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Select item 104618411.

Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation

Kazuyoshi Ohta, Masahiko Ito, Takeshi Chida, Kenji Nakashima, Satoshi Sakai, Yumi Kanegae, Hideya Kawasaki, Takuya Aoshima, Shuji Takabayashi, Hirotaka Takahashi, Kazuhito Kawata, Ikuo Shoji, Tatsuya Sawasaki, Takafumi Suda, Tetsuro Suzuki

PLoS Pathog. 2023 Aug; 19(8): e1011591. Published online 2023 Aug 16. doi: 10.1371/journal.ppat.1011591

PMCID:: PMC10461841

Article PDF–2.6M

Select item 92484352.

CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis

Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano

J Diabetes Investig. 2022 Jul; 13(7): 1129–1131. Published online 2022 Feb 18. doi: 10.1111/jdi.13766

PMCID:: PMC9248435

Article PDF–291K

Select item 89939423.

Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV

Xiaoyue Pan, M. Mahmood Hussain

Hepatology. Author manuscript; available in PMC 2023 Jul 1.

Published in final edited form as: Hepatology. 2022 Jul; 76(1): 78–93. Published online 2021 Dec 13. doi: 10.1002/hep.32196

PMCID:: PMC8993942

Article PDF–3.5M

Select item 89383354.

FACI Is a Novel CREB-H–Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity

Yun Cheng, Xiao-Zhuo Kang, Tao Cheng, Zi-Wei Ye, George L. Tipoe, Cheng-Han Yu, Chi-Ming Wong, Baohua Liu, Chi-Ping Chan, Dong-Yan Jin

Cell Mol Gastroenterol Hepatol. 2022; 13(5): 1365–1391. Published online 2022 Jan 28. doi: 10.1016/j.jcmgh.2022.01.017

PMCID:: PMC8938335

Article PDF–12M

Select item 82465945.

Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice

Christopher S. Krumm, Xu Xu, Curtis J. Bare, Corey D. Holman, Sander Kersten, Lukas E. Dow, Ann-Hwee Lee, David E. Cohen

J Biol Chem. 2021 Jul; 297(1): 100815. Published online 2021 May 21. doi: 10.1016/j.jbc.2021.100815

PMCID:: PMC8246594

Article PDF–2.2M

Select item 79668716.

Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

Hyunbae Kim, Juncheng Wei, Zhenfeng Song, Emilio Mottillo, Lobelia Samavati, Ren Zhang, Li Li, Xuequn Chen, Bhanu P. Jena, Jiandie D. Lin, Deyu Fang, Kezhong Zhang

Mol Metab. 2021 Jul; 49: 101192. Published online 2021 Feb 13. doi: 10.1016/j.molmet.2021.101192

PMCID:: PMC7966871

Article PDF–4.5M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Article PDF–2.0M

Select item 79006048.

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

Yoshimi Nakagawa, Yunong Wang, Song-iee Han, Kanako Okuda, Asayo Oishi, Yuka Yagishita, Kae Kumagai, Hiroshi Ohno, Yoshinori Osaki, Yuhei Mizunoe, Masaya Araki, Yuki Murayama, Hitoshi Iwasaki, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano

Cell Mol Gastroenterol Hepatol. 2021; 11(4): 949–971. Published online 2020 Nov 24. doi: 10.1016/j.jcmgh.2020.11.004

PMCID:: PMC7900604

Article PDF–5.7M

Select item 74842919.

Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH

Carlos Ichiro Kasano-Camones, Masayuki Takizawa, Wakana Iwasaki, Shota Sasaki, Mume Hamada, Aoi Morimoto, Masakiyo Sakaguchi, Frank J. Gonzalez, Yusuke Inoue

Biochem Biophys Res Commun. Author manuscript; available in PMC 2020 Sep 17.

Published in final edited form as: Biochem Biophys Res Commun. 2020 Sep 17; 530(2): 432–439. Published online 2020 Jun 15. doi: 10.1016/j.bbrc.2020.05.070

PMCID:: PMC7484291

Article PDF–531K

Select item 706313410.

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

Aoi Satoh, Song-iee Han, Masaya Araki, Yoshimi Nakagawa, Hiroshi Ohno, Yuhei Mizunoe, Kae Kumagai, Yuki Murayama, Yoshinori Osaki, Hitoshi Iwasaki, Motohiro Sekiya, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano

iScience. 2020 Mar 27; 23(3): 100930. Published online 2020 Feb 21. doi: 10.1016/j.isci.2020.100930

PMCID:: PMC7063134

Article PDF–4.0M

Select item 659388111.

