PMC Links for GEO Profiles (Select 24843867) - PMC

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Items: 19

Select item 98562171.

Manipulation of a Cation-π Sandwich Reveals Conformational Flexibility in Phenylalanine Hydroxylase

Emilia C. Arturo, George W. Merkel, Michael R. Hansen, Sophia Lisowski, Deeanne Almeida, Kushol Gupta, Eileen K. Jaffe

Biochimie. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Biochimie. 2021 Apr; 183: 63–77. Published online 2020 Nov 19. doi: 10.1016/j.biochi.2020.11.011

PMCID:: PMC9856217

Abstract Article PDF–2.5M

Select item 69700872.

The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis

Zheng-Zheng Li, Wen-Long Zhao, Gui-Shuan Wang, Ni-Hao Gu, Fei Sun

Biosci Rep. 2020 Jan 31; 40(1): BSR20192666. Published online 2020 Jan 17. doi: 10.1042/BSR20192666

PMCID:: PMC6970087

Abstract Article PDF–2.4M

Select item 48963963.

Domain movements upon activation of phenylalanine hydroxylase characterized by crystallography and chromatography-coupled small-angle X-ray scattering

Steve P. Meisburger, Alexander B. Taylor, Crystal A. Khan, Shengnan Zhang, Paul F. Fitzpatrick, Nozomi Ando

J Am Chem Soc. Author manuscript; available in PMC 2017 May 25.

Published in final edited form as: J Am Chem Soc. 2016 May 25; 138(20): 6506–6516. Published online 2016 May 12. doi: 10.1021/jacs.6b01563

PMCID:: PMC4896396

Abstract Article PDF–1.4M

Select item 48171734.

Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase

Shengnan Zhang, Paul F. Fitzpatrick

J Biol Chem. 2016 Apr 1; 291(14): 7418–7425. Published online 2016 Jan 28. doi: 10.1074/jbc.M115.709998

PMCID:: PMC4817173

Abstract Article PDF–1.1M

Select item 47806085.

First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer

Emilia C. Arturo, Kushol Gupta, Annie Héroux, Linda Stith, Penelope J. Cross, Emily J. Parker, Patrick J. Loll, Eileen K. Jaffe

Proc Natl Acad Sci U S A. 2016 Mar 1; 113(9): 2394–2399. Published online 2016 Feb 16. doi: 10.1073/pnas.1516967113

PMCID:: PMC4780608

Abstract Article PDF–1.4M

Select item 45511016.

The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers

Shengnan Zhang, Andrew P. Hinck, Paul F. Fitzpatrick

Biochemistry. 2015 Aug 25; 54(33): 5167–5174. Published online 2015 Aug 7. doi: 10.1021/acs.biochem.5b00616

PMCID:: PMC4551101

Abstract Article PDF–953K

Select item 42703837.

Activation of Phenylalanine Hydroxylase by Phenylalanine Does Not Require Binding in the Active Site

Kenneth M. Roberts, Crystal A. Khan, Cynthia S. Hinck, Paul F. Fitzpatrick

Biochemistry. 2014 Dec 16; 53(49): 7846–7853. Published online 2014 Nov 24. doi: 10.1021/bi501183x

PMCID:: PMC4270383

Abstract Article PDF–2.3M

Select item 36833848.

Regulation of Phenylalanine Hydroxylase: Conformational Changes Upon Phosphorylation Detected by H/D Exchange and Mass Spectrometry

Jun Li, Paul F. Fitzpatrick

Arch Biochem Biophys. Author manuscript; available in PMC 2014 Jul 15.

Published in final edited form as: Arch Biochem Biophys. 2013 Jul 15; 535(2): 115–119. Published online 2013 Mar 26. doi: 10.1016/j.abb.2013.03.006

PMCID:: PMC3683384

Abstract Article PDF–1.3M

Select item 35800159.

A New Model for Allosteric Regulation of Phenylalanine Hydroxylase: Implications for Disease and Therapeutics

Eileen K Jaffe, Linda Stith, Sarah H. Lawrence, Mark Andrake, Roland L. Dunbrack, Jr.

