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Items: 1 to 20 of 321

1.
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Vanessa Yu, Fiona Yong, Angellica Marta, Sanjay Khadayate, Adrien Osakwe, Supriyo Bhattacharya, Sneha S. Varghese, Pauline Chabosseau, Sayed M. Tabibi, Keran Chen, Eleni Georgiadou, Nazia Parveen, Mara Suleiman, Zoe Stamoulis, Lorella Marselli, Carmela De Luca, Marta Tesi, Giada Ostinelli, Luis Delgadillo-Silva, Xiwei Wu, Yuki Hatanaka, Alex Montoya, James Elliott, Bhavik Patel, Nikita Demchenko, Chad Whilding, Petra Hajkova, Pavel Shliaha, Holger Kramer, Yusuf Ali, Piero Marchetti, Robert Sladek, Sangeeta Dhawan, Dominic J. Withers, Guy A. Rutter, Steven J. Millership
Diabetologia. 2024; 67(6): 1079–1094. Published online 2024 Mar 21. doi: 10.1007/s00125-024-06123-6
PMCID:
PMC11058053
AbstractArticlePDF–7.7M
2.
High paternal homocysteine causes ventricular septal defects in mouse offspring
Lian Liu, Xuan Zhang, Hao-Ran Geng, Ya-Nan Qiao, Yong-Hao Gui, Jian-Yuan Zhao
iScience. 2024 Apr 19; 27(4): 109447. Published online 2024 Mar 7. doi: 10.1016/j.isci.2024.109447
PMCID:
PMC10960133
AbstractArticlePDF–4.8M
3.
Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals
Shuo Li, Liqing Zeng, Fen Miao, Nian Li, Weili Liao, Xiaofeng Zhou, Yongcai Chen, Hongyan Quan, Yingting He, Hao Zhang, Jiaqi Li, Xiaolong Yuan
Int J Mol Sci. 2024 Mar; 25(5): 2468. Published online 2024 Feb 20. doi: 10.3390/ijms25052468
PMCID:
PMC10930803
AbstractArticlePDF–2.9M
4.
CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses
Maja Vukic, Jihed Chouaref, Veronica Della Chiara, Serkan Dogan, Fallon Ratner, Jenna Z. M. Hogenboom, Trevor A. Epp, Kallayanee Chawengsaksophak, Kelly K. D. Vonk, Cor Breukel, Yavuz Ariyurek, David San Leon Granado, Susan L. Kloet, Lucia Daxinger
Sci Adv. 2024 Feb 9; 10(6): eadk3384. Published online 2024 Feb 9. doi: 10.1126/sciadv.adk3384
PMCID:
PMC10857554
AbstractArticlePDF–9.3M
5.
Disruption of DNA methylation–mediated cranial neural crest proliferation and differentiation causes orofacial clefts in mice
Caden M. Ulschmid, Miranda R. Sun, Christopher R. Jabbarpour, Austin C. Steward, Kenneth S. Rivera-González, Jocelyn Cao, Alexander A. Martin, Macy Barnes, Lorena Wicklund, Andy Madrid, Ligia A. Papale, Diya B. Joseph, Chad M. Vezina, Reid S. Alisch, Robert J. Lipinski
Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3): e2317668121. Published online 2024 Jan 9. doi: 10.1073/pnas.2317668121
PMCID:
PMC10801837
AbstractArticlePDF–3.4M
6.
NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte‐to‐Embryo Transition
Tie‐Gang Meng, Jia‐Ni Guo, Liu Zhu, Yike Yin, Feng Wang, Zhi‐Ming Han, Lei Lei, Xue‐Shan Ma, Yue Xue, Wei Yue, Xiao‐Qing Nie, Zheng‐Hui Zhao, Hong‐Yong Zhang, Si‐Min Sun, Ying‐Chun Ouyang, Yi Hou, Heide Schatten, Zhenyu Ju, Xiang‐Hong Ou, Zhen‐Bo Wang, Catherine C. L. Wong, Zhonghan Li, Qing‐Yuan Sun
Adv Sci (Weinh) 2023 Sep; 10(27): 2301940. Published online 2023 Jul 26. doi: 10.1002/advs.202301940
PMCID:
PMC10520637
AbstractArticlePDF–6.6M
7.
