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Items: 1 to 20 of 54

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice
Wenzhong Hou, Jianping Yao, Junjie Liu, Xiaohong Lin, JueXian Wei, Xiaofan Yin, Hongbiao Huang, Xiaohui Chen, Guo‐Yuan Yang, Xiaosong He
CNS Neurosci Ther. 2023 Nov; 29(11): 3612–3623. Published online 2023 Jun 2. doi: 10.1111/cns.14292
PMCID:
PMC10580339
AbstractArticlePDF–4.3M
3.
USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1
Dongqin Wei, Xin Tian, Longbo Zhu, Han Wang, Chao Sun
Cell Death Dis. 2023 Aug; 14(8): 566. Published online 2023 Aug 26. doi: 10.1038/s41419-023-06091-6
PMCID:
PMC10460448
AbstractArticlePDF–15M
4.
FAT10 and NUB1L cooperate to activate the 26S proteasome
Florian Brockmann, Nicola Catone, Christine Wünsch, Fabian Offensperger, Martin Scheffner, Gunter Schmidtke, Annette Aichem
Life Sci Alliance. 2023 Aug; 6(8): e202201463. Published online 2023 May 15. doi: 10.26508/lsa.202201463
PMCID:
PMC10185811
AbstractArticlePDF–2.5M
5.
USP14 promotes colorectal cancer progression by targeting JNK for stabilization
Xue-Hua Du, Shao-Bo Ke, Xin-Yi Liang, Jie Gao, Xiao-Xiao Xie, Lin-Zhi Qi, Xue-Yi Liu, Guo-Yuan Xu, Xiao-Dong Zhang, Run-Lei Du, Shang-Ze Li
Cell Death Dis. 2023 Jan; 14(1): 56. Published online 2023 Jan 24. doi: 10.1038/s41419-023-05579-5
PMCID:
PMC9873792
AbstractArticlePDF–4.7M
6.
The AAA‐ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle
Dina Aweida, Shenhav Cohen
EMBO Rep. 2022 Dec; 23(12): e55175. Published online 2022 Oct 24. doi: 10.15252/embr.202255175
PMCID:
PMC9724657
AbstractArticlePDF–3.0M
7.
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
Dongni Shi, Xianqiu Wu, Yunting Jian, Junye Wang, Chengmei Huang, Shuang Mo, Yue Li, Fengtian Li, Chao Zhang, Dongsheng Zhang, Huizhong Zhang, Huilin Huang, Xin Chen, Y. Alan Wang, Chuyong Lin, Guozhen Liu, Libing Song, Wenting Liao
Nat Commun. 2022; 13: 5644. Published online 2022 Sep 26. doi: 10.1038/s41467-022-33285-x
PMCID:
PMC9513055
AbstractArticlePDF–5.3M
8.
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy
Sheng-Li Ming, Shuang Zhang, Qi Wang, Lei Zeng, Lu-Yu Zhou, Meng-Di Wang, Ying-Xian Ma, Li-Qiang Han, Kai Zhong, He-Shui Zhu, Yi-Lin Bai, Guo-Yu Yang, Jiang Wang, Bei-Bei Chu
Autophagy. 2022; 18(8): 1801–1821. Published online 2021 Nov 25. doi: 10.1080/15548627.2021.2002101
PMCID:
PMC9450976
AbstractArticlePDF–5.3M
9.
Examination of genetic and pharmacological tools to study the proteasomal deubiquitinating enzyme ubiquitin-specific protease 14 in the nervous system
Tina Tian, John W. McLean, Julie A. Wilson, Scott M. Wilson
J Neurochem. Author manuscript; available in PMC 2021 Oct 4.
Published in final edited form as: J Neurochem. 2021 Feb; 156(3): 309–323. Published online 2020 Sep 30. doi: 10.1111/jnc.15180
PMCID:
PMC8489120
AbstractArticlePDF–1.6M
10.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
11.
The USP14–NLRC5 pathway inhibits titanium particle–induced osteolysis in mice by suppressing NF-κB and PI3K/AKT activities
Guibin Fang, Yuan Fu, Shixun Li, Junxiong Qiu, Manyuan Kuang, Sipeng Lin, Changchuan Li, Yue Ding
J Biol Chem. 2020 May 15; 295(20): 7018–7032. Published online 2020 Apr 9. doi: 10.1074/jbc.RA119.012495
PMCID:
PMC7242687
AbstractArticlePDF–5.2M
12.
Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency
Yu-Shui Ma, Xiao-Feng Wang, Fei Yu, Ting-Miao Wu, Ji-Bin Liu, Yun-Jie Zhang, Qing Xia, Zong-Yuan Jiang, Qin-Lu Lin, Da Fu
Signal Transduct Target Ther. 2020; 5: 30. Published online 2020 Apr 1. doi: 10.1038/s41392-020-0143-9
PMCID:
PMC7109122
ArticlePDF–1.1M
13.
Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14
Bin Liu, Zhijian Zhang, Yanyun Hu, Yan Lu, Duanzhuo Li, Jie Liu, Shengjie Liao, Min Hu, Yuxing Wang, Die Zhang, Yulu Chen, Qilan Qian, Xianfeng Lv, Duojiao Wu, Minjia Tan, Cheng Hu, Xuelian Xiong, Xiaoying Li
Proc Natl Acad Sci U S A. 2019 Oct 22; 116(43): 21732–21738. Published online 2019 Oct 8. doi: 10.1073/pnas.1907288116
PMCID:
PMC6815134
AbstractArticlePDF–1.4M
14.
Transgenic Rescue of ataxia Mice with Neuronal-Specific Expression of Ubiquitin-Specific Protease 14
Stephen Crimmins, Youngam Jin, Crystal Wheeler, Alexis K. Huffman, Carlene Chapman, Lynn E. Dobrunz, Alan Levey, Kevin A. Roth, Julie A. Wilson, Scott M. Wilson
J Neurosci. 2006 Nov 1; 26(44): 11423–11431. doi: 10.1523/JNEUROSCI.3600-06.2006
PMCID:
PMC6674543
AbstractArticlePDF–429K
15.
The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling
Filomena Massa, Roberta Tammaro, Miguel A Prado, Marcella Cesana, Byung-Hoon Lee, Daniel Finley, Brunella Franco, Manuela Morleo
Hum Mol Genet. 2019 Mar 1; 28(5): 764–777. Published online 2018 Nov 1. doi: 10.1093/hmg/ddy380
PMCID:
PMC6381316
AbstractArticlePDF–44M
16.
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells
Farzad Asadi, Savita Dhanvantari
Front Endocrinol (Lausanne) 2018; 9: 792. Published online 2019 Jan 18. doi: 10.3389/fendo.2018.00792
PMCID:
PMC6346685
AbstractArticlePDF–3.6M
17.
Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN
Bin Liu, Shangwen Jiang, Min Li, Xuelian Xiong, Mingrui Zhu, Duanzhuo Li, Lei Zhao, Lili Qian, Linhui Zhai, Jing Li, Han Lu, Shengnan Sun, Jiandie Lin, Yan Lu, Xiaoying Li, Minjia Tan
Nat Commun. 2018; 9: 4770. Published online 2018 Nov 13. doi: 10.1038/s41467-018-07185-y
PMCID:
PMC6233205
AbstractArticlePDF–1.6M
18.
Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation
Jianxin Wei, Su Dong, Rachel K. Bowser, Andrew Khoo, Lina Zhang, Anastasia M. Jacko, Yutong Zhao, Jing Zhao
Sci Signal. Author manuscript; available in PMC 2018 Mar 22.
Published in final edited form as: Sci Signal. 2017 Jun 13; 10(483): eaak9660. Published online 2017 Jun 13. doi: 10.1126/scisignal.aak9660
PMCID:
PMC5863726
AbstractArticlePDF–1.0M
19.
Inhibition of the deubiquitinase Usp14 diminishes direct MHC class I antigen presentation
Amy L. Palmer, Annemieke de Jong, Yves Leestemaker, Paul P. Geurink, Ruud H. Wijdeven, Huib Ovaa, Brian P. Dolan
J Immunol. Author manuscript; available in PMC 2019 Feb 1.
Published in final edited form as: J Immunol. 2018 Feb 1; 200(3): 928–936. Published online 2017 Dec 27. doi: 10.4049/jimmunol.1700273
PMCID:
PMC5782819
AbstractArticlePDF–895K
20.
Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: relevance to Alzheimer’s disease
Magdalena J. Kiprowska, Anna Stepanova, Dustin R. Todaro, Alexander Galkin, Arthur Haas, Scott M. Wilson, Maria E. Figueiredo-Pereira
Biochim Biophys Acta. Author manuscript; available in PMC 2017 Aug 9.
Published in final edited form as: Biochim Biophys Acta. 2017 Jun; 1863(6): 1157–1170. Published online 2017 Apr 1. doi: 10.1016/j.bbadis.2017.03.017
PMCID:
PMC5549686
AbstractArticlePDF–1.1M

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