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Select item 114010341.

Proximity labeling reveals dynamic changes in the SQSTM1 protein network

Alejandro N. Rondón-Ortiz, Lushuang Zhang, Peter E.A. Ash, Avik Basu, Sambhavi Puri, Sophie J.F. van der Spek, Zihan Wang, Luke Dorrian, Andrew Emili, Benjamin Wolozin

J Biol Chem. 2024 Sep; 300(9): 107621. Published online 2024 Aug 3. doi: 10.1016/j.jbc.2024.107621

PMCID:: PMC11401034

Abstract Article PDF–5.4M

Select item 113735992.

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway

Elena Prosdocimi, Veronica Carpanese, Luca Matteo Todesca, Tatiana Varanita, Magdalena Bachmann, Margherita Festa, Daniele Bonesso, Mireia Perez-Verdaguer, Andrea Carrer, Angelo Velle, Roberta Peruzzo, Silvia Muccioli, Davide Doni, Luigi Leanza, Paola Costantini, Frank Stein, Mandy Rettel, Antonio Felipe, Michael J. Edwards, Erich Gulbins, Laura Cendron, Chiara Romualdi, Vanessa Checchetto, Ildiko Szabo

Sci Adv. 2024 Sep 6; 10(36): eadn9361. Published online 2024 Sep 4. doi: 10.1126/sciadv.adn9361

PMCID:: PMC11373599

Abstract Article PDF–11M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111480224.

The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway

Jun-Jun Chen, Tian-Zhu Lu, Tao Wang, Wen-Hui Yan, Fang-Yan Zhong, Xin-Hui Qu, Xiao-Chang Gong, Jin-Gao Li, Fang-Fang Tou, Li-Ping Jiang, Xiao-Jian Han

Cell Death Dis. 2024 Jun; 15(6): 390. Published online 2024 Jun 3. doi: 10.1038/s41419-024-06736-0

PMCID:: PMC11148022

Abstract Article PDF–5.8M

Select item 106842585.

YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis

Meng Zhou, Yuzhen Liu, Haoxiang Xu, Xu Chen, Nana Zheng, Zhimin Duan, Yiping Ge, Dongqing Li, Tong Lin, Rong Zeng, Qing Chen, Min Li

J Innate Immun. 2023 Jan-Dec; 15(1): 822–835. Published online 2023 Oct 30. doi: 10.1159/000534704

PMCID:: PMC10684258

Abstract Article PDF–1.7M

Select item 106438896.

Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA

Grant R. Campbell, Pratima Rawat, Stephen A. Spector

J Innate Immun. 2023 Jan-Dec; 15(1): 96–106. Published online 2022 Jul 4. doi: 10.1159/000525292

PMCID:: PMC10643889

Abstract Article PDF–1.2M

Select item 105172167.

Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML

Joshua Bennett, Chiharu Ishikawa, Puneet Agarwal, Jennifer Yeung, Avery Sampson, Emma Uible, Eric Vick, Lyndsey C. Bolanos, Kathleen Hueneman, Mark Wunderlich, Amal Kolt, Kwangmin Choi, Andrew Volk, Kenneth D. Greis, Jan Rosenbaum, Scott B. Hoyt, Craig J. Thomas, Daniel T. Starczynowski

Blood. 2023 Sep 14; 142(11): 989–1007. Published online 2023 May 16. doi: 10.1182/blood.2022018718

PMCID:: PMC10517216

Abstract Article

Select item 103986608.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 103627979.

Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation

Lisheng Zhang, Jiao-Hui Wu, Pierre-Yves Jean-Charles, Pavitra Murali, Wenli Zhang, Aeva Jazic, Suneet Kaur, Igor Nepliouev, Jonathan A. Stiber, Kamie Snow, Neil J. Freedman, Sudha K. Shenoy

J Biol Chem. 2023 Jul; 299(7): 104911. Published online 2023 Jun 11. doi: 10.1016/j.jbc.2023.104911

PMCID:: PMC10362797

Abstract Article PDF–4.9M

Select item 1033483810.

Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6

Yehua Li, Jiayin Peng, Yuanxin Xia, Chenyu Pan, Yu Li, Weijie Gu, Jia Wang, Chaoxiong Wang, Yuang Wang, Jiawen Song, Xuan Zhou, Liya Ma, Yiao Jiang, Biao Liu, Qiongni Feng, Wenjia Wang, Shi Jiao, Liwei An, Dianfan Li, Zhaocai Zhou, Yun Zhao

Theranostics. 2023; 13(11): 3761–3780. Published online 2023 Jun 26. doi: 10.7150/thno.83676

PMCID:: PMC10334838

Abstract Article PDF–8.8M

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1008280012.

Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells

Jing Li, Yuchen Sun, Xu Zhao, Yuan Ma, Yuchen Xie, Siqi Liu, Beina Hui, Xiaobo Shi, Xuanzi Sun, Xiaozhi Zhang

Cell Death Dis. 2023 Apr; 14(4): 259. Published online 2023 Apr 8. doi: 10.1038/s41419-023-05732-0

PMCID:: PMC10082800

Abstract Article PDF–6.6M

Select item 1007290613.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 995018314.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 968913315.

Expression of IRAK1 in Hepatocellular Carcinoma, Its Clinical Significance, and Docking Characteristics with Selected Natural Compounds

Chaoying Song, Xinyu Gu, Ruifang Li

Curr Oncol. 2022 Nov; 29(11): 8904–8916. Published online 2022 Nov 18. doi: 10.3390/curroncol29110700

PMCID:: PMC9689133

Abstract Article PDF–2.5M

Select item 963732416.

Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

Youjing Zheng, Jia-Qiang He

Rev Cardiovasc Med. Author manuscript; available in PMC 2022 Nov 6.

Published in final edited form as: Rev Cardiovasc Med. 2022 Mar 12; 23(3): 97. doi: 10.31083/j.rcm2303097

PMCID:: PMC9637324

Abstract Article PDF–829K

Select item 962832817.

IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB–Induced Inflammation

Ilona Gottschalk, Uwe Kölsch, Dimitrios L. Wagner, Jonas Kath, Stefania Martini, Renate Krüger, Anne Puel, Jean-Laurent Casanova, Aleksandra Jezela-Stanek, Rainer Rossi, Salima El Chehadeh, Hilde Van Esch, Horst von Bernuth

J Clin Immunol. 2023; 43(2): 421–439. Published online 2022 Nov 2. doi: 10.1007/s10875-022-01390-7

PMCID:: PMC9628328

Abstract Article PDF–1.5M

Select item 948193318.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 926261419.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 917141120.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

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