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Select item 110438501.

Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice

Irina L. Tourkova, Quitterie C. Larrouture, Silvia Liu, Jianhua Luo, Katherine E. Shipman, Kelechi M. Onwuka, Ora A. Weisz, Vladimir Riazanski, Deborah J. Nelson, Matthew L. MacDonald, Paul H. Schlesinger, Harry C. Blair

Bone Rep. 2024 Jun; 21: 101763. Published online 2024 Apr 16. doi: 10.1016/j.bonr.2024.101763

PMCID:: PMC11043850

Abstract Article PDF–14M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 89737013.

Angiotensin-(1-7) ameliorates high glucose-induced vascular endothelial injury through suppressing chloride channel 3

Fei Cheng, Jing Liu, Zhuolin Guo, Shicheng Li, Jingfu Chen, Chang Tu, Fengzhou Fu, Bai Shen, Xiaojie Zhang, Guohua Lai, Jun Lan

Bioengineered. 2022; 13(2): 4100–4111. Published online 2022 Feb 15. doi: 10.1080/21655979.2021.1997695

PMCID:: PMC8973701

Abstract Article PDF–2.9M

Select item 83872844.

Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders

Anna R. Duncan, Maya M. Polovitskaya, Héctor Gaitán-Peñas, Sara Bertelli, Grace E. VanNoy, Patricia E. Grant, Anne O’Donnell-Luria, Zaheer Valivullah, Alysia Kern Lovgren, Elaina M. England, Emanuele Agolini, Jill A. Madden, Klaus Schmitz-Abe, Amy Kritzer, Pamela Hawley, Antonio Novelli, Paolo Alfieri, Giovanna Stefania Colafati, Dagmar Wieczorek, Konrad Platzer, Johannes Luppe, Margarete Koch-Hogrebe, Rami Abou Jamra, Juanita Neira-Fresneda, Anna Lehman, Cornelius F. Boerkoel, Kimberly Seath, Lorne Clarke, CAUSES Study, Yvette van Ierland, Emanuela Argilli, Elliott H. Sherr, Andrea Maiorana, Thilo Diel, Maja Hempel, Tatjana Bierhals, Raúl Estévez, Thomas J. Jentsch, Michael Pusch, Pankaj B. Agrawal

Am J Hum Genet. 2021 Aug 5; 108(8): 1450–1465. Published online 2021 Jun 28. doi: 10.1016/j.ajhg.2021.06.003

PMCID:: PMC8387284

Abstract Article PDF–3.1M

Select item 83653735.

The role of voltage-gated chloride channels in the epileptogenesis of temporal lobe epilepsy

Kai-Feng Shen, Xiao-Lin Yang, Guo-Long Liu, Gang Zhu, Zhong-Ke Wang, Xian-Jun Shi, Ting-Ting Wang, Zhi-Feng Wu, Sheng-Qing Lv, Shi-Yong Liu, Hui Yang, Chun-Qing Zhang

EBioMedicine. 2021 Aug; 70: 103537. Published online 2021 Aug 11. doi: 10.1016/j.ebiom.2021.103537

PMCID:: PMC8365373

Abstract Article PDF–4.1M

Select item 72270286.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 71969187.

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration

Stefanie Weinert, Niclas Gimber, Dorothea Deuschel, Till Stuhlmann, Dmytro Puchkov, Zohreh Farsi, Carmen F Ludwig, Gaia Novarino, Karen I López‐Cayuqueo, Rosa Planells‐Cases, Thomas J Jentsch

EMBO J. 2020 May 4; 39(9): e103358. Published online 2020 Mar 2. doi: 10.15252/embj.2019103358

PMCID:: PMC7196918

Abstract Article PDF–4.9M

Select item 66713428.

Role of the Vesicular Chloride Transporter ClC-3 in Neuroendocrine Tissue

Tanja Maritzen, Damien J. Keating, Ioana Neagoe, Anselm A. Zdebik, Thomas J. Jentsch

J Neurosci. 2008 Oct 15; 28(42): 10587–10598. doi: 10.1523/JNEUROSCI.3750-08.2008

PMCID:: PMC6671342

Abstract Article PDF–665K

Select item 61254339.

Transcriptional repression of human epidermal growth factor receptor 2 by ClC‐3 Cl⁻/H⁺ transporter inhibition in human breast cancer cells

Mayu Fujimoto, Hiroaki Kito, Junko Kajikuri, Susumu Ohya

Cancer Sci. 2018 Sep; 109(9): 2781–2791. Published online 2018 Jul 28. doi: 10.1111/cas.13715

PMCID:: PMC6125433

Abstract Article PDF–1.3M

Select item 570448610.

