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Select item 114627551.

The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency

Mathew Sheridan, Muhammad Ahmad Maqbool, Anne Largeot, Liam Clayfield, Jingru Xu, Natalia Moncaut, Robert Sellers, Jessica Whittle, Jerome Paggetti, Mudassar Iqbal, Romain Aucagne, Laurent Delva, Syed Murtuza Baker, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud

J Hematol Oncol. 2024; 17: 91. Published online 2024 Oct 8. doi: 10.1186/s13045-024-01610-0

PMCID:: PMC11462755

Abstract Article PDF–6.8M

Select item 111005672.

KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3

Yongqing Liu, Minghua Fan, Junhua Yang, Ljubica Mihaljević, Kevin Hong Chen, Yingzhi Ye, Shuying Sun, Zhaozhu Qiu

Sci Adv. 2024 May 17; 10(20): eadm9326. Published online 2024 May 17. doi: 10.1126/sciadv.adm9326

PMCID:: PMC11100567

Abstract Article PDF–12M

Select item 95776243.

MOZ is critical for the development of MOZ/MLL fusion–induced leukemia through regulation of Hoxa9/Meis1 expression

Takuo Katsumoto, Yoko Ogawara, Kazutsune Yamagata, Yukiko Aikawa, Ryo Goitsuka, Takuro Nakamura, Issay Kitabayashi

Blood Adv. 2022 Oct 11; 6(19): 5527–5537. Published online 2022 Aug 12. doi: 10.1182/bloodadvances.2020003490

PMCID:: PMC9577624

Abstract Article PDF–483K

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 61138905.

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1

Gina E. Elsen, Francesco Bedogni, Rebecca D. Hodge, Theo K. Bammler, James W. MacDonald, Susan Lindtner, John L. R. Rubenstein, Robert F. Hevner

Front Neurosci. 2018; 12: 571. Published online 2018 Aug 22. doi: 10.3389/fnins.2018.00571

PMCID:: PMC6113890

Abstract Article PDF–4.8M

Select item 57990236.

Chemical cross-linking mass spectrometry analysis of protein conformations and supercomplexes in heart tissue

Juan D. Chavez, Chi Fung Lee, Arianne Caudal, Andrew Keller, Rong Tian, James E. Bruce

Cell Syst. Author manuscript; available in PMC 2019 Jan 24.

Published in final edited form as: Cell Syst. 2018 Jan 24; 6(1): 136–141.e5. Published online 2017 Nov 29. doi: 10.1016/j.cels.2017.10.017

PMCID:: PMC5799023

Abstract Article PDF–730K

Select item 48194477.

Expression of the MOZ-TIF2 oncoprotein in mice represses senescence

Anne Largeot, Flor Maria Perez-Campo, Elli Marinopoulou, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud

Exp Hematol. 2016 Apr; 44(4): 231–237.e4. doi: 10.1016/j.exphem.2015.12.006

PMCID:: PMC4819447

Abstract Article

Select item 44408878.

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

Bilal N. Sheikh, Stanley C. W. Lee, Farrah El-Saafin, Hannah K. Vanyai, Yifang Hu, Swee Heng Milon Pang, Stephanie Grabow, Andreas Strasser, Stephen L. Nutt, Warren S. Alexander, Gordon K. Smyth, Anne K. Voss, Tim Thomas

Blood. 2015 Mar 19; 125(12): 1910–1921. Prepublished online 2015 Jan 20. doi: 10.1182/blood-2014-08-594655

PMCID:: PMC4440887

Abstract Article

Select item 44188519.

MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo

Bilal N. Sheikh, Natalie L. Downer, Belinda Phipson, Hannah K. Vanyai, Andrew J. Kueh, Davis J. McCarthy, Gordon K. Smyth, Tim Thomas, Anne K. Voss

Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17): 5437–5442. Published online 2015 Apr 14. doi: 10.1073/pnas.1422872112

PMCID:: PMC4418851

Abstract Article PDF–1.2M

Select item 441684010.

