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Select item 110070001.

Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG‐E8

Yu Mizote, Takako Inoue, Takashi Akazawa, Kei Kunimasa, Motohiro Tamiya, Yachiyo Kumamoto, Arisa Tsuda, Satomi Yoshida, Kumiko Tatsumi, Tomoya Ekawa, Keiichiro Honma, Kazumi Nishino, Hideaki Tahara

Cancer Sci. 2024 Apr; 115(4): 1114–1128. Published online 2024 Feb 8. doi: 10.1111/cas.16099

PMCID:: PMC11007000

Abstract Article PDF–8.3M

Select item 110039352.

MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination

Xiaohong Dong, Zhi Zhang, Xin Shu, Zi Zhuang, Pinyi Liu, Renyuan Liu, Shengnan Xia, Xinyu Bao, Yun Xu, Yan Chen

Neurosci Bull. 2024 Apr; 40(4): 483–499. Published online 2023 Nov 18. doi: 10.1007/s12264-023-01147-1

PMCID:: PMC11003935

Abstract Article PDF–17M

Select item 108509743.

PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin

Ritwik Datta, Dibyanti Mukherjee, Michael J. Podolsky, Christopher D. Yang, Diana L. Alba, Sukhmani Singh, Thomas D. Arnold, Suneil Koliwad, Carlos O. Lizama, Kamran Atabai

J Biol Chem. 2024 Feb; 300(2): 105631. Published online 2024 Jan 8. doi: 10.1016/j.jbc.2024.105631

PMCID:: PMC10850974

Abstract Article PDF–2.9M

Select item 108296974.

A vertebral skeletal stem cell lineage driving metastasis

Jun Sun, Lingling Hu, Seoyeon Bok, Alisha R Yallowitz, Michelle Cung, Jason McCormick, Ling J Zheng, Shawon Debnath, Yuzhe Niu, Adrian Y Tan, Sarfaraz Lalani, Kyle W Morse, Daniel Shinn, Anthony Pajak, Mohammed Hammad, Vincentius J Suhardi, Zan Li, Na Li, Lijun Wang, Weiguo Zou, Vivek Mittal, Mathias P.G. Bostrom, Ren Xu, Sravisht Iyer, Matthew B Greenblatt

Nature. Author manuscript; available in PMC 2024 Mar 13.

Published in final edited form as: Nature. 2023 Sep; 621(7979): 602–609. Published online 2023 Sep 13. doi: 10.1038/s41586-023-06519-1

PMCID:: PMC10829697

Abstract Article PDF–12M

Select item 101382825.

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes

Ritwik Datta, Mohammad A. Gholampour, Christopher D. Yang, Regan Volk, Sinan Lin, Michael J. Podolsky, Thomas Arnold, Florian Rieder, Balyn W. Zaro, Michael Verzi, Richard Lehner, Nada Abumrad, Carlos O. Lizama, Kamran Atabai

Cell Rep. Author manuscript; available in PMC 2023 Apr 27.

Published in final edited form as: Cell Rep. 2023 Mar 28; 42(3): 112249. Published online 2023 Mar 15. doi: 10.1016/j.celrep.2023.112249

PMCID:: PMC10138282

Abstract Article PDF–2.5M

Select item 97194926.

MFG-E8 has guiding significance for the prognosis and treatment of sepsis

Wei Wu, Jing Wang, Jingdi Chen, Jiaming Lu, Yaojia Lao, Kai Huang, Jun Lin

Sci Rep. 2022; 12: 20916. Published online 2022 Dec 3. doi: 10.1038/s41598-022-25601-8

PMCID:: PMC9719492

Abstract Article PDF–1.2M

Select item 97121137.

Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease

Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M. Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A. Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K. Peter R. Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C. Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J. Neher

Nature. 2022; 612(7938): 123–131. Published online 2022 Nov 16. doi: 10.1038/s41586-022-05440-3

PMCID:: PMC9712113

Abstract Article PDF–26M

Select item 92897098.

TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis

Yi Yang, Yifu Zhu, Shuai Zhou, Peipei Tang, Ran Xu, Yuwei Zhang, Dongping Wei, Jian Wen, Rick F Thorne, Xu Dong Zhang, Jun‐Lin Guan, Lianxin Liu, Mian Wu, Song Chen

EMBO J. 2022 Jul; 41(14): e109777. Published online 2022 Jun 7. doi: 10.15252/embj.2021109777

PMCID:: PMC9289709

Abstract Article PDF–2.3M

Select item 92368489.

MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice

Jun Hu, Hui Du, Yinglin Yuan, Peipei Guo, Junxia Yang, Xinru Yin, Jin Liu, Shengwang Wu, Jingyuan Wan, Xia Gong

Mediators Inflamm. 2022; 2022: 5791915. Published online 2022 Jun 20. doi: 10.1155/2022/5791915

PMCID:: PMC9236848

Abstract Article PDF–2.5M

Select item 902737810.

MFG-E8 Reduces Aortic Intimal Proliferation in a Murine Model of Transplant Vasculopathy

Benoit Brilland, Patrick Laplante, Pamela Thebault, Karen Geoffroy, Marie-Joëlle Brissette, Mathieu Latour, Michaël Chassé, Shijie Qi, Marie-Josée Hébert, Héloïse Cardinal, Jean-François Cailhier

Int J Mol Sci. 2022 Apr; 23(8): 4094. Published online 2022 Apr 7. doi: 10.3390/ijms23084094

PMCID:: PMC9027378

Abstract Article PDF–1.7M

Select item 901869611.

MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling

Hou-Yu Chiang, Pao-Hsien Chu, Shao-Chi Chen, Ting-Hein Lee

Commun Biol. 2022; 5: 364. Published online 2022 Apr 19. doi: 10.1038/s42003-022-03313-z

PMCID:: PMC9018696

Abstract Article PDF–12M

Select item 883916912.

Protective Effect of MFG-E8 on Necroptosis-Induced Intestinal Inflammation and Enteroendocrine Cell Function in Diabetes

Xiaomin Hua, Baoying Li, Fei Yu, Wenqian Zhao, Yuwei Tan, Xiaoli Li, Chunli Fu, Xin Yu, Haiqing Gao, Mei Cheng

Nutrients. 2022 Feb; 14(3): 604. Published online 2022 Jan 29. doi: 10.3390/nu14030604

PMCID:: PMC8839169

Abstract Article PDF–6.2M

Select item 879583413.

MFG-E8 Maintains Cellular Homeostasis by Suppressing Endoplasmic Reticulum Stress in Pancreatic Exocrine Acinar Cells

Yifan Ren, Wuming Liu, Jia Zhang, Jianbin Bi, Meng Fan, Yi Lv, Zheng Wu, Yuanyuan Zhang, Rongqian Wu

Front Cell Dev Biol. 2021; 9: 803876. Published online 2022 Jan 14. doi: 10.3389/fcell.2021.803876

Correction in:: Front Cell Dev Biol. 2022; 10: 1121052.

PMCID:: PMC8795834

Abstract Article PDF–5.7M

Select item 876101014.

Increased MFG‐E8 at neuromuscular junctions is an exacerbating factor for sarcopenia‐associated denervation

Madoka Ikemoto‐Uezumi, Heying Zhou, Tamaki Kurosawa, Yuki Yoshimoto, Masashi Toyoda, Nobuo Kanazawa, Tatsu Nakazawa, Mitsuhiro Morita, Kunihiro Tsuchida, Akiyoshi Uezumi

Aging Cell. 2022 Jan; 21(1): e13536. Published online 2021 Dec 24. doi: 10.1111/acel.13536

PMCID:: PMC8761010

Abstract Article PDF–1.8M

Select item 859579315.

Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart

Mallikarjun Patil, Sherin Saheera, Praveen K Dubey, Asher Kahn-Krell, Prem Kumar Govindappa, Sarojini Singh, Sultan Tousif, Qinkun Zhang, Hind Lal, Jianyi Zhang, Gangjian Qin, Prasanna Krishnamurthy

Circ Res. Author manuscript; available in PMC 2022 Nov 12.

Published in final edited form as: Circ Res. 2021 Nov 12; 129(11): 1006–1020. Published online 2021 Oct 8. doi: 10.1161/CIRCRESAHA.120.317900

PMCID:: PMC8595793

Abstract Article PDF–1.7M

Select item 848351016.

MFG‐E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose‐Dependent Mediation of Actin Polymerization

Hou‐Yu Chiang, Pao‐Hsien Chu, Shao‐Chi Chen, Ting‐Hein Lee

J Am Heart Assoc. 2021 Jun 1; 10(11): e020870. Published online 2021 May 27. doi: 10.1161/JAHA.121.020870

PMCID:: PMC8483510

Abstract Article PDF–5.5M

Select item 844449817.

MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy

Paula Marazuela, Montse Solé, Anna Bonaterra-Pastra, Jesús Pizarro, Jessica Camacho, Elena Martínez-Sáez, H. Bea Kuiperij, Marcel M. Verbeek, Anna M. de Kort, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Laura Castillo-Ribelles, Olalla Pancorbo, David Rodríguez-Luna, Francesc Pujadas, Pilar Delgado, Mar Hernández-Guillamon

Acta Neuropathol Commun. 2021; 9: 154. Published online 2021 Sep 16. doi: 10.1186/s40478-021-01257-9

PMCID:: PMC8444498

Abstract Article PDF–7.3M

Select item 831323918.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 810630619.

Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin

Ritwik Datta, Carlos O. Lizama, Amin K. Soltani, William Mckleroy, Michael J. Podolsky, Christopher D. Yang, Tony L. Huynh, Kelly M. Cautivo, Biao Wang, Suneil K. Koliwad, Nada A. Abumrad, Kamran Atabai

Proc Natl Acad Sci U S A. 2021 May 4; 118(18): e2102171118. Published online 2021 Apr 26. doi: 10.1073/pnas.2102171118

PMCID:: PMC8106306

Abstract Article PDF–2.4M

Select item 806446720.

MFG-E8 Plays an Important Role in Attenuating Cerulein-Induced Acute Pancreatitis in Mice

Heng-Fu Bu, Saravanan Subramanian, Hua Geng, Xiao Wang, Fangyi Liu, Pauline M. Chou, Chao Du, Isabelle G. De Plaen, Xiao-Di Tan

Cells. 2021 Apr; 10(4): 728. Published online 2021 Mar 25. doi: 10.3390/cells10040728

PMCID:: PMC8064467

Abstract Article PDF–25M

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