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Select item 112170001.

Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1

Peter Arner, Nathalie Viguerie, Lucas Massier, Mikael Rydén, Arne Astrup, Ellen Blaak, Dominique Langin, Daniel Peter Andersson

Int J Obes (Lond) 2024; 48(7): 934–940. Published online 2024 Mar 15. doi: 10.1038/s41366-024-01501-x

PMCID:: PMC11217000

Abstract Article PDF–975K

Select item 105658762.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 100914993.

Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice

Xihong Zhang, Sidhant Varma, Douglas Yee

Endocrinology. 2023 Mar; 164(3): bqac214. Published online 2023 Jan 4. doi: 10.1210/endocr/bqac214

PMCID:: PMC10091499

Abstract Article

Select item 99169654.

Overexpression of Insulin Receptor Substrate 1 (IRS1) Relates to Poor Prognosis and Promotes Proliferation, Stemness, Migration, and Oxidative Stress Resistance in Cholangiocarcinoma

Waleeporn Kaewlert, Chadamas Sakonsinsiri, Worachart Lert-itthiporn, Piti Ungarreevittaya, Chawalit Pairojkul, Somchai Pinlaor, Mariko Murata, Raynoo Thanan

Int J Mol Sci. 2023 Feb; 24(3): 2428. Published online 2023 Jan 26. doi: 10.3390/ijms24032428

PMCID:: PMC9916965

Abstract Article PDF–6.4M

Select item 97701505.

Blocking MG53^S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury

Fengxiang Lv, Yingfan Wang, Dan Shan, Sile Guo, Gengjia Chen, Li Jin, Wen Zheng, Han Feng, Xiaohu Zeng, Shuo Zhang, Yan Zhang, Xinli Hu, Rui-Ping Xiao

Circ Res. 2022 Dec 2; 131(12): 962–976. Published online 2022 Nov 7. doi: 10.1161/CIRCRESAHA.122.321055

PMCID:: PMC9770150

Abstract Article PDF–7.3M

Select item 94081346.

Insulin Receptor Substrate 1 Gly972Arg (rs1801278) Polymorphism Is Associated with Obesity and Insulin Resistance in Kashmiri Women with Polycystic Ovary Syndrome

Shayaq Ul Abeer Rasool, Mudasar Nabi, Sairish Ashraf, Shajrul Amin

Genes (Basel) 2022 Aug; 13(8): 1463. Published online 2022 Aug 17. doi: 10.3390/genes13081463

PMCID:: PMC9408134

Abstract Article PDF–765K

Select item 92792857.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92626148.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 90405569.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 900533210.

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

Danielle L. Swaney, Dana J. Ramms, Zhiyong Wang, Jisoo Park, Yusuke Goto, Margaret Soucheray, Neil Bhola, Kyumin Kim, Fan Zheng, Yan Zeng, Michael McGregor, Kari A. Herrington, Rachel O’Keefe, Nan Jin, Nathan K. VanLandingham, Helene Foussard, John Von Dollen, Mehdi Bouhaddou, David Jimenez-Morales, Kirsten Obernier, Jason F. Kreisberg, Minkyu Kim, Daniel E. Johnson, Natalia Jura, Jennifer R. Grandis, J. Silvio Gutkind, Trey Ideker, Nevan J. Krogan

Science. Author manuscript; available in PMC 2022 Apr 13.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf2911. Published online 2021 Oct 1. doi: 10.1126/science.abf2911

PMCID:: PMC9005332

Abstract Article PDF–2.0M

Select item 897367611.

Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761

Lingling Xu, Yinling Tan, Fengxia Xu, Yong Zhang

Bioengineered. 2022; 13(2): 2028–2043. Published online 2022 Jan 14. doi: 10.1080/21655979.2021.2019872

PMCID:: PMC8973676

Abstract Article PDF–4.6M

Select item 887529712.

