PMC Links for GEO Profiles (Select 27105485) - PMC

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79622524.

The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex

Xin Wang, Wei Jiang, Shuo Luo, Xiaoyu Yang, Changnan Wang, Bingying Wang, Yongjun Dang, Yin Shen, Dengke K. Ma

Mol Brain. 2021; 14: 54. Published online 2021 Mar 16. doi: 10.1186/s13041-021-00767-w

PMCID:: PMC7962252

Abstract Article PDF–6.5M

Select item 73341975.

The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J. Karczewski, Laurent C. Francioli, Grace Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo Wang, Ryan L. Collins, Kristen M. Laricchia, Andrea Ganna, Daniel P. Birnbaum, Laura D. Gauthier, Harrison Brand, Matthew Solomonson, Nicholas A. Watts, Daniel Rhodes, Moriel Singer-Berk, Eleina M. England, Eleanor G. Seaby, Jack A. Kosmicki, Raymond K. Walters, Katherine Tashman, Yossi Farjoun, Eric Banks, Timothy Poterba, Arcturus Wang, Cotton Seed, Nicola Whiffin, Jessica X. Chong, Kaitlin E. Samocha, Emma Pierce-Hoffman, Zachary Zappala, Anne H. O’Donnell-Luria, Eric Vallabh Minikel, Ben Weisburd, Monkol Lek, James S. Ware, Christopher Vittal, Irina M. Armean, Louis Bergelson, Kristian Cibulskis, Kristen M. Connolly, Miguel Covarrubias, Stacey Donnelly, Steven Ferriera, Stacey Gabriel, Jeff Gentry, Namrata Gupta, Thibault Jeandet, Diane Kaplan, Christopher Llanwarne, Ruchi Munshi, Sam Novod, Nikelle Petrillo, David Roazen, Valentin Ruano-Rubio, Andrea Saltzman, Molly Schleicher, Jose Soto, Kathleen Tibbetts, Charlotte Tolonen, Gordon Wade, Michael E. Talkowski, Genome Aggregation Database Consortium, Benjamin M. Neale, Mark J. Daly, Daniel G. MacArthur

Nature. 2020; 581(7809): 434–443. Published online 2020 May 27. doi: 10.1038/s41586-020-2308-7

Correction in:: Nature. 2021; 590(7846): E53.

PMCID:: PMC7334197

Abstract Article PDF–3.1M

Select item 73067926.

Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes

Antonio Rausell, Yufei Luo, Marie Lopez, Yoann Seeleuthner, Franck Rapaport, Antoine Favier, Peter D. Stenson, David N. Cooper, Etienne Patin, Jean-Laurent Casanova, Lluis Quintana-Murci, Laurent Abel

Proc Natl Acad Sci U S A. 2020 Jun 16; 117(24): 13626–13636. Published online 2020 Jun 2. doi: 10.1073/pnas.1917993117

PMCID:: PMC7306792

Abstract Article PDF–1.0M

Select item 63638327.

Nicotine-N’-oxidation by flavin monooxygenase enzymes

Yadira X. Perez-Paramo, Gang Chen, Joseph H. Ashmore, Christy J. W. Watson, Shamema Nasrin, Jennifer Adams-Haduch, Renwei Wang, Yu-Tang Gao, Woon-Puay Koh, Jian-Min Yuan, Philip Lazarus

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2019 Feb; 28(2): 311–320. Published online 2018 Oct 31. doi: 10.1158/1055-9965.EPI-18-0669

PMCID:: PMC6363832

Abstract Article PDF–1.1M

Select item 56287998.

An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1

Ephrem Mekonnen, Endashaw Bekele

PLoS One. 2017; 12(10): e0184931. Published online 2017 Oct 5. doi: 10.1371/journal.pone.0184931

PMCID:: PMC5628799

Abstract Article PDF–1.6M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 411633210.

Mammalian Flavin-Containing Monooxygenase (FMO) as a Source of Hydrogen Peroxide

Lisbeth K. Siddens, Sharon K. Krueger, Marilyn C. Henderson, David E. Williams

Biochem Pharmacol. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Biochem Pharmacol. 2014 May 1; 89(1): 141–147. Published online 2014 Feb 19. doi: 10.1016/j.bcp.2014.02.006

PMCID:: PMC4116332

Abstract Article PDF–1.1M

Select item 329954811.

