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Items: 1 to 20 of 102

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
MYTHO is a novel regulator of skeletal muscle autophagy and integrity
Jean-Philippe Leduc-Gaudet, Anais Franco-Romero, Marina Cefis, Alaa Moamer, Felipe E. Broering, Giulia Milan, Roberta Sartori, Tomer Jordi Chaffer, Maude Dulac, Vincent Marcangeli, Dominique Mayaki, Laurent Huck, Anwar Shams, José A. Morais, Elise Duchesne, Hanns Lochmuller, Marco Sandri, Sabah N. A. Hussain, Gilles Gouspillou
Nat Commun. 2023; 14: 1199. Published online 2023 Mar 2. doi: 10.1038/s41467-023-36817-1
PMCID:
PMC9981687
AbstractArticlePDF–13M
3.
Loss of FoxOs in muscle increases strength and mitochondrial function during aging
Christie M. Penniman, Gourav Bhardwaj, Colette J. Nowers, Chandler U. Brown, Taylor L. Junck, Cierra K. Boyer, Jayashree Jena, Jordan D. Fuqua, Vitor A. Lira, Brian T. O'Neill
J Cachexia Sarcopenia Muscle. 2023 Feb; 14(1): 243–259. Published online 2022 Nov 28. doi: 10.1002/jcsm.13124
PMCID:
PMC9891940
AbstractArticlePDF–4.8M
4.
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice
Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C. Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Nat Commun. 2022; 13: 5655. Published online 2022 Oct 5. doi: 10.1038/s41467-022-33008-2
PMCID:
PMC9535008
AbstractArticlePDF–3.1M
5.
The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity
Xiang Chen, Jia Hu, Yunfei Wang, Younghee Lee, Xiaohong Zhao, Huiping Lu, Gengzhen Zhu, Hui Wang, Yu Jiang, Fan Liu, Yongzhen Chen, Byung-Seok Kim, Qinghua Zhou, Xindong Liu, Xiaohu Wang, Seon Hee Chang, Chen Dong
J Clin Invest. 2022 Sep 15; 132(18): e147566. Published online 2022 Sep 15. doi: 10.1172/JCI147566
PMCID:
PMC9479610
AbstractArticlePDF–4.0M
6.
Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
Yating Wang, Stefano Spolitu, John A. Zadroga, Amesh K. Sarecha, Lale Ozcan
Cell Rep. Author manuscript; available in PMC 2022 Sep 6.
Published in final edited form as: Cell Rep. 2022 Aug 23; 40(8): 111259. doi: 10.1016/j.celrep.2022.111259
PMCID:
PMC9446800
AbstractArticlePDF–1.2M
7.
Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors
Gourav Bhardwaj, Christie M. Penniman, Katherine Klaus, Eric T. Weatherford, Hui Pan, Jonathan M. Dreyfuss, K. Sreekumaran Nair, C. Ronald Kahn, Brian T. O’Neill
Front Physiol. 2021; 12: 779121. Published online 2022 Feb 4. doi: 10.3389/fphys.2021.779121
PMCID:
PMC8855073
AbstractArticlePDF–12M
8.
FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth
Caitlin E Stallings, Jyoti Kapali, Brian W Evans, Stacey R McGee, Buffy S Ellsworth
Endocrinology. 2022 Feb; 163(2): bqab263. Published online 2021 Dec 31. doi: 10.1210/endocr/bqab263
PMCID:
PMC8782608
AbstractArticle
9.
FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity
Su Hyoun Lee, Sungyeon Jung, Yun Ju Lee, Minju Hyun, Kwang Chul Chung
J Biol Chem. 2021 Dec; 297(6): 101426. Published online 2021 Nov 17. doi: 10.1016/j.jbc.2021.101426
PMCID:
PMC8665361
AbstractArticlePDF–2.5M
10.
Hypoxia‐induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression
Xiao‐Hong Wang, Zhong‐Hua Jiang, Hong‐Mei Yang, Yu Zhang, Li‐Hua Xu
Clin Transl Med. 2021 Jan; 11(1): e279. Published online 2021 Jan 15. doi: 10.1002/ctm2.279
PMCID:
PMC7809603
AbstractArticlePDF–2.9M
11.
FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis
Kwang Il Lee, Sungwook Choi, Tokio Matsuzaki, Oscar Alvarez-Garcia, Merissa Olmer, Shawn P. Grogan, Darryl D. D’Lima, Martin K. Lotz
Proc Natl Acad Sci U S A. 2020 Feb 11; 117(6): 3135–3143. Published online 2020 Jan 24. doi: 10.1073/pnas.1918673117
PMCID:
PMC7022148
AbstractArticlePDF–2.7M
12.