The Chromatin Regulator Brpf1 Regulates Embryo Development and Cell Proliferation

Linya You, Kezhi Yan, Jinfeng Zou, Hong Zhao, Nicholas R. Bertos, Morag Park, Edwin Wang, Xiang-Jiao Yang

J Biol Chem. 2015 May 1; 290(18): 11349–11364. Published online 2015 Mar 15. doi: 10.1074/jbc.M115.643189

PMCID:: PMC4416840

Abstract Article PDF–7.8M

Select item 435558711.

The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

Linya You, Kezhi Yan, Jinfeng Zhou, Hong Zhao, Nicholas R. Bertos, Morag Park, Edwin Wang, Xiang-Jiao Yang

PLoS Genet. 2015 Mar; 11(3): e1005034. Published online 2015 Mar 10. doi: 10.1371/journal.pgen.1005034

Correction in:: PLoS Genet. 2015 Jun; 11(6): e1005329.

PMCID:: PMC4355587

Abstract Article PDF–4.2M

Select item 423713512.

MOZ-Mediated Repression of p16^INK⁴^a Is Critical for the Self-Renewal of Neural and Hematopoietic Stem Cells

Flor M Perez-Campo, Guilherme Costa, Michael Lie-a-Ling, Stefano Stifani, Valerie Kouskoff, Georges Lacaud

Stem Cells. 2014 Jun; 32(6): 1591–1601. Published online 2014 May 23. doi: 10.1002/stem.1606

PMCID:: PMC4237135

Abstract Article PDF–6.9M

Select item 408445513.

Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ

Kim L. Good-Jacobson, Yunshun Chen, Anne K. Voss, Gordon K. Smyth, Tim Thomas, David Tarlinton

Proc Natl Acad Sci U S A. 2014 Jul 1; 111(26): 9585–9590. Published online 2014 Jun 16. doi: 10.1073/pnas.1402485111

PMCID:: PMC4084455

Abstract Article PDF–972K

Select item 406518414.

Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos

Linya You, Lulu Chen, Janice Penney, Dengshun Miao, Xiang-Jiao Yang

Epigenetics. 2014 Jun 1; 9(6): 860–872. Published online 2014 Mar 19. doi: 10.4161/epi.28530

PMCID:: PMC4065184

Abstract Article PDF–3.4M

Select item 391064715.

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

Matthieu Giraud, Nada Jmari, Lina Du, Floriane Carallis, Thomas J. F. Nieland, Flor M. Perez-Campo, Olivier Bensaude, David E. Root, Nir Hacohen, Diane Mathis, Christophe Benoist

Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4): 1491–1496. Published online 2014 Jan 16. doi: 10.1073/pnas.1323535111

PMCID:: PMC3910647

Abstract Article PDF–1.2M

Select item 357241016.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 344218017.

MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome

Anne K. Voss, Hannah K. Vanyai, Caitlin Collin, Mathew P. Dixon, Tamara J. McLennan, Bilal N. Sheikh, Peter Scambler, Tim Thomas

Dev Cell. 2012 Sep 11; 23(3): 652–663. doi: 10.1016/j.devcel.2012.07.010

PMCID:: PMC3442180

Abstract Article

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 312173519.

Deterministic and Stochastic Allele Specific Gene Expression in Single Mouse Blastomeres

Fuchou Tang, Catalin Barbacioru, Ellen Nordman, Siqin Bao, Caroline Lee, Xiaohui Wang, Brian B. Tuch, Edith Heard, Kaiqin Lao, M. Azim Surani

PLoS One. 2011; 6(6): e21208. Published online 2011 Jun 23. doi: 10.1371/journal.pone.0021208

PMCID:: PMC3121735

Abstract Article PDF–1.0M

Select item 303987020.

PU.1-mediated upregulation of M-CSFR is critical for MOZ-leukemia stem cell potential

Yukiko Aikawa, Takuo Katsumoto, Pu Zhang, Haruko Shima, Mika Shino, Kiminori Terui, Etsuro Ito, Hiroaki Ohno, E. Richard Stanley, Harinder Singh, Daniel G Tenen, Issay Kitabayashi

Nat Med. Author manuscript; available in PMC 2011 Feb 16.

Published in final edited form as: Nat Med. 2010 May; 16(5): 580–585. Published online 2010 Apr 25. doi: 10.1038/nm.2122

PMCID:: PMC3039870

Abstract Article PDF–1.2M

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