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Items: 1 to 20 of 80

1.
A central role for regulated protein stability in the control of TFE3 and MITF by nutrients
Christopher Nardone, Brad A. Palanski, Daniel C. Scott, Richard T. Timms, Karl W. Barber, Xin Gu, Aoyue Mao, Yumei Leng, Emma V. Watson, Brenda A. Schulman, Philip A. Cole, Stephen J. Elledge
Mol Cell. Author manuscript; available in PMC 2023 Feb 14.
Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 57–73.e9. doi: 10.1016/j.molcel.2022.12.013
PMCID:
PMC9908011
AbstractArticlePDF–2.9M
2.
RNF7 Facilitated the Tumorigenesis of Pancreatic Cancer by Activating PI3K/Akt Signaling Pathway
Hao Hua, Huahua Xie, Jian Zheng, Linhan Lei, Zilei Deng, Chao Yu
Oxid Med Cell Longev. 2023; 2023: 1728463. Published online 2023 Jan 4. doi: 10.1155/2023/1728463
PMCID:
PMC9833898
AbstractArticlePDF–4.1M
3.
The SCF–FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage
Simon Hänle-Kreidler, Kai T. Richter, Ingrid Hoffmann
J Biol Chem. 2022 Dec; 298(12): 102703. Published online 2022 Nov 14. doi: 10.1016/j.jbc.2022.102703
PMCID:
PMC9764181
AbstractArticlePDF–2.1M
4.
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer
Tiantian Xu, Qisheng Ma, Yanan Li, Qing Yu, Peichen Pan, Yawen Zheng, Zhijian Li, Xiufang Xiong, Tingjun Hou, Bin Yu, Hongmin Liu, Yi Sun
Signal Transduct Target Ther. 2022; 7: 354. Published online 2022 Oct 17. doi: 10.1038/s41392-022-01182-w
PMCID:
PMC9576757
AbstractArticlePDF–6.0M
5.
Structure of CRL7FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Linus V. M. Hopf, Kheewoong Baek, Maren Klügel, Susanne von Gronau, Yue Xiong, Brenda A. Schulman
Nat Struct Mol Biol. 2022; 29(9): 854–862. Published online 2022 Aug 18. doi: 10.1038/s41594-022-00815-6
PMCID:
PMC9507964
AbstractArticlePDF–15M
6.
FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia
Hyun Mi Kang, Dae Hun Kim, Mijin Kim, Yoohong Min, Bohyeon Jeong, Kyung Hee Noh, Da Yong Lee, Hyun-Soo Cho, Nam-Soon Kim, Cho-Rok Jung, Jung Hwa Lim
Cell Biosci. 2022; 12: 110. Published online 2022 Jul 22. doi: 10.1186/s13578-022-00851-1
PMCID:
PMC9308218
AbstractArticlePDF–2.8M
7.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
8.
RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop
Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang, Qing Yang
Cell Mol Biol Lett. 2022; 27: 36. Published online 2022 May 13. doi: 10.1186/s11658-022-00337-5
PMCID:
PMC9107170
AbstractArticlePDF–5.8M
9.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
10.
Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation
Ke-Jun Han, Valeryia Mikalayeva, Scott A Gerber, Arminja N Kettenbach, Vytenis A Skeberdis, Rytis Prekeris
Life Sci Alliance. 2022 Sep; 5(9): e202101346. Published online 2022 May 5. doi: 10.26508/lsa.202101346
PMCID:
PMC9070665
AbstractArticlePDF–2.6M
11.
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation
Sebastian Kostrhon, J. Rajan Prabu, Kheewoong Baek, Daniel Horn-Ghetko, Susanne von Gronau, Maren Klügel, Jérôme Basquin, Arno F. Alpi, Brenda A. Schulman
Nat Chem Biol. 2021; 17(10): 1075–1083. Published online 2021 Sep 13. doi: 10.1038/s41589-021-00858-8
PMCID:
PMC8460447
AbstractArticlePDF–13M
12.
Not all Rabs are created equal: Methods to study the unique SOCS box domain of the Rab40 small GTPase subfamily
Emily D. Duncan, Ezra Lencer, Erik Linklater, Rytis Prekeris
Methods Mol Biol. Author manuscript; available in PMC 2021 Sep 21.
Published in final edited form as: Methods Mol Biol. 2021; 2293: 163–179. doi: 10.1007/978-1-0716-1346-7_11
PMCID:
PMC8455146
AbstractArticlePDF–1.1M
13.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
14.
Rab40–Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration
Erik S. Linklater, Emily D. Duncan, Ke-Jun Han, Algirdas Kaupinis, Mindaugas Valius, Traci R. Lyons, Rytis Prekeris
J Cell Biol. 2021 Jul 5; 220(7): e202008060. Published online 2021 May 17. doi: 10.1083/jcb.202008060
PMCID:
PMC8129794
AbstractArticlePDF–6.5M
15.
Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer
Shoufang Xu, Yilei Ma, Qingchao Tong, Jun Yang, Jia Liu, Yanzhong Wang, Guoli Li, Jin Zeng, Sining Fang, Fengying Li, Xinyou Xie, Jun Zhang
Cell Death Dis. 2021 Mar; 12(3): 265. Published online 2021 Mar 12. doi: 10.1038/s41419-021-03557-3
Correction in:
Cell Death Dis. 2021 Apr; 12(4): 369.
PMCID:
PMC7954848
AbstractArticlePDF–5.3M
16.
Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells
Guizhen Wang, Qun Zhao, Hui Zhang, Fan Liang, Chen Zhang, Jun Wang, Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou
Front Med. 2021; 15(2): 252–263. Published online 2021 Jan 29. doi: 10.1007/s11684-021-0837-6
PMCID:
PMC7843238
AbstractArticlePDF–4.2M
17.
Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity
Lisha Zhou, Jin Zhu, Wangyang Chen, Yanyu Jiang, Tao Hu, Yinxia Wang, Xiaoling Ye, Mengxi Zhan, Chenghao Ji, Zhuoming Xu, Xinran Wang, Yuanlong Gu, Lijun Jia
Cell Death Dis. 2020 Nov; 11(11): 975. Published online 2020 Nov 12. doi: 10.1038/s41419-020-03184-4
PMCID:
PMC7665193
AbstractArticlePDF–2.5M
18.
The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance
Shizhen Zhang, Yanwen Shen, Hua Li, Chao Bi, Yilun Sun, Xiufang Xiong, Wenyi Wei, Yi Sun
Cell Rep. Author manuscript; available in PMC 2020 Sep 21.
Published in final edited form as: Cell Rep. 2020 Sep 8; 32(10): 108102. doi: 10.1016/j.celrep.2020.108102
PMCID:
PMC7505520
AbstractArticlePDF–2.4M
19.
Structure and dynamics of the ASB9 CUL-RING E3 Ligase
Ryan J. Lumpkin, Richard W. Baker, Andres E. Leschziner, Elizabeth A. Komives
Nat Commun. 2020; 11: 2866. Published online 2020 Jun 8. doi: 10.1038/s41467-020-16499-9
Correction in:
Nat Commun. 2023; 14: 7463.
PMCID:
PMC7280518
AbstractArticlePDF–5.8M
20.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M

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