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Items: 1 to 20 of 162

1.
Human TDP43 is required for ALS‑related annexin A11 toxicity in Drosophila
Jodi Barnard, Rachel Hunt, Mert Yucel, David Mazaud, Bradley N. Smith, Manolis Fanto
Biomed Rep. 2024 Nov; 21(5): 165. Published online 2024 Sep 3. doi: 10.3892/br.2024.1853
PMCID:
PMC11411402
AbstractArticlePDF–3.6M
2.
Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis
Mónica Zufiría, Oihane Pikatza-Menoio, Maddi Garciandia-Arcelus, Xabier Bengoetxea, Andrés Jiménez, Amaia Elicegui, María Levchuk, Olatz Arnold-García, Jon Ondaro, Pablo Iruzubieta, Laura Rodríguez-Gómez, Uxoa Fernández-Pelayo, Mikel Muñoz-Oreja, Ana Aiastui, José Manuel García-Verdugo, Vicente Herranz-Pérez, Miren Zulaica, Juan José Poza, Rebeca Ruiz-Onandi, Roberto Fernández-Torrón, Juan Bautista Espinal, Mario Bonilla, Ana Lersundi, Gorka Fernández-Eulate, Javier Riancho, Ainara Vallejo-Illarramendi, Ian James Holt, Amets Sáenz, Edoardo Malfatti, Stéphanie Duguez, Lorea Blázquez, Adolfo López de Munain, Gorka Gerenu, Francisco Gil-Bea, Sonia Alonso-Martín
Acta Neuropathol. 2024; 148(1): 43. Published online 2024 Sep 16. doi: 10.1007/s00401-024-02794-y
PMCID:
PMC11405449
AbstractArticlePDF–15M
3.
CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis
Aya Ikeda, Hongrui Meng, Daisuke Taniguchi, Muneyo Mio, Manabu Funayama, Kenya Nishioka, Mari Yoshida, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Yohei Okubo, Takashi Sakurai, Taku Amo, Ikuko Aiba, Yufuko Saito, Yuko Saito, Shigeo Murayama, Naoki Atsuta, Ryoichi Nakamura, Genki Tohnai, Yuishin Izumi, Mitsuya Morita, Asako Tamura, Osamu Kano, Masaya Oda, Satoshi Kuwabara, Toru Yamashita, Jun Sone, Ryuji Kaji, Gen Sobue, Yuzuru Imai, Nobutaka Hattori
PNAS Nexus. 2024 Aug; 3(8): pgae319. Published online 2024 Jul 30. doi: 10.1093/pnasnexus/pgae319
PMCID:
PMC11316225
AbstractArticlePDF–1.4M
4.
cAMP/PKA signaling regulates TDP-43 aggregation and mislocalization
Diana M. Ho, Muhammad Shaban, Faisal Mahmood, Payel Ganguly, Leonardo Todeschini, David Van Vactor, Spyros Artavanis-Tsakonas
Proc Natl Acad Sci U S A. 2024 Jun 11; 121(24): e2400732121. Published online 2024 Jun 5. doi: 10.1073/pnas.2400732121
PMCID:
PMC11181030
AbstractArticlePDF–3.6M
5.
Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers
Francesco Liguori, Susanna Amadio, Cinzia Volonté
Cell Mol Life Sci. 2021 Sep; 78(17-18): 6143–6160. Published online 2021 Jul 28. doi: 10.1007/s00018-021-03905-8
PMCID:
PMC11072332
AbstractArticlePDF–1.2M
6.
Long noncoding RNAs heat shock RNA omega nucleates TBPH and promotes intestinal stem cell differentiation upon heat shock
Yinfeng Guo, Meng Wang, Jiaxin Zhu, Qiaoming Li, Haitao Liu, Yang Wang, Steven X. Hou
iScience. 2024 May 17; 27(5): 109732. Published online 2024 Apr 12. doi: 10.1016/j.isci.2024.109732
Correction in:
iScience. 2024 Jul 19; 27(7): 110314.
PMCID:
PMC11067334
AbstractArticlePDF–5.0M
7.
Invertebrate genetic models of amyotrophic lateral sclerosis
LiJun Zhou, RenShi Xu
Front Mol Neurosci. 2024; 17: 1328578. Published online 2024 Mar 4. doi: 10.3389/fnmol.2024.1328578
PMCID:
PMC10944931
AbstractArticlePDF–2.0M
8.
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD
Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, Osamu Onodera, Hideki Mochizuki, Toshiki Mizuno, Keiji Wada, Yoshitaka Nagai
Acta Neuropathol Commun. 2024; 12: 20. Published online 2024 Feb 4. doi: 10.1186/s40478-024-01729-8
PMCID:
PMC10840176
AbstractArticlePDF–2.9M
9.
TDP-43 impairs sleep in Drosophila through Ataxin-2–dependent metabolic disturbance
Alexandra E. Perlegos, Jaclyn Durkin, Samuel J. Belfer, Anyara Rodriguez, Oksana Shcherbakova, Kristen Park, Jenny Luong, Nancy M. Bonini, Matthew S. Kayser
Sci Adv. 2024 Jan 12; 10(2): eadj4457. Published online 2024 Jan 10. doi: 10.1126/sciadv.adj4457
PMCID:
PMC10780954
AbstractArticlePDF–2.1M
10.
