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Select item 112564351.

ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets

Yuehong Chen, Huan Liu, Zhongling Luo, Jiaqian Zhang, Min Dong, Geng Yin, Qibing Xie

Skelet Muscle. 2024; 14: 16. Published online 2024 Jul 18. doi: 10.1186/s13395-024-00347-1

PMCID:: PMC11256435

Abstract Article PDF–6.2M

Select item 107774412.

Regulation of NLRP3 Inflammasome Activation and Inflammatory Exosome Release in Podocytes by Acid Sphingomyelinase During Obesity

Dandan Huang, Jason M. Kidd, Yao Zou, Xiaoyuan Wu, Todd W. B. Gehr, Pin-Lan Li, Guangbi Li

Inflammation. Author manuscript; available in PMC 2024 Jan 10.

Published in final edited form as: Inflammation. 2023 Oct; 46(5): 2037–2054. Published online 2023 Jul 21. doi: 10.1007/s10753-023-01861-y

PMCID:: PMC10777441

Abstract Article PDF–3.2M

Select item 103228733.

The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells

Thaddeus J. Kunkel, Alice Townsend, Kyle A. Sullivan, Jean Merlet, Edward H. Schuchman, Daniel A. Jacobson, Andrew P. Lieberman

Nat Commun. 2023; 14: 3964. Published online 2023 Jul 5. doi: 10.1038/s41467-023-39733-6

PMCID:: PMC10322873

Abstract Article PDF–9.1M

Select item 102598394.

Ultrasound-stimulated microbubbles enhanced vascular disruption in fractionated radiotherapy-treated tumours via ASMase activation

Kai Xuan Leong, Wenyi Yang, Deepa Sharma, Stanley Liu, Gregory J. Czarnota

Dis Model Mech. 2023 Jun 1; 16(6): dmm049531. Published online 2023 Jun 6. doi: 10.1242/dmm.049531

PMCID:: PMC10259839

Abstract Article

Select item 102534725.

Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency

Ángel Gaudioso, Pilar Moreno-Huguet, Josefina Casas, Edward H. Schuchman, María Dolores Ledesma

Int J Mol Sci. 2023 Jun; 24(11): 9756. Published online 2023 Jun 5. doi: 10.3390/ijms24119756

PMCID:: PMC10253472

Abstract Article PDF–8.0M

Select item 101469006.

ZFP750 affects the cutaneous barrier through regulating lipid metabolism

Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D’Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino

Sci Adv. 2023 Apr; 9(17): eadg5423. Published online 2023 Apr 28. doi: 10.1126/sciadv.adg5423

PMCID:: PMC10146900

Abstract Article PDF–2.3M

Select item 100799617.

Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency

Ángel Gaudioso, Xuntian Jiang, Josefina Casas, Edward H. Schuchman, María Dolores Ledesma

Cell Death Dis. 2023 Apr; 14(4): 248. Published online 2023 Apr 6. doi: 10.1038/s41419-023-05784-2

PMCID:: PMC10079961

Abstract Article PDF–9.6M

Select item 96996978.

Cell-intrinsic ceramides determine T cell function during melanoma progression

Matthias Hose, Anne Günther, Eyad Naser, Fabian Schumacher, Tina Schönberger, Julia Falkenstein, Athanasios Papadamakis, Burkhard Kleuser, Katrin Anne Becker, Erich Gulbins, Adriana Haimovitz-Friedman, Jan Buer, Astrid M Westendorf, Wiebke Hansen

eLife. 2022; 11: e83073. Published online 2022 Nov 25. doi: 10.7554/eLife.83073

PMCID:: PMC9699697

Abstract Article PDF–6.0M

Select item 96729209.

Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia

Xinxu Yuan, Owais M. Bhat, Yao Zou, Xiang Li, Yang Zhang, Pin-Lan Li

J Lipid Res. 2022 Dec; 63(12): 100298. Published online 2022 Oct 15. doi: 10.1016/j.jlr.2022.100298

PMCID:: PMC9672920

Abstract Article PDF–5.2M

Select item 924704610.

Caspase-7 activates ASM to repair gasdermin and perforin pores

Kengo Nozaki, Vivien I. Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, William T. Nash, Heather N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, Jason K. Whitmire, Edward A. Miao

Nature. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Nature. 2022 Jun; 606(7916): 960–967. Published online 2022 Jun 15. doi: 10.1038/s41586-022-04825-8

PMCID:: PMC9247046

Abstract Article PDF–9.4M

Select item 898512511.

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease

Tamara Marín, Andrés E. Dulcey, Fabián Campos, Catalina de la Fuente, Mariana Acuña, Juan Castro, Claudio Pinto, María José Yañez, Cristian Cortez, David W. McGrath, Pablo J. Sáez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugán, Alejandra R. Alvarez, Silvana Zanlungo

Front Cell Dev Biol. 2022; 10: 844297. Published online 2022 Mar 18. doi: 10.3389/fcell.2022.844297

PMCID:: PMC8985125

Abstract Article PDF–3.6M

Select item 880333212.

Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension

Paola Di Pietro, Albino Carrizzo, Eduardo Sommella, Marco Oliveti, Licia Iacoviello, Augusto Di Castelnuovo, Fausto Acernese, Antonio Damato, Massimiliano De Lucia, Fabrizio Merciai, Paola Iesu, Eleonora Venturini, Raffaele Izzo, Valentina Trimarco, Michele Ciccarelli, Giuseppe Giugliano, Roberto Carnevale, Vittoria Cammisotto, Serena Migliarino, Nicola Virtuoso, Andrea Strianese, Viviana Izzo, Pietro Campiglia, Elena Ciaglia, Bodo Levkau, Annibale A. Puca, Carmine Vecchione

J Clin Invest. 2022 Feb 1; 132(3): e146343. Published online 2022 Feb 1. doi: 10.1172/JCI146343

PMCID:: PMC8803332

Abstract Article PDF–1.6M

Select item 861636313.

Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype

Paulina Roux-Biejat, Marco Coazzoli, Pasquale Marrazzo, Silvia Zecchini, Ilaria Di Renzo, Cecilia Prata, Alessandra Napoli, Claudia Moscheni, Matteo Giovarelli, Maria Cristina Barbalace, Elisabetta Catalani, Maria Teresa Bassi, Clara De Palma, Davide Cervia, Marco Malaguti, Silvana Hrelia, Emilio Clementi, Cristiana Perrotta

Cells. 2021 Nov; 10(11): 3028. Published online 2021 Nov 5. doi: 10.3390/cells10113028

PMCID:: PMC8616363

Abstract Article PDF–4.8M

Select item 851128314.

Evidence for Ceramide induced Cytotoxicity in Retinal Ganglion Cells

Jie Fan, Jiali Liu, Jian Liu, Chunhe Chen, Yiannis Koutalos, Craig E Crosson

Exp Eye Res. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Exp Eye Res. 2021 Oct; 211: 108762. Published online 2021 Sep 7. doi: 10.1016/j.exer.2021.108762

PMCID:: PMC8511283

Abstract Article PDF–794K

Select item 819880215.

mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment

Cosima Rhein, Iulia Zoicas, Lena M. Marx, Stefanie Zeitler, Tobias Hepp, Claudia von Zimmermann, Christiane Mühle, Tanja Richter-Schmidinger, Bernd Lenz, Yesim Erim, Martin Reichel, Erich Gulbins, Johannes Kornhuber

Int J Mol Sci. 2021 Jun; 22(11): 5700. Published online 2021 May 27. doi: 10.3390/ijms22115700

PMCID:: PMC8198802

Abstract Article PDF–1.2M

Select item 812208016.

Contribution of Podocyte Inflammatory Exosome Release to Glomerular Inflammation and Sclerosis during Hyperhomocysteinemia

Dandan Huang, Guangbi Li, Qinghua Zhang, Owais M. Bhat, Yao Zou, Joseph K. Ritter, Pin-Lan Li

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Jul 1; 1867(7): 166146. Published online 2021 Apr 14. doi: 10.1016/j.bbadis.2021.166146

PMCID:: PMC8122080

Abstract Article PDF–2.1M

Select item 808604217.

Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency

Joanna M. Poczobutt, Andrew M. Mikosz, Christophe Poirier, Erica L. Beatman, Karina A. Serban, Fabienne Gally, Danting Cao, Alexandra L. McCubbrey, Christina F. Cornell, Kelly S. Schweitzer, Evgeny V. Berdyshev, Irina A. Bronova, François Paris, Irina Petrache

Am J Respir Cell Mol Biol. 2021 May; 64(5): 629–640. doi: 10.1165/rcmb.2020-0229OC

PMCID:: PMC8086042

Abstract Article PDF–1.5M

Select item 793877018.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 778790519.

Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo

Waheeda A Naimi, Jacob J Gumpf, Chelsea L Cockburn, Sarah Camus, Charles E Chalfant, Pin-Lan Li, Jason A Carlyon

Pathog Dis. 2021 Feb; 79(1): ftaa072. Published online 2020 Nov 21. doi: 10.1093/femspd/ftaa072

PMCID:: PMC7787905

Abstract Article PDF–1.0M

Select item 769311420.

Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D

Yuqing Wu, Cao Li, Huiming Peng, Ashraf Swaidan, Andrea Riehle, Barbara Pollmeier, Yang Zhang, Erich Gulbins, Heike Grassmé

Cells. 2020 Nov; 9(11): 2406. Published online 2020 Nov 3. doi: 10.3390/cells9112406

PMCID:: PMC7693114

Abstract Article PDF–3.7M

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