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Select item 113274341.

The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice

Hui Yu, Angelika Chiang, Marcelo Rubinstein, Malcolm J. Low

Mol Metab. 2024 Sep; 87: 101993. Published online 2024 Jul 16. doi: 10.1016/j.molmet.2024.101993

PMCID:: PMC11327434

Abstract Article PDF–3.3M

Select item 112424532.

Protein Tyrosine Phosphatase Receptors N and N2 Control Pituitary Melanotroph Development and POMC Expression

Stephanie Constantin, Srdjan J Sokanovic, Yuta Mochimaru, Aloa Lamarca Dams, Kosara Smiljanic, Rafael M Prévide, Naseratun Nessa, Gilberto N Carmona, Stanko S Stojilkovic

Endocrinology. 2024 Aug; 165(8): bqae076. Published online 2024 Jun 26. doi: 10.1210/endocr/bqae076

PMCID:: PMC11242453

Abstract Article

Select item 111683003.

Neural basis for fasting activation of hypothalamic-pituitary-adrenal axis

Amelia M. Douglass, Jon M. Resch, Joseph C. Madara, Hakan Kucukdereli, Ofer Yizhar, Abhinav Grama, Masahito Yamagata, Zongfang Yang, Bradford B. Lowell

Nature. Author manuscript; available in PMC 2024 Jun 12.

Published in final edited form as: Nature. 2023 Aug; 620(7972): 154–162. Published online 2023 Jul 26. doi: 10.1038/s41586-023-06358-0

PMCID:: PMC11168300

Abstract Article PDF–4.7M

Select item 111433264.

AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin’s acute effects

Frankie D. Heyward, Nan Liu, Christopher Jacobs, Natalia L. S. Machado, Rachael Ivison, Aykut Uner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler Sermersheim, Linus Tsai, Evan D. Rosen

Nat Commun. 2024; 15: 4646. Published online 2024 May 31. doi: 10.1038/s41467-024-48885-y

PMCID:: PMC11143326

Abstract Article PDF–5.3M

Select item 110670485.

A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight

Daniela Rojo, Clara E. Hael, Agustina Soria, Flávio S. J. de Souza, Malcolm J. Low, Lucía F. Franchini, Marcelo Rubinstein

Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2322692121. Published online 2024 Apr 23. doi: 10.1073/pnas.2322692121

PMCID:: PMC11067048

Abstract Article PDF–11M

Select item 109176606.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104975987.

Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis

Yuying Huang, Lin Zhu, Shipeng Cheng, Ranran Dai, Chunrong Huang, Yanyan Song, Bo Peng, Xuezhen Li, Jing Wen, Yi Gong, Yunqian Hu, Ling Qian, Linyun Zhu, Fengying Zhang, Li Yu, Chunyan Yi, Wangpeng Gu, Zhiyang Ling, Liyan Ma, Wei Tang, Li Peng, Guochao Shi, Yaguang Zhang, Bing Sun

Nat Commun. 2023; 14: 5601. Published online 2023 Sep 12. doi: 10.1038/s41467-023-41319-1

PMCID:: PMC10497598

Abstract Article PDF–6.3M

Select item 102411948.

Proopiomelanocortin projections to the nucleus accumbens modulate acquisition and maintenance of operant palatable pellet administration in mice

Nicole L. Eliason, Amanda L. Sharpe

Physiol Behav. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Physiol Behav. 2023 Jun 1; 265: 114176. Published online 2023 Mar 23. doi: 10.1016/j.physbeh.2023.114176

PMCID:: PMC10241194

Abstract Article PDF–991K

Select item 101652559.

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui

iScience. 2023 May 19; 26(5): 106670. Published online 2023 Apr 14. doi: 10.1016/j.isci.2023.106670

PMCID:: PMC10165255

Abstract Article PDF–8.2M

Select item 1011344410.

Age, β-endorphin, and sex dependent effects of maternal separation on locomotor activity, anxiety-like behavior, and alcohol reward

Madison R. Scopano, Holly E. Jones, Sam G. Stea, Maya Z. Freeman, Judith E. Grisel

Front Behav Neurosci. 2023; 17: 1155647. Published online 2023 Apr 5. doi: 10.3389/fnbeh.2023.1155647

PMCID:: PMC10113444

Abstract Article PDF–5.7M

Select item 1000594811.

Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits

Xing Fang, Yuting Chen, Jiangong Wang, Ziliang Zhang, Yu Bai, Kirstyn Denney, Lin Gan, Ming Guo, Neal L. Weintraub, Yun Lei, Xin-Yun Lu

Mol Psychiatry. 2023; 28(3): 1365–1382. Published online 2022 Dec 6. doi: 10.1038/s41380-022-01872-5

PMCID:: PMC10005948

Abstract Article PDF–11M

Select item 998251112.

Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation

Zhaofei Wu, M Elena Martinez, Victoria DeMambro, Marie Francois, Arturo Hernandez

J Mol Cell Biol. 2022 Sep; 14(9): mjac078. Published online 2022 Dec 29. doi: 10.1093/jmcb/mjac078

PMCID:: PMC9982511

Abstract Article PDF–5.4M

Select item 993747613.

An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development

Jose Mario Gonzalez-Meljem, Sarah Ivins, Cynthia Lilian Andoniadou, Paul Le Tissier, Peter Scambler, Juan Pedro Martinez-Barbera

PLoS One. 2023; 18(2): e0280001. Published online 2023 Feb 17. doi: 10.1371/journal.pone.0280001

PMCID:: PMC9937476

Abstract Article PDF–3.5M

Select item 985174614.

Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man

Hironori Bando, Michelle L Brinkmeier, Frederic Castinetti, Qing Fang, Mi-Sun Lee, Alexandru Saveanu, Frédérique Albarel, Clémentine Dupuis, Thierry Brue, Sally A Camper

Hum Mol Genet. 2023 Feb 1; 32(3): 367–385. Published online 2022 Aug 11. doi: 10.1093/hmg/ddac192

PMCID:: PMC9851746

Abstract Article PDF–3.5M

Select item 981554015.

Interleukin-6 is dispensable in pituitary normal development and homeostasis but needed for pituitary stem cell activation following local injury

Emma Laporte, Silke De Vriendt, Julie Hoekx, Hugo Vankelecom

Front Endocrinol (Lausanne) 2022; 13: 1092063. Published online 2022 Dec 22. doi: 10.3389/fendo.2022.1092063

PMCID:: PMC9815540

Abstract Article PDF–7.2M

Select item 975774716.

β-Endorphin mediates radiation therapy fatigue

Andrea L. Hermann, Gillian L. Fell, Lajos V. Kemény, Claire Y. Fung, Kathryn D. Held, Peter J. Biggs, Phillip D. Rivera, Staci D. Bilbo, Vivien Igras, Henning Willers, Jong Kung, Liliana Gheorghiu, Katalin Hideghéty, Jianren Mao, Clifford J. Woolf, David E. Fisher

Sci Adv. 2022 Dec; 8(50): eabn6025. Published online 2022 Dec 16. doi: 10.1126/sciadv.abn6025

PMCID:: PMC9757747

Abstract Article PDF–1.1M

Select item 966446817.

Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans, Anne White, Bruno Ramos-Molina, John W.M. Creemers

Mol Metab. 2022 Dec; 66: 101627. Published online 2022 Oct 29. doi: 10.1016/j.molmet.2022.101627

PMCID:: PMC9664468

Abstract Article PDF–1.4M

Select item 884375318.

Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse

Vijay K. Yadav, Julian M. Berger, Parminder Singh, Perumal Nagarajan, Gerard Karsenty

J Clin Invest. 2022 Feb 15; 132(4): e153752. Published online 2022 Feb 15. doi: 10.1172/JCI153752

PMCID:: PMC8843753

Abstract Article PDF–4.9M

Select item 880989219.

The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates

Juliane Glaser, Julian Iranzo, Maud Borensztein, Mattia Marinucci, Angelica Gualtieri, Colin Jouhanneau, Aurélie Teissandier, Carles Gaston-Massuet, Deborah Bourc'his

eLife. 2022; 11: e65641. Published online 2022 Jan 20. doi: 10.7554/eLife.65641

PMCID:: PMC8809892

Abstract Article PDF–4.8M

Select item 880618620.

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

Hui Yu, Marcelo Rubinstein, Malcolm J Low

eLife. 2022; 11: e72883. Published online 2022 Jan 19. doi: 10.7554/eLife.72883

PMCID:: PMC8806186

Abstract Article PDF–26M

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