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Items: 1 to 20 of 31

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
Cynthia Bülck, Elisabeth E. L. Nyström, Tomas Koudelka, Michael Mannbar-Frahm, Gerrit Andresen, Mariem Radhouani, Florian Tran, Franka Scharfenberg, Friederike Schrell, Fred Armbrust, Eileen Dahlke, Bei Zhao, Alex Vervaeke, Franziska Theilig, Philip Rosenstiel, Philipp Starkl, Stephan P. Rosshart, Helmut Fickenscher, Andreas Tholey, Gunnar C. Hansson, Christoph Becker-Pauly
Sci Adv. 2023 Mar; 9(13): eadf4055. Published online 2023 Mar 31. doi: 10.1126/sciadv.adf4055
PMCID:
PMC10065446
AbstractArticlePDF–2.7M
3.
Meprin β expression modulates the interleukin‐6 mediated JAK2‐STAT3 signaling pathway in ischemia/reperfusion‐induced kidney injury
Shaymaa Abousaad, Faihaa Ahmed, Ayman Abouzeid, Elimelda Moige Ongeri
Physiol Rep. 2022 Sep; 10(18): e15468. Published online 2022 Sep 18. doi: 10.14814/phy2.15468
PMCID:
PMC9483619
AbstractArticlePDF–29M
4.
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease
Liana Marengo, Fred Armbrust, Caroline Schoenherr, Steffen E. Storck, Ulrich Schmitt, Silvia Zampar, Oliver Wirths, Hermann Altmeppen, Markus Glatzel, Christoph Kaether, Sascha Weggen, Christoph Becker-Pauly, Claus U. Pietrzik
Cell Mol Life Sci. 2022 Mar; 79(3): 168. Published online 2022 Mar 2. doi: 10.1007/s00018-022-04205-5
PMCID:
PMC8891209
AbstractArticlePDF–2.4M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Meprin-β activity modulates the β-catalytic subunit of protein kinase A in ischemia-reperfusion-induced acute kidney injury
Faihaa Ahmed, Jean-Marie Mwiza, Mizpha Fernander, Ismaila Yahaya, Shaymaa Abousaad, Elimelda Moige Ongeri
Am J Physiol Renal Physiol. 2020 May 1; 318(5): F1147–F1159. Published online 2020 Mar 16. doi: 10.1152/ajprenal.00571.2019
PMCID:
PMC7294336
AbstractArticle
7.
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage
Rielana Wichert, Franka Scharfenberg, Cynthia Colmorgen, Tomas Koudelka, Jeanette Schwarz, Sebastian Wetzel, Barbara Potempa, Jan Potempa, Jörg W. Bartsch, Irit Sagi, Andreas Tholey, Paul Saftig, Stefan Rose-John, Christoph Becker-Pauly
FASEB J. 2019 Nov; 33(11): 11925–11940. Published online 2019 Aug 9. doi: 10.1096/fj.201801371R
PMCID:
PMC6902663
AbstractArticle
8.
LC-MS-based metabolomics analysis to identify meprin-β-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury
Jessica Gooding, Lei Cao, Faihaa Ahmed, Jean-Marie Mwiza, Mizpha Fernander, Courtney Whitaker, Zach Acuff, Susan McRitchie, Susan Sumner, Elimelda Moige Ongeri
Am J Physiol Renal Physiol. 2019 Oct 1; 317(4): F1034–F1046. Published online 2019 Aug 14. doi: 10.1152/ajprenal.00166.2019
PMCID:
PMC6843037
AbstractArticle
9.
Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes
Florian Peters, Franka Scharfenberg, Cynthia Colmorgen, Fred Armbrust, Rielana Wichert, Philipp Arnold, Barbara Potempa, Jan Potempa, Claus U. Pietrzik, Robert Häsler, Philip Rosenstiel, Christoph Becker-Pauly
FASEB J. 2019 Jun; 33(6): 7490–7504. Published online 2019 Mar 27. doi: 10.1096/fj.201802391R
PMCID:
PMC6529335
AbstractArticle
10.
Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes
John E. Bylander, Faihaa Ahmed, Sabena M. Conley, Jean-Marie Mwiza, Elimelda Moige Ongeri
J Diabetes Res. 2017; 2017: 9035038. Published online 2017 Jul 19. doi: 10.1155/2017/9035038
Correction in:
J Diabetes Res. 2018; 2018: 2462697.
