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Select item 112544871.

Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model

Eri Adachi, Maki Murakoshi, Terumi Shibata, Kenta Shimozawa, Hiroko Sakuma, Chiaki Kishida, Tomohito Gohda, Yusuke Suzuki

Exp Anim. 2024; 73(3): 293–301. Published online 2024 Feb 16. doi: 10.1538/expanim.23-0080

PMCID:: PMC11254487

Abstract Article PDF–5.1M

Select item 110558602.

Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer

Meirion Raymant, Yuliana Astuti, Laura Alvaro-Espinosa, Daniel Green, Valeria Quaranta, Gaia Bellomo, Mark Glenn, Vatshala Chandran-Gorner, Daniel H. Palmer, Christopher Halloran, Paula Ghaneh, Neil C. Henderson, Jennifer P. Morton, Manuel Valiente, Ainhoa Mielgo, Michael C. Schmid

Nat Commun. 2024; 15: 3593. Published online 2024 Apr 27. doi: 10.1038/s41467-024-47949-3

PMCID:: PMC11055860

Abstract Article PDF–5.6M

Select item 109488793.

PhagoStat a scalable and interpretable end to end framework for efficient quantification of cell phagocytosis in neurodegenerative disease studies

Mehdi Ounissi, Morwena Latouche, Daniel Racoceanu

Sci Rep. 2024; 14: 6482. Published online 2024 Mar 18. doi: 10.1038/s41598-024-56081-7

PMCID:: PMC10948879

Abstract Article PDF–18M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108733395.

Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase

Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Hongping Ye, Xianlin Han, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie, Stephen M. Strittmatter

Nat Commun. 2024; 15: 1434. Published online 2024 Feb 16. doi: 10.1038/s41467-024-45692-3

PMCID:: PMC10873339

Abstract Article PDF–7.7M

Select item 107003506.

Increased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia

Kevin E. McElhanon, Tyler C. Huff, Dinesh Hirenallur-Shanthappa, Russell A. Miller, Nicolas Christoforou

Sci Rep. 2023; 13: 21541. Published online 2023 Dec 6. doi: 10.1038/s41598-023-47311-5

PMCID:: PMC10700350

Abstract Article PDF–1.4M

Select item 106829547.

Regulation of extracellular progranulin in medial prefrontal cortex

Azariah K. Kaplelach, Stephanie N. Fox, Anna K. Cook, Justin A. Hall, Ryan S. Dannemiller, Karen L. Jaunarajs, Andrew E. Arrant

Neurobiol Dis. Author manuscript; available in PMC 2023 Nov 28.

Published in final edited form as: Neurobiol Dis. 2023 Nov; 188: 106326. Published online 2023 Oct 12. doi: 10.1016/j.nbd.2023.106326

PMCID:: PMC10682954

Abstract Article PDF–2.2M

Select item 106553568.

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward, Ling Hao

Mol Neurodegener. 2023; 18: 87. Published online 2023 Nov 16. doi: 10.1186/s13024-023-00673-w

Correction in:: Mol Neurodegener. 2023; 18: 96.

PMCID:: PMC10655356

Abstract Article PDF–12M

Select item 105512739.

Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction

Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara

FASEB Bioadv. 2023 Oct; 5(10): 395–411. Published online 2023 Sep 20. doi: 10.1096/fba.2023-00084

PMCID:: PMC10551273

Abstract Article PDF–21M

Select item 1049292910.

Progranulin Maintains Blood Pressure and Vascular Tone Dependent on EphrinA2 and Sortilin1 Receptors and Endothelial Nitric Oxide Synthase Activation

Ariane Bruder‐Nascimento, Wanessa M. C. Awata, Juliano V. Alves, Shubhnita Singh, Rafael M. Costa, Thiago Bruder‐Nascimento

J Am Heart Assoc. 2023 Aug 15; 12(16): e030353. Published online 2023 Aug 10. doi: 10.1161/JAHA.123.030353

PMCID:: PMC10492929

Abstract Article PDF–5.7M

Select item 1037554211.

Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination

Tingting Zhang, Tuancheng Feng, Kenton Wu, Jennifer Guo, Alissa L. Nana, Guang Yang, William W. Seeley, Fenghua Hu

Acta Neuropathol. Author manuscript; available in PMC 2023 Jul 28.