DNMT1 mediates the disturbed flow-induced endothelial to mesenchymal transition through disrupting β-alanine and carnosine homeostasis
Jianan Zhao, Chuanrong Zhao, Fangfang Yang, Zhitong Jiang, Juanjuan Zhu, Weijuan Yao, Wei Pang, Jing Zhou
Theranostics. 2023; 13(13): 4392–4411. Published online 2023 Aug 6. doi: 10.7150/thno.84427
PMCID:
PMC10465216
AbstractArticlePDF–12M
8.
Epigenetic Regulation of Hepatic Lipid Metabolism by DNA Methylation
Shirong Wang, Lin Zha, Xin Cui, Yu‐Te Yeh, Ruochuan Liu, Jia Jing, Huidong Shi, Weiping Chen, John Hanover, Jun Yin, Liqing Yu, Bingzhong Xue, Hang Shi
Adv Sci (Weinh) 2023 Jul; 10(20): 2206068. Published online 2023 Jun 6. doi: 10.1002/advs.202206068
PMCID:
PMC10369300
AbstractArticlePDF–8.3M
9.
Mesenchymal stem cells, as glioma exosomal immunosuppressive signal multipliers, enhance MDSCs immunosuppressive activity through the miR-21/SP1/DNMT1 positive feedback loop
Wei Qiu, Qindong Guo, Xiaofan Guo, Chaochao Wang, Boyan Li, Yanhua Qi, Shaobo Wang, Rongrong Zhao, Xiao Han, Hao Du, Shulin Zhao, Ziwen Pan, Yang Fan, Qingtong Wang, Zijie Gao, Gang Li, Hao Xue
J Nanobiotechnology. 2023; 21: 233. Published online 2023 Jul 22. doi: 10.1186/s12951-023-01997-x
PMCID:
PMC10362641
AbstractArticlePDF–7.5M
10.
On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase
Sabrina Adam, Viviane Klingel, Nicole E Radde, Pavel Bashtrykov, Albert Jeltsch
Nucleic Acids Res. 2023 Jul 21; 51(13): 6622–6633. Published online 2023 May 29. doi: 10.1093/nar/gkad465
PMCID:
PMC10359454
AbstractArticlePDF–1.4M
11.
Pharmacological inhibition of DNMT1 restores macrophage autophagy and M2 polarization in Western diet–induced nonalcoholic fatty liver disease
Rajat Pant, Shaheen Wasil Kabeer, Shivam Sharma, Vinod Kumar, Debarun Patra, Durba Pal, Kulbhushan Tikoo
J Biol Chem. 2023 Jun; 299(6): 104779. Published online 2023 May 2. doi: 10.1016/j.jbc.2023.104779
PMCID:
PMC10248527
AbstractArticlePDF–4.2M
12.
Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation
Qing Li, Jiansen Lu, Xidi Yin, Yunjian Chang, Chao Wang, Meng Yan, Li Feng, Yanbo Cheng, Yun Gao, Beiying Xu, Yao Zhang, Yingyi Wang, Guizhong Cui, Luang Xu, Yidi Sun, Rong Zeng, Yixue Li, Naihe Jing, Guo-Liang Xu, Ligang Wu, Fuchou Tang, Jinsong Li
Nat Commun. 2023; 14: 2922. Published online 2023 May 22. doi: 10.1038/s41467-023-38528-z
PMCID:
PMC10203112
AbstractArticlePDF–11M
13.
Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice
Wanlin Cui, Yuji Nagano, Satoru Morita, Takeshi Tanoue, Hidehiro Yamane, Keiko Ishikawa, Toshiro Sato, Masato Kubo, Shohei Hori, Tadatsugu Taniguchi, Masanori Hatakeyama, Koji Atarashi, Kenya Honda
J Exp Med. 2023 Aug 7; 220(8): e20221773. Published online 2023 May 10. doi: 10.1084/jem.20221773
PMCID:
PMC10174189
AbstractArticlePDF–5.3M
14.
DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity
Nazia Parveen, Jean Kimi Wang, Supriyo Bhattacharya, Janielle Cuala, Mohan Singh Rajkumar, Alexandra E. Butler, Xiwei Wu, Hung-Ping Shih, Senta K. Georgia, Sangeeta Dhawan
Diabetes. 2023 May; 72(5): 575–589. Published online 2023 Jan 6. doi: 10.2337/db22-0506
Correction in:
Diabetes. 2023 Dec; 72(12): 1882.
PMCID:
PMC10130487
AbstractArticlePDF–1.8M
15.
The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma
Mengke Chen, Yi Fang, Meinong Liang, Ning Zhang, Xinyue Zhang, Lixia Xu, Xuxin Ren, Qingfeng Zhang, Yufeng Zhou, Sui Peng, Jun Yu, Judeng Zeng, Xiaoxing Li
J Transl Med. 2023; 21: 276. Published online 2023 Apr 23. doi: 10.1186/s12967-023-04103-9
PMCID:
PMC10124003
AbstractArticlePDF–2.7M
16.
Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors
Dae Joong Kim, Swetha Anandh, Jamie L. Null, Piotr Przanowski, Sanchita Bhatnagar, Pankaj Kumar, Sarah E. Shelton, Erin E. Grundy, Katherine B. Chiappinelli, Roger D. Kamm, David A. Barbie, Andrew C. Dudley
Nat Commun. 2023; 14: 2122. Published online 2023 Apr 14. doi: 10.1038/s41467-023-37807-z
PMCID:
PMC10101959
AbstractArticlePDF–5.0M
17.
Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1
Seema Khattri Bhandari, Nathaniel Wiest, Annahita Sallmyr, Ruofei Du, Laure Ferry, Pierre-Antoine Defossez, Alan E. Tomkinson
Sci Rep. 2023; 13: 4363. Published online 2023 Mar 16. doi: 10.1038/s41598-023-31367-4
PMCID:
PMC10020546
AbstractArticlePDF–3.7M
18.
Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development
Poonam Dhillon, Kelly Ann Mulholland, Hailong Hu, Jihwan Park, Xin Sheng, Amin Abedini, Hongbo Liu, Allison Vassalotti, Junnan Wu, Katalin Susztak
Nat Commun. 2023; 14: 559. Published online 2023 Feb 2. doi: 10.1038/s41467-023-36212-w
PMCID:
PMC9895454
AbstractArticlePDF–13M
19.
Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
Justyna A. Janas, Lichao Zhang, Jacklyn H. Luu, Janos Demeter, Lingjun Meng, Samuele G. Marro, Moritz Mall, Nancie A. Mooney, Katie Schaukowitch, Yi Han Ng, Nan Yang, Yuhao Huang, Gernot Neumayer, Or Gozani, Joshua E. Elias, Peter K. Jackson, Marius Wernig
Mol Cell. Author manuscript; available in PMC 2023 Dec 15.
Published in final edited form as: Mol Cell. 2022 Dec 15; 82(24): 4627–4646.e14. Published online 2022 Nov 22. doi: 10.1016/j.molcel.2022.11.002
PMCID:
PMC9779922
AbstractArticlePDF–3.3M
20.
Long noncoding RNA HOTAIR facilitates pulmonary vascular endothelial cell apoptosis via DNMT1 mediated hypermethylation of Bcl-2 promoter in COPD
Zhongshang Dai, Xiangming Liu, Huihui Zeng, Yan Chen
Respir Res. 2022; 23: 356. Published online 2022 Dec 17. doi: 10.1186/s12931-022-02234-z
PMCID:
PMC9758792
AbstractArticlePDF–2.7M

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