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Select item 114861861.

β-TrCP-Mediated Proteolysis of Mis18β Prevents Mislocalization of CENP-A and Chromosomal Instability

Subhash Chandra Sethi, Roshan Lal Shrestha, Vinutha Balachandra, Geetha Durairaj, Wei-Chun Au, Michael Nirula, Tatiana S. Karpova, Peter Kaiser, Munira A. Basrai

Mol Cell Biol. 2024; 44(10): 429–442. Published online 2024 Aug 13. doi: 10.1080/10985549.2024.2382445

PMCID:: PMC11486186

Abstract Article PDF–2.5M

Select item 113042782.

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1‐Mediated Proteolysis of CENP‐A

Yan Peng, Yumeng Zhang, Ruan Fang, Hao Jiang, Gongcai Lan, Zhou Xu, Yajie Liu, Zhaoyang Nie, Lu Ren, Fengcan Wang, Shou‐De Zhang, Yuyong Ma, Peng Yang, Hong‐Hua Ge, Wei‐Dong Zhang, Cheng Luo, Ang Li, Weiwei He

Adv Sci (Weinh) 2024 Aug; 11(29): 2305593. Published online 2024 Jun 14. doi: 10.1002/advs.202305593

PMCID:: PMC11304278

Abstract Article PDF–11M

Select item 111451463.

YTHDC1‐dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple‐negative breast cancer

Xi Shen, Jianxin Zhong, Pan Yu, Feng Liu, Haoran Peng, Nianyong Chen

Cancer Sci. 2024 Jun; 115(6): 1881–1895. Published online 2024 Apr 3. doi: 10.1111/cas.16137

PMCID:: PMC11145146

Abstract Article PDF–18M

Select item 106208224.

CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1

Jingyu Liao, Zeyu Chen, Ruizhi Chang, Tong Yuan, Ganxun Li, Chang Zhu, Jingyuan Wen, Yi Wei, Zhao Huang, Zeyang Ding, Liang Chu, Junnan Liang, Bixiang Zhang

Int J Biol Sci. 2023; 19(16): 5218–5232. Published online 2023 Oct 16. doi: 10.7150/ijbs.85656

PMCID:: PMC10620822

Abstract Article PDF–9.0M

Select item 103356775.

MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres

Kausika Kumar Malik, Sreerama Chaitanya Sridhara, Kaisar Ahmad Lone, Payal Deepakbhai Katariya, Deepshika Pulimamidi, Shweta Tyagi

PLoS Biol. 2023 Jun; 21(6): e3002161. Published online 2023 Jun 28. doi: 10.1371/journal.pbio.3002161

PMCID:: PMC10335677

Abstract Article PDF–3.5M

Select item 95698286.

The Sequence Dependent Nanoscale Structure of CENP-A Nucleosomes

Tommy Stormberg, Yuri L. Lyubchenko

Int J Mol Sci. 2022 Oct; 23(19): 11385. Published online 2022 Sep 27. doi: 10.3390/ijms231911385

PMCID:: PMC9569828

Abstract Article PDF–6.7M

Select item 91197367.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 86431068.

Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-A^K124ub

Catalina Salinas-Luypaert, Praveen Kumar Allu, Glennis A. Logsdon, Jennine M. Dawicki-McKenna, Craig W. Gambogi, Daniele Fachinetti, Ben E. Black

Cell Rep. Author manuscript; available in PMC 2021 Dec 4.

Published in final edited form as: Cell Rep. 2021 Nov 2; 37(5): 109924. doi: 10.1016/j.celrep.2021.109924

PMCID:: PMC8643106

Abstract Article PDF–1.9M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 801772010.

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118

PMCID:: PMC8017720

Abstract Article PDF–1.9M

Select item 799799311.

CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

Daniel Jeffery, Alberto Gatto, Katrina Podsypanina, Charlène Renaud-Pageot, Rebeca Ponce Landete, Lorraine Bonneville, Marie Dumont, Daniele Fachinetti, Geneviève Almouzni

Commun Biol. 2021; 4: 417. Published online 2021 Mar 26. doi: 10.1038/s42003-021-01941-5

PMCID:: PMC7997993

Abstract Article PDF–9.5M

Select item 795838912.

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta, Solène Hervé, Ryan R. White, Therese Wilhelm, Marie Dumont, Andrea Scelfo, Riccardo Gamba, Cheng Kit Wong, Giulia Rancati, Agata Smogorzewska, Hironori Funabiki, Daniele Fachinetti

Proc Natl Acad Sci U S A. 2021 Mar 9; 118(10): e2015634118. Published online 2021 Mar 2. doi: 10.1073/pnas.2015634118

PMCID:: PMC7958389

Abstract Article PDF–1.8M

Select item 790599813.

CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity

Roshan L. Shrestha, Austin Rossi, Darawalee Wangsa, Ann K. Hogan, Kimberly S. Zaldana, Evelyn Suva, Yang Jo Chung, Chelsea L. Sanders, Simone Difilippantonio, Tatiana S. Karpova, Baktiar Karim, Daniel R. Foltz, Daniele Fachinetti, Peter D. Aplan, Thomas Ried, Munira A. Basrai

J Cell Biol. 2021 Apr 5; 220(4): e202007195. Published online 2021 Feb 23. doi: 10.1083/jcb.202007195

PMCID:: PMC7905998

Abstract Article PDF–8.5M

Select item 775711914.

Promiscuous Histone Mis-Assembly Is Actively Prevented by Chaperones

Haiqing Zhao, David Winogradoff, Minh Bui, Yamini Dalal, Garegin A. Papoian

J Am Chem Soc. Author manuscript; available in PMC 2020 Dec 23.

Published in final edited form as: J Am Chem Soc. 2016 Oct 12; 138(40): 13207–13218. Published online 2016 Aug 12. doi: 10.1021/jacs.6b05355

PMCID:: PMC7757119

Abstract Article PDF–2.0M

Select item 765972515.

Stable inheritance of CENP-A chromatin: Inner strength versus dynamic control

Sreyoshi Mitra, Bharath Srinivasan, Lars E.T. Jansen

J Cell Biol. 2020 Oct 5; 219(10): e202005099. Published online 2020 Sep 15. doi: 10.1083/jcb.202005099

PMCID:: PMC7659725

Abstract Article PDF–3.2M

Select item 761275716.

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

Stanislau Yatskevich, Kyle W. Muir, Dom Bellini, Ziguo Zhang, Jing Yang, Thomas Tischer, Masa Predin, Tom Dendooven, Stephen H. McLaughlin, David Barford

Science. Author manuscript; available in PMC 2022 Jun 20.

Published in final edited form as: Science. 2022 May 20; 376(6595): 844–852. Published online 2022 Apr 14. doi: 10.1126/science.abn3810

PMCID:: PMC7612757

Abstract Article PDF–3.4M

Select item 756020017.

A genetic memory initiates the epigenetic loop necessary to preserve centromere position

Sebastian Hoffmann, Helena M Izquierdo, Riccardo Gamba, Florian Chardon, Marie Dumont, Veer Keizer, Solène Hervé, Shannon M McNulty, Beth A Sullivan, Nicolas Manel, Daniele Fachinetti

EMBO J. 2020 Oct 15; 39(20): e105505. Published online 2020 Sep 18. doi: 10.15252/embj.2020105505

PMCID:: PMC7560200

Abstract Article PDF–3.9M

Select item 739703018.

Guarding the Genome: CENP-A-Chromatin in Health and Cancer

Megan A. Mahlke, Yael Nechemia-Arbely

Genes (Basel) 2020 Jul; 11(7): 810. Published online 2020 Jul 16. doi: 10.3390/genes11070810

PMCID:: PMC7397030

Abstract Article PDF–2.6M

Select item 730718919.

The role of the histone H3 variant CENPA in prostate cancer

Anjan K. Saha, Rafael Contreras-Galindo, Yashar S. Niknafs, Matthew Iyer, Tingting Qin, Karthik Padmanabhan, Javed Siddiqui, Monica Palande, Claire Wang, Brian Qian, Elizabeth Ward, Tara Tang, Scott A. Tomlins, Scott D. Gitlin, Maureen A. Sartor, Gilbert S. Omenn, Arul M. Chinnaiyan, David M. Markovitz

J Biol Chem. 2020 Jun 19; 295(25): 8537–8549. Published online 2020 May 5. doi: 10.1074/jbc.RA119.010080

PMCID:: PMC7307189

Abstract Article PDF–4.1M

Select item 728710120.

Spt6 is a maintenance factor for centromeric CENP-A

Georg O. M. Bobkov, Anming Huang, Sebastiaan J. W. van den Berg, Sreyoshi Mitra, Eduard Anselm, Vasiliki Lazou, Sarah Schunter, Regina Feederle, Axel Imhof, Alexandra Lusser, Lars E. T. Jansen, Patrick Heun

Nat Commun. 2020; 11: 2919. Published online 2020 Jun 10. doi: 10.1038/s41467-020-16695-7

PMCID:: PMC7287101

Abstract Article PDF–3.8M

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