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Select item 115781001.

Constitutional MLH1 Methylation Is a Major Contributor to Mismatch Repair–Deficient, MLH1-Methylated Colorectal Cancer in Patients Aged 55 Years and Younger

Megan P. Hitchins, Estela Dámaso, Rocio Alvarez, Lisa Zhou, Yajing Hu, Marcio A. Diniz, Marta Pineda, Gabriel Capella, Rachel Pearlman, Heather Hampel

J Natl Compr Canc Netw. Author manuscript; available in PMC 2024 Nov 20.

Published in final edited form as: J Natl Compr Canc Netw. 2023 Jul; 21(7): 743–752.e11. doi: 10.6004/jnccn.2023.7020

PMCID:: PMC11578100

Abstract Article PDF–1.4M

Select item 113159292.

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex

Marisa Bedir, Emily Outwin, Rita Colnaghi, Lydia Bassett, Iga Abramowicz, Mark O’Driscoll

EMBO Rep. 2024 Aug; 25(8): 3432–3455. Published online 2024 Jun 28. doi: 10.1038/s44319-024-00184-9

PMCID:: PMC11315929

Abstract Article PDF–3.4M

Select item 112969143.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112379304.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 112099355.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111786086.

Unmasking early colorectal cancer clues: in silico and in vitro investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G in SSA polyps

Seyedeh Nasim Mirbahari, Nayeralsadat Fatemi, Sanaz Savabkar, Vahid Chaleshi, Neda Zali, Mohammad Yaghoob Taleghani, Ebrahim Mirzaei, Leili Rejali, Pardis Ketabi Moghadam, Ehsan Nazemalhosseini Mojarad

Mol Biol Rep. 2024; 51(1): 764. Published online 2024 Jun 14. doi: 10.1007/s11033-024-09683-3

PMCID:: PMC11178608

Abstract Article PDF–2.9M

Select item 111598627.

Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC‐associated familial predisposition to cancer

Y. Hirai, K. Banno, M. Suzuki, Y. Ichikawa, Y. Udagawa, K. Sugano, Y. Miki

Cancer Sci. 2008 Sep; 99(9): 1715–1719. Published online 2008 Jul 9. doi: 10.1111/j.1349-7006.2008.00886.x

PMCID:: PMC11159862

Abstract Article PDF–128K

Select item 111598408.

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer

Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park

Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x

PMCID:: PMC11159840

Abstract Article PDF–209K

Select item 111593639.

Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: Clinical and prognostic significance

Amlan Ghosh, Susmita Ghosh, Guru Prasad Maiti, Mohammad Golam Sabbir, Eugene R. Zabarovsky, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda

Cancer Sci. 2010 Jun; 101(6): 1511–1520. Published online 2010 Mar 4. doi: 10.1111/j.1349-7006.2010.01551.x

PMCID:: PMC11159363

Abstract Article PDF–891K

Select item 1115825410.

Frequent alterations of hMLH1 and RBSP3/HYA22 at chromosomal 3p22.3 region in early and late‐onset breast carcinoma: clinical and prognostic significance

Satyabrata Sinha, Ratnesh K. Singh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda

Cancer Sci. 2008 Oct; 99(10): 1984–1991. Published online 2008 Oct 14. doi: 10.1111/j.1349-7006.2008.00952.x

PMCID:: PMC11158254

Abstract Article PDF–609K

Select item 1115502911.

TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner

Vincent E. Provasek, Manohar Kodavati, Brandon Kim, Joy Mitra, Muralidhar L. Hegde

Mol Brain. 2024; 17: 32. Published online 2024 Jun 5. doi: 10.1186/s13041-024-01108-3

PMCID:: PMC11155029

Abstract Article PDF–1.7M

Select item 1110961212.

Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention

Qu Yue, Zhao Wang, Yixiong Shen, Yufei Lan, Xiangyang Zhong, Xin Luo, Tao Yang, Manqing Zhang, Boming Zuo, Tianci Zeng, Jiankun Lu, Yuankai Wang, Boyang Liu, Hongbo Guo

Adv Sci (Weinh) 2024 May; 11(19): 2309290. Published online 2024 Mar 13. doi: 10.1002/advs.202309290

PMCID:: PMC11109612

Abstract Article PDF–15M

Select item 1110851913.