Preferential association with ClC-3 permits sorting of ClC-4 into endosomal compartments

Raul E. Guzman, Stefanie Bungert-Plümke, Arne Franzen, Christoph Fahlke

J Biol Chem. 2017 Nov 17; 292(46): 19055–19065. Published online 2017 Sep 26. doi: 10.1074/jbc.M117.801951

PMCID:: PMC5704486

Abstract Article PDF–3.9M

Select item 540295211.

ClC-3 chloride channel mediates the role of parathyroid hormone [1-34] on osteogenic differentiation of osteoblasts

Xiaolin Lu, Yin Ding, Qiannan Niu, Shijie Xuan, Yan Yang, Yulong Jin, Huan Wang

PLoS One. 2017; 12(4): e0176196. Published online 2017 Apr 24. doi: 10.1371/journal.pone.0176196

PMCID:: PMC5402952

Abstract Article PDF–9.3M

Select item 492944012.

Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway

Nan-lin Xiang, Jun Liu, Yun-jian Liao, You-wei Huang, Zheng Wu, Zhi-quan Bai, Xi Lin, Jian-hua Zhang

Sci Rep. 2016; 6: 27583. Published online 2016 Jul 1. doi: 10.1038/srep27583

PMCID:: PMC4929440

Abstract Article PDF–1.3M

Select item 474635413.

ClC-3 Expression and Its Association with Hyperglycemia Induced HT22 Hippocampal Neuronal Cell Apoptosis

Feiyan Fan, Tao Liu, Xin Wang, Dongni Ren, Hui Liu, Pengxing Zhang, Zhen Wang, Nan Liu, Qian Li, Yanyang Tu, Jianfang Fu

J Diabetes Res. 2016; 2016: 2984380. Published online 2016 Jan 26. doi: 10.1155/2016/2984380

PMCID:: PMC4746354

Abstract Article PDF–2.3M

Select item 472842214.

Threonine532 phosphorylation in ClC‐3 channels is required for angiotensin II‐induced Cl⁻ current and migration in cultured vascular smooth muscle cells

Ming‐Ming Ma, Cai‐Xia Lin, Can‐Zhao Liu, Min Gao, Lu Sun, Yong‐Bo Tang, Jia‐Guo Zhou, Guan‐Lei Wang, Yong‐Yuan Guan

Br J Pharmacol. 2016 Feb; 173(3): 529–544. Published online 2016 Jan 15. doi: 10.1111/bph.13385

PMCID:: PMC4728422

Abstract Article PDF–2.2M

Select item 464624215.

Neuronal ClC-3 Splice Variants Differ in Subcellular Localizations, but Mediate Identical Transport Functions

Raul E. Guzman, Erick Miranda-Laferte, Arne Franzen, Christoph Fahlke

J Biol Chem. 2015 Oct 23; 290(43): 25851–25862. Published online 2015 Sep 4. doi: 10.1074/jbc.M115.668186

PMCID:: PMC4646242

Abstract Article PDF–4.9M

Select item 437073616.

Ion Channel Expression in the Developing Enteric Nervous System

Caroline S. Hirst, Jaime P. P. Foong, Lincon A. Stamp, Emily Fegan, Stephan Dent, Edward C. Cooper, Alan E. Lomax, Colin R. Anderson, Joel C. Bornstein, Heather M. Young, Sonja J. McKeown

PLoS One. 2015; 10(3): e0123436. Published online 2015 Mar 23. doi: 10.1371/journal.pone.0123436

PMCID:: PMC4370736

Abstract Article PDF–9.5M

Select item 408097117.

Integrin β3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl⁻ channel signalling pathway

Jia-Wei Zeng, Xiao-Guang Wang, Ming-Ming Ma, Xiao-Fei Lv, Jie Liu, Jia-Guo Zhou, Yong-Yuan Guan

Br J Pharmacol. 2014 Jul; 171(13): 3158–3170. Published online 2014 Jun 10. doi: 10.1111/bph.12654

PMCID:: PMC4080971

Abstract Article PDF–1.5M

Select item 404431418.

Increase in Hypotonic Stress-Induced Endocytic Activity in Macrophages via ClC-3

Yutao Yan, Yu Ding, Bingxia Ming, Wenjiao Du, Xiaoling Kong, Li Tian, Fang Zheng, Min Fang, Zheng Tan, Feili Gong

Mol Cells. 2014 May; 37(5): 418–425. Published online 2014 May 16. doi: 10.14348/molcells.2014.0031

PMCID:: PMC4044314

Abstract Article PDF–563K

Select item 396495519.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 381725220.

Regulation of cell proliferation by intermediate-conductance Ca²⁺-activated potassium and volume-sensitive chloride channels in mouse mesenchymal stem cells

Rong Tao, Chu-Pak Lau, Hung-Fat Tse, Gui-Rong Li

Am J Physiol Cell Physiol. 2008 Nov; 295(5): C1409–C1416. doi: 10.1152/ajpcell.00268.2008

PMCID:: PMC3817252

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