CRL4^AMBRA1 is a master regulator of D-type cyclins

Daniele Simoneschi, Gergely Rona, Nan Zhou, Yeon-Tae Jeong, Shaowen Jiang, Giacomo Milletti, Arnaldo A. Arbini, Alfie O’Sullivan, Andrew A. Wang, Sorasicha Nithikasem, Sarah Keegan, Yik Siu, Valentina Cianfanelli, Emiliano Maiani, Francesca Nazio, Francesco Cecconi, Francesco Boccalatte, David Fenyö, Drew R. Jones, Luca Busino, Michele Pagano

Nature. Author manuscript; available in PMC 2022 Apr 14.

Published in final edited form as: Nature. 2021 Apr; 592(7856): 789–793. Published online 2021 Apr 14. doi: 10.1038/s41586-021-03445-y

PMCID:: PMC8875297

Abstract Article PDF–6.0M

Select item 884313813.

Insulin Receptor Substrate 1 Gene and Glucose Metabolism Characteristics in Type 2 Diabetes Mellitus with Comorbidities

Mariya Marushchak, Inna Krynytska

Ethiop J Health Sci. 2021 Sep; 31(5): 1001–1010. doi: 10.4314/ejhs.v31i5.12

PMCID:: PMC8843138

Abstract Article PDF–408K

Select item 870036914.

TGF-β Induction of miR-143/145 Is Associated to Exercise Response by Influencing Differentiation and Insulin Signaling Molecules in Human Skeletal Muscle

Simon I. Dreher, Selina Höckele, Peter Huypens, Martin Irmler, Christoph Hoffmann, Tim Jeske, Maximilian Hastreiter, Anja Moller, Andreas L. Birkenfeld, Hans-Ulrich Häring, Andreas Peter, Johannes Beckers, Martin Hrabě de Angelis, Cora Weigert

Cells. 2021 Dec; 10(12): 3443. Published online 2021 Dec 7. doi: 10.3390/cells10123443

PMCID:: PMC8700369

Abstract Article PDF–3.6M

Select item 846570015.

miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients

Diya Sun, Zuoyou Ding, Lei Shen, Fan Yang, Jun Han, Guohao Wu

Lipids Health Dis. 2021; 20: 115. Published online 2021 Sep 25. doi: 10.1186/s12944-021-01530-9

PMCID:: PMC8465700

Abstract Article PDF–2.6M

Select item 840424116.

The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans

Xianpeng Zhang, Liping Ye, Xin Li, Ying Chen, Yaqiong Jiang, Wenhui Li, Youfeng Wen

Mol Genet Genomic Med. 2021 Aug; 9(8): e1747. Published online 2021 Jul 24. doi: 10.1002/mgg3.1747

PMCID:: PMC8404241

Abstract Article PDF–1.2M

Select item 839673917.

Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians

Surya Prakash Bhatt, Randeep Guleria

PLoS One. 2021; 16(8): e0245408. Published online 2021 Aug 27. doi: 10.1371/journal.pone.0245408

PMCID:: PMC8396739

Abstract Article PDF–634K

Select item 819123618.

The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1

Wenjuan Yu, Ramesh Singh, Zhao Wang, Bert W. O’Malley, Ping Yi

J Biol Chem. 2021 Jan-Jun; 296: 100739. Published online 2021 May 13. doi: 10.1016/j.jbc.2021.100739

PMCID:: PMC8191236

Abstract Article PDF–1.5M

Select item 817410619.

miR-144-3p通过靶向调控IRS1抑制肺腺癌细胞的侵袭和转移

白俊, 胡雅琼, 陈新璐, 陈琳, 张丽萍, 尹崇高, 李洪利

Zhongguo Fei Ai Za Zhi. 2021 May 20; 24(5): 323–330. Chinese. doi: 10.3779/j.issn.1009-3419.2021.104.05

PMCID:: PMC8174106

Abstract Article PDF–8.6M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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