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Select item 110374051.

MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2

Hui Yu, Xianrong Xu, Lirong Zhu, Shengjie Chen, Jincheng He

J Cell Mol Med. 2024 Apr; 28(8): e18216. Published online 2024 Apr 23. doi: 10.1111/jcmm.18216

PMCID:: PMC11037405

Abstract Article PDF–12M

Select item 106367202.

Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner

Da Young Lee, Sanghoon Lee, Young Sik Kim, Soonbum Park, Sang-Mun Bae, Eun A Cho, Eun-Jung Park, Hyun Ho Park, Sang-Yeob Kim, Insuk So, Jung Nyeo Chun, Ju-Hong Jeon

Oncol Rep. 2023 Dec; 50(6): 218. Published online 2023 Oct 25. doi: 10.3892/or.2023.8655

PMCID:: PMC10636720

Abstract Article PDF–2.7M

Select item 102812913.

Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer

Xuemei Xie, Gaurav B. Chauhan, Ramakrishna Edupuganti, Takahiro Kogawa, Jihyun Park, Moises Tacam, Alex W. Tan, Mohd Mughees, Fnu Vidhu, Diane D. Liu, Juliana M. Taliaferro, Mary Kathryn Pitner, Luke S. Browning, Ju-Hyeon Lee, François Bertucci, Yu Shen, Jian Wang, Naoto T. Ueno, Savitri Krishnamurthy, Gabriel N. Hortobagyi, Debu Tripathy, Steven J. Van Laere, Geoffrey Bartholomeusz, Kevin N. Dalby, Chandra Bartholomeusz

Cancer Res Commun. 2023 Jun; 3(6): 1078–1092. Published online 2023 Jun 20. doi: 10.1158/2767-9764.CRC-22-0330

Correction in:: Cancer Res Commun. 2024 Jan; 4(1): 236.

PMCID:: PMC10281291

Abstract Article PDF–12M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101792745.

Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer

Łukasz Szymański, Krystyna Lieto, Robert Zdanowski, Sławomir Lewicki, Jean-Pierre Tassan, Jacek Z. Kubiak

Int J Mol Sci. 2023 May; 24(9): 8089. Published online 2023 Apr 30. doi: 10.3390/ijms24098089

PMCID:: PMC10179274

Abstract Article PDF–4.5M

Select item 94819336.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 93568677.

Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-κB Signaling Axis through MicroRNA-497-5p

Yingchi Zhang, Rui Lu, Xiaojian Huang, Enzhi Yin, Yong Yang, Chengla Yi, Hongbo You, Xianzhou Song, Xuefeng Yuan

Contrast Media Mol Imaging. 2022; 2022: 7614497. Published online 2022 Jul 30. doi: 10.1155/2022/7614497

PMCID:: PMC9356867

Abstract Article PDF–2.0M

Select item 92317038.

Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer

Ashley A. Hardeman, Yoo Jane Han, Tatyana A. Grushko, Jeffrey Mueller, Maria J. Gomez, Yonglan Zheng, Olufunmilayo I. Olopade

PLoS One. 2022; 17(6): e0268693. Published online 2022 Jun 24. doi: 10.1371/journal.pone.0268693

PMCID:: PMC9231703

Abstract Article PDF–1.6M

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910523510.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 901909311.

xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade

Bufu Tang, Jinyu Zhu, Fangming Liu, Jiayi Ding, Yajie Wang, Shiji Fang, Liyun zheng, Rongfang Qiu, Minjiang Chen, Gaofeng Shu, Min Xu, Chenying Lu, Zhongwei Zhao, Yang Yang, Jiansong Ji

Cell Death Dis. 2022 Apr; 13(4): 373. Published online 2022 Apr 19. doi: 10.1038/s41419-022-04827-4

PMCID:: PMC9019093

Abstract Article PDF–9.4M

Select item 882010812.

Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer

Corey Speers, Shuang G. Zhao, Vishal Kothari, Alyssa Santola, Meilan Liu, Kari Wilder-Romans, Joseph Evans, Nidhi Batra, Harry Bartelink, Daniel F. Hayes, Theodore S. Lawrence, Powel H. Brown, Lori J. Pierce, Felix Y. Feng

Clin Cancer Res. Author manuscript; available in PMC 2022 Feb 7.

Published in final edited form as: Clin Cancer Res. 2016 Dec 1; 22(23): 5864–5875. Published online 2016 May 25. doi: 10.1158/1078-0432.CCR-15-2711

PMCID:: PMC8820108

Abstract Article PDF–1.7M

Select item 866444313.

A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

Lin Zhou, Siqi Zheng, Fernando R Rosas Bringas, Bjorn Bakker, Judith E Simon, Petra L Bakker, Hinke G Kazemier, Michael Schubert, Maurits Roorda, Marcel A T M van Vugt, Michael Chang, Floris Foijer

G3 (Bethesda) 2021 Dec; 11(12): jkab335. Published online 2021 Sep 22. doi: 10.1093/g3journal/jkab335

PMCID:: PMC8664443

Abstract Article PDF–1.6M

Select item 852757814.

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity

Yuehui Zhang, Limin Shang, Jing Zhang, Yuchen Liu, Chaozhi Jin, Yanan Zhao, Xiaobo Lei, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang, Fuchu He, Pei-Hui Wang, Jian Wang

Cell Chem Biol. 2022 Jan 20; 29(1): 5–18.e6. Published online 2021 Oct 20. doi: 10.1016/j.chembiol.2021.10.008

PMCID:: PMC8527578

Abstract Article PDF–4.5M

Select item 849538415.

Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells

Hongzhi Sun, Hongmei Ma, Hao Zhang, Minjun Ji

Int J Biol Sci. 2021; 17(14): 3875–3888. Published online 2021 Sep 7. doi: 10.7150/ijbs.62517

PMCID:: PMC8495384

Abstract Article PDF–2.8M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 814845317.

Ectopic expression of MELK in oral squamous cell carcinoma and its correlation with epithelial mesenchymal transition

Bo Li, Xinghuanyu Xu, Xin Bin, Jiang Zhou, Zhangui Tang

Aging (Albany NY) 2021 May 15; 13(9): 13048–13060. Published online 2021 May 7. doi: 10.18632/aging.202986

PMCID:: PMC8148453

Abstract Article PDF–1.6M

Select item 808636918.

KLF5-induced BBOX1-AS1 contributes to cell malignant phenotypes in non-small cell lung cancer via sponging miR-27a-5p to up-regulate MELK and activate FAK signaling pathway

Jiang Shi, Chao Yang, Jinlu An, Dexun Hao, Cong Liu, Jumin Liu, Jing Sun, Junguang Jiang

J Exp Clin Cancer Res. 2021; 40: 148. Published online 2021 Apr 30. doi: 10.1186/s13046-021-01943-5

PMCID:: PMC8086369

Abstract Article PDF–9.2M

Select item 780173419.

Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies

Emilie Jaune, Elisa Cavazza, Cyril Ronco, Oleksandr Grytsai, Patricia Abbe, Nedra Tekaya, Marwa Zerhouni, Guillaume Beranger, Lisa Kaminski, Frédéric Bost, Maeva Gesson, Meri Tulic, Paul Hofman, Robert Ballotti, Thierry Passeron, Thomas Botton, Rachid Benhida, Stéphane Rocchi

Cell Death Dis. 2021 Jan; 12(1): 64. Published online 2021 Jan 11. doi: 10.1038/s41419-020-03344-6

PMCID:: PMC7801734

Abstract Article PDF–2.6M

Select item 770849020.

MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma

Qin Tang, Wan Li, Xiangjin Zheng, Liwen Ren, Jinyi Liu, Sha Li, Jinhua Wang, Guanhua Du

Signal Transduct Target Ther. 2020; 5: 279. Published online 2020 Dec 2. doi: 10.1038/s41392-020-00288-3

Correction in:: Signal Transduct Target Ther. 2024; 9: 186.

PMCID:: PMC7708490

Abstract Article PDF–6.9M

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