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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109107972.

LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion

YaJing Liu, Fei Liu, YiKe Li, YueLing Li, YuHeng Feng, JiaShuo Zhao, Cheng Zhou, ChunJie Li, JieFei Shen, YanYan Zhang

J Headache Pain. 2024; 25(1): 28. Published online 2024 Mar 4. doi: 10.1186/s10194-024-01733-2

PMCID:: PMC10910797

Abstract Article PDF–9.1M

Select item 107699153.

Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease

Pranay Srivastava, Shuhei Nishiyama, Fang Zhou, Sonia H. Lin, Akriti Srivastava, Chienwen Su, Yuehang Xu, Weiyi Peng, Michael Levy, Michael Schwarzschild, Xiqun Chen

J Neuroimmune Pharmacol. 2023; 18(4): 704–717. Published online 2023 Dec 19. doi: 10.1007/s11481-023-10094-7

PMCID:: PMC10769915

Abstract Article PDF–1.6M

Select item 104317204.

Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy

Xuejing Guan, Bohan Chen, Deepak K. Malhotra, Amira F. Gohara, Lance D. Dworkin, Rujun Gong

Kidney Int. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Kidney Int. 2023 Feb; 103(2): 331–342. Published online 2022 Oct 28. doi: 10.1016/j.kint.2022.09.025

PMCID:: PMC10431720

Abstract Article PDF–2.8M

Select item 89080495.

The Neuropeptide Alpha-Melanocyte–Stimulating Hormone Is Critical for Corneal Endothelial Cell Protection and Graft Survival after Transplantation

Zala Lužnik Marzidovšek, Tomas Blanco, Zhongmou Sun, Hamid Alemi, Gustavo Ortiz, Hayate Nakagawa, Sunil K. Chauhan, Andrew W. Taylor, Ula V. Jurkunas, Jia Yin, Reza Dana

Am J Pathol. 2022 Feb; 192(2): 270–280. doi: 10.1016/j.ajpath.2021.10.016

PMCID:: PMC8908049

Abstract Article PDF–1.5M

Select item 88678466.

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen

Mol Neurodegener. 2022; 17: 16. Published online 2022 Feb 23. doi: 10.1186/s13024-022-00520-4

PMCID:: PMC8867846

Abstract Article PDF–4.3M

Select item 86401777.

Melanocortin 1 Receptor Deficiency in Hematopoietic Cells Promotes the Expansion of Inflammatory Leukocytes in Atherosclerotic Mice

James J. Kadiri, Sina Tadayon, Keshav Thapa, Anni Suominen, Maija Hollmén, Petteri Rinne

Front Immunol. 2021; 12: 774013. Published online 2021 Nov 19. doi: 10.3389/fimmu.2021.774013

PMCID:: PMC8640177

Abstract Article PDF–21M

Select item 76769698.

Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice

Siming Fu, Xu Luo, Xuan Wu, Tongyu Zhang, Linggui Gu, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie

Oxid Med Cell Longev. 2020; 2020: 8864100. Published online 2020 Nov 12. doi: 10.1155/2020/8864100

PMCID:: PMC7676969

Abstract Article PDF–2.5M

Select item 70053149.

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Trinidad Montero-Melendez, Ai Nagano, Claude Chelala, Andrew Filer, Christopher D. Buckley, Mauro Perretti

Nat Commun. 2020; 11: 745. Published online 2020 Feb 6. doi: 10.1038/s41467-020-14421-x

PMCID:: PMC7005314

Abstract Article PDF–5.5M

Select item 648633010.

miR-142 controls metabolic reprogramming that regulates dendritic cell activation

Yaping Sun, Katherine Oravecz-Wilson, Sydney Bridges, Richard McEachin, Julia Wu, Stephanie H. Kim, Austin Taylor, Cynthia Zajac, Hideaki Fujiwara, Daniel Christopher Peltier, Thomas Saunders, Pavan Reddy

J Clin Invest. 2019 May 1; 129(5): 2029–2042. Published online 2019 Apr 8. doi: 10.1172/JCI123839

PMCID:: PMC6486330

Abstract Article PDF–4.4M

Select item 644673211.

Widespread dynamic and pleiotropic expression of the melanocortin‐1‐receptor (MC1R) system is conserved across chick, mouse and human embryonic development

Anna C. Thomas, Pauline Heux, Chloe Santos, Wisenave Arulvasan, Nita Solanky, Magalie E. Carey, Dianne Gerrelli, Veronica A. Kinsler, Heather C. Etchevers

Birth Defects Res. 2018 Mar 15; 110(5): 443–455. Published online 2018 Jan 8. doi: 10.1002/bdr2.1183

PMCID:: PMC6446732

Abstract Article PDF–1.7M

Select item 608508312.

The Melanoma-Linked “Redhead” MC1R Influences Dopaminergic Neuron Survival

Xiqun Chen, Hongxiang Chen, Waijiao Cai, Michael Maguire, Bailiu Ya, Fuxing Zuo, Robert Logan, Hui Li, Katey Robinson, Charles R. Vanderburg, Yang Yu, Yinsheng Wang, David E. Fisher, Michael A. Schwarzschild

Ann Neurol. Author manuscript; available in PMC 2018 Aug 9.