Regulation of hepatic autophagy by stress-sensing transcription factor CREBH

Hyunbae Kim, Dreana Williams, Yining Qiu, Zhenfeng Song, Zhao Yang, Victoria Kimler, Andrew Goldberg, Ren Zhang, Zengquan Yang, Xuequn Chen, Li Wang, Deyu Fang, Jiandie D. Lin, Kezhong Zhang

FASEB J. 2019 Jul; 33(7): 7896–7914. Published online 2019 Mar 26. doi: 10.1096/fj.201802528R

Correction in:: FASEB J. 2020 Aug; 34(8): 11311.

PMCID:: PMC6593881

Article

Select item 641698712.

Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

Philip M. M. Ruppert, Jong-Gil Park, Xu Xu, Kyu Yeon Hur, Ann-Hwee Lee, Sander Kersten

BMC Genomics. 2019; 20: 199. Published online 2019 Mar 11. doi: 10.1186/s12864-019-5563-y

PMCID:: PMC6416987

Article PDF–5.6M

Select item 623633613.

HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination

Juncheng Wei, Lu Chen, Fei Li, Yanzhi Yuan, Yajun Wang, Wanjun Xia, Yuehui Zhang, Yuanming Xu, Zhao Yang, Beixue Gao, Chaozhi Jin, Johanna Melo‐Cardenas, Richard M Green, Hui Pan, Jian Wang, Fuchu He, Kezhong Zhang, Deyu Fang

EMBO J. 2018 Nov 15; 37(22): e98942. Published online 2018 Nov 2. doi: 10.15252/embj.201898942

PMCID:: PMC6236336

Article PDF–3.8M

Select item 623633114.

Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

Asmita Bhattacharya, Shengyi Sun, Heting Wang, Ming Liu, Qiaoming Long, Lei Yin, Sander Kersten, Kezhong Zhang, Ling Qi

EMBO J. 2018 Nov 15; 37(22): e99277. Published online 2018 Nov 2. doi: 10.15252/embj.201899277

PMCID:: PMC6236331

Article PDF–4.1M

Select item 572221115.

Loss of transcription factor CREBH accelerates diet-induced atherosclerosis in Ldlr^−/− mice

Jong-Gil Park, Xu Xu, Sungyun Cho, Ann-Hwee Lee

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Dec 8.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9): 1772–1781. Published online 2016 Jul 14. doi: 10.1161/ATVBAHA.116.307790

PMCID:: PMC5722211

Article PDF–1.4M

Select item 553036916.

CREBH mediates metabolic inflammation to hepatic VLDL overproduction and hyperlipoproteinemia

Yongyan Song, Miaoyun Zhao, Xiao Cheng, Jing Shen, Rituraj Khound, Kezhong Zhang, Qiaozhu Su

J Mol Med (Berl) Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: J Mol Med (Berl). 2017 Aug; 95(8): 839–849. Published online 2017 Apr 28. doi: 10.1007/s00109-017-1534-4

PMCID:: PMC5530369

Article PDF–722K

Select item 549217617.

CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis

Hyunbae Kim, Ze Zheng, Paul D. Walker, Gregory Kapatos, Kezhong Zhang

Mol Cell Biol. 2017 Jul 15; 37(14): e00048-17. Prepublished online 2017 May 1. Published online 2017 Jun 29. doi: 10.1128/MCB.00048-17

PMCID:: PMC5492176

Article PDF–4.6M

Select item 515989118.

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

Yoshimi Nakagawa, Aoi Satoh, Hitomi Tezuka, Song-iee Han, Kenta Takei, Hitoshi Iwasaki, Shigeru Yatoh, Naoya Yahagi, Hiroaki Suzuki, Yasumasa Iwasaki, Hirohito Sone, Takashi Matsuzaka, Nobuhiro Yamada, Hitoshi Shimano

Sci Rep. 2016; 6: 39182. Published online 2016 Dec 16. doi: 10.1038/srep39182

PMCID:: PMC5159891

Article PDF–1.7M

Select item 509543119.

Very Low Density Lipoprotein Assembly Is Required for cAMP-responsive Element-binding Protein H Processing and Hepatic Apolipoprotein A-IV Expression

Dongmei Cheng, Xu Xu, Trang Simon, Elena Boudyguina, Zhiyong Deng, Melissa VerHague, Ann-Hwee Lee, Gregory S. Shelness, Richard B. Weinberg, John S. Parks

J Biol Chem. 2016 Nov 4; 291(45): 23793–23803. Published online 2016 Sep 21. doi: 10.1074/jbc.M116.749283

PMCID:: PMC5095431

Article PDF–1.9M

Select item 508773320.

Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin

Aditya Dandekar, Yining Qiu, Hyunbae Kim, Jiemei Wang, Xia Hou, Xuebao Zhang, Ze Zheng, Roberto Mendez, Fu-Shin Yu, Ashok Kumar, Deyu Fang, Fei Sun, Kezhong Zhang

J Biol Chem. 2016 Oct 28; 291(44): 23149–23158. Published online 2016 Sep 16. doi: 10.1074/jbc.M116.755728

PMCID:: PMC5087733

Article PDF–2.1M

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