A systematic survey of loss-of-function variants in human protein-coding genes

Daniel G. MacArthur, Suganthi Balasubramanian, Adam Frankish, Ni Huang, James Morris, Klaudia Walter, Luke Jostins, Lukas Habegger, Joseph K. Pickrell, Stephen B. Montgomery, Cornelis A. Albers, Zhengdong Zhang, Donald F. Conrad, Gerton Lunter, Hancheng Zheng, Qasim Ayub, Mark A. DePristo, Eric Banks, Min Hu, Robert E. Handsaker, Jeffrey Rosenfeld, Menachem Fromer, Mike Jin, Xinmeng Jasmine Mu, Ekta Khurana, Kai Ye, Mike Kay, Gary Ian Saunders, Marie-Marthe Suner, Toby Hunt, If H.A. Barnes, Clara Amid, Denise R. Carvalho-Silva, Alexandra H Bignell, Catherine Snow, Bryndis Yngvadottir, Suzannah Bumpstead, David N. Cooper, Yali Xue, Irene Gallego Romero, 1000 Genomes Project Consortium, Jun Wang, Yingrui Li, Richard A. Gibbs, Steven A. McCarroll, Emmanouil T. Dermitzakis, Jonathan K. Pritchard, Jeffrey C. Barrett, Jennifer Harrow, Matthew E. Hurles, Mark B. Gerstein, Chris Tyler-Smith

Science. Author manuscript; available in PMC 2012 Aug 17.

Published in final edited form as: Science. 2012 Feb 17; 335(6070): 823–828. doi: 10.1126/science.1215040

Correction in:: volume 336 on page 296

PMCID:: PMC3299548

Abstract Article PDF–1.0M

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 295791813.

Evaluation of Candidate Genes for Cholinesterase Activity in Farmworkers Exposed to Organophosphorus Pesticides: Association of Single Nucleotide Polymorphisms in BCHE

Timothy D. Howard, Fang-Chi Hsu, Joseph G. Grzywacz, Haiying Chen, Sara A. Quandt, Quirina M. Vallejos, Lara E. Whalley, Wei Cui, Stephanie Padilla, Thomas A. Arcury

Environ Health Perspect. 2010 Oct; 118(10): 1395–1399. Published online 2010 Jun 8. doi: 10.1289/ehp.0901764

PMCID:: PMC2957918

Abstract Article PDF–1.5M

Select item 271244114.

Characterization of Sulfoxygenation and Structural Implications of Human Flavin-Containing Monooxygenase Isoform 2 (FMO2.1) Variants S195L and N413K

Sharon K. Krueger, Marilyn C. Henderson, Lisbeth K. Siddens, Jonathan E. VanDyke, Abby D. Benninghoff, P. Andrew Karplus, Bjarte Furnes, Daniel Schlenk, David E. Williams

Drug Metab Dispos. 2009 Aug; 37(8): 1785–1791. Published online 2009 May 6. doi: 10.1124/dmd.109.027201

PMCID:: PMC2712441

Abstract Article PDF–200K

Select item 268365815.

Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide

Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips, Elizabeth A. Shephard

Drug Metab Dispos. 2009 Jan; 37(1): 178–186. Published online 2008 Oct 23. doi: 10.1124/dmd.108.024158

PMCID:: PMC2683658

Abstract Article PDF–354K

Select item 266633216.

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa

Krishna R. Veeramah, Mark G. Thomas, Michael E. Weale, David Zeitlyn, Ayele Tarekegn, Endashaw Bekele, Nancy R. Mendell, Elizabeth A. Shephard, Neil Bradman, Ian R. Phillips

Pharmacogenet Genomics. Author manuscript; available in PMC 2009 Oct 1.

Published in final edited form as: Pharmacogenet Genomics. 2008 Oct; 18(10): 877–886. doi: 10.1097/FPC.0b013e3283097311

PMCID:: PMC2666332

Abstract Article PDF–469K

Select item 262625017.

Metabolism of the Anti-Tuberculosis Drug Ethionamide by Mouse and Human FMO1, FMO2 and FMO3 and Mouse and Human Lung Microsomes

Marilyn C. Henderson, Lisbeth K. Siddens, Jeffrey T. Morré, Sharon K. Krueger, David E. Williams

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2009 Dec 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2008 Dec 15; 233(3): 420–427. Published online 2008 Oct 1. doi: 10.1016/j.taap.2008.09.017

PMCID:: PMC2626250

Abstract Article PDF–267K

Select item 182860218.

Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism

Sharon K. Krueger, David E. Williams

Pharmacol Ther. Author manuscript; available in PMC 2007 Mar 19.

Published in final edited form as: Pharmacol Ther. 2005 Jun; 106(3): 357–387. doi: 10.1016/j.pharmthera.2005.01.001

PMCID:: PMC1828602

Abstract Article PDF–865K

Select item 135612919.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 135103920.

Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics

Sharon K. Krueger, Lisbeth K. Siddens, Marilyn C. Henderson, Eric A. Andreasen, Robert L. Tanguay, Clifford B. Pereira, Erwin T. Cabacungan, Ronald N. Hines, Kristin G. Ardlie, David E. Williams

Pharmacogenet Genomics. Author manuscript; available in PMC 2006 Jan 25.

Published in final edited form as: Pharmacogenet Genomics. 2005 Apr; 15(4): 245–256. doi: 10.1097/01213011-200504000-00008

PMCID:: PMC1351039

Abstract Article PDF–429K

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