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
R. Keating Godfrey, Eric Alsop, Reed T. Bjork, Brijesh S. Chauhan, Hillary C. Ruvalcaba, Jerry Antone, Lauren M. Gittings, Allison F. Michael, Christi Williams, Grace Hala’ufia, Alexander D. Blythe, Megan Hall, Rita Sattler, Kendall Van Keuren-Jensen, Daniela C. Zarnescu
Acta Neuropathol Commun. 2023; 11: 168. Published online 2023 Oct 20. doi: 10.1186/s40478-023-01656-0
PMCID:
PMC10588218
AbstractArticlePDF–30M
11.
TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1
Sarah Krupp, Isabel Hubbard, Oliver Tam, Gale M. Hammell, Josh Dubnau
PLoS Genet. 2023 Sep; 19(9): e1010973. Published online 2023 Sep 25. doi: 10.1371/journal.pgen.1010973
PMCID:
PMC10553832
AbstractArticlePDF–3.0M
12.
Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration
Marta Marzullo, Giulia Romano, Claudia Pellacani, Federico Riccardi, Laura Ciapponi, Fabian Feiguin
Cell Death Discov. 2023; 9: 357. Published online 2023 Sep 27. doi: 10.1038/s41420-023-01643-3
PMCID:
PMC10533867
AbstractArticlePDF–2.2M
13.
Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration
Marina L. Garcia-Vaquero, Marjorie Heim, Barbara Flix, Marcelo Pereira, Lucile Palin, Tânia M. Marques, Francisco R. Pinto, Javier de Las Rivas, Aaron Voigt, Florence Besse, Margarida Gama-Carvalho
BMC Genomics. 2023; 24: 576. Published online 2023 Sep 27. doi: 10.1186/s12864-023-09562-4
PMCID:
PMC10523761
AbstractArticlePDF–3.2M
14.
A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy
Luca Lo Piccolo, Takanari Umegawachi, Ranchana Yeewa, Saranyapin Potikanond, Wutigri Nimlamool, Virapong Prachayasittikul, Yusuke Gotoh, Hideki Yoshida, Masamitsu Yamaguchi, Salinee Jantrapirom
Neurotherapeutics. 2023 Sep; 20(5): 1330–1346. Published online 2023 Jul 26. doi: 10.1007/s13311-023-01406-z
PMCID:
PMC10480388
AbstractArticlePDF–5.7M
15.
The tardigrade Dsup protein enhances radioresistance in Drosophila melanogaster and acts as an unspecific repressor of transcription
Mikhail Zarubin, Talyana Azorskaya, Olga Kuldoshina, Sergey Alekseev, Semen Mitrofanov, Elena Kravchenko
iScience. 2023 Jul 21; 26(7): 106998. Published online 2023 May 29. doi: 10.1016/j.isci.2023.106998
PMCID:
PMC10391675
AbstractArticlePDF–3.0M
16.
Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies
Stefania Santarelli, Chiara Londero, Alessia Soldano, Carlotta Candelaresi, Leonardo Todeschini, Luisa Vernizzi, Paola Bellosta
Front Neurosci. 2023; 17: 1082047. Published online 2023 May 18. doi: 10.3389/fnins.2023.1082047
PMCID:
PMC10232775
AbstractArticlePDF–2.4M
17.
C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD
Pedro Ervilha Pereira, Nika Schuermans, Antoon Meylemans, Pontus LeBlanc, Lauren Versluys, Katie E. Copley, Jack D. Rubien, Christopher Altheimer, Myra Peetermans, Elke Debackere, Olivier Vanakker, Sandra Janssens, Jonathan Baets, Kristof Verhoeven, Martin Lammens, Sofie Symoens, Boel De Paepe, Sami J. Barmada, James Shorter, Jan L. De Bleecker, Elke Bogaert, Bart Dermaut
Acta Neuropathol. 2023; 145(6): 793–814. Published online 2023 Mar 31. doi: 10.1007/s00401-023-02565-1
PMCID:
PMC10175433
AbstractArticlePDF–6.1M
18.
Repetitive elements in aging and neurodegeneration
Katie E. Copley, James Shorter
Trends Genet. Author manuscript; available in PMC 2024 May 1.
Published in final edited form as: Trends Genet. 2023 May; 39(5): 381–400. Published online 2023 Mar 17. doi: 10.1016/j.tig.2023.02.008
PMCID:
PMC10121923
AbstractArticlePDF–935K
19.
Next-generation large-scale binary protein interaction network for Drosophila melanogaster
Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao, István A. Kovács, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H. Wan, Joel S. Bader, Dawit Balcha, Wenting Bian, Benjamin W. Booth, Atina G. Coté, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J. Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P. Roth, Jan Tavernier, Michael A. Calderwood, David E. Hill, Susan E. Celniker, Marc Vidal, Norbert Perrimon, Stephanie E. Mohr
Nat Commun. 2023; 14: 2162. Published online 2023 Apr 15. doi: 10.1038/s41467-023-37876-0
PMCID:
PMC10105736
AbstractArticlePDF–3.2M
20.
The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD
Yu Li, Ji Geng, Suman Rimal, Haochuan Wang, Xiangguo Liu, Bingwei Lu, Shuangxi Li
J Biol Chem. 2023 Mar; 299(3): 102995. Published online 2023 Feb 9. doi: 10.1016/j.jbc.2023.102995
PMCID:
PMC10011831
AbstractArticlePDF–2.4M

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