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Select item 112958841.

Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway

Taiyang Liao, Lei Shi, Chenglong He, Deren Liu, Yibao Wei, Zhenyuan Ma, Peimin Wang, Jun Mao, Peng Wu

J Transl Med. 2024; 22: 715. Published online 2024 Aug 1. doi: 10.1186/s12967-024-05540-w

PMCID:: PMC11295884

Abstract Article PDF–9.2M

Select item 112226592.

Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation

Jeong-Hwan Yoon, Eunjin Bae, Yasuo Nagafuchi, Katsuko Sudo, Jin Soo Han, Seok Hee Park, Susumu Nakae, Tadashi Yamashita, Ji Hyeon Ju, Isao Matsumoto, Takayuki Sumida, Keiji Miyazawa, Mitsuyasu Kato, Masahiko Kuroda, In-Kyu Lee, Keishi Fujio, Mizuko Mamura

Life Sci Alliance. 2024 Sep; 7(9): e201900581. Published online 2024 Jul 3. doi: 10.26508/lsa.201900581

PMCID:: PMC11222659

Abstract Article PDF–5.3M

Select item 112177833.

Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

Davy Vanhoutte, Tobias G. Schips, Rachel A. Minerath, Jiuzhou Huo, Naga Swathi Sree Kavuri, Vikram Prasad, Suh-Chin Lin, Michael J. Bround, Michelle A. Sargent, Christopher M. Adams, Jeffery D. Molkentin

Cell Rep. Author manuscript; available in PMC 2024 Jul 2.

Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114149. Published online 2024 Apr 26. doi: 10.1016/j.celrep.2024.114149

PMCID:: PMC11217783

Abstract Article PDF–3.2M

Select item 109333444.

A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction

Sibei Tang, Junxun Zhang, Fangzhou Lou, Hong Zhou, Xiaojie Cai, Zhikai Wang, Libo Sun, Yang Sun, Xiangxiao Li, Li Fan, Yan Li, Xinping Jin, Siyu Deng, Qianqian Yin, Jing Bai, Hong Wang, Honglin Wang

EMBO Rep. 2024 Mar; 25(3): 1208–1232. Published online 2024 Jan 30. doi: 10.1038/s44319-024-00070-4

PMCID:: PMC10933344

Abstract Article PDF–4.9M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106559186.

The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis

Jingyue Xu, Han Liu, Yu Lan, Rulang Jiang

Development. 2022 Nov 1; 149(21): dev200667. Published online 2022 Oct 28. doi: 10.1242/dev.200667

PMCID:: PMC10655918

Abstract Article

Select item 106462337.

Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3‐Dependent Podocyte‐Mesenchymal Transition

Qiong‐ Dan Hu, Hong‐Lian Wang, Jian Liu, Tao He, Rui‐Zhi Tan, Qiong Zhang, Hong‐Wei Su, Fahsai Kantawong, Hui‐Yao Lan, Li Wang

Adv Sci (Weinh) 2023 Nov; 10(32): 2304360. Published online 2023 Sep 25. doi: 10.1002/advs.202304360

PMCID:: PMC10646233

Abstract Article PDF–10M

Select item 104923068.

circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer

Zhongjie Zhao, Wenbo Yang, Rui Kong, Yangyang Zhang, Le Li, Zengfu Song, Hongze Chen, Yan Luo, Tao Zhang, Chundong Cheng, Guanqun Li, Danxi Liu, Xinglong Geng, Hua Chen, Yongwei Wang, Shangha Pan, Jisheng Hu, Bei Sun

Mol Cancer. 2023; 22: 152. Published online 2023 Sep 9. doi: 10.1186/s12943-023-01847-2

PMCID:: PMC10492306

Abstract Article PDF–16M

Select item 103804929.

Smad3 Mediates Diabetic Dyslipidemia and Fatty Liver in db/db Mice by Targeting PPARδ

Huijun He, Yu Zhong, Honglian Wang, Patrick Ming-Kuen Tang, Vivian Weiwen Xue, Xiaocui Chen, Jiaoyi Chen, Xiaoru Huang, Cheng Wang, Huiyao Lan

Int J Mol Sci. 2023 Jul; 24(14): 11396. Published online 2023 Jul 13. doi: 10.3390/ijms241411396

PMCID:: PMC10380492

Abstract Article PDF–5.3M

Select item 1033483110.

