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Select item 106976621.

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology

Juan A. Gerez, Natalia C. Prymaczok, Edward Rockenstein, Uli S. Herrmann, Petra Schwarz, Anthony Adame, Radoslav I. Enchev, Thibault Courtheoux, Paul J. Boersema, Roland Riek, Matthias Peter, Adriano Aguzzi, Eliezer Masliah, Paola Picotti

Sci Transl Med. Author manuscript; available in PMC 2023 Dec 5.

Published in final edited form as: Sci Transl Med. 2019 Jun 5; 11(495): eaau6722. doi: 10.1126/scitranslmed.aau6722

PMCID:: PMC10697662

Abstract Article PDF–2.4M

Select item 100927552.

Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol-related liver disease by restoring p62-mediated mitophagy

Ruibing Li, Zhe Dai, Xiaoman Liu, Chunling Wang, Jia Huang, Ting Xin, Ying Tong, Yijin Wang

Int J Biol Sci. 2023; 19(6): 1831–1845. Published online 2023 Mar 21. doi: 10.7150/ijbs.81447

PMCID:: PMC10092755

Abstract Article PDF–10M

Select item 88329733.

Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization

Cheng Chen, Lijie Gu, David J. Matye, Yung-Dai Clayton, Mohammad Nazmul Hasan, Yifeng Wang, Jacob E. Friedman, Tiangang Li

Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2111737119. Published online 2022 Feb 3. doi: 10.1073/pnas.2111737119

PMCID:: PMC8832973

Abstract Article PDF–2.2M

Select item 83132394.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82993985.

The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

Marvin Wirianto, Jiah Yang, Eunju Kim, Song Gao, Keshav Raj Paudel, Jong Min Choi, Jeehwan Choe, Gabrielle F. Gloston, Precious Ademoji, Randika Parakramaweera, Jianping Jin, Karyn A. Esser, Sung Yun Jung, Yong-Jian Geng, Hyun Kyoung Lee, Zheng Chen, Seung-Hee Yoo

Cell Rep. Author manuscript; available in PMC 2021 Jul 23.

Published in final edited form as: Cell Rep. 2020 Sep 15; 32(11): 108140. doi: 10.1016/j.celrep.2020.108140

PMCID:: PMC8299398

Abstract Article PDF–2.3M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 75849167.

Neddylation is critical to cortical development by regulating Wnt/β-catenin signaling

Lei Zhang, Hongyang Jing, Haiwen Li, Wenbing Chen, Bin Luo, Hongsheng Zhang, Zhaoqi Dong, Lei Li, Huabo Su, Wen-Cheng Xiong, Lin Mei

Proc Natl Acad Sci U S A. 2020 Oct 20; 117(42): 26448–26459. Published online 2020 Oct 5. doi: 10.1073/pnas.2005395117

PMCID:: PMC7584916

Abstract Article PDF–3.2M

Select item 73684948.

The sperm associated antigen 6 interactome and its role in spermatogenesis

Yunhao Liu, Ling Zhang, Wei Li, Yuhong Li, Junpin Liu, Shiyang Zhang, Guanglun Pin, Shizhen Song, Pierre F Ray, Christophe Arnoult, Chunghee Cho, Balbina Garcia-Reyes, Uwe Knippschild, Jerome F. Strauss, III, Zhibing Zhang

Reproduction. Author manuscript; available in PMC 2020 Jul 18.

Published in final edited form as: Reproduction. 2019 Aug; 158(2): 181–197. doi: 10.1530/REP-18-0522

PMCID:: PMC7368494

Abstract Article PDF–1.8M

Select item 70961619.

SKP1 drives the prophase I to metaphase I transition during male meiosis

Yongjuan Guan, N. Adrian Leu, Jun Ma, Lukáš Chmátal, Gordon Ruthel, Jordana C. Bloom, Michael A. Lampson, John C. Schimenti, Mengcheng Luo, P. Jeremy Wang

Sci Adv. 2020 Mar; 6(13): eaaz2129. Published online 2020 Mar 25. doi: 10.1126/sciadv.aaz2129

PMCID:: PMC7096161

Abstract Article PDF–3.1M

Select item 634668510.

Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells

Farzad Asadi, Savita Dhanvantari

Front Endocrinol (Lausanne) 2018; 9: 792. Published online 2019 Jan 18. doi: 10.3389/fendo.2018.00792

PMCID:: PMC6346685

Abstract Article PDF–3.6M

Select item 590077411.

Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCF^Fbxw7 in a manner dependent on the kinase GSK-3

Shogo Nakayama, Kanae Yumimoto, Atsuki Kawamura, Keiichi I. Nakayama

J Biol Chem. 2018 Apr 13; 293(15): 5705–5714. Published online 2018 Feb 22. doi: 10.1074/jbc.RA117.000741

PMCID:: PMC5900774

Abstract Article PDF–1.6M

Select item 587178012.

Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice

Buqing Ye, Benyu Liu, Lu Hao, Xiaoxiao Zhu, Liuliu Yang, Shuo Wang, Pengyan Xia, Ying Du, Shu Meng, Guanling Huang, Xiwen Qin, Yanying Wang, Xinlong Yan, Chong Li, Junfeng Hao, Pingping Zhu, Luyun He, Yong Tian, Zusen Fan

Nat Commun. 2018; 9: 1261. Published online 2018 Mar 28. doi: 10.1038/s41467-018-03008-2

PMCID:: PMC5871780

Abstract Article PDF–4.7M

Select item 556842813.

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

Hi-Jai R. Shin, Hyunkyung Kim, Sungryong Oh, Jun-Gi Lee, Minjung Kee, Hyun-Jeong Ko, Mi-Na Kweon, Kyoung-Jae Won, Sung Hee Baek

Nature. Author manuscript; available in PMC 2017 Aug 23.

Published in final edited form as: Nature. 2016 Jun 23; 534(7608): 553–557. Published online 2016 Jun 15. doi: 10.1038/nature18014

PMCID:: PMC5568428

Abstract Article PDF–5.2M

Select item 509495114.

Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation

Mengmeng Cheng, Shurong Hu, Zhengting Wang, Yaofei Pei, Rong Fan, Xiqiang Liu, Lei Wang, Jie Zhou, Sichang Zheng, Tianyu Zhang, Yun Lin, Maochen Zhang, Ran Tao, Jie Zhong

Oncotarget. 2016 Jun 14; 7(24): 35643–35654. Published online 2016 May 21. doi: 10.18632/oncotarget.9543

Correction in:: Oncotarget. 2018 Dec 18; 9(99): 37343.

PMCID:: PMC5094951

Abstract Article PDF–4.5M

Select item 488721115.

Lys29-linkage of ASK1 by Skp1−Cullin 1−Fbxo21 ubiquitin ligase complex is required for antiviral innate response

Zhou Yu, Taoyong Chen, Xuelian Li, Mingjin Yang, Songqing Tang, Xuhui Zhu, Yan Gu, Xiaoping Su, Meng Xia, Weihua Li, Xuemin Zhang, Qingqing Wang, Xuetao Cao, Jianli Wang

eLife. 2016; 5: e14087. Published online 2016 Apr 11. doi: 10.7554/eLife.14087

PMCID:: PMC4887211

Abstract Article PDF–5.1M

Select item 472832216.

Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung

Hilda Tateossian, Susan Morse, Michelle M. Simon, Charlotte H. Dean, Steve D. M. Brown

Dis Model Mech. 2015 Dec 1; 8(12): 1531–1542. doi: 10.1242/dmm.022426

PMCID:: PMC4728322

Abstract Article

Select item 462657317.

Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

Ryan M McCormack, Kirill Lyapichev, Melissa L Olsson, Eckhard R Podack, George P Munson

eLife. 2015; 4: e06505. Published online 2015 Sep 29. doi: 10.7554/eLife.06505

PMCID:: PMC4626573

Abstract Article PDF–4.5M

Select item 440034718.

Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7: INVOLVEMENT OF CYCLIN B-CYCLIN-DEPENDENT KINASE 1-MEDIATED PHOSPHORYLATION OF THR¹⁷⁶ IN GATA-BINDING PROTEIN 2

Tomomi Nakajima, Kyoko Kitagawa, Tatsuya Ohhata, Satoshi Sakai, Chiharu Uchida, Kiyoshi Shibata, Naoko Minegishi, Kanae Yumimoto, Keiichi I. Nakayama, Kazuma Masumoto, Fuminori Katou, Hiroyuki Niida, Masatoshi Kitagawa

J Biol Chem. 2015 Apr 17; 290(16): 10368–10381. Published online 2015 Feb 10. doi: 10.1074/jbc.M114.613018

PMCID:: PMC4400347

Abstract Article PDF–2.2M

Select item 407349419.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 394590820.

F-box Protein FBXL16 Binds PP2A-B55α and Regulates Differentiation of Embryonic Stem Cells along the FLK1+ Lineage

Narimon Honarpour, Christopher M. Rose, Justin Brumbaugh, Jody Anderson, Robert L. J. Graham, Michael J. Sweredoski, Sonja Hess, Joshua J. Coon, Raymond J. Deshaies

Mol Cell Proteomics. 2014 Mar; 13(3): 780–791. Published online 2014 Jan 5. doi: 10.1074/mcp.M113.031765

PMCID:: PMC3945908

Abstract Article PDF–995K

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