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Select item 111057581.

Farnesoid X receptor alpha (FXRα) is a critical actor of the development and pathologies of the male reproductive system

Manon Garcia, Laura Thirouard, Mélusine Monrose, Hélène Holota, Angélique De Haze, Françoise Caira, Claude Beaudoin, David H. Volle

Cell Mol Life Sci. 2019 Dec; 76(24): 4849–4859. Published online 2019 Aug 12. doi: 10.1007/s00018-019-03247-6

PMCID:: PMC11105758

Abstract Article PDF–975K

Select item 110047292.

FXR1 is an IL-19 responsive RNA binding protein that destabilizes Pro-inflammatory transcripts in vascular smooth muscle cells

Allison B. Herman, Christine N. Vrakas, Mitali Ray, Sheri E. Kelemen, Michael J. Sweredoski, Annie Moradian, Dale S. Haines, Michael V. Autieri

Cell Rep. Author manuscript; available in PMC 2024 Apr 10.

Published in final edited form as: Cell Rep. 2018 Jul 31; 24(5): 1176–1189. doi: 10.1016/j.celrep.2018.07.002

PMCID:: PMC11004729

Abstract Article PDF–1.9M

Select item 105649693.

FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms

Amanda St. Paul, Cali Corbett, Amanda Peluzzo, Sheri Kelemen, Rachael Okune, Dale S. Haines, Kyle Preston, Satoru Eguchi, Michael V. Autieri

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Apr 25; 42(4): 112381. Published online 2023 Apr 11. doi: 10.1016/j.celrep.2023.112381

PMCID:: PMC10564969

Abstract Article PDF–2.6M

Select item 102359684.

ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation

Gui-Feng Zhou, Jing Tang, Yuan-Lin Ma, Xian Fu, Jun-Yan Liu, Ren-Zhi Yang, Hong-Sheng Zhang, Xiang-Hai Cai, Jing-Wen Wang, Xiao-Yong Xie, Li Song, Biao Luo, Jian Chen, Long Chen, Xiao-Juan Deng, Guo-Jun Chen

Proc Natl Acad Sci U S A. 2023 May 30; 120(22): e2220148120. Published online 2023 May 22. doi: 10.1073/pnas.2220148120

PMCID:: PMC10235968

Abstract Article PDF–6.5M

Select item 101552705.

Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces Senescence in Vascular Smooth Muscle Cells

Cali B. Corbett, Amanda St Paul, Tani Leigh, Sheri E. Kelemen, Amanda M. Peluzzo, Rachael N. Okune, Satoru Eguchi, Dale S. Haines, Michael V. Autieri

Am J Pathol. 2023 May; 193(5): 638–653. doi: 10.1016/j.ajpath.2023.01.006

PMCID:: PMC10155270

Abstract Article PDF–2.5M

Select item 88324616.

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis

Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun

Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247

PMCID:: PMC8832461

Abstract Article

Select item 87442577.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Abstract Article PDF–6.0M

Select item 85215708.

FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors

Minjie Shen, Yu Guo, Qiping Dong, Yu Gao, Michael E. Stockton, Meng Li, Sudharsan Kannan, Tomer Korabelnikov, Keegan A. Schoeller, Carissa L. Sirois, Chen Zhou, Jonathan Le, Daifeng Wang, Qiang Chang, Qian-Quan Sun, Xinyu Zhao

Mol Psychiatry. Author manuscript; available in PMC 2022 Jan 16.

Published in final edited form as: Mol Psychiatry. 2021 Nov; 26(11): 6845–6867. Published online 2021 Apr 16. doi: 10.1038/s41380-021-01096-z

PMCID:: PMC8521570

Abstract Article PDF–2.7M

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 826661710.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 760457912.

Fxr1 regulates sleep and synaptic homeostasis

Jivan Khlghatyan, Alesya Evstratova, Lusine Bozoyan, Simon Chamberland, Dipashree Chatterjee, Aleksandra Marakhovskaia, Tiago Soares Silva, Katalin Toth, Valerie Mongrain, Jean‐Martin Beaulieu

EMBO J. 2020 Nov 2; 39(21): e103864. Published online 2020 Sep 7. doi: 10.15252/embj.2019103864

PMCID:: PMC7604579

Abstract Article PDF–4.3M

Select item 741271013.

LncRNA TUG1 regulates ApoM to promote atherosclerosis progression through miR‐92a/FXR1 axis

Liu Yang, Tie Li

J Cell Mol Med. 2020 Aug; 24(15): 8836–8848. Published online 2020 Jun 28. doi: 10.1111/jcmm.15521

PMCID:: PMC7412710

Abstract Article PDF–1.5M

Select item 736849414.

The sperm associated antigen 6 interactome and its role in spermatogenesis

Yunhao Liu, Ling Zhang, Wei Li, Yuhong Li, Junpin Liu, Shiyang Zhang, Guanglun Pin, Shizhen Song, Pierre F Ray, Christophe Arnoult, Chunghee Cho, Balbina Garcia-Reyes, Uwe Knippschild, Jerome F. Strauss, III, Zhibing Zhang

Reproduction. Author manuscript; available in PMC 2020 Jul 18.

Published in final edited form as: Reproduction. 2019 Aug; 158(2): 181–197. doi: 10.1530/REP-18-0522

PMCID:: PMC7368494

Abstract Article PDF–1.8M

Select item 729503315.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 723606016.

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism

Arielle N. Valdez-Sinon, Austin Lai, Liang Shi, Carly L. Lancaster, Avanti Gokhale, Victor Faundez, Gary J. Bassell

iScience. 2020 May 22; 23(5): 101132. Published online 2020 May 1. doi: 10.1016/j.isci.2020.101132

PMCID:: PMC7236060

Abstract Article PDF–6.1M

Select item 714710617.

FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells

Jean A. Smith, Ennessa G. Curry, R. Eric Blue, Christine Roden, Samantha E.R. Dundon, Anthony Rodríguez-Vargas, Danielle C. Jordan, Xiaomin Chen, Shawn M. Lyons, John Crutchley, Paul Anderson, Marko E. Horb, Amy S. Gladfelter, Jimena Giudice

J Cell Biol. 2020 Apr 6; 219(4): e201911129. Published online 2020 Mar 13. doi: 10.1083/jcb.201911129

PMCID:: PMC7147106

Abstract Article PDF–6.6M

Select item 669277018.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 660230019.

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules

Richa Das, Lukas Schwintzer, Stanislav Vinopal, Eva Aguado Roca, Marc Sylvester, Ana-Maria Oprisoreanu, Susanne Schoch, Frank Bradke, Meike Broemer

J Cell Sci. 2019 Jun 15; 132(12): jcs229252. Published online 2019 Jun 17. doi: 10.1242/jcs.229252

PMCID:: PMC6602300

Abstract Article

Select item 647922620.

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang

Nat Med. Author manuscript; available in PMC 2019 Apr 24.

Published in final edited form as: Nat Med. 2018 Dec; 24(12): 1919–1929. Published online 2018 Nov 5. doi: 10.1038/s41591-018-0222-4

PMCID:: PMC6479226

Abstract Article PDF–2.5M

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