Zhou Xu

Genetics. 2023 Jan; 223(1): iyac171. Published online 2022 Nov 7. doi: 10.1093/genetics/iyac171

PMCID:: PMC9836022

Abstract Article PDF–1.0M

Select item 972820617.

Mec1 Modulates Interhomolog Crossover and Interplays with Tel1 at Post Double-Strand Break Stages

Min-Su Lee, Jung Whan Joo, Hyungseok Choi, Hyun Ah Kang, Keunpil Kim

J Microbiol Biotechnol. 2020 Mar 28; 30(3): 469–475. Published online 2019 Dec 4. doi: 10.4014/jmb.1909.09020

PMCID:: PMC9728206

Abstract Article PDF–5.0M

Select item 925038518.

Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone

Brenda A. Schilke, Elizabeth A. Craig

Mol Biol Cell. 2022 Mar 1; 33(3): br3. Published online 2022 Feb 18. doi: 10.1091/mbc.E21-10-0493

PMCID:: PMC9250385

Abstract Article PDF–1.2M

Select item 920981119.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224