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Select item 111364131.

The urokinase receptor: a ligand or a receptor? Story of a sociable molecule

P. Ragno

Cell Mol Life Sci. 2006 May; 63(9): 1028–1037. Published online 2006 Feb 7. doi: 10.1007/s00018-005-5428-1

PMCID:: PMC11136413

Abstract Article PDF–277K

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108146883.

Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin

Eun Young Kim, Stuart E. Dryer

Cells. 2024 Jan; 13(2): 172. Published online 2024 Jan 17. doi: 10.3390/cells13020172

PMCID:: PMC10814688

Abstract Article PDF–3.6M

Select item 106503414.

Urokinase-Type Plasminogen Activator Receptor Regulates Prosurvival and Angiogenic Properties of Cardiac Mesenchymal Stromal Cells

Konstantin Dergilev, Zoya Tsokolaeva, Yulia Goltseva, Irina Beloglazova, Elizaveta Ratner, Yelena Parfyonova

Int J Mol Sci. 2023 Nov; 24(21): 15554. Published online 2023 Oct 25. doi: 10.3390/ijms242115554

PMCID:: PMC10650341

Abstract Article PDF–5.8M

Select item 103620375.

SuPAR mediates viral response proteinuria by rapidly changing podocyte function

Changli Wei, Prasun K. Datta, Florian Siegerist, Jing Li, Sudhini Yashwanth, Kwi Hye Koh, Nicholas W. Kriho, Anis Ismail, Shengyuan Luo, Tracy Fischer, Kyle T. Amber, David Cimbaluk, Alan Landay, Nicole Endlich, Jay Rappaport, Michigan Medicine COVID−19 Investigators, Salim S. Hayek, Jochen Reiser

Nat Commun. 2023; 14: 4414. Published online 2023 Jul 21. doi: 10.1038/s41467-023-40165-5

PMCID:: PMC10362037

Abstract Article PDF–2.2M

Select item 102200236.

Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis

Chengyi Dai, Yuhang Lin

Sci Rep. 2023; 13: 8533. Published online 2023 May 26. doi: 10.1038/s41598-023-35548-z

PMCID:: PMC10220023

Abstract Article PDF–13M

Select item 101321597.

suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury

Christian Nusshag, Changli Wei, Eunsil Hahm, Salim S. Hayek, Jing Li, Beata Samelko, Christoph Rupp, Roman Szudarek, Claudius Speer, Florian Kälble, Matthias Schaier, Florian Uhle, Felix C.F. Schmitt, Mascha O. Fiedler, Ellen Krautkrämer, Yanxia Cao, Ricardo Rodriguez, Uta Merle, Jesper Eugen-Olsen, Martin Zeier, Markus A. Weigand, Christian Morath, Thorsten Brenner, Jochen Reiser

JCI Insight. 2023 Apr 10; 8(7): e165740. Published online 2023 Apr 10. doi: 10.1172/jci.insight.165740

PMCID:: PMC10132159

Abstract Article PDF–6.1M

Select item 93234748.

The PLAUR signaling promotes chronic pruritus

Weiwei Chen, Yanqing Li, Martin Steinhoff, Wenhao Zhang, Joerg Buddenkotte, Timo Buhl, Renkai Zhu, Xinrong Yan, Zhiping Lu, Song Xiao, Jiafu Wang, Jianghui Meng

FASEB J. 2022 Jun; 36(6): e22368. Published online 2022 May 21. doi: 10.1096/fj.202200079R

PMCID:: PMC9323474

Abstract Article PDF–12M

Select item 86885629.

Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease

Yang Cheng, Tyler R. Hall, Xiao Xu, Ivy Yung, Donald Souza, Jie Zheng, Felix Schiele, Matthias Hoffmann, M. Lamine Mbow, James P. Garnett, Jun Li

EBioMedicine. 2022 Jan; 75: 103758. Published online 2021 Dec 18. doi: 10.1016/j.ebiom.2021.103758

PMCID:: PMC8688562

Abstract Article PDF–4.4M

Select item 855130310.

TGF-β regulation of the uPA/uPAR axis modulates mesothelial-mesenchymal transition (MesoMT)

Ranisha Logan, Ann Jeffers, Wenyi Qin, Shuzi Owens, Prashant Chauhan, Satoshi Komatsu, Mitsuo Ikebe, Steven Idell, Torry A. Tucker

Sci Rep. 2021; 11: 21210. Published online 2021 Oct 27. doi: 10.1038/s41598-021-99520-5

PMCID:: PMC8551303

Abstract Article PDF–7.1M

Select item 775707511.

TLR4 Response to LPS Is Reinforced by Urokinase Receptor

Yulia Kiyan, Sergey Tkachuk, Song Rong, Anna Gorrasi, Pia Ragno, Inna Dumler, Hermann Haller, Nelli Shushakova

Front Immunol. 2020; 11: 573550. Published online 2020 Dec 9. doi: 10.3389/fimmu.2020.573550

PMCID:: PMC7757075

Abstract Article PDF–5.1M

Select item 724420312.

Urokinase-Type Plasminogen Activator Protects Cerebral Cortical Neurons from Soluble Aβ-Induced Synaptic Damage

Ariel Diaz, Paola Merino, Ji-Dong Guo, Manuel A. Yepes, Patrick McCann, Tapasya Katta, Elise M. Tong, Enrique Torre, Srikant Rangaraju, Manuel Yepes

J Neurosci. 2020 May 20; 40(21): 4251–4263. doi: 10.1523/JNEUROSCI.2804-19.2020

PMCID:: PMC7244203

Abstract Article PDF–3.1M

Select item 695654413.

Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse

Paola Merino, Ariel Diaz, Enrique R. Torre, Manuel Yepes

J Biol Chem. 2020 Jan 10; 295(2): 619–630. Published online 2019 Dec 9. doi: 10.1074/jbc.RA119.010644

PMCID:: PMC6956544

Abstract Article PDF–1.9M

Select item 693307914.

Further Evidence that the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes

Efrat Harel, Jun Shoji, Vivek Abraham, Loan Miller, Zoltan G. Laszik, Andrew King, Dejan Dobi, Gyula Szabo, Byron Hann, Minnie M. Sarwal, Charles S. Craik, Flavio Vincenti

Transplantation. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Transplantation. 2020 Jan; 104(1): 54–60. doi: 10.1097/TP.0000000000002930

PMCID:: PMC6933079

Abstract Article PDF–1.1M

Select item 674186615.

Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type-Specific Deficits, Epilepsy, and Behavioral Dysfunction

Elizabeth M. Powell, Daniel B. Campbell, Gregg D. Stanwood, Caleb Davis, Jeffrey L. Noebels, Pat Levitt

J Neurosci. 2003 Jan 15; 23(2): 622–631. doi: 10.1523/JNEUROSCI.23-02-00622.2003

PMCID:: PMC6741866

Abstract Article PDF–347K

Select item 665307016.

The urokinase‐type plasminogen activator system as drug target in retinitis pigmentosa: New pre‐clinical evidence in the rd10 mouse model

Maurizio Cammalleri, Massimo Dal Monte, Filippo Locri, Valeria Pecci, Mario De Rosa, Vincenzo Pavone, Paola Bagnoli

J Cell Mol Med. 2019 Aug; 23(8): 5176–5192. Published online 2019 Jun 28. doi: 10.1111/jcmm.14391

PMCID:: PMC6653070

Abstract Article PDF–1.9M

Select item 648635317.

uPAR isoform 2 forms a dimer and induces severe kidney disease in mice

Changli Wei, Jing Li, Brian D. Adair, Ke Zhu, Jian Cai, Michael Merchant, Beata Samelko, Zhongji Liao, Kwi Hye Koh, Nicholas J. Tardi, Ranadheer R. Dande, Shuangxin Liu, Jianchao Ma, Salvatore Dibartolo, Stefan Hägele, Vasil Peev, Salim S. Hayek, David J. Cimbaluk, Melissa Tracy, Jon Klein, Sanja Sever, Sanford J. Shattil, M. Amin Arnaout, Jochen Reiser

J Clin Invest. 2019 May 1; 129(5): 1946–1959. Published online 2019 Apr 2. doi: 10.1172/JCI124793

PMCID:: PMC6486353

Abstract Article PDF–16M

Select item 648365118.

C3a and suPAR drive versican V1 expression in tubular cells of focal segmental glomerulosclerosis

Runhong Han, Shuai Hu, Weisong Qin, Jinsong Shi, Qin Hou, Xia Wang, Xiaodong Xu, Minchao Zhang, Caihong Zeng, Zhihong Liu, Hao Bao

JCI Insight. 2019 Apr 4; 4(7): e122912. Published online 2019 Apr 4. doi: 10.1172/jci.insight.122912

Correction in:: JCI Insight. 2019 Jul 11; 4(13): e130986.

PMCID:: PMC6483651

Abstract Article PDF–3.0M

Select item 617690919.

VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution

Revu Ann Alexander, Gerald W. Prager, Judit Mihaly-Bison, Pavel Uhrin, Stefan Sunzenauer, Bernd R. Binder, Gerhard J. Schütz, Michael Freissmuth, Johannes M. Breuss

Cardiovasc Res. Author manuscript; available in PMC 2018 Oct 9.

Published in final edited form as: Cardiovasc Res. 2012 Apr 1; 94(1): 125–135. Published online 2012 Jan 26. doi: 10.1093/cvr/cvs017

PMCID:: PMC6176909

Abstract Article PDF–2.3M

Select item 601932620.

A tripartite complex of suPAR, APOL1 risk variants and α_vβ₃ integrin on podocytes mediates chronic kidney disease

Salim S Hayek, Kwi Hye Koh, Morgan E Grams, Changli Wei, Yi-An Ko, Jing Li, Beata Samelko, Hyun Lee, Ranadheer R Dande, Ha Won Lee, Eunsil Hahm, Vasil Peev, Melissa Tracy, Nicholas J Tardi, Vineet Gupta, Mehmet M Altintas, Garrett Garborcauskas, Nikolina Stojanovic, Cheryl A Winkler, Michael S Lipkowitz, Adrienne Tin, Lesley A Inker, Andrew S Levey, Martin Zeier, Barry I Freedman, Jeffrey B Kopp, Karl Skorecki, Josef Coresh, Arshed A Quyyumi, Sanja Sever, Jochen Reiser

Nat Med. Author manuscript; available in PMC 2018 Jun 26.

Published in final edited form as: Nat Med. 2017 Aug; 23(8): 945–953. Published online 2017 Jun 26. doi: 10.1038/nm.4362

PMCID:: PMC6019326

Abstract Article PDF–1.7M

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