Published in final edited form as: Acta Neuropathol. 2023 Jul; 146(1): 97–119. Published online 2023 Apr 30. doi: 10.1007/s00401-023-02578-w

PMCID:: PMC10375542

Abstract Article PDF–3.9M

Select item 1037182912.

AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b^−/−Grn^−/− mice

Tuancheng Feng, Gregory Minevich, Pengan Liu, Henry Xin Qin, Glenn Wozniak, Jenny Pham, Khanh Pham, Akshata Korgaonkar, Michael Kurnellas, Nadine A. Defranoux, Hua Long, Ananya Mitra, Fenghua Hu

iScience. 2023 Jul 21; 26(7): 107247. Published online 2023 Jun 28. doi: 10.1016/j.isci.2023.107247

PMCID:: PMC10371829

Abstract Article PDF–6.9M

Select item 1014842513.

Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations

Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant

Acta Neuropathol Commun. 2023; 11: 70. Published online 2023 Apr 28. doi: 10.1186/s40478-023-01571-4

PMCID:: PMC10148425

Abstract Article PDF–2.4M

Select item 1006382914.

Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice

Tingting Chen, Rubing Shi, Qian Suo, Shengju Wu, Chang Liu, Shuxian Huang, Khan Haroon, Ze Liu, Yuyan He, Heng-Li Tian, Yongting Wang, Yaohui Tang, Guo-Yuan Yang, Zhijun Zhang

J Cereb Blood Flow Metab. 2023 Apr; 43(4): 505–517. Published online 2022 Dec 14. doi: 10.1177/0271678X221145090

PMCID:: PMC10063829

Abstract Article PDF–24M

Select item 1001411015.

Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations

Elise Marsan, Dmitry Velmeshev, Arren Ramsey, Ravi K. Patel, Jiasheng Zhang, Mark Koontz, Madeline G. Andrews, Martina de Majo, Cristina Mora, Jessica Blumenfeld, Alissa N. Li, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Erik M. Ullian, Matthew F. Krummel, Arnold R. Kriegstein, Eric J. Huang

J Clin Invest. 2023 Mar 15; 133(6): e164919. Published online 2023 Mar 15. doi: 10.1172/JCI164919

PMCID:: PMC10014110

Abstract Article PDF–31M

Select item 991043916.

PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases

Xiangli Zhao, Yi Lin, Benjamin Liou, Wenyu Fu, Jinlong Jian, Venette Fannin, Wujuan Zhang, Kenneth D. R. Setchell, Gregory A. Grabowski, Ying Sun, Chuan-ju Liu

Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2210442120. Published online 2022 Dec 27. doi: 10.1073/pnas.2210442120

PMCID:: PMC9910439

Abstract Article PDF–6.4M

Select item 988126817.

Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration

Anne-Sophie Cabron, Uwe Borgmeyer, Julia Richter, Helga Peisker, Katharina Gutbrod, Peter Dörmann, Anja Capell, Markus Damme

Acta Neuropathol Commun. 2023; 11: 21. Published online 2023 Jan 27. doi: 10.1186/s40478-023-01510-3

PMCID:: PMC9881268

Abstract Article PDF–4.5M

Select item 981497118.

Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system

Madelyn C. Houser, Oihane Uriarte Huarte, Rebecca L. Wallings, Cody E. Keating, Kathryn P. MacPherson, Mary K. Herrick, George T. Kannarkat, Sean D. Kelly, Jianjun Chang, Nicholas H. Varvel, Jessica E. Rexach, Malú Gámez Tansey

Front Immunol. 2022; 13: 1056417. Published online 2022 Dec 22. doi: 10.3389/fimmu.2022.1056417

PMCID:: PMC9814971

Abstract Article PDF–2.5M

Select item 971543419.

DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis

Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa

Life Sci Alliance. 2021 Jul; 4(7): e202101022. Published online 2021 Jun 15. doi: 10.26508/lsa.202101022

PMCID:: PMC9715434

Abstract Article PDF–4.7M

Select item 957038820.

Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology

Yachao He, Xiaoqun Zhang, Ivana Flais, Per Svenningsson

Int J Mol Sci. 2022 Oct; 23(19): 12056. Published online 2022 Oct 10. doi: 10.3390/ijms231912056

PMCID:: PMC9570388

Abstract Article PDF–2.4M

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