Arch Biochem Biophys. Author manuscript; available in PMC 2014 Feb 15.

Published in final edited form as: Arch Biochem Biophys. 2013 Feb 15; 530(2): 73–82. Published online 2013 Jan 11. doi: 10.1016/j.abb.2012.12.017

PMCID:: PMC3580015

Abstract Article PDF–3.5M

Select item 317805910.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 301926311.

Direct Evidence for a Phenylalanine Site in the Regulatory Domain of Phenylalanine Hydroxylase

Jun Li, Udayar Ilangovan, S. Colette Daubner, Andrew P. Hinck, Paul F. Fitzpatrick

Arch Biochem Biophys. Author manuscript; available in PMC 2012 Jan 15.

Published in final edited form as: Arch Biochem Biophys. 2011 Jan 15; 505(2): 250–255. Published online 2010 Oct 14. doi: 10.1016/j.abb.2010.10.009

PMCID:: PMC3019263

Abstract Article PDF–1.2M

Select item 294556312.

Activation of Phenylalanine Hydroxylase Induces Positive Cooperativity toward the Natural Cofactor

Søren W. Gersting, Michael Staudigl, Marietta S. Truger, Dunja D. Messing, Marta K. Danecka, Christian P. Sommerhoff, Kristina F. Kemter, Ania C. Muntau

J Biol Chem. 2010 Oct 1; 285(40): 30686–30697. Published online 2010 Jul 27. doi: 10.1074/jbc.M110.124016

PMCID:: PMC2945563

Abstract Article PDF–1.5M

Select item 251832713.

Characterization of Metal Ligand Mutants of Phenylalanine Hydroxylase: Insights into the Plasticity of a 2-Histidine-1-Carboxylate Triad

Jun Li, Paul F. Fitzpatrick

Arch Biochem Biophys. Author manuscript; available in PMC 2009 Jul 15.

Published in final edited form as: Arch Biochem Biophys. 2008 Jul 15; 475(2): 164–168. Published online 2008 Apr 30. doi: 10.1016/j.abb.2008.04.029

PMCID:: PMC2518327

Abstract Article PDF–666K

Select item 194516714.

Insights into the Catalytic Mechanisms of Phenylalanine and Tryptophan Hydroxylase from Kinetic Isotope Effects on Aromatic Hydroxylation

Jorge Alex Pavon, Paul F. Fitzpatrick

Biochemistry. Author manuscript; available in PMC 2007 Sep 12.

Published in final edited form as: Biochemistry. 2006 Sep 12; 45(36): 11030–11037. doi: 10.1021/bi0607554

PMCID:: PMC1945167

Abstract Article PDF–169K

Select item 168291115.

Updated listing of haplotypes at the human phenylalanine hydroxylase (PAH) locus.

R C Eisensmith, S L Woo

Am J Hum Genet. 1992 Dec; 51(6): 1445–1448.

PMCID:: PMC1682911

Summary Page Browse PDF–401K

Select item 122110016.

Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase.

E R Werner, H J Habisch, A C Gorren, K Schmidt, L Canevari, G Werner-Felmayer, B Mayer

Biochem J. 2000 Jun 15; 348(Pt 3): 579–583.

PMCID:: PMC1221100

Summary PDF–119K

Select item 38332217.

High-Density Rat Radiation Hybrid Maps Containing Over 24,000 SSLPs, Genes, and ESTs Provide a Direct Link to the Rat Genome Sequence

Anne E. Kwitek, Jo Gullings-Handley, Jiaming Yu, Danilo C. Carlos, Kimberly Orlebeke, Jeff Nie, Jeffrey Eckert, Angela Lemke, Jaime Wendt Andrae, Susan Bromberg, Dean Pasko, Dan Chen, Todd E. Scheetz, Thomas L. Casavant, M. Bento Soares, Val C. Sheffield, Peter J. Tonellato, Howard J. Jacob

Genome Res. 2004 Apr; 14(4): 750–757. doi: 10.1101/gr.1968704