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Select item 111593841.

Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication

Kou Motani, Kouji Kawase, Ryu Imamura, Takeshi Kinoshita, Hiroko Kushiyama, Takashi Suda

Cancer Sci. 2010 Aug; 101(8): 1822–1827. Published online 2010 May 3. doi: 10.1111/j.1349-7006.2010.01610.x

PMCID:: PMC11159384

Abstract Article PDF–510K

Select item 111316472.

PYCARD gene polymorphisms and susceptibility to periodontal and coronary heart diseases

Zina Ali Daily, Batool Hassan Al-Ghurabi, Ahmed Makki Al-Qarakhli

J Med Life. 2024 Feb; 17(2): 195–200. doi: 10.25122/jml-2023-0263

PMCID:: PMC11131647

Abstract Article PDF–259K

Select item 100672593.

Kinetic Properties of ASC Protein Aggregation in Epithelial Cells

Jun Cheng, Andrea L. Waite, Eric R. Tkaczyk, Kevin Ke, Neil Richards, Alan J. Hunt, Deborah L. Gumucio

J Cell Physiol. Author manuscript; available in PMC 2023 Apr 2.

Published in final edited form as: J Cell Physiol. 2010 Mar; 222(3): 738–747. doi: 10.1002/jcp.22005

PMCID:: PMC10067259

Abstract Article PDF–2.9M

Select item 98611314.

The Mechanism of Osteoprotegerin-Induced Osteoclast Pyroptosis In Vitro

Jiaqiao Zhu, Yonggang Ma, Jie Wang, Yangyang Wang, Waseem Ali, Hui Zou, Hongyan Zhao, Xishuai Tong, Ruilong Song, Zongping Liu

Int J Mol Sci. 2023 Jan; 24(2): 1518. Published online 2023 Jan 12. doi: 10.3390/ijms24021518

PMCID:: PMC9861131

Abstract Article PDF–3.1M

Select item 95081675.

USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation

Wanxin Zhuang, Lei Zhang, Yi Zheng, Bingyu Liu, Chunhong Ma, Wei Zhao, Suxia Liu, Feng Liu, Chengjiang Gao

Cell Mol Immunol. 2022 Oct; 19(10): 1141–1152. Published online 2022 Sep 1. doi: 10.1038/s41423-022-00917-7

PMCID:: PMC9508167

Abstract Article PDF–3.8M

Select item 94994776.

The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC

Dominik Alexander Machtens, Ian Philipp Bresch, Jan Eberhage, Thomas Frank Reubold, Susanne Eschenburg

Int J Mol Sci. 2022 Sep; 23(18): 10269. Published online 2022 Sep 7. doi: 10.3390/ijms231810269

PMCID:: PMC9499477

Abstract Article PDF–1.7M

Select item 93429587.

A nucleation barrier spring-loads the CBM signalosome for binary activation

Alejandro Rodriguez Gama, Tayla Miller, Jeffrey J Lange, Jay R Unruh, Randal Halfmann

eLife. 2022; 11: e79826. Published online 2022 Jun 21. doi: 10.7554/eLife.79826

PMCID:: PMC9342958

Abstract Article PDF–7.3M

Select item 93021798.

Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

Nawar Naseer, Jenna Zhang, Renate Bauer, David A. Constant, Timothy J. Nice, Igor E. Brodsky, Isabella Rauch, Sunny Shin

Infect Immun. 2022 Jul; 90(7): e00663-21. Published online 2022 Jun 9. doi: 10.1128/iai.00663-21

PMCID:: PMC9302179

Abstract Article PDF–2.0M

Select item 92792859.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 916359110.

The central inflammasome adaptor protein ASC activates the inflammasome after transition from a soluble to an insoluble state

Evan R. Prather, Mikhail A. Gavrilin, Mark D. Wewers

J Biol Chem. 2022 Jun; 298(6): 102024. Published online 2022 May 11. doi: 10.1016/j.jbc.2022.102024

PMCID:: PMC9163591

Abstract Article PDF–1.2M

Select item 876258011.

SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

Huanzhou Xu, Ibukun A. Akinyemi, Siddhi A. Chitre, Julia C. Loeb, John A. Lednicky, Michael T. McIntosh, Sumita Bhaduri-McIntosh

Virology. 2022 Mar; 568: 13–22. Published online 2022 Jan 17. doi: 10.1016/j.virol.2022.01.003

PMCID:: PMC8762580

Abstract Article PDF–6.4M

Select item 864327712.

Phase Separation Drives RNA Virus-Induced Activation of the NLRP6 Inflammasome

Chen Shen, Runzhi Li, Roberto Negro, Jiewei Cheng, Setu Vora, Tian-Min Fu, Anmin Wang, Kaixin He, Liudmila Andreeva, Pu Gao, Zhigang Tian, Richard Flavell, Shu Zhu, Hao Wu

Cell. Author manuscript; available in PMC 2022 Nov 11.

Published in final edited form as: Cell. 2021 Nov 11; 184(23): 5759–5774.e20. Published online 2021 Oct 21. doi: 10.1016/j.cell.2021.09.032

PMCID:: PMC8643277

Abstract Article PDF–3.1M

Select item 861896913.

Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients

Xinyang Zhou, Shehan M. Fernando, Alexander Y. Pan, Rebecca Laposa, Kathryn R. Cullen, Bonnie Klimes-Dougan, Ana C. Andreazza

Int J Mol Sci. 2021 Nov; 22(22): 12513. Published online 2021 Nov 19. doi: 10.3390/ijms222212513

PMCID:: PMC8618969

Abstract Article PDF–1.0M

Select item 859571414.

Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma

Mitsuhito Koizumi, Takao Watanabe, Junya Masumoto, Kotaro Sunago, Yoshiki Imamura, Kozue Kanemitsu, Teru Kumagi, Yoichi Hiasa

Sci Rep. 2021; 11: 22351. Published online 2021 Nov 16. doi: 10.1038/s41598-021-01465-2

PMCID:: PMC8595714

Abstract Article PDF–12M

Select item 856401415.

Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

Yingying Liu, Samantha Gokhale, Jaeyong Jung, Sining Zhu, Chang Luo, Debanjan Saha, Jessie Yanxiang Guo, Huaye Zhang, Saw Kyin, Wei-Xing Zong, Eileen White, Ping Xie

Front Immunol. 2021; 12: 670338. Published online 2021 Oct 20. doi: 10.3389/fimmu.2021.670338

PMCID:: PMC8564014

Abstract Article PDF–18M

Select item 855271816.

Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells

Akshaya Ramachandran, Binod Kumar, Gulam Waris, David Everly

Microbiol Spectr. 2021 Jul-Aug; 9(1): 10.1128/spectrum.00755-21. Published online 2021 Aug 25. doi: 10.1128/spectrum.00755-21

PMCID:: PMC8552718

Abstract Article PDF–2.2M

Select item 846327317.

Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Qi Lv, Yao Xing, Jian Liu, Dong Dong, Yue Liu, Hongzhi Qiao, Yinan Zhang, Lihong Hu

Acta Pharm Sin B. 2021 Sep; 11(9): 2880–2899. Published online 2021 Mar 9. doi: 10.1016/j.apsb.2021.03.011

PMCID:: PMC8463273

Abstract Article PDF–5.4M

Select item 835294518.

TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Ying Qin, Qi Li, Wenbo Liang, Rongzhen Yan, Li Tong, Mutian Jia, Chunyuan Zhao, Wei Zhao

Nat Commun. 2021; 12: 4794. Published online 2021 Aug 9. doi: 10.1038/s41467-021-25033-4

PMCID:: PMC8352945

Abstract Article PDF–2.9M

Select item 832922519.

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Pan Pan, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Keli Chen, Mingfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pin Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu, Geng Li, Yongkui Li, Jianguo Wu

Nat Commun. 2021; 12: 4664. Published online 2021 Aug 2. doi: 10.1038/s41467-021-25015-6

Correction in:: Nat Commun. 2021; 12: 5306.

PMCID:: PMC8329225

Abstract Article PDF–15M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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