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Select item 109727481.

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Pengbiao Xu, Ying Liu, Chong Liu, Baptiste Guey, Lingyun Li, Pauline Melenec, Jonathan Ricci, Andrea Ablasser

Nature. 2024; 627(8005): 873–879. Published online 2024 Feb 28. doi: 10.1038/s41586-024-07112-w

PMCID:: PMC10972748

Abstract Article PDF–17M

Select item 103561372.

Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

Arian Mansur, Remi Joseph, Euri S Kim, Pierre M Jean-Beltran, Namrata D Udeshi, Cadence Pearce, Hanjie Jiang, Reina Iwase, Miroslav P Milev, Hashem A Almousa, Elyshia McNamara, Jeffrey Widrick, Claudio Perez, Gianina Ravenscroft, Michael Sacher, Philip A Cole, Steven A Carr, Vandana A Gupta

eLife. 2023; 12: e81966. Published online 2023 Jul 11. doi: 10.7554/eLife.81966

PMCID:: PMC10356137

Abstract Article PDF–12M

Select item 99080113.

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients

Christopher Nardone, Brad A. Palanski, Daniel C. Scott, Richard T. Timms, Karl W. Barber, Xin Gu, Aoyue Mao, Yumei Leng, Emma V. Watson, Brenda A. Schulman, Philip A. Cole, Stephen J. Elledge

Mol Cell. Author manuscript; available in PMC 2023 Feb 14.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 57–73.e9. doi: 10.1016/j.molcel.2022.12.013

PMCID:: PMC9908011

Abstract Article PDF–2.9M

Select item 98338984.

RNF7 Facilitated the Tumorigenesis of Pancreatic Cancer by Activating PI3K/Akt Signaling Pathway

Hao Hua, Huahua Xie, Jian Zheng, Linhan Lei, Zilei Deng, Chao Yu

Oxid Med Cell Longev. 2023; 2023: 1728463. Published online 2023 Jan 4. doi: 10.1155/2023/1728463

PMCID:: PMC9833898

Abstract Article PDF–4.1M

Select item 97641815.

The SCF–FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage

Simon Hänle-Kreidler, Kai T. Richter, Ingrid Hoffmann

J Biol Chem. 2022 Dec; 298(12): 102703. Published online 2022 Nov 14. doi: 10.1016/j.jbc.2022.102703

PMCID:: PMC9764181

Abstract Article PDF–2.1M

Select item 95767576.

A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer

Tiantian Xu, Qisheng Ma, Yanan Li, Qing Yu, Peichen Pan, Yawen Zheng, Zhijian Li, Xiufang Xiong, Tingjun Hou, Bin Yu, Hongmin Liu, Yi Sun

Signal Transduct Target Ther. 2022; 7: 354. Published online 2022 Oct 17. doi: 10.1038/s41392-022-01182-w

PMCID:: PMC9576757

Abstract Article PDF–6.0M

Select item 95079647.

Structure of CRL7^FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation

Linus V. M. Hopf, Kheewoong Baek, Maren Klügel, Susanne von Gronau, Yue Xiong, Brenda A. Schulman

Nat Struct Mol Biol. 2022; 29(9): 854–862. Published online 2022 Aug 18. doi: 10.1038/s41594-022-00815-6

PMCID:: PMC9507964

Abstract Article PDF–15M

Select item 93082188.

FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia

Hyun Mi Kang, Dae Hun Kim, Mijin Kim, Yoohong Min, Bohyeon Jeong, Kyung Hee Noh, Da Yong Lee, Hyun-Soo Cho, Nam-Soon Kim, Cho-Rok Jung, Jung Hwa Lim

Cell Biosci. 2022; 12: 110. Published online 2022 Jul 22. doi: 10.1186/s13578-022-00851-1

PMCID:: PMC9308218

Abstract Article PDF–2.8M

Select item 92792859.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 910717010.

RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop

Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang, Qing Yang

Cell Mol Biol Lett. 2022; 27: 36. Published online 2022 May 13. doi: 10.1186/s11658-022-00337-5

PMCID:: PMC9107170

Abstract Article PDF–5.8M

Select item 910630311.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 907066512.

Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation

Ke-Jun Han, Valeryia Mikalayeva, Scott A Gerber, Arminja N Kettenbach, Vytenis A Skeberdis, Rytis Prekeris

Life Sci Alliance. 2022 Sep; 5(9): e202101346. Published online 2022 May 5. doi: 10.26508/lsa.202101346

PMCID:: PMC9070665

Abstract Article PDF–2.6M

Select item 846044713.

CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation

Sebastian Kostrhon, J. Rajan Prabu, Kheewoong Baek, Daniel Horn-Ghetko, Susanne von Gronau, Maren Klügel, Jérôme Basquin, Arno F. Alpi, Brenda A. Schulman

Nat Chem Biol. 2021; 17(10): 1075–1083. Published online 2021 Sep 13. doi: 10.1038/s41589-021-00858-8

PMCID:: PMC8460447

Abstract Article PDF–13M

Select item 845514614.

Not all Rabs are created equal: Methods to study the unique SOCS box domain of the Rab40 small GTPase subfamily

Emily D. Duncan, Ezra Lencer, Erik Linklater, Rytis Prekeris

Methods Mol Biol. Author manuscript; available in PMC 2021 Sep 21.

Published in final edited form as: Methods Mol Biol. 2021; 2293: 163–179. doi: 10.1007/978-1-0716-1346-7_11

PMCID:: PMC8455146

Abstract Article PDF–1.1M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812979416.

Rab40–Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration

Erik S. Linklater, Emily D. Duncan, Ke-Jun Han, Algirdas Kaupinis, Mindaugas Valius, Traci R. Lyons, Rytis Prekeris

J Cell Biol. 2021 Jul 5; 220(7): e202008060. Published online 2021 May 17. doi: 10.1083/jcb.202008060

PMCID:: PMC8129794

Abstract Article PDF–6.5M

Select item 795484817.

Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer

Shoufang Xu, Yilei Ma, Qingchao Tong, Jun Yang, Jia Liu, Yanzhong Wang, Guoli Li, Jin Zeng, Sining Fang, Fengying Li, Xinyou Xie, Jun Zhang

Cell Death Dis. 2021 Mar; 12(3): 265. Published online 2021 Mar 12. doi: 10.1038/s41419-021-03557-3

Correction in:: Cell Death Dis. 2021 Apr; 12(4): 369.

PMCID:: PMC7954848

Abstract Article PDF–5.3M

Select item 795013218.

The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases

Ryan J. Lumpkin, Alla S. Ahmad, Rachel Blake, Christopher J. Condon, Elizabeth A. Komives

Mol Cell Proteomics. 2021; 20: 100019. Published online 2021 Jan 6. doi: 10.1074/mcp.RA120.002414

PMCID:: PMC7950132

Abstract Article PDF–3.1M

Select item 784323819.

Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

Guizhen Wang, Qun Zhao, Hui Zhang, Fan Liang, Chen Zhang, Jun Wang, Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou

Front Med. 2021; 15(2): 252–263. Published online 2021 Jan 29. doi: 10.1007/s11684-021-0837-6

PMCID:: PMC7843238

Abstract Article PDF–4.2M

Select item 766519320.

Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity

Lisha Zhou, Jin Zhu, Wangyang Chen, Yanyu Jiang, Tao Hu, Yinxia Wang, Xiaoling Ye, Mengxi Zhan, Chenghao Ji, Zhuoming Xu, Xinran Wang, Yuanlong Gu, Lijun Jia

Cell Death Dis. 2020 Nov; 11(11): 975. Published online 2020 Nov 12. doi: 10.1038/s41419-020-03184-4

PMCID:: PMC7665193

Abstract Article PDF–2.5M

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