PMCID:
PMC5540529
AbstractArticlePDF–3.1M
11.
Meprin β contributes to collagen deposition in lung fibrosis
V. Biasin, M. Wygrecka, L. M. Marsh, C. Becker-Pauly, L. Brcic, B. Ghanim, W. Klepetko, A. Olschewski, G. Kwapiszewska
Sci Rep. 2017; 7: 39969. Published online 2017 Jan 6. doi: 10.1038/srep39969
PMCID:
PMC5216360
AbstractArticlePDF–3.3M
12.
Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
Caroline Schönherr, Jessica Bien, Simone Isbert, Rielana Wichert, Johannes Prox, Hermann Altmeppen, Sathish Kumar, Jochen Walter, Stefan F. Lichtenthaler, Sascha Weggen, Markus Glatzel, Christoph Becker-Pauly, Claus U. Pietrzik
Mol Neurodegener. 2016; 11: 19. Published online 2016 Feb 19. doi: 10.1186/s13024-016-0084-5
PMCID:
PMC4759862
AbstractArticlePDF–1.7M
13.
Basement membrane protein nidogen-1 is a target of meprin β in cisplatin nephrotoxicity
Christian Herzog, Raju Marisiddaiah, Randy S. Haun, Gur P. Kaushal
Toxicol Lett. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Toxicol Lett. 2015 Jul 16; 236(2): 110–116. Published online 2015 May 6. doi: 10.1016/j.toxlet.2015.05.005
PMCID:
PMC4457671
AbstractArticlePDF–2.1M
14.
Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury
Jean-Marie V. Niyitegeka, Adam C. Bastidas, Robert H. Newman, Susan S. Taylor, Elimelda Moige Ongeri
Am J Physiol Renal Physiol. 2015 Jan 1; 308(1): F56–F68. Published online 2014 Oct 29. doi: 10.1152/ajprenal.00167.2014
PMCID:
PMC4281694
AbstractArticle
15.
Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus
André Schütte, Anna Ermund, Christoph Becker-Pauly, Malin E. V. Johansson, Ana M. Rodriguez-Pineiro, Fredrik Bäckhed, Stefan Müller, Daniel Lottaz, Judith S. Bond, Gunnar C. Hansson
Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34): 12396–12401. Published online 2014 Aug 11. doi: 10.1073/pnas.1407597111
PMCID:
PMC4151749
AbstractArticlePDF–1.3M
16.
Meprin Metalloproteases Inactivate Interleukin 6
Timothy R. Keiffer, Judith S. Bond
J Biol Chem. 2014 Mar 14; 289(11): 7580–7588. Published online 2014 Jan 28. doi: 10.1074/jbc.M113.546309
PMCID:
PMC3953271
AbstractArticlePDF–1.2M
17.
Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength
Claudia Broder, Philipp Arnold, Sandrine Vadon-Le Goff, Moritz A. Konerding, Kerstin Bahr, Stefan Müller, Christopher M. Overall, Judith S. Bond, Tomas Koudelka, Andreas Tholey, David J. S. Hulmes, Catherine Moali, Christoph Becker-Pauly
Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35): 14219–14224. Published online 2013 Aug 12. doi: 10.1073/pnas.1305464110
PMCID:
PMC3761563
AbstractArticlePDF–954K
18.
CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells
Louise H. Slater, Erik C. Hett, Anne E. Clatworthy, Kevin G. Mark, Deborah T. Hung
Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24): 9932–9937. Published online 2013 May 28. doi: 10.1073/pnas.1302257110
PMCID:
PMC3683768
AbstractArticlePDF–488K
19.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
20.
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
Tamara Jefferson, Ulrich auf dem Keller, Caroline Bellac, Verena V. Metz, Claudia Broder, Jana Hedrich, Anke Ohler, Wladislaw Maier, Viktor Magdolen, Erwin Sterchi, Judith S. Bond, Arumugam Jayakumar, Heiko Traupe, Athena Chalaris, Stefan Rose-John, Claus U. Pietrzik, Rolf Postina, Christopher M. Overall, Christoph Becker-Pauly
Cell Mol Life Sci. 2013 Jan; 70(2): 309–333. Published online 2012 Sep 1. doi: 10.1007/s00018-012-1106-2
PMCID:
PMC3535375
AbstractArticlePDF–3.6M

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