Tsp-1⁺ microglia attenuate retinal neovascularization by maintaining the expression of Smad3 in endothelial cells through exosomes with decreased miR-27a-5p

Qian Luo, Zihua Jiang, Jingyi Jiang, Linxi Wan, Yan Li, Yuke Huang, Jin Qiu, Keming Yu, Jing Zhuang

Theranostics. 2023; 13(11): 3689–3706. Published online 2023 Jun 26. doi: 10.7150/thno.84236

PMCID:: PMC10334831

Abstract Article PDF–12M

Select item 1030952711.

Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC

Hong-Qiang Yu, Feng Li, HaoJun Xiong, Lei Fang, Jie Zhang, Ping Bie, Chuan-Ming Xie

Hepatol Commun. 2023 Jul; 7(7): e00198. Published online 2023 Jun 28. doi: 10.1097/HC9.0000000000000198

PMCID:: PMC10309527

Abstract Article PDF–2.1M

Select item 1011912112.

Topologically associating domain boundaries are required for normal genome function

Sudha Rajderkar, Iros Barozzi, Yiwen Zhu, Rong Hu, Yanxiao Zhang, Bin Li, Ana Alcaina Caro, Yoko Fukuda-Yuzawa, Guy Kelman, Adyam Akeza, Matthew J. Blow, Quan Pham, Anne N. Harrington, Janeth Godoy, Eman M. Meky, Kianna von Maydell, Riana D. Hunter, Jennifer A. Akiyama, Catherine S. Novak, Ingrid Plajzer-Frick, Veena Afzal, Stella Tran, Javier Lopez-Rios, Michael E. Talkowski, K. C. Kent Lloyd, Bing Ren, Diane E. Dickel, Axel Visel, Len A. Pennacchio

Commun Biol. 2023; 6: 435. Published online 2023 Apr 20. doi: 10.1038/s42003-023-04819-w

PMCID:: PMC10119121

Abstract Article PDF–3.2M

Select item 1006636613.

Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang

Nat Commun. 2023; 14: 1794. Published online 2023 Mar 31. doi: 10.1038/s41467-023-37515-8

PMCID:: PMC10066366

Abstract Article PDF–14M

Select item 1002316114.

The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

Valeria Taliani, Giulia Buonaiuto, Fabio Desideri, Adriano Setti, Tiziana Santini, Silvia Galfrè, Leonardo Schirone, Davide Mariani, Giacomo Frati, Valentina Valenti, Sebastiano Sciarretta, Emerald Perlas, Carmine Nicoletti, Antonio Musarò, Monica Ballarino

eLife. 2023; 12: e81360. Published online 2023 Mar 6. doi: 10.7554/eLife.81360

PMCID:: PMC10023161

Abstract Article PDF–4.8M

Select item 1001303915.

Transforming Growth Factor-β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models

Gani Oruqaj, Srikanth Karnati, Lakshmi Kanth Kotarkonda, Eistine Boateng, Marek Bartkuhn, Wenming Zhang, Clemens Ruppert, Andreas Günther, Laurent Bartholin, Wei Shi, Eveline Baumgart-Vogt

Am J Pathol. 2023 Mar; 193(3): 259–274. doi: 10.1016/j.ajpath.2022.11.006

PMCID:: PMC10013039

Abstract Article PDF–3.9M

Select item 995159416.

Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation

Georgia Zarkada, Joel P. Howard, Xue Xiao, Hyojin Park, Mathilde Bizou, Severine Leclerc, Steffen E. Künzel, Blanche Boisseau, Jinyu Li, Gael Cagnone, Jean Sebastien Joyal, Gregor Andelfinger, Anne Eichmann, Alexandre Dubrac

Dev Cell. Author manuscript; available in PMC 2023 Feb 24.

Published in final edited form as: Dev Cell. 2021 Aug 9; 56(15): 2237–2251.e6. Published online 2021 Jul 16. doi: 10.1016/j.devcel.2021.06.021