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Select item 114271791.

Non-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

Heidi H. Pak, Allison N. Grossberg, Rachel R. Sanderfoot, Reji Babygirija, Cara L. Green, Mikaela Koller, Monika Dzieciatkowska, Daniel A. Paredes, Dudley W. Lamming

Cell Rep. Author manuscript; available in PMC 2024 Sep 27.

Published in final edited form as: Cell Rep. 2024 Sep 24; 43(9): 114663. Published online 2024 Aug 20. doi: 10.1016/j.celrep.2024.114663

PMCID:: PMC11427179

Abstract Article PDF–3.4M

Select item 112848182.

Reprogramming Tumor-Associated Macrophages to Outcompete Endovascular Endothelial Progenitor Cells and Suppress Tumor Neoangiogenesis

Mytrang H. Do, Wei Shi, Liangliang Ji, Erik Ladewig, Xian Zhang, Raghvendra M. Srivastava, Kristelle J. Capistrano, Chaucie Edwards, Isha Malik, Briana G. Nixon, Efstathios G. Stamatiades, Ming Liu, Shun Li, Peng Li, Chun Chou, Ke Xu, Ting-Wei Hsu, Xinxin Wang, Timothy A. Chan, Christina S. Leslie, Ming O. Li

Immunity. Author manuscript; available in PMC 2024 Nov 14.

Published in final edited form as: Immunity. 2023 Nov 14; 56(11): 2555–2569.e5. doi: 10.1016/j.immuni.2023.10.010

PMCID:: PMC11284818

Abstract Article PDF–3.8M

Select item 111416173.

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis

Nolwenn Samson, Cristina R. Bosoi, Christian Roy, Laurie Turcotte, Laura Tribouillard, Mathilde Mouchiroud, Line Berthiaume, Jocelyn Trottier, Heitor C. G. Silva, Thomas Guerbette, Ana Belén Plata-Gómez, Aurèle Besse-Patin, Alicia Montoni, Nicolò Ilacqua, Jennifer Lamothe, Yemima R. Citron, Yves Gélinas, Stéphane Gobeil, Roberto Zoncu, Alexandre Caron, Mathieu Morissette, Luca Pellegrini, Patrick J. Rochette, Jennifer L. Estall, Alejo Efeyan, Michael Shum, Étienne Audet-Walsh, Olivier Barbier, André Marette, Mathieu Laplante

Sci Adv. 2024 May 31; 10(22): eadk9681. Published online 2024 May 31. doi: 10.1126/sciadv.adk9681

PMCID:: PMC11141617

Abstract Article PDF–5.4M

Select item 109659484.

The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling

Meng Xie, Markéta Kaiser, Yaakov Gershtein, Daniela Schnyder, Ruslan Deviatiiarov, Guzel Gazizova, Elena Shagimardanova, Tomáš Zikmund, Greet Kerckhofs, Evgeny Ivashkin, Dominyka Batkovskyte, Phillip T. Newton, Olov Andersson, Kaj Fried, Oleg Gusev, Hugo Zeberg, Jozef Kaiser, Igor Adameyko, Andrei S. Chagin

Nat Commun. 2024; 15: 2367. Published online 2024 Mar 26. doi: 10.1038/s41467-024-46030-3

PMCID:: PMC10965948

Abstract Article PDF–9.9M

Select item 109487705.

Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver

Ana Belén Plata-Gómez, Lucía de Prado-Rivas, Alba Sanz, Nerea Deleyto-Seldas, Fernando García, Celia de la Calle Arregui, Camila Silva, Eduardo Caleiras, Osvaldo Graña-Castro, Elena Piñeiro-Yáñez, Joseph Krebs, Luis Leiva-Vega, Javier Muñoz, Ajay Jain, Guadalupe Sabio, Alejo Efeyan

Nat Commun. 2024; 15: 1878. Published online 2024 Mar 18. doi: 10.1038/s41467-024-46032-1

PMCID:: PMC10948770

Abstract Article PDF–4.4M

Select item 109426296.

The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function

Lena H Nguyen, Youfen Xu, Maanasi Nair, Angelique Bordey

eLife. 2024; 12: RP91010. Published online 2024 Feb 27. doi: 10.7554/eLife.91010

PMCID:: PMC10942629

Abstract Article PDF–5.5M

Select item 106468187.

TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice

Xiaoling Xie, Wuju Zhang, Min Xiao, Tiantian Wei, Yingqi Qiu, Jingyang Qiu, Hao Wang, Zeyou Qiu, Sheng Zhang, Yating Pan, Linlin Mao, Yuhua Li, Bin Guo, Wanwen Yang, Yuxing Hu, Shujie Hu, Yan Gong, Jun Yang, Guozhi Xiao, Yue Zhang, Xiaochun Bai

Blood. 2023 Jun 29; 141(26): 3184–3198. Published online 2023 Apr 5. doi: 10.1182/blood.2022018619

PMCID:: PMC10646818

Abstract Article

Select item 106423708.