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
Jessica Segalés, Eusebio Perdiguero, Antonio L. Serrano, Pedro Sousa-Victor, Laura Ortet, Mercè Jardí, Andrei V. Budanov, Laura Garcia-Prat, Marco Sandri, David M. Thomson, Michael Karin, Jun Hee Lee, Pura Muñoz-Cánoves
Nat Commun. 2020; 11: 189. Published online 2020 Jan 13. doi: 10.1038/s41467-019-13832-9
PMCID:
PMC6955241
AbstractArticlePDF–1.5M
13.
FoxO transcription factors 1 regulate mouse preimplantation embryo development
Nilay Kuscu, Nazli Ece Gungor-Ordueri, Berna Sozen, Dileyra Adiguzel, Ciler Celik-Ozenci
J Assist Reprod Genet. 2019 Oct; 36(10): 2121–2133. Published online 2019 Aug 8. doi: 10.1007/s10815-019-01555-1
Correction in:
J Assist Reprod Genet. 2019 Dec; 36(12): 2605.
PMCID:
PMC6823425
AbstractArticlePDF–3.1M
14.
Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity
Christie M. Penniman, Pablo A. Suarez Beltran, Gourav Bhardwaj, Taylor L. Junck, Jayashree Jena, Kennedy Poro, Michael F. Hirshman, Laurie J. Goodyear, Brian T. O'Neill
Mol Metab. 2019 Dec; 30: 203–220. Published online 2019 Oct 10. doi: 10.1016/j.molmet.2019.10.001
PMCID:
PMC6819874
AbstractArticlePDF–3.2M
15.
Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion
Abdelfattah El Ouaamari, InSug O-Sullivan, Jun Shirakawa, Giorgio Basile, Wenwei Zhang, Sandra Roger, Thomas Thomou, Shanshan Xu, Guifen Qiang, Chong Wee Liew, Rohit N. Kulkarni, Terry G. Unterman
J Biol Chem. 2019 Jan 18; 294(3): 1059–1069. Published online 2018 Nov 20. doi: 10.1074/jbc.RA118.006031
PMCID:
PMC6341384
AbstractArticlePDF–1.9M
16.
FoxO transcription factors influence cartilage maturation, homeostasis and osteoarthritis pathogenesis by modulating autophagy and proteoglycan 4
Tokio Matsuzaki, Oscar Alvarez-Garcia, Sho Mokuda, Keita Nagira, Merissa Olmer, Ramya Gamini, Kohei Miyata, Yukio Akasaki, Andrew I. Su, Hiroshi Asahara, Martin K. Lotz
Sci Transl Med. Author manuscript; available in PMC 2019 Feb 14.
Published in final edited form as: Sci Transl Med. 2018 Feb 14; 10(428): eaan0746. doi: 10.1126/scitranslmed.aan0746
PMCID:
PMC6204214
AbstractArticlePDF–1.2M
17.
microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function
Fanny Langlet, Marcel Tarbier, Rebecca A. Haeusler, Stefania Camastra, Eleuterio Ferrannini, Marc R. Friedländer, Domenico Accili
Mol Metab. 2018 Nov; 17: 49–60. Published online 2018 Aug 11. doi: 10.1016/j.molmet.2018.08.003
PMCID:
PMC6197154
AbstractArticlePDF–2.3M
18.
FoxO function is essential for maintenance of autophagic flux and neuronal morphogenesis in adult neurogenesis
Iris Schäffner, Georgia Minakaki, M. Amir Khan, Elli-Anna Balta, Ursula Schlötzer-Schrehardt, Tobias J. Schwarz, Ruth Beckervordersandforth, Beate Winner, Ashley E. Webb, Ronald A. DePinho, Jihye Paik, Wolfgang Wurst, Jochen Klucken, D. Chichung Lie
Neuron. Author manuscript; available in PMC 2019 Sep 19.
Published in final edited form as: Neuron. 2018 Sep 19; 99(6): 1188–1203.e6. Published online 2018 Sep 6. doi: 10.1016/j.neuron.2018.08.017
PMCID:
PMC6186958
AbstractArticlePDF–6.0M
19.
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration
Oscar Alvarez‐Garcia, Tokio Matsuzaki, Merissa Olmer, Kohei Miyata, Sho Mokuda, Daisuke Sakai, Koichi Masuda, Hiroshi Asahara, Martin K. Lotz
Aging Cell. 2018 Oct; 17(5): e12800. Published online 2018 Jul 2. doi: 10.1111/acel.12800
PMCID:
PMC6156454
AbstractArticlePDF–4.8M
20.
WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4
Shintaro Mandai, Takayasu Mori, Naohiro Nomura, Taisuke Furusho, Yohei Arai, Hiroaki Kikuchi, Emi Sasaki, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Sci Rep. 2018; 8: 9101. Published online 2018 Jun 14. doi: 10.1038/s41598-018-27414-0
PMCID:
PMC6002401
AbstractArticlePDF–4.9M

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