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases

Lorraine Springuel, Elisabeth Losdyck, Pascale Saussoy, Béatrice Turcq, François-Xavier Mahon, Laurent Knoops, Jean-Christophe Renauld

Cell Mol Life Sci. 2016 Dec; 73(24): 4739–4748. Published online 2016 Jul 19. doi: 10.1007/s00018-016-2310-2

PMCID:: PMC11108519

Abstract Article PDF–1.2M

Select item 1082424914.

Variable Expression of MSH6 in Endometrial Carcinomas with Intact Mismatch Repair and with MLH1 Loss due to MLH1 Methylation

Nidhi Tandon, Courtney Hudgens, Bryan Fellman, Michael T. Tetzlaff, Russell R. Broaddus

Int J Gynecol Pathol. Author manuscript; available in PMC 2024 Jan 29.

Published in final edited form as: Int J Gynecol Pathol. 2020 Nov; 39(6): 507–513. doi: 10.1097/PGP.0000000000000655

PMCID:: PMC10824249

Abstract Article PDF–1.8M

Select item 1080927115.

Rare single‐nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome

Seyed Mohsen Mirabdolhosseini, Mohammad Yaghoob Taleghani, Leili Rejali, Hossein Sadeghi, Nayeralsadat Fatemi, Mehdi Tavallaei, Amin Famil Meyari, Narges Saeidi, Pardis Ketabi Moghadam, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad

Cancer Rep (Hoboken) 2024 Jan; 7(1): e1930. Published online 2023 Nov 2. doi: 10.1002/cnr2.1930

PMCID:: PMC10809271

Abstract Article PDF–4.7M

Select item 1068521916.

MLH1 rs1800734 Pathogenic Variant among Patients with Colorectal Cancer in the Lower Northeastern Region of Thailand

Malinee Pongsavee, Kamol Wisuwan, Kritpipat Pongsavee

Asian Pac J Cancer Prev. 2023; 24(8): 2911–2916. doi: 10.31557/APJCP.2023.24.8.2911

PMCID:: PMC10685219

Abstract Article PDF–390K

Select item 1067094117.

MLH1 Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis

Ileana Wanda Carnevali, Giulia Cini, Laura Libera, Nora Sahnane, Sofia Facchi, Alessandra Viel, Fausto Sessa, Maria Grazia Tibiletti

Genes (Basel) 2023 Nov; 14(11): 2060. Published online 2023 Nov 9. doi: 10.3390/genes14112060

PMCID:: PMC10670941

Abstract Article PDF–1.5M

Select item 1051946918.

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study

Masanao Kaneko, Mitsuko Nakashima, Kiichi Sugiura, Natsuki Ishida, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Satoshi Osawa, Kyota Tatsuta, Kiyotaka Kurachi, Satoshi Baba, Yuji Iwashita, Tomio Arai, Haruhiko Sugimura, Masato Maekawa, Ken Sugimoto, Moriya Iwaizumi

Medicine (Baltimore) 2023 Sep 22; 102(38): e35022. Published online 2023 Sep 22. doi: 10.1097/MD.0000000000035022

PMCID:: PMC10519469

Abstract Article PDF–708K

Select item 1050888819.

Prevalence of Somatic MutL Homolog 1 Promoter Hypermethylation in Lynch Syndrome Colorectal Cancer

Leticia Moreira, Jenifer Muñoz, Míriam Cuatrecasas, Isabel Quintanilla, Maria Liz Leoz, Sabela Carballal, Teresa Ocaña, María López-Cerón, Maria Pellise, Sergi Castellví-Bel, Rodrigo Jover, Montserrat Andreu, Angel Carracedo, Rosa Maria Xicola, Xavier Llor, Clement Richard Boland, Ajay Goel, Antoni Castells, Francesc Balaguer, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association

Cancer. Author manuscript; available in PMC 2023 Sep 19.

Published in final edited form as: Cancer. 2015 May 1; 121(9): 1395–1404. Published online 2014 Dec 29. doi: 10.1002/cncr.29190

PMCID:: PMC10508888

Abstract Article PDF–418K

Select item 1039734420.

Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα

May-Britt Firnau, Guido Plotz, Stefan Zeuzem, Angela Brieger

Sci Rep. 2023; 13: 12503. Published online 2023 Aug 2. doi: 10.1038/s41598-023-39750-x

PMCID:: PMC10397344

Abstract Article PDF–1.7M

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