Arginine reprograms metabolism in liver cancer via RBM39

Dirk Mossmann, Christoph Müller, Sujin Park, Brendan Ryback, Marco Colombi, Nathalie Ritter, Diana Weißenberger, Eva Dazert, Mairene Coto-Llerena, Sandro Nuciforo, Lauriane Blukacz, Caner Ercan, Veronica Jimenez, Salvatore Piscuoglio, Fatima Bosch, Luigi M. Terracciano, Uwe Sauer, Markus H. Heim, Michael N. Hall

Cell. 2023 Nov 9; 186(23): 5068–5083.e23. doi: 10.1016/j.cell.2023.09.011

PMCID:: PMC10642370

Abstract Article

Select item 105848119.

Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis

Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki

Nat Commun. 2023; 14: 6584. Published online 2023 Oct 18. doi: 10.1038/s41467-023-42334-y

PMCID:: PMC10584811

Abstract Article PDF–4.4M

Select item 1047696610.

A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

R Samuel Herron, Alexander K Kunisky, Jessica R Madden, Vivian I Anyaeche, May Z Maung, Hun-Way Hwang

eLife. 2023; 12: e85036. Published online 2023 Sep 4. doi: 10.7554/eLife.85036

PMCID:: PMC10476966

Abstract Article PDF–1.9M

Select item 1044930911.

miR-926-3p influences myocardial injury in septic mice through regulation of mTOR signaling pathway by targeting TSC1

Feng Yan, Qian Wang, Huiyu Yang, Hui Lv, Weiwei Qin

Aging (Albany NY) 2023 May 15; 15(9): 3826–3838. Published online 2023 May 11. doi: 10.18632/aging.204716

Correction in:: Aging (Albany NY). 2024 Sep 30; 16(18): 12667.

PMCID:: PMC10449309

Abstract Article PDF–1.4M

Select item 1041071712.

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve

Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120

PMCID:: PMC10410717

Abstract Article PDF–3.9M

Select item 1036324213.

Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis

Xiaojuan Chao, Shaogui Wang, Xiaowen Ma, Chen Zhang, Hui Qian, Sha Neisha Williams, Zhaoli Sun, Zheyun Peng, Wanqing Liu, Feng Li, Namratha Sheshadri, Wei-Xing Zong, Hong-Min Ni, Wen-Xing Ding

Hepatology. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Hepatology. 2023 Aug 1; 78(2): 503–517. Published online 2023 Apr 1. doi: 10.1097/HEP.0000000000000373

PMCID:: PMC10363242

Abstract Article PDF–2.1M

Select item 1034478714.

mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission

Nuria Martinez-Lopez, Pamela Mattar, Miriam Toledo, Henrietta Bains, Manu Kalyani, Marie Louise Aoun, Mridul Sharma, Laura Beth J. McIntire, Leslie Gunther-Cummins, Frank P. Macaluso, Jennifer T. Aguilan, Simone Sidoli, Mathieu Bourdenx, Rajat Singh

Nat Cell Biol. 2023; 25(7): 989–1003. Published online 2023 Jun 29. doi: 10.1038/s41556-023-01163-3

PMCID:: PMC10344787

Abstract Article PDF–23M

Select item 1030785215.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 1009797516.

Mechanosensitive mTORC1 signaling maintains lymphatic valves

Cansaran Saygili Demir, Amélie Sabine, Muyun Gong, Olivier Dormond, Tatiana V. Petrova

J Cell Biol. 2023 Jun 5; 222(6): e202207049. Published online 2023 Apr 10. doi: 10.1083/jcb.202207049

PMCID:: PMC10097975

Abstract Article PDF–9.6M

Select item 1004897117.

Activation of the PI3K/AKT/mTOR Pathway in Cajal–Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures

Nasim Ramezanidoraki, Driss El Ouardi, Margaux Le, Stéphanie Moriceau, Mahboubeh Ahmadi, Dossi Elena, Danae Rolland, Philippe Bun, Gwenaëlle Le Pen, Guillaume Canaud, Nadia Bahi-Buisson, Nathalie Rouach, Rebecca Piskorowski, Alessandra Pierani, Pierre Billuart

Int J Mol Sci. 2023 Mar; 24(6): 5376. Published online 2023 Mar 11. doi: 10.3390/ijms24065376

PMCID:: PMC10048971

Abstract Article PDF–3.2M

Select item 994693518.

Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling

Fuchun Yang, Shiva Kalantari, Banzhan Ruan, Shaogang Sun, Zhaoqun Bian, Jun-Lin Guan

Nat Commun. 2023; 14: 978. Published online 2023 Feb 22. doi: 10.1038/s41467-023-36562-5

PMCID:: PMC9946935

Abstract Article PDF–3.7M

Select item 989195619.

Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai

J Cachexia Sarcopenia Muscle. 2023 Feb; 14(1): 198–213. Published online 2022 Nov 17. doi: 10.1002/jcsm.13121

PMCID:: PMC9891956

Abstract Article PDF–4.2M

Select item 985254320.

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

Pranetha Baskaran, Simeon R. Mihaylov, Elin Vinsland, Kriti Shah, Lucy Granat, Sila K. Ultanir, Andrew R. Tee, Jernej Murn, Joseph M. Bateman

J Biol Chem. 2023 Jan; 299(1): 102788. Published online 2022 Dec 9. doi: 10.1016/j.jbc.2022.102788

PMCID:: PMC9852543

Abstract Article PDF–2.8M

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