Published in final edited form as: Ann Neurol. 2017 Mar; 81(3): 395–406. Published online 2017 Jan 23. doi: 10.1002/ana.24852

PMCID:: PMC6085083

Abstract Article PDF–1.2M

Select item 590281513.

Palmitoylation-dependent activation of MC1R prevents melanomagenesis

Shuyang Chen, Bo Zhu, Chengqian Yin, Wei Liu, Changpeng Han, Baoen Chen, Tongzheng Liu, Xin Li, Xiang Chen, Chunying Li, Limin Hu, Jun Zhou, Zhi-Xiang Xu, Xiumei Gao, Xu Wu, Colin R. Goding, Rutao Cui

Nature. Author manuscript; available in PMC 2018 Apr 17.

Published in final edited form as: Nature. 2017 Sep 21; 549(7672): 399–403. Published online 2017 Sep 6. doi: 10.1038/nature23887

PMCID:: PMC5902815

Abstract Article PDF–1.9M

Select item 577931914.

Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E^−/− Mice

Petteri Rinne, James J. Kadiri, Mauricio Velasco-Delgado, Salla Nuutinen, Miro Viitala, Maija Hollmén, Martina Rami, Eriika Savontaus, Sabine Steffens

Arterioscler Thromb Vasc Biol. 2018 Feb; 38(2): 313–323. Published online 2018 Jan 24. doi: 10.1161/ATVBAHA.117.310418

PMCID:: PMC5779319

Abstract Article PDF–2.3M

Select item 554992115.

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin

Nisma Mujahid, Yanke Liang, Ryo Murakami, Hwan Geun Choi, Allison S. Dobry, Jinhua Wang, Yusuke Suita, Qing Yu Weng, Jennifer Allouche, Lajos V. Kemeny, Andrea L. Hermann, Elisabeth M. Roider, Nathanael S. Gray, David E. Fisher

Cell Rep. Author manuscript; available in PMC 2017 Aug 9.

Published in final edited form as: Cell Rep. 2017 Jun 13; 19(11): 2177–2184. doi: 10.1016/j.celrep.2017.05.042

PMCID:: PMC5549921

Abstract Article PDF–1.6M

Select item 551846116.

Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages

Petteri Rinne, Martina Rami, Salla Nuutinen, Donato Santovito, Emiel P.C. van der Vorst, Raquel Guillamat-Prats, Leo-Pekka Lyytikäinen, Emma Raitoharju, Niku Oksala, Larisa Ring, Minying Cai, Victor J. Hruby, Terho Lehtimäki, Christian Weber, Sabine Steffens

Circulation. Author manuscript; available in PMC 2018 Jul 4.

Published in final edited form as: Circulation. 2017 Jul 4; 136(1): 83–97. Published online 2017 Apr 27. doi: 10.1161/CIRCULATIONAHA.116.025889

PMCID:: PMC5518461

Abstract Article PDF–1.2M

Select item 539103217.

EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling

Makoto Takeo, Wendy Lee, Piul Rabbani, Qi Sun, Hai Hu, Chae Ho Lim, Prashiela Manga, Mayumi Ito

Cell Rep. Author manuscript; available in PMC 2017 Apr 13.

Published in final edited form as: Cell Rep. 2016 May 10; 15(6): 1291–1302. Published online 2016 Apr 28. doi: 10.1016/j.celrep.2016.04.006

PMCID:: PMC5391032

Abstract Article PDF–2.2M

Select item 512509918.

In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin

Hequn Wang, Sam Osseiran, Vivien Igras, Alexander J. Nichols, Elisabeth M. Roider, Joachim Pruessner, Hensin Tsao, David E. Fisher, Conor L. Evans

Sci Rep. 2016; 6: 37986. Published online 2016 Nov 28. doi: 10.1038/srep37986

PMCID:: PMC5125099

Abstract Article PDF–1.6M

Select item 504200419.

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

Anja E. Eisenhardt, Adrian Sprenger, Michael Röring, Ricarda Herr, Florian Weinberg, Martin Köhler, Sandra Braun, Joachim Orth, Britta Diedrich, Ulrike Lanner, Natalja Tscherwinski, Simon Schuster, Nicolas Dumaz, Enrico Schmidt, Ralf Baumeister, Andreas Schlosser, Jörn Dengjel, Tilman Brummer

Oncotarget. 2016 May 3; 7(18): 26628–26652. Published online 2016 Mar 28. doi: 10.18632/oncotarget.8427

PMCID:: PMC5042004

Abstract Article PDF–7.5M

Select item 504198320.

Inhibition of melanocortin 1 receptor slows melanoma growth, reduces tumor heterogeneity and increases survival

Rita G. Kansal, Matthew S. McCravy, Jacob H. Basham, Joshua A. Earl, Stacy L. McMurray, Chelsey J. Starner, Michael A. Whitt, Lorraine M. Albritton

Oncotarget. 2016 May 3; 7(18): 26331–26345. Published online 2016 Mar 25. doi: 10.18632/oncotarget.8372

PMCID:: PMC5041983

Abstract Article PDF–4.5M

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